Patents by Inventor Andreas Krebs
Andreas Krebs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5358924Abstract: There are provided new 3-hydroxy-4-aryl-5-oxo-pyrazoline derivatives of the formula (I) ##STR1## in which A and B are identical or different and independently of one another in each case represent hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkythioalkyl, cycloalkyl or optionally substituted aryl orA and B together represent the bivalent radical of a saturated or unsaturated, optionally substituted, mono-, bi-, tri- or polycyclic system,X represents alkyl, halogen or alkoxy,Y represents hydrogen, alkyl, halogen, alkoxy or halogenoalkyl,Z represents alkyl, halogen or alkoxy,n represents a number 0, 1, 2 or 3,G represents hydrogen (a) or the groups ##STR2## in which E represents a metal ion equivalent or an ammonium ion,L and M represents oxygen and/or sulphur,and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have the meaning given in the text of the application.Type: GrantFiled: December 31, 1992Date of Patent: October 25, 1994Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kruger, Reiner Fischer, Heinz-Jurgen Bertram, Thomas Bretschneider, Stefan Bohm, Andreas Krebs, Thomas Schenke, Hans-Joachim Santel, Klaus Lurssen, Robert R. Schmidt, Christoph Erdelen, Ulrike Wachendorff-Neumann, Wilhelm Stendel
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Patent number: 5332720Abstract: There are provided new 3-hydroxy-4-aryl-5-oxo-pyrazoline derivatives of the formula (I) ##STR1## The new 3-hydroxy-4-aryl-5-oxo-pyrazoline derivatives of the formula (I) have a particularly pronounced activity against animal pests, in particular against insects and arachnids, and against weeds.Type: GrantFiled: December 16, 1992Date of Patent: July 26, 1994Assignee: Bayer AktiengesellschaftInventors: Bernd-Wieland Kruger, Reiner Fischer, Heinz-Jurgen Bertram, Thomas Bretschneider, Stefan Bohm, Andreas Krebs, Thomas Schenke, Hans-Joachim Santel, Klaus Lurssen, Robert R. Schmidt, Christoph Erdelen, Ulrike Wachendorff-Neumann, Wilhelm Stendel
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Patent number: 5312823Abstract: The invention relates to new quinolonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.Type: GrantFiled: June 19, 1992Date of Patent: May 17, 1994Assignee: Bayer AktiengesellschaftInventors: Uwe Petersen, Andreas Krebs, Thomas Schenke, Klaus Grohe, Klaus-Dieter Bremm, Rainer Endermann, Karl-Georg Metzger, Hans-Joachim Zeiler
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Patent number: 5304650Abstract: Alkyl N-(hydroxyalkyl)-carbamates of the formula (I) ##STR1## in which R.sup.1 represents alkyl and R.sup.2 to R.sup.8 are identical or different and represent hydrogen or alkyl, or R.sup.2 and R.sup.3 together with the atoms to which they are bonded, form an optionally alkyl-substituted monocyclic ring, and n denotes 0 or 1,can be obtained in high purity and very good space-time-yields when amino alcohols of the formula (II) ##STR2## in which R.sup.2 to R.sup.8 and n have the abovementioned meaning are reacted with chloroformates of the formula (III) ##STR3## in which R.sup.1 has the abovementioned meaning, in the presence of aqueous alkali metal hydroxide solutions and if appropriate in the presence of an organic solvent at temperatures between 30.degree. C. and 110.degree. C.The substances prepared according to the invention can be employed as active compounds in agents for repelling insects and mites (cf. EP-A 289,842).Type: GrantFiled: October 1, 1992Date of Patent: April 19, 1994Assignee: Bayer AktiengesellschaftInventors: Andreas Krebs, Bernd-Wieland Kruger
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Patent number: 5284855Abstract: The invention relates to new 7-(2,7-Diazabicyclo[3.3.0]octyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives, processes for their preparation, and anti-bacterial agents and feed additives containing them.Type: GrantFiled: November 12, 1992Date of Patent: February 8, 1994Assignee: Bayer AktiengesellschaftInventors: Uwe Petersen, Thomas Schenke, Michael Schriewer, Klaus Grohe, Andreas Krebs, Ingo Haller, Karl G. Metzger, Klaus-Dieter Bremm, Rainer Endermann, Hans-Joachim Zeiler
