Abstract: The invention relates to a method for producing molecule libraries at predetermined locations on a substrate surface by means of sequential chemical reactions involving the use of combinatorial sealing matrices. The topological structures applied to the sealing matrices cover individual areas of the substrate surface in a defined order thereby preventing different partial areas of the substrate surface from undergoing chemical conversions. Several sealing matrices having different topological relief structures can be used in a number of reaction cycles for the synthesis of molecule libraries consisting of complex chemical compounds. The sealing matrices are made of an elastic material such as polydimethylsiloxane. The synthesis involves the use of simple and highly optimized standard methods and standard chemicals of the solid phase synthesis. The reaction rate is accelerated by carrying out the reaction steps in a microfluidic flow-through system.

Abstract: Use of an antagonist compound of protein ESM-1 for the production of a drug for the treatment of a cancer.

Abstract: The invention relates to a method for highly parallel production of complex molecule libraries on the surface of a substrate with the aid of regeneratable matrix dies. According to prior art, the production of molecule libraries on a support is expensive, and requires a lot of time and a large amount of apparatus. By using regeneratable matrix dies it is possible to simplify and accelerate the production of molecule libraries, especially DNA and protein libraries, in a significant manner. The matrix-10 die is made of an elastic material such as polydimethylsiloxane and includes locally-bound matrix molecules on the surface thereof, said molecules being used as a model for the synthesis of copy molecules. The copy molcules are transferred to the target surface by means of a contact printing method. The matrix molecules remain on the die for further synthesis and print cycles which can repeated several times. The inventive method is suitable for copying and reproducing differently produced molecule arrays.

Abstract: A thin layer of hafnium oxide or stacking of thin layers comprising hafnium oxide layers for producing surface treatments of optical components, or optical components, characterised in that at least one layer of hafnium oxide is in amorphous form with a density less than 8 gm/cm3.

Abstract: A feeder device for feeding animals with food product includes a housing divided into a plurality of compartments with individual pivotable bottom walls and an operating system mounted on the housing to control opening of the bottom walls to release the food product contained therein. The operating system includes a locking mechanism located adjacent each bottom wall to releasably secure it in a closed position. An opening mechanism successively activates the locking mechanisms and opens the bottom walls. A timer device including an electronic controller and a limit switch electrically coupled to the opening mechanism controls the operation of the latter at the beginning of a pre-determined time interval. The limit switch is activated by the opening mechanism and stops operation of the opening mechanism during the pre-determined time interval.

Abstract: The invention concerns a kit for the detection of protein ESM-1 in a sample, comprising:

Abstract: Proteins and peptides derived from protein ESM-1 are used in the treatment and diagnosis of diseases linked to leukocyte migration.

Abstract: A method for fabricating silicone elastomer stamps with hydrophilic surfaces is provided. The concept of polymer grafting is used to produce the stamps. The stamps thus produced have the great advantage that grafting of a thin hydrophilic polymer on a hydrophobic PDMS surface can render PDMS stamps permanently hydrophilic. With such stamps it becomes possible to print aqueous or highly polar inks reproducibly over days and weeks.

Abstract: A method and also a device is proposed for identification of a substance, preferably comprising biochemical molecules. In a first step a probe and said substance will be brought into contact, afterwards in a second step the probe and said substance will be withdrawn from each other, while measuring the value of at least one physical parameter characterizing the interaction between said probe and said substance and comparing said measured value with a reference value for identification.

Abstract: For a point-of-sales rug selection from a stack thereof, a method of working a raised stack from the bottom up so that a rug assuming successively the bottom position is permitted to descend, each in turn, to a floor display position and, after the first descent using lowering cables, the cables having a length portion in a taut vertical condition to serve as tracking guides for the vertical descent by gravity of successive rugs.

Abstract: A feeder device for feeding animals with food product includes a housing divided into a plurality of compartments with individual pivotable bottom walls and an operating system mounted on the housing to control opening of the bottom walls to release the food product contained therein. The operating system includes a locking mechanism located adjacent each bottom wall to releasably secure it in a closed position. An opening mechanism successively activates the locking mechanisms and opens the bottom walls. A timer device including an electronic controller and a limit switch electrically coupled to the opening mechanism controls the operation of the latter at a pre-determined time interval. The limit switch is activated by the opening mechanism and stops operation of said opening mechanism during the pre-determined time interval.

Abstract: A method for fabricating silicone elastomer stamps with hydrophilic surfaces is provided. The concept of polymer grafting is used to produce the stamps. The stamps thus produced have the great advantage that grafting of a thin hydrophilic polymer on a hydrophobic PDMS surface can render PDMS stamps permanently hydrophilic. With such stamps it becomes possible to print aqueous or highly polar inks reproducibly over days and weeks.

Abstract: For a point-of-sales rug selection from a stack thereof, a method of working a raised stack from the bottom up so that a rug assuming successively the bottom position is permitted to descend, each in turn, to a floor display position and, after the first descent using lowering cables, the cables having a length portion in a taut vertical condition to serve as tracking guides for the vertical descent by gravity of successive rugs.

Abstract: In the jet straying of ink droplets in a decorative pattern onto a fabric during which a jet spray head shuttles across the fabric changing directions at opposite selvage edges, the provision in an interposed position between the spray head and upstanding selvage edge fibers of shields preventing contact therebetween which maintains bubble closures over exit openings in the jet spray head intact and obviates inadvertent gravity flow of ink as might mar the decorative pattern.

Abstract: This invention relates to aggregates comprised of particles which contain silicon dioxide and to elastomers reinforced therewith. The invention also relates to tires having treads composed of such reinforced elastomers.

Abstract: The removal of albedo in the preparation of a citrus fruit for consumption, in which a known aqueous solution of pectinase enzyme is used for its known albedo-removal function, but in the present circumstances a vacuum is used to primarily draw the pectinase enzyme to the interface of the albedo and the citrus fruit and only nominally to the interface of the albedo and the peel of the citrus fruit, so that removal of the peel carries with it the albedo and uncovers the citrus fruit in a desirable albedo-free condition.

Abstract: An orientation aid for use when swimming on one's back comprises a hollow tubular support (20), an end piece (10 ) at one end of the support enabling the support to be held in a swimmer's mouth, and viewing means (30) attached to an opposite end of the support which is disposed above water during use.

Abstract: The invention relates to aggregates comprised of particles which contain silicon dioxide and to elastomers reinforced therewith. The invention also relates to tires having treads composed of such reinforced elastomers.

Abstract: A purified nucleic acid encoding the IQGAP1 protein, a novel member of the GTPase activating protein family, useful in the diagnosis and treatment of tumors.