Abstract: Compounds and methods of treating HIV-1 in a human infected with HIV-1 or preventing HIV-1 infection in a human susceptible to infection with HIV-1 are provided. The compounds are of formula (I), (II), and (IA), wherein R1-R7, X, X?, Y, Y?, Z, and n are defined herein, and the methods comprises administering therapeutically effective amounts of these compounds to the human.

Abstract: An illumination device for a display screen operable in an open-viewing mode B1 and a restricted-viewing mode B2 where light is emitted in a limited angular range. It includes a backlight emitting the limited-angular-range light, a plate-shaped light guide with large surfaces and narrow connecting sides in front of the backlight in a viewing direction. The light guide has outcoupling elements on the surfaces or within its volume, and is at least 50% transparent to backlight light. Outcoupling elements have a function surface for coupling out light guide light. Illuminants are arranged laterally of the narrow sides. The backlight is on and the illuminants off in mode B2, and the illuminants are on in mode B1. Some outcoupling elements have a structure causing scattering in a preferential direction that is stronger by a factor of at least 1.2 than in a direction perpendicular to the preferential direction, yielding anisotropic scattering.

Abstract: Targeting metastasis stem cells through a fatty acid receptor. The disclosure provides the use of blockers or inhibitors of CD36 activity or expression for the treatment of oral squamous cell cancer (OSCC), particularly for the treatment of generated metastases and for diminish is generation from primary tumours. Apart from shRNAs, anti-CD36 antibodies are provided as blockers or inhibitors, especially those that block the binding of CD36 to oxidized LDL and fatty acids and their incorporation into cells, because the promotion of their transport is indicated as the mechanism by which CD36 promote metastases dissemination and growth. Also provided is a method for identifying candidates to anticancer agents, particularly for OSCC metastasis, among those that promote in CD36+ cells, in vivo or in vitro, effects associated to CD36 depletion or blocking such as decrease of growth accumulation of lipid droplets and decrease of size in the case of metastases.

Abstract: A method includes inserting an array of multiple electrodes, fitted at a distal end of a catheter, into a cavity in an organ of a patient. The array is brought into contact with an inner surface of the cavity. An input is received from a user, the input specifying one or more tissue segments to be ablated on the inner surface. In response to the input, using a processor, one or more pairs of the electrodes in the array are selected that, when driven with irreversible electroporation (IRE) signals, would ablate the specified tissue segments. The specified tissue segments are ablated by applying the IRE signals to the pairs of the electrodes.

Abstract: Disclosed methods and systems allow a central server to monitor electronic units of work accessible to a group of computers and generate a nodal data structure representing the units of work. The server then uses various protocols, such as hashing algorithms and/or executing artificial intelligence and machine learning models to identify similar and/or related units of work. The server then merges/links the nodes corresponding to the similar/related units of work. The server also monitors all user activities. When a user or a software system/service accesses electronic content on his, her, or its electronic device, the server identifies a node corresponding to the accessed electronic content and associated unit(s) of work and presents searchable data and actions related to the identified node and any related/linked nodes.

Abstract: An exemplary method of imaging tissue of a subject using a rolling shutter imager to provide a video stream comprises: sequentially resetting a plurality of rows of pixels of the rolling shutter imager from a first row to a last row; transitioning a liquid crystal shutter from a closed state to an open state; after the liquid crystal shutter is transitioned into the open state and after resetting the last row, illuminating the tissue of the subject with an illumination light for an illumination period to accumulate charge at the plurality of rows of pixels, and after the illumination period ends, sequentially reading the accumulated charge at the rows of pixels from the first row to the last row; generating an image frame from the sequentially read accumulated charge at the plurality of rows of pixels; and adding the image frame to the video stream.

Abstract: The present invention relates to diltiazem for use as an agent for activating the expression of at least one gene encoding a type III interferon, in the prevention and/or treatment of infections by at least one pathogenic microorganism of the epithelia of the respiratory and/or intestinal tracts.

Abstract: A gutter for recovering lubrication oil, particularly for a mechanical reducer, comprising un corps principal comprising an annular main body around a central axis, and a deflector attached to the main body and configured to allow the evacuation of the oil radially from an inner cavity of the main body toward the outside of the gutter, the deflector comprising a main sleeve disposed in the extension of the main body, and an evacuation channel configured to deflect oil from the main sleeve and having a curved shape such that a first end of the evacuation channel, communicating with the inner cavity, is tangent to the main body, and a second end of the evacuation channel is directed outward with respect to the annular main body.

Abstract: Alteration of an input image to provide an interpretability of a trained classifier. The altered image may be determined by optimizing at least: a classification score of the altered image to reduce a distance between a classification of the altered image and a target classification, and a similarity score to reduce a distance between an average filter activation difference and a measure for a difference in filter activations between the input image and the altered image.

