Patents by Inventor Andreas Vogel
Andreas Vogel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952602Abstract: The present invention relates to polypeptide variants of porcine trypsin, to nucleic acid molecules encoding these variants, and to host cells comprising such nucleic acid molecules. It also relates to the use of these variants in methods for producing insulin. The invention further relates to the use of these variants as medicaments, as food ingredients, or as feed ingredients and to the use of these variants within a process of manufacturing a food ingredient or a feed ingredient.Type: GrantFiled: October 27, 2022Date of Patent: April 9, 2024Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Thomas Stillger, Sebastian Rissom, Claudia Feller, Andreas Vogel
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Patent number: 11953669Abstract: An optical observation instrument according to the invention, in particular a surgical microscope or exoscope, comprises an optics unit with an objective arrangement and at least one electronic image recorder, wherein the optics unit has a first stereo channel with a first beam path and a second stereo channel with a second beam path for recording a stereo image of an object field with the at least one electronic image recorder and wherein the first and the second beam path extend through the objective arrangement.Type: GrantFiled: January 11, 2021Date of Patent: April 9, 2024Assignee: KARL STORZ SE & Co. KGInventors: Jonas Forster, Sebastian Barth, Andreas Heni, Benedikt Köhler, Walter Vogel
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Patent number: 11925694Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject. i.e., vaccine RNA encoding vaccine antigen.Type: GrantFiled: March 18, 2022Date of Patent: March 12, 2024Assignee: BioNTech SEInventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
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Publication number: 20240075165Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.Type: ApplicationFiled: November 16, 2022Publication date: March 7, 2024Inventors: Ugur Sahin, Alptekin Güler, Andreas Kuhn, Alexander Muik, Annette Vogel, Kerstin Walzer, Sonja Witzel, Stephanie Hein, Özlem Türeci
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Publication number: 20240033703Abstract: The present invention relates to a process for the preparation of biodegradable microcapsules, in particular biodegradable protein- and/or polysaccharide-based microcapsules, as well as dispersions of such microcapsules (microcapsule slurry) that enclose at least one hydrophobic active ingredient. In addition, the present invention relates to biodegradable microcapsules obtainable by the process according to the invention. In another aspect, the present invention relates to the use of the microcapsules and dispersions as an ingredient in consumer products.Type: ApplicationFiled: August 6, 2020Publication date: February 1, 2024Inventors: Britta Raabe, Benjamin Rost, Christina Koepke, Julian Alexander Georgi, Ralf Bertram, Daniela Gregor, Andreas Vogel
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Publication number: 20230313078Abstract: The present invention relates to a process for the preparation of biodegradable microcapsules, in particular biodegradable protein- and/or polysaccharide-based microcapsules, as well as dispersions of such microcapsules (microcapsule slurry) that enclose at least one hydrophobic active ingredient. In addition, the present invention relates to biodegradable microcapsules obtainable by the process according to the invention. In another aspect, the present invention relates to the use of the microcapsules and dispersions as an ingredient in consumer products.Type: ApplicationFiled: August 5, 2021Publication date: October 5, 2023Inventors: Katherine Tecchio, Britta Raabe, Benjamin Rost, Christina Koepke, Julian Alexander Georgi, Ralf Bertram, Daniela Gregor, Andreas Vogel
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Publication number: 20230313077Abstract: The present invention relates to a process for the preparation of polyurea/polyurethane microcapsules enclosing at least one lipophilic active ingredient, preferably perfume- or aroma-containing polyurea/polyurethane microcapsules, which can be carried out independently of pH compared to the processes for the preparation of polyurea/polyurethane microcapsules of the prior art. In addition, the present invention relates to polyurea/polyurethane microcapsules obtainable by the process of the invention. In another aspect, the invention described herein relates to the use of such microcapsules or microcapsule dispersions for the manufacture of household products, textile care products, detergents, fabric softeners, cleaning products, scent boosters, scent lotions and fragrance enhancers, cosmetics, personal care products, agricultural products, pharmaceutical products, print coatings for paper and the like.Type: ApplicationFiled: August 6, 2020Publication date: October 5, 2023Inventors: Julian Alexander Georgi, Ralf Bertram, Britta Raabe, Benjamin Rost, Andreas Vogel, Daniela Gregor, Christina Koepke
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Publication number: 20230304055Abstract: The invention relates to a process for the preparation of a glycosylated organic compound by in vitro glycosylation of an organic compound having a nucleophilic group with a saccharide under catalysis of a Leloir glycosyltrans-ferase system comprising at least a first glycosyl transferase and a second glycosyl transferase. The invention further relates to a composition comprising a glycosylated organic compound that is obtainable by the process according to the invention.Type: ApplicationFiled: June 29, 2021Publication date: September 28, 2023Applicant: C-LEcta GmbHInventors: Andreas VOGEL, Claudia FELLER, Christopher David BAYER, Gregor HOFFMANN, Stefan SCHOENERT
