Abstract: The present invention relates to an imaging sensor system (26) having a high detection accuracy. The system (26) comprises a plurality of pixel sensors (1) and at least one light source. The pixel sensors (1) are grouped in clusters, wherein each pixel sensor (1) comprises a photodetector (2) and a local controlling circuit (18). The plurality of sensors (1) in each cluster are configured, using local controlling circuits (18), to output a global detection signal (15) when detecting a local detection signal (10) from at least two outputs of the photodetectors (2) of said cluster. The system (26) has a high detection accuracy due to ruling out false positive detections, since each detection requires at least two positive outputs of the photodetectors (2) of said cluster.

Abstract: A method for radiographic imaging of a body cavity includes imaging the body cavity using computerized tomography (CT) to form a CT image, registering a tracking system with the CT image, inserting into the body cavity a guidewire, including a position sensor, operating in the tracking system, attached to a distal end of the guidewire, in response to signals from the position sensor acquired by the tracking system, displaying a position of the distal end of the guidewire on the CT image. The method further includes assigning voxels within a predefined imaging volume relative to the distal end and having a radiodensity less than a predetermined threshold to have a uniform radiodensity of a predefined default value, incorporating the voxels with the assigned predefined default value into the CT image so as to form an updated CT image, and displaying the updated CT image.

Abstract: The present invention relates to a high-speed imaging sensor system in which single-photon detectors are provided in an architecture adapted for high-speed processing of the output of the detectors with high reliability to filter out false positives.

Abstract: A method for marking a workpiece (6) uses a device, wherein the workpiece (6) is formed at least partially in a thermal master or forming process, comprises a surface (10) directed towards the workpiece (6), wherein a number of individually controllable heating elements (2) is distributed behind the surface (10) for a local heating of a workpiece surface portion. Each of the heating elements (2) comprises a solid material (11) having a surface structure and a heating structure (3), wherein the surface (10) directed towards the workpiece (6) encompassing the surface structures (40) has a uniform smooth surface allowing to dark, burn or foam the surface (7) of the workpiece (6) through heat introduction.

Abstract: A method for marking a workpiece (6) uses a device, wherein the workpiece (6) is formed at least partially in a thermal master or forming process, comprises a surface (10) directed towards the workpiece (6), wherein a number of individually controllable heating elements (2) is distributed behind the surface (10) for a local heating of a workpiece surface portion. Each of the heating elements (2) comprises a solid material (11) having a surface structure and a heating structure (3), wherein the surface (10) directed towards the workpiece (6) encompassing the surface structures (40) has a uniform smooth surface allowing to dark, burn or foam the surface (7) of the workpiece (6) through heat introduction.

Abstract: Embodiments concern a high-precision, measurement device operative to measure the water content in media and/or water transport rate by media with high precision and with high dynamic range concerning the flow rate value. Based on a molecular transducer principle, captured water reacts with a reactant characterized by its ability to generate gas as a reaction product. By using an electro-chemical transducing element, an electric signal is generated in accordance with a stoichiometric volume of gas produced and water transferred, which is related to the flow rate of the circulating aqueous solution.

Abstract: A device for marking a work piece that is at least partially formed or reshaped through a thermal process is provided. The device includes a plurality of heating elements distributed laterally on a surface that is placed against the work piece and can be individually controlled for local heating of a work piece surface. Each of the heating elements includes a solid material with a surface structure and a heating structure. The surface structure includes at least one of a specifically or randomly varied topography. The surface structure can be at least partially heated through the heating structure.

Abstract: Systems, methods and apparatus are included that are configured to model microvascular obstruction (MVO) in patients. According to one aspect of the present disclosure, a multi-scale model is configured to mimic myocardial microcirculation of coronary vessels. The model includes collaterals configured to provide alternative pathways possibly bypassing the MVO, and configured to model coronary artery compliance for spatially resolved fluid transport through the coronary vessels. The model is configured to simulate the MVO by increasing flow resistance in at least one of the modelled coronary vessels, or by blocking the at least one of the modelled coronary vessels completely. The model is also configured to mimic behavior of fluid transport in the coronary vessels during diagnostics or treatment, to design and optimize therapy protocols for the MVO.

