Abstract: A method for determining a mechanical load to which a component was exposed. The component comprises at least one sensor that is arranged in a force flow of the mechanical load and that emits a measurement signal in the event of a mechanical load.

Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.

Abstract: Methods for driving a tunable laser with integrated tuning elements are disclosed. The methods can include modulating the tuning current and laser injection current such that the laser emission wavelength and output power are independently controllable. In some examples, the tuning current and laser injection current are modulated simultaneously and a wider tuning range can result. In some examples, one or both of these currents is sinusoidally modulated. In some examples, a constant output power can be achieved while tuning the emission wavelength. In some examples, the output power and tuning can follow a linear relationship. In some examples, injection current and tuning element drive waveforms necessary to achieve targeted output power and tuning waveforms can be achieved through optimization based on goodness of fit values between the targeted and actual output power and tuning waveforms.

Abstract: An orthopedic joint device having a lower leg part, a foot part that is arranged on the lower leg part about a swivel axis such that it can be swivelled, at least a first energy store, and a coupling element. The coupling element can be brought into a coupling position, in which a swivelling of the foot part relative to the lower leg part about the swivel axis in a plantar flexion direction leads to an increase in the amount of energy stored in the first energy store, and a de-coupling position. The orthopedic joint device also has at least one release element, which can be brought into a release position and a locked position. The energy stored in the first energy store can be released by bringing the release element into the release position.

Abstract: A surgical microscope for generating an image of an object region includes an eyepiece and an objective conjointly defining a viewing beam path, an image capturing device and a beam path switching device for out-coupling image information. The switching device is switchable between a first switching state wherein light in the viewing beam path is split into a first component along a first beam path to the eyepiece at an intensity IT1 and a second component along a second beam path to the image capturing device at an intensity IT2 and a second switching state wherein the light in the viewing beam path is deflected into the second beam path to the image capturing device at an intensity IU. The switching device includes a beam splitter movable in and out of the viewing beam path and a deflecting element movable into and out of the viewing beam path.

Abstract: Methods for driving a tunable laser with integrated tuning elements are disclosed. The methods can include modulating the tuning current and laser injection current such that the laser emission wavelength and output power are independently controllable. In some examples, the tuning current and laser injection current are modulated simultaneously and a wider tuning range can result. In some examples, one or both of these currents is sinusoidally modulated. In some examples, a constant output power can be achieved while tuning the emission wavelength. In some examples, the output power and tuning can follow a linear relationship. In some examples, injection current and tuning element drive waveforms necessary to achieve targeted output power and tuning waveforms can be achieved through optimization based on goodness of fit values between the targeted and actual output power and tuning waveforms.

Abstract: A disclosed fan system includes a housing having side walls, an inflow side, and an outflow side; a fan secured in the housing by a mounting; and a backflow blocker mounted to the side walls within the housing on the outflow side of the housing partially blocking a cross-sectional area of the outflow side. The backflow blocker is positioned approximately centrally in a flow path of the housing and is configured to block part of an airflow cross section such that, between side walls of the housing and side walls of the backflow blocker, an annular duct is formed as an air passage. Further, the backflow blocker has a thickness that is greater than 5% of a width of the housing, and is less than 20% of an axial design height of the fan system.

Abstract: An input coupling module selectively couples a beam path into a first or second stereoscopic component beam in a surgical microscope having an optical interface for guiding a beam path to be coupled-in. The input coupling module has a first beam splitter arranged in the first component beam and a second beam splitter arranged in the second component beam. The input coupling module contains an adjustable optics assembly, which selectively guides a beam path provided at the optical interface for coupling into the first or second component beam to the first beam splitter or the second beam splitter. The adjustable optics assembly includes an optical element displaceable by a linear movement from a first position to a second, position, and vice versa, for switching the beam path. The displaceable optical element is arranged in the beam path to be coupled-in in the first position and/or the second position.

Abstract: A microscope having an observation beam path including a main objective, an OCT device including a first detection beam path, a wavefront measuring device including a second detection beam path, a first, a second and a third optics group is provided, wherein the first detection beam path contains the main objective and the first to third optics group, and the first to third optics group forms an afocal imaging optical unit of the first detection beam path and the second detection beam path contains the main objective, the first optics group and the second optics group, and the main objective and the first and second optics group form an afocal imaging optical unit of the second detection beam path.

Abstract: In a method for the control and protection of a gas turbine a gas turbine performance and lifetime indicative process quantity is estimated from a set of available process signals. The gas turbine performance and lifetime indicative process quantity is simultaneously evaluated by two different estimation methods, whereby a first estimation method has a high prediction accuracy, and a second estimation method has a high availability, a continuous adaptation of the second estimation method is conducted in order to align the output signals of the two estimation methods, and in case of a failure detected in the supervision of the first estimation method the adaptation of the second estimation method is stopped, and the output of the first estimation method is switched to the output of the second estimation method.

