Abstract: The invention relates to drug development and synthetic chemistry, in particular to the manufacture of biologically active compounds based on naturally occurring molecules. It also relates to novel biologically active compounds, for example aminoglycoside antibiotics, in a substantially pure regioisomeric form. More particularly, the present invention relates to methods for the chemo- or regioselective derivatization of a target compound with multiple reactive groups, some of which may be derivatezed, and other which will not be derivatized.

Abstract: A method of making a printed circuit board and a printed circuit board including a plurality of plastic substrate parts having one or more first substrate parts each having at least one coupling means, and one or more second substrate parts each having at least one receiving means to receive the coupling mean. At least one of the plurality of plastic substrate parts is formed with a further structural element, and at least two of the plurality of plastic substrate parts are connected to each other through the at least one coupling means and the at least one receiving means. The connected substrate parts include a circuit.

Abstract: Influenza virus binding peptides and methods for using these peptides are disclosed. In an embodiment a peptide having from 8 to 40 amino acids includes a sequence X1-X2-X3-X4-Asp-X5-X6-X7 (SEQ ID NO:2), wherein X1 to X7 are selected from Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr and Val, and wherein SEQ ID NO:2 has at least 62.5% sequence identity and at most 87.5% sequence identity with the sequence Phe-Tyr-Asp-Tyr-Asp-Val-Phe-Tyr (SEQ ID NO:1).

Abstract: The invention relates to kit of parts comprising a solution, a porous zirconia article, optionally application equipment, the solution comprising cation(s) of non-coloring agent(s) selected from ions of Y, Gd, La, Yb, Tm, Mg, Ca and mixtures thereof, solvent(s) for the ion(s), optionally complexing agent(s), optionally thickening agent(s), optionally organic marker substance(s), optionally additive(s), the porous zirconia article showing a N2 adsorption and/or desorption of isotherm type IV according to IUPAC classification. The invention also relates to a method for enhancing the translucency of a zirconia article comprising the steps of providing a porous zirconia article and a solution, applying the solution to at least a part of the outer surface of the porous zirconia article, optionally drying the porous zirconia article of the preceding step, sintering the porous zirconia article to obtain a zirconia ceramic article.

Abstract: The present invention relates to the field of perfumery. More particularly, it concerns co-polymers, derived from aspartic acid and comprising at least one ?- or ?-aspartic acid derivative capable of liberating an active molecule such as, for example, an ?,?-unsaturated ketone or aldehyde. The present invention concerns also the use of polymers or co-polymers in perfumery as part of a perfuming or malodor counteracting composition, as well as the perfuming compositions or perfumed articles comprising the invention's compounds.

Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone through a non-covalent linker including abiotin-binding domain and a biotin domain, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the conjugates.

Abstract: The present invention relates to a delivery system based on photosensitive acetal or ketal compounds capable of liberating upon exposure to light an active volatile carbonyl compound in a controlled manner from a surface into the surrounding. The delivery system can be used to release active substances such as flavors, fragrances, malodor counteractants, insect attractants or insect repellents. The invention also relates to the use of said acetal or ketal compounds in perfumery, as well as in perfuming compositions or perfumed consumer articles.

Abstract: A method for applying a heating system on a surface includes providing an imprint form including a basic form and an arm, tampon printing a plurality of heating elements on the surface with the imprint form such that each heating element has the basic form of the imprint form and is produced with a guide arm by the arm of the respective imprint form, where two adjacent heating elements are connected by the guide arm, and the heating elements are made from a conductive substrate including conductive particles, and connecting the heating elements to at least one heating conductor or heating segment.

Abstract: An exterior rear view mirror of an exterior rear view mirror assembly for a motor vehicle is described. The exterior rear view mirror includes: an exterior rear view mirror housing, a base bracket, at least partly accommodated in the exterior rear view mirror housing, a frame with walls, which surround an opening arranged on the rear side of the exterior rear view mirror housing, for a mirror glass, and an adjusting device, attached to the base bracket, for the mirror glass. The frame is attached to the adjusting device. In addition, a process for assembly of an exterior rear view mirror of this type is described.

