Abstract: The present disclosure relates to a method for targeted integration of a donor vector into a specific pre-defined genomic location of an isolated eukaryotic host cell. The vector and host cell together comprise nucleic acid components allowing for the selection of cells having integrated the donor vector into the pre-defined genomic location of the host cell. More specifically, the present method provides for the selection of sequence optimized nucleic acid sequence variants. Such optimized nucleic acid sequence variants may comprise sequence optimized expression vector components for subsequent use in recombinant protein production.

Abstract: A handheld power tool (1) is disclosed comprising an electronic control unit (3), a housing (4) accommodating the electronic control unit (3), an actuator (5) movably arranged on the housing (4) between a first position and a second position, and a switch assembly (6) comprising a magnet (M) and a sensor (S) configured to sense the magnitude of a magnetic field. One of the sensor (S) and the magnet (M) is arranged in the housing (4) and the other of the sensor (S) and the magnet (M) is arranged on a portion (5?) of the actuator (5) such that the relative distance between the magnet (M) and the sensor (S) is different when the actuator (5) is in the second position than when the actuator (5) is in the first position.

Abstract: Electrically powered construction equipment (100, 1200, 1300, 1400, 1500) comprising an electric motor (120) arranged to power an abrasive cutting tool (130) via a drive arrangement (200), the abrasive cutting tool (130) comprising abrasive elements (131) arranged on a carrier (132) of the cutting tool (130), where the abrasive elements (131) are arranged distanced from each other on the carrier (132) and follow a closed path during operation of the construction equipment, the construction equipment (100, 1200, 1300, 1400, 1500) further comprising a vibration device (120, 300, 350, 400, 500, 600, 700, 800) arranged to generate a controlled amount of vibration of the abrasive cutting tool (130), wherein the vibration is generated in a frequency band below 15 kHz.

Abstract: An inspection tool (100) for inspection of a concrete surface (180), the tool comprising a vision-based sensor (110) arranged to be directed at a section of the concrete surface (180), guiding means (120) for allowing an operator (170) to move the vision-based sensor (110) over the concrete surface (180), a trigger (130) arranged to receive a command from the operator (170), wherein the vision-based sensor (110) is arranged to capture at least one image of the concrete surface in response to the command, a control system arranged to analyze the at least one image of the concrete surface in terms of a surface quality of the section of the concrete surface (180), and a display unit (140) arranged to present a result of the surface quality analysis to the operator (170).

Abstract: A handheld power tool (1) is disclosed comprising a tool (30) and an engine (10) configured to power the tool (30). The power tool (1) comprises a handle portion (4) and an engine portion (6) resiliently suspended to the handle portion (4). The power tool (1) has a void space (12, 12?) between the handle portion (4) and the engine portion (6) extending along a separation plane (Sp). The separation plane (Sp) is transversal to a horizontal centre plane (Hcp) and to a vertical centre plane (Vcp) of the power tool (1). The power tool (1) comprises a control device (28) mounted to the handheld power tool (1) such that the angle (a1) between the separation plane (Sp) and one of two larger sides (s1, s1?) of the control device (28) is less than 35 degrees or is less than 25 degrees.

Abstract: A handheld power tool (1) is disclosed comprising an electronic control unit (3), a housing (4) accommodating the electronic control unit (3), an actuator (5) movably arranged on the housing (4) between a first position and a second position, and a switch assembly (6) comprising a magnet (M) and a sensor (S) configured to sense the magnitude of a magnetic field. One of the sensor (S) and the magnet (M) is arranged in the housing (4) and the other of the sensor (S) and the magnet (M) is arranged on a portion (5?) of the actuator (5) such that the relative distance between the magnet (M) and the sensor (S) is different when the actuator (5) is in the second position than when the actuator (5) is in the first position.

Abstract: A surface electromyography system, sensors for use in a surface electromyography system, and methods for use thereof. The surface electromyography system comprises a plurality of sensors for detecting muscular electrical activity, and an output unit coupleable to the plurality of sensors, the output unit operable to provide outputs representing the outputs of each of the plurality of sensors. The sensors of the plurality of sensors each comprise a pair of electrodes and are operable to provide an output representing the potential difference between the pair of electrodes.

Abstract: The present disclosure relates to a method for targeted integration of a donor vector into a specific pre-defined genomic location of an isolated eukaryotic host cell. The vector and host cell together comprise nucleic acid components allowing for the selection of cells having integrated the donor vector into the pre-defined genomic location of the host cell. In addition, it provides for the identification of any random integrations of the donor vector(s) into other parts of the host cell genome. Once identified, such cells present an excellent alternative for subsequent recombinant protein production.

Abstract: A gear shifter assembly for a vehicle is described herein. The gear shifter assembly includes a base to be fixed in a vehicle, a shifter yoke mounted to the base by a main pivot shaft, a shift lever mounted to the shifter yoke by a pivotal bearing arranged to allow pivotal movements about a second pivotal axis perpendicular to the first pivotal axis, and an intermediate joint that provides the pivotal bearing of the shift lever. The intermediate joint is attached to the lower end of the shift lever by receiving select pivot pins projecting from the shift lever in recesses of the intermediate joint. The intermediate joint comprises opposite through holes aligned with an aperture in the shift lever for receiving the main pivot shaft. The intermediate joint is made of material having a lower modulus of elasticity than the materials of the shift lever and the shifter yoke.