Abstract: The inventive waveguide structure comprises a first waveguide region having a constant first width adapted to guide electromagnetic waves mode sustainably along its longitudinal axis; a second waveguide region adapted to guide electromagnetic waves mode sustainably along its longitudinal axis, wherein the longitudinal axis of the first waveguide region and the longitudinal axis of the second waveguide region form a common longitudinal axis of the waveguide structure, wherein a first end face of the first waveguide region and a first end face of the second waveguide region are aligned with each other, the width of the first end face of the second waveguide region corresponding to the first width, and the width of the second waveguide region along its longitudinal axis widens from the first end face to a second end face to a second width greater than the first width.

Abstract: The present invention relates to novel compounds of the formula (II) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.

Abstract: Methods for driving a tunable laser with integrated tuning elements are disclosed. The methods can include modulating the tuning current and laser injection current such that the laser emission wavelength and output power are independently controllable. In some examples, the tuning current and laser injection current are modulated simultaneously and a wider tuning range can result. In some examples, one or both of these currents is sinusoidally modulated. In some examples, a constant output power can be achieved while tuning the emission wavelength. In some examples, the output power and tuning can follow a linear relationship. In some examples, injection current and tuning element drive waveforms necessary to achieve targeted output power and tuning waveforms can be achieved through optimization based on goodness of fit values between the targeted and actual output power and tuning waveforms.

Abstract: A microscope having an observation beam path including a main objective, an OCT device inlcuding a first detection beam path, a wavefront measuring device including a second detection beam path, a first, a second and a third optics group is provided, wherein the first detection beam path contains the main objective and the first to third optics group, and the first to third optics group forms an afocal imaging optical unit of the first detection beam path and the second detection beam path contains the main objective, the first optics group and the second optics group, and the main objective and the first and second optics group form an afocal imaging optical unit of the second detection beam path.

Abstract: The present invention relates to novel compounds that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.

Abstract: Disclosed is a Vernier effect DBR laser that has uniform laser injection current pumping along the length of the laser. The laser can include one or more tuning elements, separate from the laser injection element, and these tuning elements can be used to control the temperature or modal refractive index of one or more sections of the laser. The refractive indices of each diffraction grating can be directly controlled by temperature changes, electro optic effects, or other means through the one or more tuning elements. With direct control of the temperature and/or refractive indices of the diffraction gratings, the uniformly pumped Vernier effect DBR laser can be capable of a wider tuning range. Additionally, uniform pumping of the laser through a single electrode can reduce or eliminate interfacial reflections caused by, for example, gaps between metal contacts atop the laser ridge, which can minimize multi-mode operation and mode hopping.

Abstract: Methods for driving a tunable laser with integrated tuning elements are disclosed. The methods can include modulating the tuning current and laser injection current such that the laser emission wavelength and output power are independently controllable. In some examples, the tuning current and laser injection current are modulated simultaneously and a wider tuning range can result. In some examples, one or both of these currents is sinusoidally modulated. In some examples, a constant output power can be achieved while tuning the emission wavelength. In some examples, the output power and tuning can follow a linear relationship. In some examples, injection current and tuning element drive waveforms necessary to achieve targeted output power and tuning waveforms can be achieved through optimization based on goodness of fit values between the targeted and actual output power and tuning waveforms.

Abstract: The invention relates to a tube for a surgical microscope. The tube has a base part, an intermediate part, which is pivotable about a rotational axis on the base part, and an ocular part which is pivotable about a rotational axis on the intermediate part. The imaging beam path is guided through the base part, the intermediate part and the pivotable ocular part. The tube has a tube lens system which transfers a parallel imaging beam paths into an intermediate image. The parallel imaging beam path enters via an opening in a connecting piece of the base part. The tube has a first displaceable mirror element which can be moved about the rotational axis on the base part. The tube lens system is a telesystem which has a lens unit having positive refractive power and a lens unit having negative refractive power.

Abstract: A stereomicroscope includes a stereoscopic main observer beam path having a main observer zoom system, a stereoscopic co-observer beam path having a co-observer zoom system, and a main objective common to the main observer beam path and the co-observer beam path. The co-observer beam path is coupled out from the main observer beam path via a geometrical beam splitter arranged between the main objective and the main observer zoom system, wherein in the co-observer beam path the co-observer zoom system succeeds the geometrical beam splitter and is constructed from lenses having dimensions such that both a first and a second stereoscopic partial beam of the co-observer beam path in each case pass through the lenses.

Abstract: A method of controlling beam quality and stability of a laser apparatus, the laser apparatus comprising, a diode laser (10) providing first radiation of at least a first wavelength, and a frequency conversion unit (12) configured to frequency-convert the first radiation from the diode laser and to output the frequency-converted radiation (213), the frequency-converted radiation having at least a second wavelength different from the first wavelength, the diode laser (10) comprising at least a first and a second section (222,223), a first contact (220) for injecting a first current (I1) into the first section (222), a second contact (221) for injecting a second current (I2) into the second section (223), and means for controlling a temperature of the diode laser; wherein the method comprises monitoring a first parameter indicative of the power content of a dominant lobe of the first radiation; iteratively determining a combination of respective values of the first current, the second current and the temperature