Abstract: Provided herein are, inter alia, complexes useful for editing (e.g., repairing, modifying) DNA in a cell in vitro and in vivo. The complexes provided herein include a DNA editing agent bound to a phosphorothioate nucleic acid through a chemical linker. The chemical linker (e.g., disulfide linker) may be a linker that dissociates once the complex has entered the inside of the cell, thereby releasing the DNA editing agent and allowing the DNA editing agent to access and edit a cellular target sequence. The complexes provided herein exhibit high transfection efficiency and editing efficacy and therefore provide for useful therapeutic and diagnostic tools.

Abstract: A method for determining a switching point of a solenoid valve. A solenoid coil is energized to raise a solenoid armature to unblock a flow opening. For a signal profile characteristic of a current profile in the solenoid coil, multiple periods each different from one another and each having the same predefined temporal length are determined. Within each period, a minimal and a maximal value of the signal profile and associated points in time are ascertained and a product of a difference between the maximal and minimal value and a difference between the associated points in time are ascertained. On the basis of the points in time of the minimal and maximal value of that period, which corresponds to a maximal value of the product, the switching point is determined.

Abstract: Provided herein are, inter alia, nucleic acid compounds useful for targeting CTLA-4-expressing cells and modulating cell activity of the CTLA-4-expressing cells. The compositions provided herein may be part of pharmaceutical compositions and may be used for treatment of cancer, inflammatory diseases, infectious diseases or metabolic diseases.

Abstract: An internal multi-function rearview device for use with a vehicle includes a rearview element comprising at least one of a reflective element, a camera, or a display element; a housing configured to be attached to the vehicle and configured to be moveable relative to the vehicle; a bezel configured to be affixed to an opening defined by the housing and configured to surround the rearview element; and a foot configured to be fixed to the vehicle and relative to which the housing and bezel is moveable. The bezel is coated and a coating of the bezel is at least one of a decorative coating, an advanced surface technology, or a spectrally controlling system, and the rearview element is coupled to at least one of the bezel or the housing.

Abstract: An assembly set for assembling an external rearview system for a motor vehicle is provided. The external rearview system when assembled may include a base assembly provided for arrangement on the motor vehicle, and a head assembly attached to the base assembly. The assembly set may include (i) a first head assembly comprising a first rearview device comprising at least one reflective element in form of a mirror glass, and (ii) a second head assembly with at least one component of a camera monitor system. The head assembly may be configured to be detachable and is selected to be the first or second head assembly, with the first and second head assembly being exchangeable with each other.

Abstract: A multi-function rearview device for use with a vehicle includes a housing configured to be attached to the vehicle and to be moveable relative to the vehicle, a rearview element including at least one of a reflective element, a camera and a display element, a bezel formed at an outer portion of the multi-function rearview device surrounding the rearview element, with the rearview element being attached to at least one of the bezel and the housing, one or more light assemblies providing at least one or more light function indications, including a Human Machine Interface (HMI), and at least one sensor, the sensor controlling the one or more light assemblies or the display element.

Abstract: Provided herein are, inter alia, nucleic acid conjugates including a non-cell penetrating ribonucleic acid compound attached at its 3? end to a phosphorothioate polymer. Attachment of the phosphorothioate polymer to the non-cell penetrating ribonucleic acid conveys stability to and allows for efficient intracellular delivery of the non-cell penetrating ribonucleic acid. The nucleic acid conjugates provided herein including embodiments thereof are useful, inter alia, for the treatment of cancer, inflammatory disease, and pain.

Abstract: The disclosure refers to an internal rearview device (1) adapted for use with a motor vehicle, comprising: a rearview element comprising at least one of a reflective element (10) and a display element, with the rearview element having a normal state and at least one anti-glare state, in which a glare experienced by a driver of the vehicle as a result of light reflected at the rearview element is reduced; a bezel (32) surrounding the rearview element and being surrounded by a housing (60); control means comprising sensor means connected to at least one printed circuit board (40, 50), which is arranged between the housing (60) and the rearview element, for controlling at least the state of the rearview element; and a mount assembly (70) which is configured to attach the housing (60) to the vehicle; wherein the perimeter edge (31) of the bezel (32) is exposed to and is viewable by the driver of the vehicle when said device (1) is normally mounted in the vehicle; said perimeter edge (31) comprises a curved surfac

Abstract: An external rearview device for a motor vehicle includes a housing, and one or more of at least one light emitting or a receiving device, including one or more of at least one light producing device or at least one camera device arranged within the housing, and at least one at least partially transparent element closing an opening provided by the housing, the at least partially transparent element being provided in form of a first module attached to the housing, and the one or more of the light producing device or the camera device being provided in form of a second module attached to the first module, the first module and the second module being mechanically releasably coupled.

Abstract: An antenna housing for mounting on a vehicle or on a vehicle roof surface includes an electrical circuit including at least one source element for emitting luminescent radiation, the at least one source element being located internally within the housing so as not to be visible externally, an indicating element for releasing luminescent radiation received from the at least one source element for viewing externally, and an optical conduit for providing an optical couple between the at least one source element and the indicating element. A combined antenna and indicator module for mounting on a vehicle includes the antenna housing, and a vehicle includes the combined antenna and indicator module.