Abstract: A valve arrangement including: a valve inlet, a valve outlet arranged downstream of the valve inlet, a first chamber arranged directly downstream of the inlet, and a second chamber arranged between the first chamber and the valve outlet. The valve arrangement further includes a measuring nipple comprising a measuring channel for receiving a measuring device, and a closing arrangement having open positions and a closed position, wherein the closing arrangement in its closed position is configured to prevent fluid communication between the first chamber and the second chamber via the closing arrangement, and wherein the closing arrangement in its open positions is configured to allow for fluid communication between the first chamber and the second chamber via the closing arrangement.

Abstract: The present invention relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for the treatment of disease in mammals including humans.

Abstract: A gear shifter assembly for a vehicle is described herein. The gear shifter assembly includes a base to be fixed in a vehicle, a shifter yoke mounted to the base by a main pivot shaft, a shift lever mounted to the shifter yoke by a pivotal bearing arranged to allow pivotal movements about a second pivotal axis perpendicular to the first pivotal axis, and an intermediate joint that provides the pivotal bearing of the shift lever. The intermediate joint is attached to the lower end of the shift lever by receiving select pivot pins projecting from the shift lever in recesses of the intermediate joint. The intermediate joint comprises opposite through holes aligned with an aperture in the shift lever for receiving the main pivot shaft. The intermediate joint is made of material having a lower modulus of elasticity than the materials of the shift lever and the shifter yoke.

Abstract: A valve arrangement including: a valve inlet, a valve outlet arranged downstream of the valve inlet, a first chamber arranged directly downstream of the inlet, and a second chamber arranged between the first chamber and the valve outlet. The valve arrangement further includes a measuring nipple comprising a measuring channel for receiving a measuring device, and a closing arrangement having open positions and a closed position, wherein the closing arrangement in its closed position is configured to prevent fluid communication between the first chamber and the second chamber via the closing arrangement, and wherein the closing arrangement in its open positions is configured to allow for fluid communication between the first chamber and the second chamber via the closing arrangement.

Abstract: A chain bar unit for a wall saw is presented herein. The chain bar unit can include a bar configured to receive a circulating chain or wire around a perimeter of the bar. The chain bar unit also can include a driving gear for driving the chain or wire around the bar, the driving gear configured to be coupled to an output shaft of the wall saw. The chain bar unit further includes the bar being tapered from an end proximate to the driving gear to a distal end having a distal end radius, wherein a width of the bar at the proximate end, is at least two times the distal end radius of the distal end.

Abstract: Systems and methods to provide social analytics information are disclosed. An exemplary system may include a database and a server coupled to the database. The server may include a business analytics module configured to receive data related to a business and generate, based on the received data, a set of business analytics information, and store the business analytics information in the database. The server further may include an interactive display module configured to generate an interactive object based on the business analytics information, provide controlled access to the interactive object to a first user of a predefined group of users, and provide a display of the interactive object to a second user of the predefined group of users.

Abstract: Systems and methods to provide predictive alerting are disclosed. Trends and characteristics in the data may be identified in advance of actual occurrence, with an expected event being predicted or extrapolated based on data and a predictive model associated with stored and/or incoming data. This may be done by, for example, developing a set of rules associated with the model that may then be used to trigger predictive alerts based on predicted trends. Various data and associated characteristics may be determined based on past data and/or analogous data taken from similarly modeled systems. For example, seasonal trends may be factored into the model so that a prediction is based on both a received set of data and expected seasonal (or other temporal) trends. Various other characteristics may also be used in the predictive model.

Abstract: An interchangeable concrete cutting chain-saw cutting assembly (500) adapted for installation upon a drive assembly (112) in exchange for a removed, different type cutting head assembly. The chainsaw cutting assembly (500) includes a housing (703) that has fasteners that releasably attach the housing (703) to a drive assembly (112) in an installed configuration. A ratio transmission (525) has a plurality of interconnected rotatable members (533, 535), each rotatable member (533, 535) having a mounting shaft (641, 643) positioned at a fixed location on the housing (703) by a bearing assembly (640, 642). The driven member (533) has a receiver that interconnects with a driveshaft (372) of the drive assembly (112) in the installed configuration whereby the driven member (533) is rotated by the drive assembly (112). The cutting chain drive member (535) operatively interconnected with a drive sprocket (707) whereby rotation of the cutting chain drive member (535) rotates the drive sprocket (707).

Abstract: A blade guard for a circular saw blade. The blade guard includes at least two pieces coupled together. The blade guard also includes at least one bottom plate having a slot formed therein for accommodating the circular saw blade and at least one top cover. Additionally, the blade guard includes a plurality of fastening rods for coupling the bottom plate with the top cover, the plurality of fastening rods further configured to secure the at least two pieces to the at least one bottom plate and the at least one top cover.

Abstract: This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis, diagnostics, and imaging.

Abstract: A rod support system has an upper gripper assembly and a lower gripper assembly. Each gripper assembly has a top plate having a first track. The first track has a first substantially arcuate portion having a first radius of curvature and a second substantially arcuate portion having a second and smaller radius of curvature. A jaw is constrained to move in a path defined by the first track. A bottom plate of the assembly has a second track that is congruent with the first track also engaging the jaw, so that the jaw is constrained to move in a path defined by the first track and the second track in cooperation. The jaws can support a rod when the jaws move from a position along the first arcuate portion of the first and second tracks to a position along the second arcuate portion of the first and second tracks.