Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

Abstract: Described herein are methods and system for electronic workflow management having a central server that periodically scans data accessible to multiple computers and data interacted with by different users to generate a nodal data structure comprising of interrelated nodes where each node corresponds to a workflow component, such as files, messages, tasks, and the like. The server then executes various analytical protocols to identify and link/merge nodes corresponding to related content. Upon receiving a set of notifications for a user, the server augments the notifications with data retrieved/derived from the nodal data structure. The server then prioritizes outputting the notifications based on their respective contextualized data and/or based on attributes received from the user.

Abstract: An access control terminal (1), comprising an electronic circuit (11) and an ultra-wide-band transceiver (10) connected to the electronic circuit (11) wherein the electronic circuit (11) exchanges messages with a mobile device (2) to determine a distance (d) of the mobile device (2) from the access control terminal (1), and to transmit to the mobile device (2) one or more update messages configured to update access rights data in the mobile device (2), if the mobile device (2) is within the pre-determined proximity range (P).

Abstract: A method includes determining an operational condition associated with an unmanned aerial vehicle (UAV). The method includes, responsive to determining the operational condition, causing the UAV to perform a pre-flight check. The pre-flight check includes hovering the UAV above a takeoff location. The pre-flight check includes, while hovering the UAV, moving one or more controllable components of the UAV in accordance with a predetermined sequence of movements. The pre-flight check includes obtaining, by one or more sensors of the UAV, sensor data indicative of a flight response of the UAV to moving the one or more controllable components while hovering the UAV. The pre-flight check includes comparing the sensor data to expected sensor data associated with an expected flight response to the predetermined sequence of movements while hovering the UAV. The pre-flight check includes, based on comparing the sensor data to the expected sensor data, evaluating performance of the UAV.

Abstract: A method for measuring autophagosome flux is provided. The autophagosome pool size in a single cell is quantified, where the pool size is the total number of autophagosomes in the cell. Fusion between the autophagosomes and lysosomes in the cell is then inhibited. The autophagosome pool size is quantified over one or more time points after fusion has been inhibited, and the autophagosome flux is calculated as the initial rate of change of the autophagosome pool size at the time point after fusion has been inhibited. The method can be used to determine basal autophagosome flux, whether a cell is diseased or dysfunctional, or to diagnose a subject with a disease, disorder or dysfunction. The transition time, the time required to clear an autophagosome pool, can also be derived from the autophagosome flux. A molecule can also be characterized according to its ability to modulate autophagosome flux in a cell.

Abstract: A tow attachment for a watercraft is disclosed. The tow attachment is configured to attach a tow rope to the watercraft, and has a first part and a second part that is connected to the first part by a connecting portion. The first part is configured for rigid connection to the watercraft, and the second part is configured to attach to the tow rope. The second part disconnects from the first part about the connecting portion in response to the tow rope applying a load above a predetermined load to the second part. A tow pylon assembly having a tow pylon and the tow attachment connected to the tow pylon is also disclosed. A watercraft with the tow attachment and a watercraft with the tow pylon assembly are also disclosed.

Abstract: A user classification system is provided. The system includes a sensor for producing a sensor signal and a user device. The system classifies a user of the system based on the sensor signal.

Abstract: An example device includes a connection engine to establish a secure connection with a second device. The device includes a security engine to determine a shared security state for the first device and the second device based on a security state of the first device and a security state of the second device. The security engine is to detect a change in the security state of the first device should occur. The security engine is to change the shared security state at the first device. The security engine is to indicate to the second device the change in the shared security state at the first device.

Abstract: The present invention relates to methods, systems, and apparatus for learning-based automated call flow testing. An exemplary method of testing a first Session Initiation Protocol (SIP) call processing entity includes the steps of: performing a twinning configuration procedure on a second SIP call processing entity operating in a production network; generating configuration information for use in configuring the first SIP call processing entity in a lab environment for a plurality of test cases based on configuration information obtained during the twinning configuration procedure, the plurality of test cases including a first test case based on a first reference call flow record for a first SIP call processed by the second SIP call processing entity; and executing the first test case while the first SIP call processing entity is operating in the lab environment and has been configured using the generated configuration information.

Abstract: Disclosed is a storage cabinet. An embodiment has one or more shelves, one or more doors for enclosing the cabinet, and an electromagnetic lock for locking the door or doors. The shelves have one or more cameras, an opened- or closed-door state sensor, and a weight sensor arranged to measure weight of products placed on said shelves. An electronic data processor carries out a machine learning computer vision method for processing data received from cameras and sensors to identify products removed from said shelves. The processor detects when a cabinet door is in an open state, acquires image and weight data from the associated camera and weight sensor. When a weight change at a shelf is detected, processing of image data acquired including when the weight change occurred occurs, with said machine learning computer vision method.

Abstract: Provided are methods for reducing the amount of a contaminant in a sample containing an oligomeric compound. The method may comprise chromatography using a mobile phase comprising a strong salt and a chaotrope. Also provided are oligomeric compounds prepared by the method.

Abstract: We describe an optical and magnetic stimulation, OMS, wound therapy device comprising: a light source configured to generate an optical field for an OMS wound therapy; an electric circuit coupled to the light source for driving the light source to generate the optical field; a coil configured to generate a magnetic field for the OMS wound therapy; and a magnetic field shield arranged between the coil on the one hand and the light source and electric circuit on the other hand, and wherein the magnetic field shield is configured to shield the electric circuit and the light source from the magnetic field generated by the coil.

Abstract: The present disclosure relates to techniques for imaging tissue of a subject. An exemplary method comprises transitioning a (liquid crystal) light shutter to an open state to allow reflected light from illuminating the tissue of the subject with a visible-light illumination source to accumulate charge at a plurality of rows of pixels of an imager; transitioning the light shutter to a closed state to prevent the imager from receiving visible light; during a first readout period, reading accumulated charge to produce a first set of imaging data; while the light shutter is in the closed state, illuminating the tissue of the subject with a fluorescence excitation illumination source; during a second readout period after the first readout period, reading accumulated charge to produce a second set of imaging data; and generating image frames based on the first set of imaging data and the second set of imaging data.

Abstract: Various technologies described herein pertain to systems and methods for mitigating radar signal power fading. In one embodiment, a diversity of radar sensor units having different vertical positions, or an offset, are provided. The different vertical positions introduce a phase shift to the received radar signal(s) so that when one radar sensor unit is receiving a destructive combination of signals, the other radar sensor unit is receiving a constructive combination of signals. This reduces the effect of signal power fade due to, among other things, ground bounce of radar signals destructively interfering with a radar sensor unit's ability to detect an object.

Abstract: Embodiments disclosed herein include socketing apparatuses with environmental sealing options. In an embodiment, such an apparatus comprises a first substrate, and a second substrate over the first substrate. In an embodiment, a socket structure is provided between the first substrate and the second substrate, where the socket structure comprises a plurality of electrical interconnects between the first substrate and the second substrate. In an embodiment, a die is over the second substrate, and a third substrate is over the die. In an embodiment, a ring is around the socket structure, and the ring is coupled to the first substrate and the third substrate.