Abstract: According to one aspect, a thermal system of a vehicle which provides cooling to within the vehicle, e.g., within a driver and passenger carrying cabin or compartment, is effectively leveraged to provide cooling capabilities to autonomous vehicle systems. Some coolant flowing through a coolant loop included in the thermal system of a vehicle may be diverted to an offshoot loop which provides cooling to coolant included in a coolant loop configured to cool autonomous vehicle systems, e.g., a compute system that is part of an autonomous vehicle. The coolant from the thermal system of the vehicle may flow past coolant from the coolant loop configured to cool autonomous vehicle systems, and the cooled coolant from the coolant loop configured to cool the autonomous vehicle systems may flow near the autonomous vehicle systems to cool the autonomous vehicle systems.

Abstract: System involved with but not limited to an apparatus including an outdoor griddle station with a system capable of communicating grease and other food byproducts from the cooking surface to a receptacle. A downwardly sloping opening in the cooking surface of the griddle member is disposed in nesting relation to and fluid communication with a basin situated beneath the griddle member. The basin is attached to a duct, forming a fluid transfer assembly that may pass through the heat source housing of the griddle station. The fluid transfer assembly is disposed over a receptacle capable of holding fluids. The receptacle may be removably supported by a bracket seat attached to the base of the griddle station such that the receptacle may be capable of being removed and replaced. In addition, other aspects are described in the claims, drawings, and text forming a part of the present disclosure.

Abstract: Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods are disclosed. A representative method in accordance with an embodiment of the disclosure includes creating a therapeutic effect and a sensation in a patient by delivering to the patient first pulses having a first set of first signal delivery parameters and second pulses having a second set of second signal delivery parameters, wherein a first value of at least one first parameter of the first set is different than a second value of a corresponding second parameter of the second set, and wherein the first pulses, the second pulses or both the first and second pulses are delivered to the patient's spinal cord.

Abstract: Methods and apparatuses are disclosed for layer reduction criteria. In one embodiment, a network node is configured to determine a number of multiple-input multiple-output, MIMO, layers for a wireless device, WD, the determined number of MIMO layers being adjusted as compared to a maximum number of MIMO layers for the wireless device based at least in part on at least one parameter associated with at least one of the wireless device and the network node; and signal an indication of the determined number of MIMO layers to the wireless device. In one embodiment, a wireless device is configured to receive an indication of a number of multiple-input multiple-output, MIMO, layers, the indicated number of MIMO layers being adjusted as compared to a maximum number of MIMO layers for the wireless device based at least in part on at least one parameter associated with at least one of the wireless device and a network node.

Abstract: Described herein are methods and systems to dampen oscillations of a payload coupled to a tether of a winch system arranged on an unmanned aerial vehicle (UAV). For example, the UAV's control system may dampen the oscillations by causing the UAV to switch to a forward flight mode in which movement of the UAV results in drag on the payload, thereby damping the oscillations. In another example, the control system may cause the UAV to reduce an extent flight stabilization along at least one dimension, thereby resulting in damping of the detected oscillations due to energy dissipation during movement of the UAV along the dimension. In this way, the control system could select and carry out one or more such techniques, and could do so during retraction and/or deployment of the tether.

Abstract: A blade includes a root to be mounted in a slot of plural slots which open out at an outer periphery of a rotor disk of a movable wheel of a low-pressure turbine of an aeronautical propulsion system, the rotor disk being centered on a longitudinal axis and the slots being circumferentially distributed about the longitudinal axis, the rotor disk having an upstream surface and a downstream surface, each slot being delimited by a bottom surface, the rotor disk including blades circumferentially distributed at the outer periphery of the rotor disk, each blade being mounted in a corresponding slot, the root including a first platform which has a radially outer surface; a shroud having a second platform which has a radially inner surface; and an airfoil extending from the root to the shroud, the airfoil having a leading edge and a trailing edge.

Abstract: Systems and methods for identifying a status of components of hydraulic fracturing units including a prime mover and a hydraulic fracturing pump to pump fracturing fluid into a wellhead via a manifold may include a diagnostic control assembly. The diagnostic control assembly may include sensors associated with the hydraulic fracturing units or the manifold, and a supervisory control unit to determine whether the sensors are generating signals outside a calibration range, determine whether a fluid parameter associated with an auxiliary system of the hydraulic fracturing units is indicative of a fluid-related problem, determine whether lubrication associated with the prime mover, the hydraulic fracturing pump, or a transmission of the hydraulic fracturing units has a lubrication fluid temperature greater than a maximum lubrication temperature, or determine an extent to which a heat exchanger assembly associated with the hydraulic fracturing units is cooling fluid passing through the heat exchanger assembly.

Abstract: A method for producing a structural component part (1) from a fiber-reinforced plastic according to a three-dimensional winding process. Threadlike or strand-shaped fiber material (12) supplied on at least one bobbin (18) is wound around at least one filament carrier (11) in at least one winding pattern by at least one computer-controlled winding device (10). The fiber material (12) is laid down on the filament carrier (11) with a filament tensile force (FZN) that is preadjusted by a control device (14). The filament tensile force (FZist) is controlled depending on location and/or depending on path in order to take into account specific lay-down locations (29) on the filament carrier (11) in which a lay-down path (28) predefined by the winding pattern is departed from owing to the local geometry at preadjusted filament tensile force (FZN).