Abstract: The invention relates to A curable composition for producing dental composite crowns, the composition comprising a resin matrix comprising polymerizable (meth)acrylate(s) not comprising a urethane moiety, polymerizable urethane(meth)acrylate(s), wherein the polymerizable (meth)acrylate(s) not comprising an urethane moiety are used in excess over the polymerizable urethane(meth)acrylate(s), a filler matrix comprising nanocluster(s), fumed silica in an amount below 8 wt. % with respect to the weight of the whole composition, an initiator system comprising photoinitiator(s), organic dye(s), the curable composition not comprising softener in an amount of more than 5 wt. % with respect to the weight of the whole composition, the curable composition having a viscosity below 150 Pa*s at 23° C. and a shear rate of 1 s?1. The invention also relates to a cured article obtained by radiation curing this curable composition by use of an additive-manufacturing method.

Abstract: Systems and methods are provided for generating a rear view image display for a motor vehicle. A rear view system includes an optical sensor disposed at the motor vehicle and configured to capture image data, a computational unit coupled to the optical sensor by a cable connection and configured to execute program instructions stored on a computer-readable medium to modify the image data for presentation, and a display device coupled to the computational unit and configured to receive the modified image data from the computational unit and display the modified image data to a driver of the motor vehicle. The computational unit is further configured to receive software calibration to optimize modification of the image data.

Abstract: An external rearview device for a motor vehicle includes a housing, and one or more of at least one light emitting or a receiving device, including one or more of at least one light producing device or at least one camera device arranged within the housing, and at least one at least partially transparent element closing an opening provided by the housing, the at least partially transparent element being provided in form of a first module attached to the housing, and the one or more of the light producing device or the camera device being provided in form of a second module attached to the first module, the first module and the second module being mechanically releasably coupled.

Abstract: A method for displaying and processing an image captured by an optical system used to simulate a rear-view system of a vehicle, includes capturing the image, identifying primary edges of a first image of the plurality of images, locating a first border within the first image that extends to part of a first edge of the first image, identifying secondary edges of a second image of the plurality of images, selecting a second edge from the secondary edges closest in position and orientation to the part of the first edge of the first image, locating a second border within the second image that extends to the second edge, and adjusting the second image such that a second part of the second border of the second image aligns with the first border of the first image, wherein the optical system simultaneously simulates both a plane mirror and a spotter mirror in form of a spherical mirror in the single image to provide a plurality of optical subsystems.

Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone through a non-covalent linker including a biotin-binding domain and a biotin domain, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the conjugates.

Abstract: Provided herein are cell penetrating conjugates. The conjugates include non-cell penetrating proteins connected through a phosphorothioate nucleic acid, wherein the phosphorothioate nucleic acid enhances intracellular delivery of the non-cell penetrating proteins. Also provided are methods and kits including the conjugates provided herein.

Abstract: Described herein is a process for a preparation of microcapsules based on cleavable multi-alcohols. Also described herein are cleavable multi-alcohol-based microcapsules. Also described herein are perfuming compositions and consumer products including such capsules, in particular perfumed consumer products in the form of home care or personal care products.

Abstract: The present disclosure refers to a rear view system for a vehicle, comprising a rear view device comprising at least one camera module and/or at least one reflective element, wherein the rear view device is configured to be mounted to the vehicle, in particular to a door or a body of the vehicle, in order to capture a field-of-view (FOV) in a scenery at least around a rear part of the vehicle and to be moved between at least two states relative to the door and/or the body of the vehicle, in particular between a folded and unfolded state, characterized by a time-of-flight (ToF) sensor for emitting at least one light signal, and a processing unit for determining at least one of the states of the rear view device when the rear view device is mounted to the vehicle, wherein the ToF sensor is configured to be mounted to the rear view device or to the vehicle separate from the rear view device, and wherein the processing unit is configured to operate the ToF sensor to emit the at least one light signal towards the

Abstract: The invention relates to A curable composition for producing dental composite crowns, the composition comprising a resin matrix comprising polymerizable (meth)acrylate(s) not comprising a urethane moiety, polymerizable urethane(meth)acrylate(s), wherein the polymerizable (meth)acrylate(s) not comprising an urethane moiety are used in excess over the polymerizable urethane(meth)acrylate(s), a filler matrix comprising nanocluster(s), fumed silica in an amount below 8 wt. % with respect to the weight of the whole composition, an initiator system comprising photoinitiator(s), organic dye(s), the curable composition not comprising softener in an amount of more than 5 wt. % with respect to the weight of the whole composition, the curable composition having a viscosity below 150 Pa*s at 23° C. and a shear rate of 1 s?1. The invention also relates to a cured article obtained by radiation curing this curable composition by use of an additive-manufacturing method.

Abstract: The present disclosure refers to a rear view system for a vehicle, comprising a rear view device comprising at least one camera module and/or at least one reflective element, wherein the rear view device is configured to be mounted to the vehicle, in particular to a door or a body of the vehicle, in order to capture a field-of-view (FOV) in a scenery at least around a rear part of the vehicle and to be moved between at least two states relative to the door and/or the body of the vehicle, in particular between a folded and unfolded state, characterized by a time-of-flight (ToF) sensor for emitting at least one light signal, and a processing unit for determining at least one of the states of the rear view device when the rear view device is mounted to the vehicle, wherein the ToF sensor is configured to be mounted to the rear view device or to the vehicle separate from the rear view device, and wherein the processing unit is configured to operate the ToF sensor to emit the at least one light signal towards the