Patents by Inventor Andre Frank
Andre Frank has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200008770Abstract: A respiratory motion signal generation method operates on emission data (22) of an imaging subject in an imaging field of view (FOV) acquired by a positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging device (10). An array of regions (32) is defined in the imaging FOV without reference to anatomy of the imaging subject. For each region of the array of regions defined in the imaging FOV, an activity position versus time curve (54) is computed from the emission data acquired by the PET or SPECT imaging device. Frequency-selective filtering of the activity position versus time curves is performed to generate filtered activity position versus time curves. At least one motion signal (66) is generated by combining the filtered activity position versus time curves of at least a selected sub-set of the regions.Type: ApplicationFiled: March 24, 2017Publication date: January 9, 2020Inventors: Andre Frank SALOMON, Bin ZHANG, Andreas GOEDICKE, Patrick OLIVIER
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Publication number: 20190355158Abstract: Imaging data (20) are acquired by a PET scanner (6) or other imaging device. Iterative image reconstruction of the imaging data is performed to generate a reconstructed image (22). The iterative image reconstruction includes performing an update step (24) that includes an edge preserving prior (28) having a spatially varying edge preservation threshold (30) whose value at each image voxel depends on a noise metric (32) in a local neighborhood of the image voxel. The noise metric may be computed as an aggregation of the intensities of neighborhood image voxels of the reconstructed image in the local neighborhood of the image voxel. The edge preserving prior may be a Relative Difference Prior (RDP). For further noise suppression, during the iterative image reconstruction image values of image features of the reconstructed image that have spatial extent smaller than a threshold (38) may be reduced.Type: ApplicationFiled: December 12, 2017Publication date: November 21, 2019Inventors: Andre Frank SALOMON, Andreas GOEDICKE, Chuanyong BAI, Andriy ANDREYEV
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Publication number: 20190339403Abstract: A time of flight (TOF) positron emission tomography (PET) image (38) is generated from TOF PET imaging data (10) acquired of a subject using a TOF PET imaging data acquisition device (6). Iterative image reconstruction (30) of the TOF PET imaging data is performed with TOF localization of counts along respective lines of response (LORs) to iteratively update a reconstructed image (32). Values for at least one regularization or filtering parameter are assigned to the TOF PET imaging data or to voxels of the reconstructed image based on an estimated TOF localization resolution for the TOF PET imaging data or voxels. Regularization (34) or filtering (36) of the reconstructed image is performed using the assigned values for the at least one regularization or filtering parameter. In some embodiments, the varying TOF localization resolution for the TOF PET imaging data or voxels is estimated based on related N acquisition characteristics such as count rates or operating temperature of the detectors.Type: ApplicationFiled: December 18, 2017Publication date: November 7, 2019Inventors: Chuanyong BAI, Andriy ANDREYEV, Andre Frank SALOMON, Andreas GOEDICKE, Jinghan YE, Yu-Lung HSIEH, Bin ZHANG, Xiyun SONG, Manoj NARAYANAN, Zhiqiang HU
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Publication number: 20190080438Abstract: Patient imaging systems, such as PET imaging systems, for example, may suffer from the introduction of artificially introduced noise. This noise is, typically, introduced during iterations of reconstruction algorithms, such as the least-squares algorithms, which attempts to recreate a 2D or a 3D image from raw acquisition information. The noise appears as “hot-spots” in the reconstructed image. Approaches to address these artefacts use filtering approaches. Typically, a least-squares reconstruction is supplemented with a penalty term, an approach known as “Relative Difference Penalty”. The penalty parameter causes the reconstruction algorithm to filter more or less strongly at certain regions of the reconstruction. The present application proposes an approach which supplements the penalty term with continuous probability information about the likelihood of an edge being present in a portion of an image.Type: ApplicationFiled: April 5, 2017Publication date: March 14, 2019Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Thomas DEY, Andreas GOEDICKE, Andre Frank SALOMON
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Publication number: 20170306407Abstract: The present invention relates to a method for diagnosis of Inflammatory Bowel Disease (IBD) based on the determination of expression profiles of miRNAs representative for diagnosis of IBD compared to a reference. In addition, the present invention relates to a kit for diagnosis of IBD comprising means for determining expression profiles of miRNAs representative for IBD.Type: ApplicationFiled: July 23, 2015Publication date: October 26, 2017Inventors: Thomas Brefort, Andre Franke, Georg Hemmrich-Stanisak, Matthias Hubenthal, Matthias Scheffler