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Patent number: 5252734Abstract: Antibacterial 5-alkylquinolonecarboxylic acids of the formula ##STR1## in which R.sup.3 is C.sub.1 -C.sub.4 - alkyl,R.sup.1 is optionally substituted alkyl or cycloalkyl, alkenyl, alkoxy, amino or alkylamino or optionally substituted phenyl,R.sup.2 is hydrogen or optionally substituted alkyl,R.sup.4 is a nitrogen-containing heterocyclic radical, andA is hydrogen, halogen, methyl, cyano or nitro, or forms a bridge with R.sup.1.and hydrates and salts thereof.Type: GrantFiled: February 5, 1992Date of Patent: October 12, 1993Assignee: Bayer AktiengesellschaftInventors: Michael Schriewer, Klaus Grohe, Andreas Krebs, Uwe Petersen, Thomas Schenke, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
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Patent number: 5202337Abstract: The invention relates to new 7-(2,7-Diazabicyclo[3.3.0]octyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives, processes for their preparation, and antibacterial agents and feed additives containing them.Type: GrantFiled: October 3, 1991Date of Patent: April 13, 1993Assignee: Bayer AktiengesellschaftInventors: Uwe Petersen, Thomas Schenke, Michael Schriewer, Klaus Grohe, Andreas Krebs, Ingo Haller, Karl G. Metzger, Klaus-Dieter Bremm, Rainer Endermann, Hans-Joachim Zeiler
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Patent number: 5186737Abstract: Insecticidal, acaricidal, herbicidal and antimycotic 3-aryl-pyrrolidine-2,4-diones of the formula ##STR1## in which X represents alkyl, halogen or alkoxy,Y represents hydrogen, alkyl, halogen, alkoxy or halogenoalkyl,Z represents alkyl, halogen or alkoxy,n represents a number from 0-3,R represents hydrogen or represents the groups --CO--R.sup.1 or --CO--O--R.sup.2,in whichR.sup.1 represents alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl, polyalkoxyalkyl or cycloalkyl which can be interrupted by hetero atoms, each of which radicals is optionally substituted by halogen, or represents optionally substituted phenyl, optionally substituted phenylalkyl, substituted hetaryl, substituted phenoxyalkyl or substituted hetaryloxyalkyl, or represents optionally substituted phenyl, optionally substituted phenylalkyl, substituted hetaryl, substituted phenoxyalkyl and substituted hetaryloxyalkyl, andR.sup.Type: GrantFiled: April 1, 1991Date of Patent: February 16, 1993Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Bernd Baasner, Hermann Hageman, Andreas Krebs, Albrecht Marhold, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen, Benedikt Becker, Klaus Schaller, Harry Strang
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Patent number: 5142065Abstract: An acylamino ester of the formula ##STR1## wherein X is C.sub.1-6 alkyl, or halogen,Y is hydrogen, C.sub.1-6 alkyl, halogen, or C.sub.1-3 halogenalkyl,Z is C.sub.1-6 alkyl, or halogen,n is 0 to 3,provided that when n is O,Y is not hydrogen, andR.sup.3 is C.sub.1-6 alkyl.Type: GrantFiled: June 5, 1991Date of Patent: August 25, 1992Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Hermann Hagemann, Andreas Krebs, Albrecht Marhold, Klaus Lurssen, Robert R. Schmidt, Hans-Joachim Santel, Benedikt Becker, Klaus Schaller, Wilhelm Stendel
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Patent number: 5140033Abstract: Antibacterial 5-alkylquinolonecarboxylic acids of the formula ##STR1## in which R.sup.3 is C.sub.1 -C.sub.4 -alkyl,R.sup.1 is optionally substituted alkyl or cycloalkyl, alkenyl, alkoxy, amino or alkylamino or optionally substituted phenyl,R.sup.2 is hydrogen or optionally substituted alkyl,R.sup.4 is a nitrogen-containing heterocyclic radical, andA is hydrogen, halogen, methyl, cyano or nitro, or forms a bridge with R.sup.1.and hydrates and salts thereof.Type: GrantFiled: October 1, 1990Date of Patent: August 18, 1992Assignee: Bayer AktiengesellschaftInventors: Michael Schriewer, Klaus Grohe, Andreas Krebs, Uwe Petersen, Thomas Schenke, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
