Patents by Inventor Andreas P. Termin

Andreas P. Termin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CGRP receptor antagonists
    Patent number: 7842686
    Abstract: The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: November 30, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Corey Don Anderson, Andreas P. Termin, Pramod Joshi, Sara S. Hadida Ruah, Daniele Bergeron, Sanghee Yoo, Jingrong Cao
  • Derivatives for modulation of ion channels
    Patent number: 7842819
    Abstract: Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: November 30, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Esther Martinborough, Andreas P. Termin, Timothy D. Neubert, Nicole Zimmermann, Corey Don Gutierrez
  • Dihydrospiroindene modulators of muscarinic receptors
    Patent number: 7786141
    Abstract: The present invention relates to dihydrospiroindene modulators of muscarinic receptors. The present invention also provides compositions comprising such dihydrospiroindene modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: August 31, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS
    Publication number: 20100160316
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 1, 2010
    Publication date: June 24, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jesus E. Gonzalez, III, Dean M. Wilson, Andreas P. Termin, Peter D. J. Grootenhuis, Yulian Zhang, Benjamin J. Petzoldt, Lev Tyler Dewey Fanning, Timothy D. Neubert, Roger D. Tung, Esther Martinborough, Nicole Zimmerman
  • Quinazolines useful as modulators of ion channels
    Patent number: 7713983
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: May 11, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jesus E. Gonzalez, III, Dean M. Wilson, Andreas P. Termin, Peter D. J. Grootenhuis, Yulian Zhang, Benjamin J. Petzoldt, Lev Tyler Dewey Fanning, Timothy D. Neubert, Roger D. Tung, Esther Martinborough, Nicole Zimmerman
  • Benzimidazoles useful as modulators of ion channels
    Patent number: 7705031
    Abstract: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: April 27, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean M. Wilson, Andreas P. Termin, Jesus E. Gonzalez, III, Nicole Zimmermann, Yulian Zhang, Lev T. D. Fanning
  • Compositions Useful as Inhibitors of Voltage-Gated Sodium Channels
    Publication number: 20100087479
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 10, 2009
    Publication date: April 8, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jesus E. Gonzalez, III, Andreas P. Termin, Esther Martinborough, Nicole Zimmerman
  • Compositions useful as inhibitors of voltage-gated sodium channels
    Patent number: 7615563
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: November 10, 2009
    Inventors: Jesus E. Gonzalez, III, Andreas P. Termin, Esther Martinborough, Nicole Zimmerman
  • Modulators of Muscarinic Receptors
    Publication number: 20090227614
    Abstract: The present invention relates to modulators of muscarnic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: February 22, 2007
    Publication date: September 10, 2009
    Inventors: Lewis R. Makings, Miguel Garcia-Guzman Blanco, Dennis J. Hurley, Ioana Drutu, Gabriel Raffai, Daniele M. Bergeron, Akiko Nakatani, Andreas P. Termin, Alina Silina
  • CGRP RECEPTOR ANTAGONISTS
    Publication number: 20090186882
    Abstract: The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
    Type: Application
    Filed: January 21, 2009
    Publication date: July 23, 2009
    Inventors: Corey Don Anderson, Andreas P. Termin, Pramod Joshi, Sara S. Hadida Ruah, Daniele Bergeron, Sanghee Yoo
  • BENZIMIDAZOLES USEFUL AS MODULATORS OF ION CHANNELS
    Publication number: 20080306129
    Abstract: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: November 1, 2007
    Publication date: December 11, 2008
    Inventors: Dean M. Wilson, Andreas P. Termin, Jesus E. Gonzalez, III, Nicole Zimmermann, Yulian Zhang, Lev T.D. Fanning
  • ION CHANNEL MODULATORS AND METHODS OF USE
    Publication number: 20080293737
    Abstract: In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
    Type: Application
    Filed: May 21, 2008
    Publication date: November 27, 2008
    Inventors: Esther Martinborough, Tim Neubert, Tara Whitney, Danielle Lehsten, Tara Hampton, Nicole Zimmerman, Andreas P. Termin
  • Benzimidazoles useful as modulators of ion channels
    Patent number: 7309716
    Abstract: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: December 18, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean M. Wilson, Andreas P. Termin, Jesus E. Gonzalez, III, Nicole Zimmermann, Yulian Zhang, Lev T. D. Fanning
  • Method for measurement of no contents
    Patent number: 5514594
    Abstract: The present invention relates to a method and a device for the measurement of NO contents in liquids using an inert carder gas. The device consists of a micro reaction part FIG. 1 which is divided into an inert gas inlet nozzle 1, the microreaction vessel 2 with frit 3, at least one inlet nozzle for the injection of the liquid to be analyzed 4, as well as a cooled outlet nozzle for the inert gas loaded with NO 5, and a detector 6, with which the NO content of the inset liquid is measured and evaluated, and where the NO.sub.2 - ions present in the solution are reduced back to NO using a reaction mixture consisting out of 1,1'-dimethylferrocene in acetonitrile in an acidic medium, preferably perchloric acid.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: May 7, 1996
    Inventor: Andreas P. Termin
  • Device for measurement of no contents
    Patent number: 5374397
    Abstract: The present invention relates to a device for the measurement of NO contents in liquids using an inert carrier gas, where the device consists out of micro reaction part FIG. 1 which is divided into an inert gas inlet nozzle 1, the microreaction vessel 2 with frit 3, at least one inlet nozzle for the injection of the liquid to be analyzed 4, as well as a cooled outlet nozzle for the inert gas loaded with NO 5, and a detector 6, with which the NO content of the inlet liquid is measured and evaluated, and where the NO.sub.2.sup.- ions present in the solution are reduced back to NO using a reaction mixture consisting out of 1,1'dimethylferrocene in acetonitrile in an acidic medium, preferably perchloric acid.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: December 20, 1994
    Inventor: Andreas P. Termin