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Patent number: 9599731Abstract: An imaging system includes a magnetic resonance portion that produces an electric field and a second imaging portion, including a detector with a two dimensional array of detector tiles, wherein adjacent tiles along an axial direction are spaced apart by an electrically conductive material, which shields the tiles from the electric field. An imaging system includes a first imaging portion having a detector, which includes an array of scintillation crystals and a photo-sensor coupled to the array of scintillation crystals, wherein an output of the photo-sensor includes a unique ratio of information that identifies each crystal.Type: GrantFiled: March 14, 2013Date of Patent: March 21, 2017Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Volkmar Schulz, Andre Frank Salomon
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Patent number: 9122266Abstract: In a method for collision-free interaction between a machine having mobile machine elements and objects in its vicinity, safety regions are established and monitored using the knowledge of the current position and the dynamic behavior. In particular, image data of the mobile machine element are recorded by means of an image acquisition system and are correlated with a database compiled in a training phase with image data of at least one mobile machine element. The database contains image data relating to a plurality of movement phases within the movement process of the machine. Using the database, both the current position of the mobile machine element is ascertained and a future position, reachable within the stopping time, is estimated. The dynamic behavior of the machine in the event of collision risk is optimized on the basis of this estimation.Type: GrantFiled: January 30, 2009Date of Patent: September 1, 2015Assignee: PILZ GMBH & CO. KGInventors: Andre Franke, Lars Krueger, Christian Woehler
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Publication number: 20140264041Abstract: An imaging system includes a magnetic resonance portion that produces an electric field and a second imaging portion, including a detector with a two dimensional array of detector tiles, wherein adjacent tiles along an axial direction are spaced apart by an electrically conductive material, which shields the tiles from the electric field. An imaging system includes a first imaging portion having a detector, which includes an array of scintillation crystals and a photo-sensor coupled to the array of scintillation crystals, wherein an output of the photo-sensor includes a unique ratio of information that identifies each crystal.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: KONINKLIJKE PHILIPS ELECTRONICS N. V.Inventors: Volkmar SCHULZ, Andre Frank SALOMON
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Patent number: 8600136Abstract: A magnetic resonance (MR) image segmentation processor (32) is configured to identify one or more geometrical regions of a subject using an MR image of the subject. An emission data reconstruction processor (40) is configured to generate an attenuation map (54) of the subject by assigning initial attenuation values (52) to the geometrical regions of the subject, and to: (i) process (56) emission data acquired from the subject to generate an emission image (58) of the subject, the processing employing the attenuation map of the subject; (ii) update (60) the attenuation map based on corrections calculated using the emission image of the subject; and (iii) iterate operations (i) and (ii) to iteratively generate a reconstructed emission image of the subject.Type: GrantFiled: September 9, 2009Date of Patent: December 3, 2013Assignee: Koninklijke Philips N.V.Inventors: Bernd Schweizer, Andre Frank Salomon
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Patent number: 8574845Abstract: A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347 in which G is substituted by A.Type: GrantFiled: October 8, 2008Date of Patent: November 5, 2013Assignee: Christian-Albrechts-Universitat zu KielInventors: Stefan Schreiber, Andre Franke
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Patent number: 8359798Abstract: A foundation, particularly a foundation of a wind turbine, is provided. The foundation includes a central foundation member and a plurality of foundation segments which are segments of a circular, ring shaped or polygonal foundation element and which are connected to the central foundation member using a plurality of locking elements.Type: GrantFiled: October 29, 2009Date of Patent: January 29, 2013Assignee: Siemens AktiengesellschaftInventors: Achim Armbrecht, André Frank
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Publication number: 20110158497Abstract: A magnetic resonance (MR) image segmentation processor (32) is configured to identify one or more geometrical regions of a subject using an MR image of the subject. An emission data reconstruction processor (40) is configured to generate an attenuation map (54) of the subject by assigning initial attenuation values (52) to the geometrical regions of the subject, and to: (i) process (56) emission data acquired from the subject to generate an emission image (58) of the subject, the processing employing the attenuation map of the subject; (ii) update (60) the attenuation map based on corrections calculated using the emission image of the subject; and (iii) iterate operations (i) and (ii) to iteratively generate a reconstructed emission image of the subject.Type: ApplicationFiled: September 9, 2009Publication date: June 30, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Bernd Schweizer, Andre Frank Salomon
