Patents by Inventor Andreas Bunge
Andreas Bunge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11350855Abstract: A sensor system detects a presence or concentration of an analyte in a medium. The sensor system contains a sensor having a sensor head with a chamber. The sensor head has a permeable area through which the analyte can pass into the chamber when the sensor head contacts the medium. A cross-linked hydrogel fills the chamber, the hydrogel is configured to undergo a change in volume when contacting the analyte passed into the chamber which leads to a change in pressure in the chamber. A pressure sensor is configured to measure the pressure in the chamber for detecting the presence or concentration of the analyte.Type: GrantFiled: December 5, 2017Date of Patent: June 7, 2022Assignee: BIOTRONIK SE & Co. KGInventors: Andreas Bunge, Henning Ebert, Olaf Skerl, Alexander Borck
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Patent number: 10610617Abstract: A method for coating a medical implant applies at least one coating to at least one surface of the implant by plasma polymerization. The implant has pores sized in the nanometer range. The method stabilizes the pores. The plasma polymerization is conducted in the presence of a coating gas and oxygen. A coating parameter can be selected so that a rough surface of the implant is coated. An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.Type: GrantFiled: October 21, 2015Date of Patent: April 7, 2020Assignees: BIOTRONIK SE & Co. KG, Albert-Ludwigs-Universitat FreiburgInventors: Andreas Bunge, Michael Bergmann, Loic Ledernez, Alexander Borck, Gerald Urban
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Publication number: 20200093964Abstract: An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.Type: ApplicationFiled: November 12, 2019Publication date: March 26, 2020Inventors: Andreas Bunge, Michael Bergmann, Loic Ledernez, Alexander Borck, Gerald Urban
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Patent number: 10274408Abstract: Embodiments of the invention include a biosensor, such as an implantable biosensor, that includes a sensor material sensitive to at least one analyte in a pressure measurement chamber coupled to a pressure sensor. In embodiments of the invention, a pressure prevailing in the pressure measurement chamber may be determined by the pressure sensor. The sensor material is coupled in the pressure measurement chamber to a compensation material, which includes a relationship between a temperature and a volume of the pressure. The relationship is opposite to a temperature-dependent change in pressure or volume of the sensor material and at least partially compensates for a cross-sensitivity-induced change in volume of the sensor material.Type: GrantFiled: May 31, 2016Date of Patent: April 30, 2019Assignee: Biotronik SE & Co. KGInventors: Henning Ebert, Andreas Bunge
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Publication number: 20180153453Abstract: A sensor system detects a presence or concentration of an analyte in a medium. The sensor system contains a sensor having a sensor head with a chamber. The sensor head has a permeable area through which the analyte can pass into the chamber when the sensor head contacts the medium. A cross-linked hydrogel fills the chamber, the hydrogel is configured to undergo a change in volume when contacting the analyte passed into the chamber which leads to a change in pressure in the chamber. A pressure sensor is configured to measure the pressure in the chamber for detecting the presence or concentration of the analyte.Type: ApplicationFiled: December 5, 2017Publication date: June 7, 2018Inventors: Andreas Bunge, Henning Ebert, Olaf Skerl, Alexander Borck
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Publication number: 20170354360Abstract: The invention relates to a medical sensor system (10) for detecting a feature (12), such as an analyte, in a human or animal body. The system (10) includes at least one sensor (14; 34) having a reservoir (18) with a cap (16) designed as a controllable organic membrane (20), wherein (for example) application of a voltage of a particular magnitude, or application of a voltage for a particular time, effects a change in the permeability of the membrane (20).Type: ApplicationFiled: June 23, 2017Publication date: December 14, 2017Inventors: Sven Bode, Andreas Bunge, Sarah Biela, Hoc Khiem Trieu
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Publication number: 20170304501Abstract: A method for treating a medical implant uses plasma polymerization to apply a coating At least one treatment parameter is selected so that the reactive chemical groups of the coating are chemically modified to prevent an adsorption of interfering substances into the coating. An implant includes a plasma polymer coating that is biocompatible, and includes a antibiotically acting metal.Type: ApplicationFiled: October 21, 2015Publication date: October 26, 2017Inventors: Andreas Bunge, Michael Bergmann, Loic Ledernez, Josef Horak, Gerald Urban
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Publication number: 20170296709Abstract: A method for coating a medical implant applies at least one coating to at least one surface of the implant by plasma polymerization. The implant has pores sized in the nanometer range. The method stabilizes the pores. The plasma polymerization is conducted in the presence of a coating gas and oxygen. A coating parameter can be selected so that a rough surface of the implant is coated. An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.Type: ApplicationFiled: October 21, 2015Publication date: October 19, 2017Inventors: Andreas BUNGE, Michael Bergmann, Loic Ledernez, Alexander Borck, Gerald Urban
