Abstract: The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease. Precursors for the preparation of the compounds according to the present invention are also provided.

Abstract: An input coupling module selectively couples a beam path into a first or second stereoscopic component beam in a surgical microscope having an optical interface for guiding a beam path to be coupled-in. The input coupling module has a first beam splitter arranged in the first component beam and a second beam splitter arranged in the second component beam. The input coupling module contains an adjustable optics assembly, which selectively guides a beam path provided at the optical interface for coupling into the first or second component beam to the first beam splitter or the second beam splitter. The adjustable optics assembly includes an optical element displaceable by a linear movement from a first position to a second, position, and vice versa, for switching the beam path. The displaceable optical element is arranged in the beam path to be coupled-in in the first position and/or the second position.

Abstract: In a method for the control and protection of a gas turbine a gas turbine performance and lifetime indicative process quantity is estimated from a set of available process signals. The gas turbine performance and lifetime indicative process quantity is simultaneously evaluated by two different estimation methods, whereby a first estimation method has a high prediction accuracy, and a second estimation method has a high availability, a continuous adaptation of the second estimation method is conducted in order to align the output signals of the two estimation methods, and in case of a failure detected in the supervision of the first estimation method the adaptation of the second estimation method is stopped, and the output of the first estimation method is switched to the output of the second estimation method.

Abstract: A stereomicroscope including a stereoscopic main observer beam path having a main observer zoom system, a stereoscopic co-observer beam path having a co-observer zoom system, and a main objective common to the main observer beam path and the co-observer beam path. The co-observer beam path is coupled out from the main observer beam path via a geometrical beam splitter arranged between the main objective and the main observer zoom system, wherein in the co-observer beam path the co-observer zoom system succeeds the geometrical beam splitter and is constructed from lenses having dimensions such that both a first and a second stereoscopic partial beam of the co-observer beam path in each case pass through the lenses.

Abstract: The present invention relates in a first aspect to a process for hydrogenation of ketones having at least a carbon-carbon double bond in the y,8-position to the keto group by hydrogen in the presence of at least one chiral iridium complex of formula (I), where R1 represents a group of formula (II) or (III) or (IV). It has been shown that this process leads to a strong increase in preferential formation of a single isomer. The process is particularly suitable for the hydrogenation of y,8-unsaturated ketones which can be used as flavors and fragrances or for the preparation of vitamin E and its derivatives or of flavors and fragrances.

Abstract: This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.

Abstract: A method of controlling beam quality and stability of a laser apparatus, the laser apparatus comprising, a diode laser (10) providing first radiation of at least a first wavelength, and a frequency conversion unit (12) configured to frequency-convert the first radiation from the diode laser and to output the frequency-converted radiation (213), the frequency-converted radiation having at least a second wavelength different from the first wavelength, the diode laser (10) comprising at least a first and a second section (222,223), a first contact (220) for injecting a first current (I1) into the first section (222), a second contact (221) for injecting a second current (I2) into the second section (223), and means for controlling a temperature of the diode laser; wherein the method comprises monitoring a first parameter indicative of the power content of a dominant lobe of the first radiation; iteratively determining a combination of respective values of the first current, the second current and the temperature

Abstract: It is proposed a gas turbine and a method to operate the gas turbine. A fluid is supplied to the gas turbine by means of fluid paths. A first fluid path is divided into a second and third fluid path. A first control valve controls a fluid mass flow in the first fluid path. A second control valve controls a ratio of fluid mass flows in the second and third fluid paths.

Abstract: The present invention relates in a first aspect to a process for hydrogenation of ketones having at least a carbon-carbon double bond in the y,8-position to the keto group by hydrogen in the presence of at least one chiral iridium complex of formula (I), where R1 represents a group of formula (II) or (III) or (IV). It has been shown that this process leads to a strong increase in preferential formation of a single isomer. The process is particularly suitable for the hydrogenation of y,8-unsaturated ketones which can be used as flavours and fragrances or for the preparation of vitamin E and its derivatives or of flavours and fragrances.

Abstract: An estimation unit can estimate, on a real-time basis, a maximum power generation capacity of a single cycle or combined cycle gas turbine power plant. For example, the actual power output and the maximum power generation capacity can be calculated relying on a mathematical process model. Subsequently, the calculated actual power output can be compared with the measured power output yielding a model-estimation error. Based on the model-estimation error, a correction signal can be deduced, to correct the calculated maximum power generation capacity. A controller can maintain a specified power reserve. The controller can use an estimate of the maximum power generation capacity as a reference, subtract a load offset, and apply the resulting signal as upper limit of the load set-point.