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Publication number: 20230303994Abstract: The present invention relates to polypeptide variants of porcine trypsin, to nucleic acid molecules encoding these variants, and to host cells comprising such nucleic acid molecules. It also relates to the use of these variants in methods for producing insulin. The invention further relates to the use of these variants as medicaments, as food ingredients, or as feed ingredients and to the use of these variants within a process of manufacturing a food ingredient or a feed ingredient.Type: ApplicationFiled: October 27, 2022Publication date: September 28, 2023Inventors: Thomas STILLGER, Sebastian RISSOM, Claudia FELLER, Andreas VOGEL
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Publication number: 20230287308Abstract: The present invention relates to a process for preparing biodegradable polyurea/polyurethane microcapsules, preferably perfume-containing polyurea/polyurethane microcapsules, which have improved biodegradability compared to prior art microcapsules. In addition, the present invention relates to biodegradable polyurea/polyurethane microcapsules comprising at least one lipophilic active ingredient obtainable by the process according to the invention. In another aspect, the invention described herein relates to the use of such microcapsules or microcapsule dispersions comprising the microcapsules according to the invention for the manufacture of household products, textile care products, detergents, fabric softeners, cleaning agents, scent boosters, scent lotions or scent enhancers, cosmetics, personal care products, agricultural products, pharmaceutical products or printing coatings for paper.Type: ApplicationFiled: August 6, 2020Publication date: September 14, 2023Inventors: Julian Alexander Georgi, Britta Raabe, Benjamin Rost, Andreas Vogel, Ralf Bertram, Daniela Gregor, Christina Koepke, Stefanie Bargsten
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Publication number: 20230272362Abstract: The invention is mainly in the field of the production of food and luxury foods, for example coffee and coffee substitute products. Enzymes are provided which are capable of degrading acrylamide - preferably also at temperatures above 50° C., in particular in temperature ranges which occur in the production of coffee/coffee substitute products, and/or at a pH value between pH 4 and pH 7, as is usual in the production of coffee/coffee substitute products. Furthermore, methods for degrading acrylamide from preparations selected from semi-finished goods as well as finished goods are provided. Also, the present invention relates to preparations having a reduced acrylamide content compared to preparations which have not been subjected to the method for removing acrylamide according to the invention by means of the enzymes according to the invention.Type: ApplicationFiled: January 21, 2021Publication date: August 31, 2023Inventors: Oliver SÜSSE-HERRMANN, Sabrina KÖPKE, Andreas VOGEL, Claudia FELLER, Sebastian BARTSCH
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Publication number: 20230272361Abstract: The invention is mainly in the field of the production of food and luxury foods, for example coffee and coffee substitute products. Enzymes are provided which are capable of degrading acrylamide—preferably also at temperatures above 50° C., in particular in temperature ranges which occur in the production of coffee/coffee substitute products, and/or at a pH value between pH 4 and pH 7, as is usual in the production of coffee/coffee substitute products. Furthermore, methods for degrading acrylamide from preparations selected from semi-finished goods as well as finished goods are provided. Also, the present invention relates to preparations having a reduced acrylamide content compared to preparations which have not been subjected to the method for removing acrylamide according to the invention by means of the enzymes according to the invention.Type: ApplicationFiled: January 21, 2021Publication date: August 31, 2023Inventors: Oliver SÜSSE-HERRMANN, Sabrina KÖPKE, Andreas VOGEL, Claudia FELLER, Sebastian BARTSCH
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Publication number: 20230193220Abstract: The present invention relates to a method for producing trehalose, comprising the steps of mixing and reacting, in any order, (i) at least one alpha-phosphorylase capable of catalyzing the production of alpha-D-glucose 1-phosphate intermediate from a saccharide raw material, and from at least one phosphorus source; (ii) at least one trehalose phosphorylase capable of catalyzing the production of trehalose from an alpha-D-glucose 1-phosphate intermediate and a glucose substrate, wherein the trehalose phosphorylase is a trehalose phosphorylase variant with an amino acid sequence which differs from the amino acid sequence of a wild type trehalose phosphorylase in at least one amino acid position, (iii) at least one saccharide raw material which produces an alpha-D-glucose 1-phosphate intermediate and a co-product by catalytic action of the alpha-phosphorylase; and (iv) at least one phosphorus source selected from the group consisting of a phosphoric acids and an inorganic salt thereof.Type: ApplicationFiled: July 12, 2022Publication date: June 22, 2023Inventors: Christopher David BAYER, Andreas VOGEL, Marc STRUHALLA, Birgit BRUCHER
