Patents by Inventor Andreas P. Termin

Andreas P. Termin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of muscarinic receptors
    Patent number: 8263605
    Abstract: The present invention relates to modulators of muscarinic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: September 11, 2012
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Spiroindoline modulators of muscarinic receptors
    Patent number: 8258148
    Abstract: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: September 4, 2012
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • ION CHANNEL MODULATORS AND METHODS OF USE
    Publication number: 20120208790
    Abstract: In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
    Type: Application
    Filed: April 27, 2012
    Publication date: August 16, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Esther Martinborough, Tim Neubert, Tara Whitney, Danielle Lehsten, Tara Hampton, Nicole Zimmermann, Andreas P. Termin
  • Bicyclic derivatives as modulators of voltage gated ION channels
    Patent number: 8236829
    Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: August 7, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Timothy Donald Neubert, Aarti Sameer Kawatkar, Esther Ann Martinborough, Andreas P. Termin, Nicole Hilgraf
  • PHENYL SULPHONAMIDES AS MODULATORS OF ION CHANNELS
    Publication number: 20120178713
    Abstract: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
    Type: Application
    Filed: March 14, 2012
    Publication date: July 12, 2012
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Esther Martinborough, Lev T.D. Fanning, Urvi Sheth, Dean Wilson, Andreas P. Termin, Timothy D. Neubert, Nicole Hilgraf, Tara Leanne Hampton, Tara Whitney, Aarti Sameer Kawatkar, Danielle Lehsten, Dean Stamos, Jinglan Zhou, Vijayalaksmi Arumugam, Corey Anderson
  • Heterocyclic derivatives for modulation of calcium channels
    Patent number: 8211935
    Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: July 3, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Andreas P. Termin, Esther Ann Martinborough, Nicole Hilgraf, Charles J. Cohen, Corey Anderson
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Patent number: 8202861
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: June 19, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E Gonzales, III, Andreas P Termin, Esther Martinborough, Nicole Zimmerman
  • Ion channel modulators and methods of use
    Patent number: 8193194
    Abstract: In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: June 5, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Tim Neubert, Tara Whitney, Danielle Lehsten, Tara Hampton, Nicole Zimmermann, Andreas P. Termin
  • Pyrrolidinyl phenyl sulphonamides as modulators of ion channels
    Patent number: 8163720
    Abstract: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: April 24, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Lev T. D. Fanning, Urvi Sheth, Dean Wilson, Andreas P. Termin, Timothy D. Neubert, Nicole Hilgraf, Tara Leanne Hampton, Tara Whitney, Aarti Sameer Kawatkar, Danielle Lehsten, Dean Stamos, Jinglan Zhou, Vijayalaksmi Arumugam, Corey Anderson
  • Derivatives for modulation of ion channels
    Patent number: 8129546
    Abstract: Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: March 6, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Andreas P. Termin, Timothy D. Neubert, Nicole Hilgraf, Corey Anderson
  • COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED ION CHANNELS
    Publication number: 20120040935
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: May 18, 2011
    Publication date: February 16, 2012
    Applicant: Vertex Pharmaceuticals, Inc.
    Inventors: Dean M. Wilson, Andreas P. Termin, Timothy D. Neubert, Jian Wang, Yulian Zhang, Jesus E. Gonzalez, III, Esther Martinborough, Nicole Zimmerman
  • HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS
    Publication number: 20110178061
    Abstract: Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
    Type: Application
    Filed: December 17, 2010
    Publication date: July 21, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Andreas P. Termin, Esther Ann Martinborough, Nicole Hilgraf, Charles J. Cohen, Corey Anderson
  • Compositions useful as inhibitors of voltage-gated ion channels
    Patent number: 7968545
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: June 28, 2011
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Dean M. Wilson, Andreas P. Termin, Timothy D. Neubert, Jian Wang, Yulian Zhang, Jesus E. Gonzalez, III, Esther Martinborough, Nicole Zimmerman
  • Bicyclic Derivatives as Modulators of Voltage Gated ION Channels
    Publication number: 20110112156
    Abstract: Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
    Type: Application
    Filed: November 3, 2010
    Publication date: May 12, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Timothy Donald Neubert, Aarti Sameer Kawatkar, Esther Ann Martinborough, Andreas P. Termin, Nicole Hilgraf
  • PHENYL SULFONAMIDES AS MODULATORS OF ION CHANNELS
    Publication number: 20110082117
    Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: July 27, 2010
    Publication date: April 7, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Esther Martinborough, Lev T.D. Fanning, Urvi Sheth, Dean Wilson, Andreas P. Termin, Timothy D. Neubert, Nicole Hilgraf, Tara Leanne Hampton, Tara Whitney, Aarti Sameer Kawatkar, Danielle Lehsten, Dean Stamos, Jinglan Zhou, Vijayalaksmi Arumugam, Corey Anderson
  • DERIVATIVES FOR MODULATION OF ION CHANNELS
    Publication number: 20110077269
    Abstract: Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
    Type: Application
    Filed: September 10, 2010
    Publication date: March 31, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Esther Martinborough, Andreas P. Termin, Timothy D. Neubert, Nicole Hilgraf, Corey Anderson
  • BICYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS
    Publication number: 20110059965
    Abstract: Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
    Type: Application
    Filed: July 6, 2010
    Publication date: March 10, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Aarti Sameer Kawatkar, Tara Whitney, Timothy D. Neubert, Nicole Hilgraf, Andreas P. Termin, Esther Martinborough
  • Spiroindoline modulators of muscarinic receptors
    Patent number: 7879834
    Abstract: The present invention relates to spiroindoline modulators of muscarinic receptors. The present invention also provides compositions comprising such spiroindoline modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: February 1, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis R. Hurley, Ioana Drutu, Gabriel Raffai, Daniele J. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • Spiro compounds as modulators of muscarinic receptors
    Patent number: 7858635
    Abstract: The present invention relates to spiro compounds of formula XX as modulators of muscarinic receptors, wherein R1, R2, R3, Z1, Z2, L, G, n, m, t and p are defined herein. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: December 28, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • MODULATORS OF MUSCARINIC RECEPTORS
    Publication number: 20100311746
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: June 4, 2010
    Publication date: December 9, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina