Abstract: Provided are methods of screening to identify molecules capable of binding to CD4 and capable of activating CD4+CD25+ regulatory T cells. Further provided are antibodies and antibody fragments capable of activating CD4+CD25+ regulatory T cells and methods and uses involving the antibodies and fragments thereof.

Abstract: A sample-and-hold circuit, which includes a hold capacitor at its output terminal and at least one intermediate capacitor, intermittently receives an input voltage, and a first value of a switch enable signal causes the sample-and-hold circuit to sample the input voltage and to charge the at least one intermediate capacitor and the hold capacitor to the input voltage, and when it is not receiving the input voltage, a second value of the switch enable signal causes the sample-and-hold circuit to hold, at its output terminal, the input voltage until the hold capacitor discharges, which starts to discharge only after the at least one intermediate capacitor has substantially discharged.

Abstract: The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumor growth.

Abstract: Embodiments relate to the emulation of the effect of Forward Error Correction (FEC) codes, e.g., GF10 Reed Solomon (RS) FEC codes, on the bit error ratio (BER) of received Pseudo-Random Binary Sequences (PRBS) patterns. In particular, embodiments group errors into RS-FEC symbols and codewords in order to determine if the errors are correctable. By emulating the error correction capabilities of FEC codes in order to determine which errors are correctable by the code, embodiments afford a more accurate representation of the post-FEC BER of RS FEC codes from links carrying PRBS patterns. This FEC code emulation provides error correction statistics, for stand-alone use or for error correction in connection with Bit Error Rate Testers (BERTs).

Abstract: Body tissue ablation is carried out by inserting a probe into a body of a living subject, urging the probe into contact with a tissue in the body, generating energy at a power output level, and transmitting the generated energy into the tissue via the probe. While transmitting the generated energy the ablation is further carried out by determining a measured temperature of the tissue and a measured power level of the transmitted energy, and controlling the power output level responsively to a function of the measured temperature and the measured power level. Related apparatus for carrying out the ablation is also described.

Abstract: Systems, methods, and computer program products to perform an operation comprising creating, by a kernel, a temporary effective address associated with a virtual segment identifier (VSID), wherein the VSID is received by a processor in an asynchronous interrupt generated by a coherent accelerator in response to a page fault generated by the coherent accelerator in executing an instruction, accessing the temporary effective address by the processor to recreate the page fault on the processor, and resolving the page fault by an operating system executing on the processor.

Abstract: The present invention is directed to a closure for an outlet opening of a container comprising a first component which snaps onto an outlet opening and provides a seal for an outlet opening said first component snaps with a second component of said closure; wherein the first component comprises one or more rails to enable stability of the assembly and defines the direction of movement of the second component relative to the first component; a second component comprising a dispensing orifice of said second component, said second component, snaps with said first component; wherein the second component comprises ribs which engage the rail(s) of said first component; a dispensing orifice positioned directly adjacent to the open portion of the container body; wherein one or more directions of the movement of the second component relative to the first component are independently controlled by rails and ribs.

Abstract: Disclosed are systems, methods, and computer-readable storage media for adaptive telemetry based on in-network cross domain intelligence. A telemetry server can receive at least a first telemetry data stream and a second telemetry data stream. The first telemetry data stream can provide data collected from a first data source and the second telemetry data stream can provide data collected from a second data source. The telemetry server can determine correlations between the first telemetry data stream and the second telemetry data stream that indicate redundancies between data included in the first telemetry data stream and the second telemetry data stream, and then adjust, based on the correlations between the first telemetry data stream and the second telemetry data stream, data collection of the second telemetry data stream to reduce redundant data included in the first telemetry data stream and the second telemetry data stream.

Abstract: A method for preparing nanosized sulfide catalysts includes providing an aqueous solution having an organometallic complex, mixing the organometallic complex with a sulfiding agent, an emulsifier, and a hydrocarbon oil to prepare a water-in-oil nanoemulsion; subjecting the water-in-oil nanoemulsion to thermal decomposition and isolating a solid product from the liquid.

Abstract: The invention relates to a filter (10) having at least a first bayonet joint (22). The first bayonet joint (22) has a first bayonet slotted guide (26) with two locking positions that are axially spaced apart from one another for a first bayonet projection (24) of the first bayonet joint (22). By rotating a filter part for releasing the first bayonet joint (22), the first bayonet projection (24) may be moved from the second locking position into the first locking position. The filter (10) preferably has a second bayonet joint (28). The second bayonet joint (28) is preferably embodied such that, by further rotation in the same direction of rotation, it is released in that a second bayonet projection (30) is moved out of a third locking position of a second bayonet slotted guide (32) of the second bayonet joint (28) after the first bayonet projection (24) has been stopped in the first locking position.

Abstract: Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications. In particular embodiments, aspects of the foregoing modulation therapies may be implemented by systems and devices that have simplified functionalities.

Abstract: An anisotropic composite material assembly comprising a first layer with a tensile modulus different from its compressive modulus and that exhibits variable modulus behavior. The first layer elastically buckle under compressions. A second layer has a tensile modulus substantially the same as its compressive modulus. The first and second layers are joined together, and the assembly is bendable in a first direction with an outer surface of the first layer being in compression and the assembly has a first bending stiffness during bending in the first direction. The assembly is bendable in a second direction opposite the first direction with the outer surface of the first layer being in tension, and the assembly has a second bending stiffness greater than the first bending stiffness during bending in the second direction.

Abstract: A method involving periodic implementation, during the same operating cycle of the reactor, the method including following steps of: a) calculating, from measurements provided by sensors present in the reactor, the three-dimensional distribution of the local power in the core, b) simulating at least one accidental transient occurrence of power applied to the calculated three-dimensional distribution of local power, c) identifying, using thermomechanical calculations, at least one rod which is the most likely to be subject to a fracture of the cladding thereof during the simulated transient occurrence of power, and d) determining, using thermomechanical calculations on the rod identified, the value of the parameter which is representative of the operability of the reactor.

Abstract: A submicron structure includes a silica body defining a plurality of pores that are suitable to receive molecules therein, the silica body further defining an outer surface between pore openings of the plurality of pores; and a plurality of anionic molecules attached to the outer surface of the silica body. The anionic molecules provide hydrophilicity to the submicron structure and are suitable to provide repulsion between other similar submicron structures, and the submicron structure has a maximum dimension less than one micron.

Abstract: A magnetic refrigeration system provides flow-balanced channels between fluid control valves and the magnetocaloric beds to eliminate inefficiencies caused by unequal utilization of the magnetic beds from flow variations.

Abstract: Methods and apparatus consistent with the invention provide the ability to organize, index, search, and present time series data based on searches. Time series data are sequences of time stamped records occurring in one or more usually continuous streams, representing some type of activity. In one embodiment, time series data is stored as discrete events time stamps. A search is received and relevant event information is retrieved based in whole or in part on the time stamp, a keyword indexing mechanism, or statistical indices calculated at the time of the search.

Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.