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Patent number: 5116836Abstract: Novel 3-aryl-pyrrolidine 2,4-dione derivatives of the formula ##STR1## having pesticidal activity.Type: GrantFiled: August 15, 1990Date of Patent: May 26, 1992Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Hermann Hagemann, Andreas Krebs, Albrecht Marhold, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen, Benedikt Becker, Wilhelm Stendel, Christoph Erdelen
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Patent number: 5091537Abstract: A 3-aryl-pyrrolidine-2,4-dione (e) derivative of the formula (I) ##STR1## in which X represents alkyl, halogen and alkoxy,Y represents hydrogen, alkyl, halogen, alkoxy and halogenoalkyl,Z represents alkyl, halogen and alkoxy,m represents a number from 1-4,n represents a number from 0-3,R represents hydrogen, ##STR2## or A, where A represents a metal cation equivalent or represents an ammonium ion,R.sup.1 represents optionally halogen-substituted alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl, polyalkoxyalkyl and optionally substituted cycloalkyl which can be interrupted by hetero atoms, or represents optionally substituted phenyl, optionally substituted phenylalkyl, substituted hetaryl, substituted phenoxyalkyl and substituted hetaryloxyalkyl andR.sup.2 represents optionally halogen-substituted alkyl, cycloalkyl, alkenyl, alkoxyalkyl, polyalkoxyalkyl and optionally substituted phenyl,as well as the pure enantiomeric forms of compounds of the formula (I).Type: GrantFiled: August 8, 1990Date of Patent: February 25, 1992Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Hermann Hagemann, Andreas Krebs, Albrecht Marhold, Klaus Lurssen, Robert R. Schmidt, Hans-Joachim Santel, Benedikt Becker, Klaus Schaller, Wilhelm Stendel
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Patent number: 5061712Abstract: Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##Type: GrantFiled: May 25, 1990Date of Patent: October 29, 1991Assignee: Bayer AktiengesellschaftInventors: Uwe Petersen, Andreas Krebs, Thomas Schenke, Klaus Grohe, Michael Schriewer, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
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Patent number: 5059597Abstract: 7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen,X.sup.2 is hydrogen, halogen, amino or other radical,R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical,R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical,R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1,and addition products thereof.Type: GrantFiled: September 10, 1990Date of Patent: October 22, 1991Assignee: Bayer AktiengesellschaftInventors: Uwe Petersen, Thomas Schenke, Andreas Krebs, Klaus Grohe, Michael Schriewer, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
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Patent number: 5045560Abstract: Insecticidal, acaricidal, herbicidal and antimycotic 3-aryl-pyrrolidine-2,4-diones of the formula ##STR1## in which X represents alkyl, halogen or alkoxy,Y represents hydrogen, alkyl, halogen, alkoxy or halogenoalkyl,Z represents alkyl, halogen or alkoxy,n represents a number from 0-3,R represents hydrogen or represents the groups --CO--R.sup.1 or --CO--O--R.sup.2, in whichR.sup.1 represents alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl, polyalkoxyalkyl or cycloalkyl which can be interrupted by hetero atoms, each of which radicals is optionally substituted by halogen, or represents optionally substituted phenyl, optionally substituted phenylalkyl, substituted hetaryl, substituted phenoxyalkyl or substituted hetaryloxyalkyl, or represents optionally substituted phenyl, optionally substituted phenylalkyl, substituted hetaryl, substituted phenoxyalkyl and substituted hetaryloxyalkyl, andR.sup.Type: GrantFiled: January 2, 1990Date of Patent: September 3, 1991Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Bernd Baasner, Hermann Hagemann, Andreas Krebs, Albrecht Marhold, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen, Benedikt Becker, Klaus Schaller, Harry Strang