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Patent number: 11674129Abstract: The present invention relates to polypeptide, preferably to a glucose isomerase, comprising an amino acid sequence, wherein the amino acid sequence of the polypeptide, preferably the glucose isomerase, is at least 95% identical to an amino acid sequence of SEQ ID NO:1, wherein the amino acid sequence of the polypeptide, preferably the glucose isomerase, comprises an amino acid substitution at one or more amino acid positions, wherein the one or more amino acid positions is/are each and independently selected from the group consisting of SEQ ID NO: 1 amino acid positions 89, 90, 95, 0, 33, 34, 35, and 59. The present invention further relates to methods preparing glucose including the use of the polypeptides of the invention for preparing glucose.Type: GrantFiled: June 9, 2021Date of Patent: June 13, 2023Assignees: NEW MATTERHORN, LLC, C-LEcta GmbHInventors: Birgit Brucher, Andreas Vogel, Hanna Maria Dudek, Rico Czaja
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Patent number: 11518988Abstract: The present invention relates to polypeptide variants of porcine trypsin, to nucleic acid molecules encoding these variants, and to host cells comprising such nucleic acid molecules. It also relates to the use of these variants in methods for producing insulin. The invention further relates to the use of these variants as medicaments, as food ingredients, or as feed ingredients and to the use of these variants within a process of manufacturing a food ingredient or a feed ingredient.Type: GrantFiled: February 22, 2019Date of Patent: December 6, 2022Assignee: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Thomas Stillger, Sebastian Rissom, Claudia Feller, Andreas Vogel
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Publication number: 20220304937Abstract: The present invention relates to pediatric drug formulation. Especially, this invention relates to the manufacturing of granules comprising a core comprising a drug having an unpleasant taste, which may be a primary bile acid, such as for example cholic acid, and a taste-masking coating. The purpose of the invention is to fully mask unpleasant taste of the drug, while ensuring its availability at the duodenum biological site.Type: ApplicationFiled: June 14, 2022Publication date: September 29, 2022Inventors: Bernard DESCHAMPS, Antoine FERRY, Andreas VOGEL
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Patent number: 11421207Abstract: The present invention relates to a method for producing trehalose, comprising the steps of mixing and reacting, in any order, (i) at least one alpha-phosphorylase capable of catalyzing the production of alpha-D-glucose 1-phosphate intermediate from a saccharide raw material, and from at least one phosphorus source; (ii) at least one trehalose phosphorylase capable of catalyzing the production of trehalose from an alpha-D-glucose 1-phosphate intermediate and a glucose substrate, wherein the trehalose phosphorylase is a trehalose phosphorylase variant with an amino acid sequence which differs from the amino acid sequence of a wild type trehalose phosphorylase in at least one amino acid position, (iii) at least one saccharide raw material which produces an alpha-D-glucose 1-phosphate intermediate and a co-product by catalytic action of the alpha-phosphorylase; and (iv) at least one phosphorus source selected from the group consisting of a phosphoric acids and an inorganic salt thereof.Type: GrantFiled: November 28, 2018Date of Patent: August 23, 2022Assignees: C-Lecta GmbH, New Matterhorn, LLCInventors: Christopher David Bayer, Andreas Vogel, Marc Struhalla, Birgit Brucher
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Patent number: 11286466Abstract: Disclosed are ketoreductases and the use thereof. The disclosed ketoreductases are particularly useful for enzymatically catalyzing the reduction of ketones to chiral or non-chiral secondary alcohols and oxidation of chiral or non-chiral secondary alcohols to ketones.Type: GrantFiled: January 13, 2020Date of Patent: March 29, 2022Assignee: C-LECTA GMBHInventors: Sabrina Koepke, Sebastian Bartsch, Andreas Vogel
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Patent number: 11286474Abstract: The invention relates to a process for the manufacturing and purification of recombinant enzyme products, in particular of food enzyme products and the use thereof. The invention particularly relates to a process for the processing of enzyme products from a microbial fermentation broth by methods of separation, enzymatic treatment and filtration procedures.Type: GrantFiled: November 13, 2019Date of Patent: March 29, 2022Assignee: C-LECTA GMBHInventors: Stefan Schoenert, Mathias Salomo, Thomas Schultchen, Andreas Vogel, Sabrina Koepke, Sebastian Bartsch, Birgit Brucher, Claudia Feller
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Publication number: 20210380954Abstract: The present invention is related to a trehalose phosphorylase comprising an amino acid sequence, wherein the amino acid sequence of the trehalose phosphorylase is at least 80% identical to and/or at least 80% homologous to an amino acid sequence of SEQ ID NO: 1, wherein the amino acid sequence of the trehalose phosphorylase comprises an amino acid substitution at one or more amino acid positions, wherein the one or more amino acid positions is/are selected from the group consisting of amino acid positions of SEQ ID NO: 1712, 383, 10, 114, 118, 192, 197, 220, 225, 304, 306, 318, 323, 339, 349, 357, 459, 476, 481, 484, 487, 488, 506, 511, 526, 530, 532, 533, 537, 550, 556, 564, 590, 649, 667, 703 and 705.Type: ApplicationFiled: June 10, 2021Publication date: December 9, 2021Inventors: Birgit Brucher, Andreas Vogel