Abstract: A catalog application includes data for key indicators for performance measurement of applications. The catalog application comprises data for a large number of key indicators that may be compatible for different application. A monitoring application utilizes data for key indicators to measure performance of external applications. A catalog service interface is instantiated to process requests from the monitoring application to the catalog application. The external applications run in different technical environments and are part of different technical landscapes. A request to provide data for key indicators compatible with a first application is received at the instantiated service interface. The key indicators in the catalog application are filtered based on matching the technical characteristics of the first application with the key indicators' prerequisites.

Abstract: The invention relates to transaminases and their use. The ATAs according to the invention are particularly useful for catalyzing the conversion of amines to ketones and/or vice versa. Preferably, the transaminase (ATA) according to the invention comprises an amino acid sequence with at least 80% homology to SEQ ID NO:1, wherein the amino acid sequence is engineered compared to SEQ ID NO:1 such that it comprises at least a substitution selected from the group consisting of F255L, F255A, F255C, F255D, F255E, F255G, F255H, F255K, F255M, F255N, F255P, F255Q, F255R, F255S, F255T, F255V, F255W, and F255Y.

Abstract: The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the reduction of ketones to chiral secondary alcohols.

Abstract: The invention relates to transaminases that are particularly useful for catalyzing the conversion of amine substrates to ketone products and/or vice versa.

Abstract: The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the reduction of ketones to chiral secondary alcohols.

Abstract: For producing dentures, a new method and device render it possible to evaluate and shape movements generated by the individual jaw joints of the patient such that work with appropriate articulators becomes possible, which employ the individual jaw joints as articulation joints and thus carry out the identical movements. The known articulators are equipped with joint-space duplicates such that they can be employed with optimal equipment for the respective patient. The support pin is moved back as fixing pin in the retral space of the articulator such that it does not constitute an impediment when working on and when inspecting the jaw models arranged on the frame upper part and the frame base part. Moreover, setting different biting positions is made significantly easier, because the frame upper part is fixed to a swivel arch of the frame base part by an adjustable position stabilizer but can also be detached.

Abstract: The invention relates to a cellobiose phosphorylase, which catalyzes, among other things, the synthesis of cellobiose from glucose 1-phosphate and glucose. The cellobiose phosphorylase according to the invention can be understood as a mutation of the cellobiose phosphorylase from Cellulomonas uda. In comparison to cellobiose phosphorylase of the wild type, the cellobiose phosphorylase according to the invention is distinguished by improved activity and process stability, in particular temperature stability, and lower product inhibition and therefore is especially suitable for use in industrial processes.

Abstract: The present invention relates to pediatric drug formulation. Especially, this invention relates to the manufacturing of granules comprising a core comprising a drug having an unpleasant taste, which may be a primary bile acid, such as for example cholic acid, and a taste-masking coating. The purpose of the invention is to fully mask unpleasant taste of the drug, while ensuring its availability at the duodenum biological site.

Abstract: The invention provides engineered enzymes of transsialidase and/or sialyl transferase activity that have increased regioselectivity and/or increased thermostability.

Abstract: The invention relates to a method for determining and regulating the temperature of an article with inductive properties which is heated inductively by means of an induction device, wherein the induction device contains an induction coil, means for producing an induction resonant circuit and a support element arranged above the induction coil and having a first side, which acts as support face for the article, and a second side, which is directed towards the inductive coil. At least one temperature sensor is fitted to the second side. The resonant frequency of the induction resonant circuit is measured via detection means and the temperature of the article is calculated from the measured resonant frequency, wherein the resonant frequency is related to the temperature of the article by virtue of a mathematical function, and the function is determined by determining at least two absolute temperature calibration values of the article at respectively different resonant frequencies.

Abstract: Mutated fucosidases are provided demonstrating improved properties in terms of thermal stability and transfucosidase synthetic performance compared with a wild type transfucosidase isolated from Bifidobacterium longum subsp. infantis.

Abstract: A technique for determining and presenting marketing scenarios based on market characteristics are described herein. The technique includes receiving data regarding market environment and an expected change in the market environment. A number of market characteristics are calculated based on the collected data for a number of alternative marketing scenarios for addressing the change. A number of graphical objects corresponding to the marketing scenarios are displayed in a coordinate system to show correlation between a number of selected market characteristics. A number of additional components are assigned to the graphical objects to indicate additional characteristics of the presented marketing scenarios.

Abstract: In order to at least approximately determine statistical properties of raw measured values, e.g., measurement noise and/or average errors, without knowledge of a filter applied to raw measured values and only with the aid of a useful signal obtained from the filtering, i.e., in order to make statements regarding measurement conditions by assuming a few frequently encountered boundary conditions, statistical properties of raw measured values are determined from the useful signal, which is composed of a temporal sequence of filter output values.

Abstract: The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the reduction of ketones to chiral secondary alcohols.

Abstract: A catalog application includes data for key indicators for performance measurement of applications. The catalog application comprises data for a large number of key indicators that may be compatible for different application. A monitoring application utilizes data for key indicators to measure performance of external applications. A catalog service interface is instantiated to process requests from the monitoring application to the catalog application. The external applications run in different technical environments and are part of different technical landscapes. A request to provide data for key indicators compatible with a first application is received at the instantiated service interface. The key indicators in the catalog application are filtered based on matching the technical characteristics of the first application with the key indicators' prerequisites.

Abstract: The present invention relates to a formulation comprising cholic acid, for oral administration, where the unpleasant taste of cholic acid is masked.

Abstract: Switch apparatus (1) for switching on and off a power tool, including a pushbutton element (10), which is pivotable reversibly about a pivot point (S) between a switch-on position and a switch-off position, wherein in the switch-on position the machine tool is switched on and in the switch-off position the machine tool is switched off; and a locking device (30) for releasably locking the pushbutton element (10) in the switch-on position. The locking device (30) includes a stop element (38) and the pushbutton element (10) includes a counter-stop element (40), wherein the stop element (38) is movable reversibly between a locking position, in which the stop element (38) bears against the counter-stop element (40) and the pushbutton element (10) is held in the switch-on position, and a release position, in which the pushbutton element (10) is returnable to the switch-off position.

Abstract: In a method for the machining of a workpiece (2) which is driven in rotary movement about a workpiece axis (Z) and whose shape includes a periodic structure, specifically a workpiece with gear teeth, a cutting tool which has gear-like teeth with a cutting edge formed at a frontal end of the teeth and which is driven in rotary movement about a cutting tool axis that is radially spaced apart from the workpiece axis, is brought into a rolling engagement with the workpiece under a crossing angle between the two rotary axes, wherein the cutting edge removes material from the workpiece through a cutting movement that has a component in the direction parallel to the workpiece axis, and wherein for the machining of the workpiece over a desired axial range the cutting tool is in addition made to perform a feed movement having a component parallel to the workpiece axis.

Abstract: In an embodiment, a method of providing an arranged display of data associated with a set of time periods is presented. In this method, values of a first data type are accessed, the values being observed during each of multiple time periods. An order for the time periods is determined based on the values of the first data type. A selectable region for each of the time periods is displayed, the regions being arranged according to the order. In response to a user selection of one of the selectable regions, a value of a second data type is displayed, the value of the second data type being observed during the time period of the selected one of the selectable regions.

Abstract: A method for creating a directory of road sections of a digital road map for a navigation system is provided. Furthermore, a method for ascertaining all road sections within a search area is provided. Moreover, a computer program for performing a method for creating a directory of road sections and a method for ascertaining all road sections within a search area is provided.