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Patent number: 9687182Abstract: The invention relates to a medical sensor system (10) for detecting a feature (12), such as an analyte, in a human or animal body. The system (10) includes at least one sensor (14; 34) having a reservoir (18) with a cap (16) designed as a controllable organic membrane (20), wherein (for example) application of a voltage of a particular magnitude, or application of a voltage for a particular time, effects a change in the permeability of the membrane (20).Type: GrantFiled: September 29, 2011Date of Patent: June 27, 2017Assignee: BIOTRONIK SE & Co. KGInventors: Sven Bode, Andreas Bunge, Sarah Biela, Hoc Khiem Trieu
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Publication number: 20160349162Abstract: Embodiments of the invention include a biosensor, such as an implantable biosensor, that includes a sensor material sensitive to at least one analyte in a pressure measurement chamber coupled to a pressure sensor. In embodiments of the invention, a pressure prevailing in the pressure measurement chamber may be determined by the pressure sensor. The sensor material is coupled in the pressure measurement chamber to a compensation material, which includes a relationship between a temperature and a volume of the pressure. The relationship is opposite to a temperature-dependent change in pressure or volume of the sensor material and at least partially compensates for a cross-sensitivity-induced change in volume of the sensor material.Type: ApplicationFiled: May 31, 2016Publication date: December 1, 2016Applicant: Biotronik SE & Co. KGInventors: Henning EBERT, Andreas BUNGE
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Patent number: 9492109Abstract: A medical sensor system (10, 10?) for detecting at least one characteristic (12) of an human and/or animal body has a sensor (14), a first characteristic carrier (16), and a characteristic carrier receptor (18). The first characteristic carrier (16) differs, in terms of at least one characteristic parameter, from a second characteristic carrier (20) which is present at least at the time of detection. The sensor (14) is preferably located in vivo at the time of detection of the at least one characteristic.Type: GrantFiled: October 5, 2011Date of Patent: November 15, 2016Assignee: Biotronik SE & Co. KGInventors: Andreas Bunge, Sarah Biela, Sven Bode, Joerg Naehring, Hoc Khiem Trieu, Gerald Urban
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Publication number: 20120130209Abstract: A sensor unit functionally stable in an implant, for performing qualitative and/or quantitative in vivo determination of an analyte, including a connection area (3) having at least one binding site for the analyte (7), the connection area undergoing a spatial change when the analyte binds to the binding site. The sensor unit further includes first (1) and second (5/9) fluorescently active regions bound to the connection area (3) in a manner such that, when a spatial change occurs to the connection area (3) due to the analyte binding to the connection area (3), the distance between the first fluorescently active region (1) and the second fluorescently active region (5/9) changes without the bonds of the fluorescently active regions (1, 5/9) to the connection area (3) being broken, and wherein one or both of the fluorescently active regions (1, 5/9) includes more than 60% by weight of an anorganic material.Type: ApplicationFiled: November 11, 2011Publication date: May 24, 2012Applicant: BIOTRONIK SE & CO. KGInventor: Andreas Bunge
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Publication number: 20120123235Abstract: A theranostic article has one or more specific molecular recognition markers for cells on the surface thereof, wherein the recognition markers are selected from the group consisting of peptides, proteins, antibodies, antigens, aptamers, molecular imprinted polymers and polynucleotides. When the article is implanted in a body, cellular ingrowth is controlled, with desired cell types anchoring and proliferating on the implant's surface to generate a thin layer, and thereafter ceasing accumulation. The cellular layer thereby presents a biomimetic surface acceptable to the body, and also presents a low barrier to diffusion of analytes with at least substantially constant diffusion characteristics, allowing use of an analyte sensor within the article.Type: ApplicationFiled: October 26, 2011Publication date: May 17, 2012Inventors: Alexander BORCK, Andreas BUNGE, Sarah BIELA
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Publication number: 20120088994Abstract: The invention relates to a medical sensor system (10) for detecting a feature (12), such as an analyte, in a human or animal body. The system (10) includes at least one sensor (14; 34) having a reservoir (18) with a cap (16) designed as a controllable organic membrane (20), wherein (for example) application of a voltage of a particular magnitude, or application of a voltage for a particular time, effects a change in the permeability of the membrane (20).Type: ApplicationFiled: September 29, 2011Publication date: April 12, 2012Inventors: Sven Bode, Andreas Bunge, Sarah Biela, Hoc Khiem Trieu
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Publication number: 20120088990Abstract: A medical sensor system (10, 10?) for detecting at least one characteristic (12) of an human and/or animal body has a sensor (14), a first characteristic carrier (16), and a characteristic carrier receptor (18). The first characteristic carrier (16) differs, in terms of at least one characteristic parameter, from a second characteristic carrier (20) which is present at least at the time of detection. The sensor (14) is preferably located in vivo at the time of detection of the at least one characteristic.Type: ApplicationFiled: October 5, 2011Publication date: April 12, 2012Inventors: Andreas Bunge, Sarah Biela, Sven Bode, Joerg Naehring, Hoc Khiem Trieu, Gerald Urban