Abstract: A fishing lure that simulates the appearance of an elongated aquatic animal swimming through water.

Abstract: A device for marking a work piece that is at least partially formed or reshaped through a thermal process is provided. The device includes a plurality of heating elements distributed laterally on a surface that is placed against the work piece and can be individually controlled for local heating of a work piece surface. Each of the heating elements includes a solid material with a surface structure and a heating structure. The surface structure includes at least one of a specifically or randomly varied topography. The surface structure can be at least partially heated through the heating structure.

Abstract: A fishing lure that simulates the appearance of an elongated aquatic animal swimming through water.

Abstract: The invention concerns a kit for the detection of protein ESM-1 in a sample, comprising: a) a first antibody specifically binding to the N-terminal region of protein ESM-1 contained between the amino acid in position 20 and the amino acid in position 78 of the amino acid sequence of this protein; and b) a second antibody specifically binding to the C-terminal region contained between the amino acid in position 79 and the amino acid in position 184 of the amino acid sequence of protein ESM-1.

Abstract: Use of an antagonist compound of protein ESM-1 for the production of a drug for the treatment of a cancer.

Abstract: The invention relates to a method for producing molecule libraries at predetermined locations on a substrate surface by means of sequential chemical reactions involving the use of combinatorial sealing matrices. The topological structures applied to the sealing matrices cover individual areas of the substrate surface in a defined order thereby preventing different partial areas of the substrate surface from undergoing chemical conversions. Several sealing matrices having different topological relief structures can be used in a number of reaction cycles for the synthesis of molecule libraries consisting of complex chemical compounds. The sealing matrices are made of an elastic material such as polydimethylsiloxane. The synthesis involves the use of simple and highly optimized standard methods and standard chemicals of the solid phase synthesis. The reaction rate is accelerated by carrying out the reaction steps in a microfluidic flow-through system.

Abstract: Use of an antagonist compound of protein ESM-1 for the production of a drug for the treatment of a cancer.

Abstract: The invention relates to a method for highly parallel production of complex molecule libraries on the surface of a substrate with the aid of regeneratable matrix dies. According to prior art, the production of molecule libraries on a support is expensive, and requires a lot of time and a large amount of apparatus. By using regeneratable matrix dies it is possible to simplify and accelerate the production of molecule libraries, especially DNA and protein libraries, in a significant manner. The matrix-10 die is made of an elastic material such as polydimethylsiloxane and includes locally-bound matrix molecules on the surface thereof, said molecules being used as a model for the synthesis of copy molecules. The copy molcules are transferred to the target surface by means of a contact printing method. The matrix molecules remain on the die for further synthesis and print cycles which can repeated several times. The inventive method is suitable for copying and reproducing differently produced molecule arrays.

Abstract: A thin layer of hafnium oxide or stacking of thin layers comprising hafnium oxide layers for producing surface treatments of optical components, or optical components, characterised in that at least one layer of hafnium oxide is in amorphous form with a density less than 8 gm/cm3.

Abstract: A feeder device for feeding animals with food product includes a housing divided into a plurality of compartments with individual pivotable bottom walls and an operating system mounted on the housing to control opening of the bottom walls to release the food product contained therein. The operating system includes a locking mechanism located adjacent each bottom wall to releasably secure it in a closed position. An opening mechanism successively activates the locking mechanisms and opens the bottom walls. A timer device including an electronic controller and a limit switch electrically coupled to the opening mechanism controls the operation of the latter at the beginning of a pre-determined time interval. The limit switch is activated by the opening mechanism and stops operation of the opening mechanism during the pre-determined time interval.

Abstract: The invention concerns a kit for the detection of protein ESM-1 in a sample, comprising: