Patents by Inventor Andreas PHILIPP
Andreas PHILIPP has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11840515Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: GrantFiled: March 16, 2021Date of Patent: December 12, 2023Assignee: ACADIA Pharmaceuticals Inc.Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Publication number: 20220024871Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: ApplicationFiled: March 16, 2021Publication date: January 27, 2022Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Patent number: 10981870Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: GrantFiled: January 15, 2020Date of Patent: April 20, 2021Assignee: ACADIA Pharmaceuticals Inc.Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Patent number: 10981871Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: GrantFiled: February 10, 2020Date of Patent: April 20, 2021Assignee: ACADIA Pharmaceuticals Inc.Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Patent number: 10923251Abstract: An arrangement has a coaxial resistor. The coaxial resistor is to be placed on an electrically conductive housing, and sensor lines of the coaxial resistor are to be guided through an interior of the coaxial resistor into the interior of the electrically conductive housing and to be connected to an electrical interface in the electrically conductive housing.Type: GrantFiled: December 12, 2018Date of Patent: February 16, 2021Assignee: Siemens AktiengesellschaftInventors: Wilhelm Delchmann, Michael Hofstetter, Andreas Philipp, Michael Zorawik
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Publication number: 20200300283Abstract: The present invention relates to a connecting element for non-detachably connecting at least two components by means of friction welding when the connecting element is rotated about a longitudinal axis of the connecting element. The connecting element includes a stem formed along the longitudinal axis with a stem face at a free end of the stem for penetrating at least one component, and a head connected to the stem for transmitting a torque about the longitudinal axis from a turning tool to the stem. The stem face has a stem end face which has a convex envelope with a blunt shape.Type: ApplicationFiled: November 8, 2018Publication date: September 24, 2020Applicant: ARNOLD UMFORMTECHNIK GmbH & Co. KGInventors: Dominik FRÖHLICH, Georg VOGEL, Andreas PHILIPP, Patrick ROMINGER, Klaus TRUETSCH
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Publication number: 20200181087Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: ApplicationFiled: February 10, 2020Publication date: June 11, 2020Applicant: ACADIA Pharmaceuticals Inc.Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Publication number: 20200165202Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N,-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —OR, or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-4 alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N- methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobemzyl)-N-(1-methylpiperidin-4-yl)-N?,-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: ApplicationFiled: January 15, 2020Publication date: May 28, 2020Applicant: ACADIA Pharmaceuticals Inc.Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Patent number: 10597363Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: GrantFiled: July 19, 2016Date of Patent: March 24, 2020Assignee: ACADIA Pharmaceuticals Inc.Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Patent number: 10530644Abstract: A method for establishing a communication connection between a first network entity and a second network entity via at least two different network flows includes: transmitting a first request, by the first network entity, directed to the second network entity via a first network flow; transmitting at least one second request, by the first network entity, directed to the second network entity via at least one second network flow, wherein the at least one second request is transmitted by the first network entity before the first network entity receives a reply to the first request from the second network entity; and establishing the communication connection between the first network entity and the second network entity based on at least one of the first request or the at least one second request.Type: GrantFiled: July 27, 2017Date of Patent: January 7, 2020Assignee: DEUTSCHE TELEKOM AGInventors: Markus Amend, Eckard Bogenfeld, Andreas Philipp Matz
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Patent number: 10468884Abstract: A device controls a load flow in an alternating-voltage network. The device is distinguished by a module series circuit of two-pole switching modules that can be inserted in series into a phase line of the alternating-voltage network. Each switching module has an energy store and controllable power semiconductors that can be switched on an off and each switching module can be controlled in such a way that a switching-module voltage can be produced at the poles thereof, which switching-module voltage corresponds to a positive or negative energy-store voltage or a voltage having the value of zero. A control apparatus for controlling the switching modules is provided, which control apparatus is configured to control the switching modules in such a way that a periodic longitudinal voltage can be produced at the module series circuit. A method for controlling a load flow in an alternating-voltage network is performed by the device.Type: GrantFiled: December 14, 2015Date of Patent: November 5, 2019Assignee: Siemens AktiengesellschaftInventors: Friedemann Augsburger, Dominik Ergin, Hans-Joachim Knaak, Andreas Philipp, Jochen Schaefer
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Publication number: 20190180893Abstract: An arrangement has a coaxial resistor. The coaxial resistor is to be placed on an electrically conductive housing, and sensor lines of the coaxial resistor are to be guided through an interior of the coaxial resistor into the interior of the electrically conductive housing and to be connected to an electrical interface in the electrically conductive housing.Type: ApplicationFiled: December 12, 2018Publication date: June 13, 2019Inventors: WILHELM DELCHMANN, MICHAEL HOFSTETTER, ANDREAS PHILIPP, MICHAEL ZORAWIK