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Patent number: 4990517Abstract: 7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen,X.sup.2 is hydrogen, halogen, amino or other radical,R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical,R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical,R.sup.3 is ##STR2## A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1, and addition products thereof.Type: GrantFiled: June 30, 1989Date of Patent: February 5, 1991Assignee: Bayer AktiengesellschaftInventors: Uwe Petersen, Thomas Schenke, Andreas Krebs, Klaus Grohe, Michael Schriewer, Ingo Haller, Karl G. Metzger, Rainer Endermann, Hans-Joachim Zeiler
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Patent number: 4985063Abstract: A 3-aryl-pyrrolidine-2,4-dione (e) derivative of the formula (I) ##STR1## in which X represents alkyl, halogen and alkoxy,Y represents hydrogen, alkyl, halogen, alkoxy and halogenoalkyl,Z represents alkyl, halogen and alkoxy,m represents a number from 1-4,n represents a number from 0-3, R represents hydrogen, ##STR2## or A where A represents a metal cation equivalent or represents an ammonium ion,R.sup.1 represents optionally halogen-substituted alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl, polyalkoxyalkyl and optionally substituted cycloalkyl which can be interrupted by hetero atoms, or represents optionally substituted phenyl, optionally substituted phenylalkyl, substituted hetaryl, substituted phenoxyalkyl and substituted hetaryloxyalkyl andR.sup.2 represents optionally halogen-substituted alkyl, cycloalkyl, alkenyl, alkoxyalkyl, polyalkoxyalkyl and optionally substituted phenyl,as well as the pure enantiomeric forms of compounds of the formula (I).Type: GrantFiled: August 8, 1989Date of Patent: January 15, 1991Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Hermann Hagemann, Andreas Krebs, Albrecht Marhold, Klaus Lurssen, Robert R. Schmidt, Hans-Joachim Santel, Benedikt Becker, Klaus Schaller, Wilhelm Stendel
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Patent number: 4910319Abstract: A process for preparing a 3-amino-1-benzyl-pyrrolidine of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is H or alkyl, andPh is phenyl,comprising reacting a 1-benzyl-.DELTA..sup.3 -pyrroline-2,5-dione of the formula ##STR2## in which R.sup.3 and R.sup.4 each independently is H or alkyl, with a nitrogen nucleophile of the formulaR.sup.5 NH.sub.2 (III)in whichR.sup.5 is H, benzyl, naphthylmethyl or phenyl-CHR.sup.6, andR.sup.6 is C.sub.1 -C.sub.6 -alkyl or phenyl,to give an optionally substituted 3-amino-1-benzylpyrrolidine-2,5-dione of the formula ##STR3## and, if R.sup.5 .noteq.H, the protecting group R.sup.5 is subsequently cleaved off to give a 3-amino-1-benzylpyrrolidine-2,5-dione of the formula ##STR4## and completely reducing the carbonyl groups to form the 3-amino-1-benzylpyrrolidine of the formula (I).Type: GrantFiled: September 28, 1988Date of Patent: March 20, 1990Assignee: Bayer AktiengesellschaftInventors: Andreas Krebs, Thomas Schenke
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Patent number: 4865641Abstract: Herbicidally active compounds of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents hydrogen or alkyl,with the proviso that R.sup.1 and R.sup.2 do not simultaneously represent hydrogen,X represents oxygen or sulphur,R.sup.3 represents hydrogen, halogen, nitro, amino, cyano, alkyl, halogenoalkyl, alkoxy or halogenoalkoxy,wherein the radicals R.sup.3 can be identical or different,n represents a number from 1-4,U represents oxygen or sulphur,V represents a ##STR2## group, R.sup.4 and R.sup.5 independently of one another repreesnt hydrogen, alkyl, alkoxyalkyl or halogenoalkyl,W represents a radical ##STR3## D represents carbon or silicon, E represents oxygen or sulphur, andR.sup.6 through R.sup.12 can have various meanings.The starting materials wherein -U-V-W together are OH are also new.Type: GrantFiled: March 9, 1988Date of Patent: September 12, 1989Assignee: Bayer AktiengesellschaftInventors: Klaus Sasse, Reiner Fischer, Hermann Hagemann, Andreas Krebs, Michael Schwamborn, Hans-Joachim Santel, Robert R. Schmidt, Robert H. Strang
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Patent number: 4777283Abstract: Alkoxycarbonyl isocyanates are prepared from carbamic acid esters by reacting these with phosgene and adding a catalyst.Type: GrantFiled: December 31, 1986Date of Patent: October 11, 1988Assignee: Bayer AktiengesellschaftInventors: Andreas Krebs, Hermann Hagemann