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Patent number: 7871519Abstract: Provided is a method comprising introducing a sample comprising a plurality of oligonucleotides into an ion pair high performance liquid chromatography column having a buffered mobile phase and allowing at least a portion of the oligonucleotides to separate; allowing the oligonucleotides to elute from the column; and introducing the oligonucleotides into a mass spectrometer and quantifying at least a portion of the oligonucleotides by mass spectrometry. In the method, at least a portion of the oligonucleotides are co-eluting oligonucleotides that differ in mass by no more than 20%; and the buffered mobile phase causes at least 50 mole percent of co-eluting oligonucleotides to have the same charge when they enter the mass spectrometer.Type: GrantFiled: March 31, 2006Date of Patent: January 18, 2011Assignee: Isis Pharmaceuticals, Inc.Inventors: Christine Kurata, Daniel Capaldi, Zhiwei Wang, Nhuy Luu, Hans-joachim Gaus, Claus André Frank Rentel
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Publication number: 20100279297Abstract: A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347 in which G is substituted by A.Type: ApplicationFiled: October 8, 2008Publication date: November 4, 2010Applicant: CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIELInventors: Stefan Schreiber, Andre Franke
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Publication number: 20100167285Abstract: The invention provides methods for evaluating irritable bowel disease (IBD), including Crohn Disease and Ulcerative Colitis, methods for determining a patient's susceptibility to developing an IBD, and methods for determining a patient's IBD genotype. The invention includes methods, polynucleotides, polypeptides, and antibodies relating to disclosed variants of, and polymorphisms in, the nel-like 1 precursor (NELL1), as well as the 5p13.1 locus, and other genes disclosed herein to be associated with IBD. Thus, the invention provides diagnostic and/or therapeutic targets for IBD, as well as diagnostic and therapeutic agents for IBD.Type: ApplicationFiled: March 26, 2008Publication date: July 1, 2010Inventors: Stefan Schreiber, Philip Rosenstiel, Andreas Ruether, Andre Franke, John Raelson, Randall D. Little, Tim Keith, Helene Fournier
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Publication number: 20100099083Abstract: The present invention relates to the ATG16l1 gene and genetic variants associated with Crohn's disease. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.Type: ApplicationFiled: July 26, 2007Publication date: April 22, 2010Applicant: GENIZON BIOSCIENCES INCInventors: John Verner Raelson, Stefan Schreiber, Randall David Little, Andre Franke, Jochen Hampe, Tim Keith, Vanessa Bruat, Abdelmajid Belouchi
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Publication number: 20100043318Abstract: A foundation, particularly a foundation of a wind turbine, is provided. The foundation includes a central foundation member and a plurality of foundation segments which are segments of a circular, ring shaped or polygonal foundation element and which are connected to the central foundation member using a plurality of locking elements.Type: ApplicationFiled: October 29, 2009Publication date: February 25, 2010Inventors: Achim Armbrecht, Andre Frank
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Publication number: 20090222134Abstract: In modern industrial robots which move at considerable speeds, collisions generally cause serious damage to the robots and the collision objects. This can lead to injuries and expensive production stoppages. In a method for collision-free interaction between a machine having mobile machine elements and objects in its vicinity, safety regions are established and monitored using the knowledge of the current position and the dynamic behavior. In particular, image data of the mobile machine element are recorded by means of an image acquisition system and are correlated with a database, which has been compiled in a training phase with image data of at least one mobile machine element. The database contains image data relating to a plurality of movement phases within the movement process of the machine.Type: ApplicationFiled: January 30, 2009Publication date: September 3, 2009Inventors: Andre Franke, Lars Krueger, Christian Woehler
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Publication number: 20090095896Abstract: Provided is a method comprising introducing a sample comprising a plurality of oligonucleotides into an ion pair high performance liquid chromatography column having a buffered mobile phase and allowing at least a portion of the oligonucleotides to separate; allowing the oligonucleotides to elute from the column; and introducing the oligonucleotides into a mass spectrometer and quantifying at least a portion of the oligonucleotides by mass spectrometry. In the method, at least a portion of the oligonucleotides are co-eluting oligonucleotides that differ in mass by no more than 20%; and the buffered mobile phase causes at least 50 mole percent of co-eluting oligonucleotides to have the same charge when they enter the mass spectrometer.Type: ApplicationFiled: March 31, 2006Publication date: April 16, 2009Applicant: IsIs Pharmaceuticales , Inc.Inventors: Christine Kurata, Daniel Capaldi, Zhiwei Wang, Nhuy Luu, Hans-Joachim Gaus, Claus Andre Frank Rental
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Patent number: 7427675Abstract: The present invention relates to oligonucleotide synthesis. In particular, the present invention provides methods for characterizing samples useful for making oligonucleotides.Type: GrantFiled: August 22, 2005Date of Patent: September 23, 2008Assignee: Isis Pharmaceuticals, Inc.Inventors: Daniel C. Capaldi, Hans-Joachim Josef Gaus, Claus Andre Frank Rentel, Philip Dmitri Olsen, Christine C. Kurata, Quanlai Song