Abstract: A method for manufacturing an automotive mirror, in particular a side mirror, includes forming a printed circuit board as flexible printed circuit board with n+1 branches, n?N, providing n modules each including at least one electronic element housed within a plastic casting and connected to conducting paths on at least one of the surfaces of the plastic casting, and at least one standard gripping point, guiding structure, snap connection element and/or sealing member provided by the plastic casting, connecting up to n of said branches to one module each and connecting one branch to cables or a cable harness to be connected to a power supply and/or a control unit outside the mirror, providing mirror parts free of electronic elements, and assembling the mirror parts and the modules.

Abstract: A dental coloring stamp has a transfer pad for transferring a dental coloring solution to a precursor of a dental restoration. The transfer pad is at least partially formed of an open-celled elastic sponge and has a free transfer surface. The cross-section of the transfer pad is greater than a circular area of 10 mm in diameter so that a side of a dental restoration precursor can be stamped and thus colored. The invention helps facilitating the coloring of dental restorations.

Abstract: The invention provides for a RANKL-specific antagonistic agent recognizing human platelet-expressed receptor activator of nuclear factor kappa-B ligand (pRANKL), for use in treating a cancer patient to prevent or reduce premetastatic lesions in blood.

Abstract: The present invention relates to water-dispersable microcapsules comprising an oil phase, e.g. a perfume, containing a photolabile polymer comprising ?-ketoacid or ?-ketoester group capable of generating a gas upon exposure to light. The gas is able to cause an extension or the breaking of the microcapsule allowing the release of the oil phase and thus increasing the long-lastingness of the odor perception. The present invention concerns also the use of said microcapsules in perfumery as well as perfuming compositions or perfumed articles comprising the invention's microcapsules to provide a prolonged release of fragrant molecules.

Abstract: A head section for a rear view device for a motor vehicle includes a casing means including at least one housing section and a lid section arranged on a side of the housing section which faces away from a driving direction of the motor vehicle, at least one electronic unit arranged in a hollow area formed between the housing section and the lid section, a first rear view means for displaying an area of the motor vehicle, and a second rear view means for displaying a second are of the motor vehicle, where the second rear view means is arranged on the lid section, with the lid section and the second rear view means includes a combined, single-piece component, and where the lid section includes a polymeric substrate, which is coated with a chromium-based reflective coating.

Abstract: The present invention relates to the field of perfumery. More particularly, it concerns polymers derived from siloxane derivatives and comprising at least one ?-thio carbonyl moiety capable of liberating an active molecule such as, for example, an ?,?-unsaturated ketone or aldehyde. The present invention concerns also the use of polymers in perfumery as part of a perfuming or malodor counteracting composition as well as the perfuming compositions or perfumed articles comprising the invention's compounds.

Abstract: The present invention relates to the field of perfumery. More particularly, it concerns short chain ?-sulfur carbonyl moieties capable of liberating an active molecule, such as a perfuming ?,?-unsaturated ketone or aldehyde. The present invention concerns also the use of said compounds in perfumery as well as the perfuming compositions or perfumed articles comprising the invention's compounds.

Abstract: The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, comprising contacting the carbohydrate substrate in a solvent in the presence of a transition metal catalyst complex with an oxidizing agent to yield a mono-oxidized carbohydrate.

Abstract: The present invention relates to water-dispersable microcapsules comprising an oil phase, e.g. a perfume, containing a photolabile ?-ketoacid or ?-ketoester capable of generating a gas upon exposure to light. The gas is able to cause an extension or the breaking of the microcapsule allowing the release of the oil phase and thus increasing the long-lastingness of the odor perception. The present invention concerns also the use of said microcapsules in perfumery as well as the perfuming compositions or perfumed articles comprising the invention's microcapsules to provide a prolonged release of fragrant molecules.

Abstract: An adjustment assembly for adjusting the reflecting surface of a glass assembly in an external rearview vehicle mirror, where two linear adjusting motors act on two points of the glass assembly, where the adjusting motors are positioned between the glass assembly and a mirror carrier in the mirror head. The adjusting motors are connected to the glass assembly and/or the mirror carrier via at least one elastomeric connecting piece.

Abstract: A control circuit controls at least one lighting device in a vehicle, preferably in a motor vehicle and includes at least a first output channel and at least a second output channel. The first output channel is adapted to provide a first maximum current, and the second output channel is adapted to provide a second maximum current. At least the first and second output channels are suited to be combined into a third output channel, wherein the third output channel provides a third maximum current. The third maximum current corresponds to the sum of at least a share of the first maximum current and at least a share of the second maximum current.