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Patent number: 10243357Abstract: An apparatus switches a direct current in a high-voltage line. The apparatus contains a multiplicity of switching units, which are arranged so as to form a series circuit in the high-voltage line. Each switching unit in this case contains a switching element and a surge arrester arranged in a parallel circuit with the switching element, the threshold voltage of the surge arrester being higher than a rated voltage of the switching element. A sum of the rated voltages of the switching elements corresponds at least to an operating voltage of the high-voltage line. The switching elements are mechanical switches, and each mechanical switch contains a contact arrangement having two disconnectable contact pieces and is configured to build up an arcing voltage on disconnection of the contact pieces with a magnitude which is higher than the rated voltage of the mechanical switch.Type: GrantFiled: December 20, 2013Date of Patent: March 26, 2019Assignee: Siemens AktiengesellschaftInventors: Hans-Guenter Eckel, Dominik Ergin, Herbert Gambach, Hans-Joachim Knaak, Andreas Philipp, Hubert Schierling
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Publication number: 20190047955Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluoroben-zyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: ApplicationFiled: July 19, 2016Publication date: February 14, 2019Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Patent number: 10163546Abstract: A field control device for a high-voltage system includes a shielding element for field control, which can be connected to an electrical conductor of the high-voltage system in an electrically conductive manner and, when connected to the conductor, at least partly delimits a weak-electric-field spatial region. A cooling body, which can be connected to the electrical conductor in a thermally conductive manner and which is disposed within the weak-field spatial region, has an outer surface area which is greater than an outer surface area of the shielding element. A high-voltage system having the field control device is also provided.Type: GrantFiled: November 1, 2016Date of Patent: December 25, 2018Assignee: Siemens AktiengesellschaftInventors: Michael Hofstetter, Jochen Schaefer, Andreas Philipp
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Publication number: 20180358808Abstract: A device controls a load flow in an alternating-voltage network. The device is distinguished by a module series circuit of two-pole switching modules that can be inserted in series into a phase line of the alternating-voltage network. Each switching module has an energy store and controllable power semiconductors that can be switched on an off and each switching module can be controlled in such a way that a switching-module voltage can be produced at the poles thereof, which switching-module voltage corresponds to a positive or negative energy-store voltage or a voltage having the value of zero. A control apparatus for controlling the switching modules is provided, which control apparatus is configured to control the switching modules in such a way that a periodic longitudinal voltage can be produced at the module series circuit. A method for controlling a load flow in an alternating-voltage network is performed by the device.Type: ApplicationFiled: December 14, 2015Publication date: December 13, 2018Inventors: FRIEDEMANN AUGSBURGER, DOMINIK ERGIN, HANS-JOACHIM KNAAK, ANDREAS PHILIPP, JOCHEN SCHAEFER
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Publication number: 20180268963Abstract: A field control device for a high-voltage system includes a shielding element for field control, which can be connected to an electrical conductor of the high-voltage system in an electrically conductive manner and, when connected to the conductor, at least partly delimits a weak-electric-field spatial region. A cooling body, which can be connected to the electrical conductor in a thermally conductive manner and which is disposed within the weak-field spatial region, has an outer surface area which is greater than an outer surface area of the shielding element. A high-voltage system having the field control device is also provided.Type: ApplicationFiled: November 1, 2016Publication date: September 20, 2018Inventors: MICHAEL HOFSTETTER, JOCHEN SCHAEFER, ANDREAS PHILIPP
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Patent number: 10032589Abstract: An actuating device for a vacuum switching tube has a connecting element which can be connected to an electric contact of the vacuum switching tube, an electromagnetic actuating device for displacing the connecting element between a first and a second position, and a retaining yoke, relative to which the connecting element can be displaced and has a first magnetic element. The first magnetic element generates a first and a second magnetic circuit in the retaining yoke. The actuating device further has a ferromagnetic retaining anchor, which is arranged on the connecting element. The retaining anchor is located in the first position of the connecting element in the first magnetic circuit and in the second position of the connecting element in the second magnetic circuit. The connecting element is held in the first and in the second position by a respective magnetic force between the retaining yoke and the retaining anchor.Type: GrantFiled: September 11, 2013Date of Patent: July 24, 2018Assignee: Siemens AktiengesellschaftInventors: Georg Bachmaier, Dominik Ergin, Andreas Goedecke, Sylvio Kosse, Andreas Philipp
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Publication number: 20180034691Abstract: A method for establishing a communication connection between a first network entity and a second network entity via at least two different network flows includes: transmitting a first request, by the first network entity, directed to the second network entity via a first network flow; transmitting at least one second request, by the first network entity, directed to the second network entity via at least one second network flow, wherein the at least one second request is transmitted by the first network entity before the first network entity receives a reply to the first request from the second network entity; and establishing the communication connection between the first network entity and the second network entity based on at least one of the first request or the at least one second request.Type: ApplicationFiled: July 27, 2017Publication date: February 1, 2018Inventors: Markus AMEND, Eckard BOGENFELD, Andreas Philipp MATZ
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Patent number: 9806532Abstract: A method for switching an operating current in a meshed DC voltage network enables operating currents in a DC voltage network to be switched economically in both directions. At least one converter connected to the DC voltage network is controlled in such a way that a zero current is generated in a switching branch having a mechanical switch and the mechanical switch is actuated in accordance with the generated zero current.Type: GrantFiled: February 22, 2013Date of Patent: October 31, 2017Assignee: Siemens AktiengesellschaftInventors: Dominik Ergin, Hans-Joachim Knaak, Andreas Philipp