Abstract: A tube of a surgical microscope has a base part, intermediate part pivotable about a rotational axis on the base part, and an ocular part pivotable about a rotational axis on the intermediate part. An imaging beam path passes through the base part, intermediate part and ocular part. The tube has a tube lens system which transfers a parallel imaging beam path into an intermediate image. The parallel imaging beam path enters via an opening in a connecting piece of the base part. The tube has a first mirror movable about the rotational axis on the base part and a further mirror movable on the intermediate part about the rotational axis. The first mirror directs the imaging beam path to the further mirror. The first mirror and further mirror are mounted in the imaging beam path between a lens unit having positive refractive power and a lens unit having negative refractive power.

Abstract: An estimation unit can estimate, on a real-time basis, a maximum power generation capacity of a single cycle or combined cycle gas turbine power plant. For example, the actual power output and the maximum power generation capacity can be calculated relying on a mathematical process model. Subsequently, the calculated actual power output can be compared with the measured power output yielding a model-estimation error. Based on the model-estimation error, a correction signal can be deduced, to correct the calculated maximum power generation capacity. A controller can maintain a specified power reserve. The controller can use an estimate of the maximum power generation capacity as a reference, subtract a load offset, and apply the resulting signal as upper limit of the load set-point.

Abstract: A vacuum pump system includes a vacuum pump with a brushless, multi-phase, synchronous motor with a permanently magnetically excited rotor, and a pump type recognition element, a control unit for controlling the vacuum pump and having a drive microcontroller and a final stage, and a further microcontroller that monitors a rotational speed of the motor and turning off the final stage in case the rotational speed of the motor exceeds a maximum allowable rotational speed of the motor, and that forms part of the control unit.

Abstract: A tube of a surgical microscope has a base part, intermediate part pivotable about a rotational axis on the base part, and an ocular part pivotable about a rotational axis on the intermediate part. The imaging beam path is guided through the base part, intermediate part and pivotable ocular part. The tube has a tube lens system which transfers a parallel imaging beam path into an intermediate image. The parallel imaging beam path enters via an opening in a connecting piece of the base part. The tube has a first displaceable mirror element movable about the rotational axis on the base part. The tube has a further displaceable mirror element movable on the intermediate part about the rotational axis. The first mirror element directs the imaging beam path to the further mirror element. The first mirror element and further mirror element are mounted in the imaging beam path between a lens unit having positive refractive power and a lens unit having negative refractive power.

Abstract: The present invention, among other things, relates to a front-lens attachment (20) for an optical observation device (10), in particular for a microscope. The front-lens attachment (20) has a retaining element (38) that has a retaining element (32), on which at least one lens element (33, 34) is disposed. Further, it provides a positioning device (21) for positioning the retaining element (32) and the at least one lens element (33, 34) disposed thereon, relative to the optical observation device (10), whereby retaining device (32) is disposed on positioning device (21). Finally, a fastening means (35) for fastening the retaining device (38) to the front-lens attachment (20) is provided. In order to be able to provide such a front-lens attachment (20) in a structurally simple and cost-effective manner, it is provided, for example, that positioning device (21) has at least two positioning components (22, 28), which are joined together via a joint (31).

Abstract: This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.

Abstract: This invention relates to derivatives of Iodine-labeled homoglutamic acids and glutamic acids and their analogues suitable for labeling or already labeled by Iodine, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging or radiotherapy.

Abstract: The invention relates to a method for the enzymatic reduction of alkyne derivatives of the formula (1), wherein R1 represents H, C1-C6-alkyl, C2-C6-alkenyl, or an optionally substituted carbocyclic or heterocyclic, aromatic or non-aromatic group, R2 represents H, C1-C6-alkyl, C2-C6-alkenyl, by reaction in the presence of special reductases.

Abstract: A multi-piece piston (1) is disclosed, for fixing to the high pressure side end (3) of a piston rod (5) running axially in a casting cylinder (7) of a cold chamber casting machine. The piston comprises a piston crown (9) forming a piston front face (13) on the high pressure side and a piston body (15) in the form of a bush connected to the piston crown (9) on the low pressure side. The piston body (15) can be connected to the piston crown (9) by means of fixing screws (23) to form a module. Complementary bayonet looking means (25, 27) are provided, for axial fixing of the piston (1) to the end (3) of the piston rod (5), on the piston crown (9) and the end (3).

Abstract: The invention relates to a process for the production of optically active Citronellal by enzymatic reduction of Citral with a reductase from Zymomonas mobilis.