Abstract: The disclosures herein relate to novel compounds of Formula (1); and salts thereof, wherein A1, A2, Q, X, R1, R2 and R3 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with CGRP receptors.

Abstract: The invention generally relates to capturing, amplifying, and sequencing nucleic acids. In certain embodiments, copies of the sense and antisense strands of a duplex template nucleic acid are captured using linked capture probes and multiple binding and extension steps to improve specificity over traditional single binding target capture techniques. Methods of seeding sequencing clusters with sense and antisense strands of a target nucleic acid are also disclosed including identifying the strands using sense-specific barcodes and confirming base calls using two sense-specific sequencing reads. Linked adapters may be used to increase adapter ligation selectively or efficiency and yield.

Abstract: Systems and methods are described for training a model for detecting manufacturing anomalies. A test response parameter is identified at a computing device, and a first plurality of component waveforms associated with the test response parameter are received at the computing device. Each waveform of the plurality of waveforms comprises a plurality of datapoints. A model is generated at the computing device, and the model is trained at the computing device and on the first plurality of component waveforms, thereby generating one or more parameters associated with the model. A second plurality of component waveforms associated with the test response parameter is received, and the trained model is accessed. It is indicated using the trained model, whether any of the second plurality of component waveforms comprises an anomaly. For each indicated waveform, the indicated waveform is reviewed and, for each reviewed waveform not comprising an anomaly, the waveform is labelled.

Abstract: A data processor, such as a graphics processor, is disclosed. The data processor includes a set of one or more counters, and a control circuit that maintains a cache-like pool of corresponding entries. In response to a request for a counter, the control circuit may allocate an entry of the cache-like pool to thereby allocate a counter of the set.

Abstract: A system for detecting a cover sound profile, the cover sound profile including at least one sound sample produced from sound diffracted by a cover. The system includes a device comprising a housing and at least one speaker driver, at least on microphone, and at least one processor. The device is configured to selectively couple the cover via the housing and produce a sound via the at least one speaker driver. The at least one microphone configured to detect the sound and produce an electrical signal from the detected sound. The at least one processor is configured to receive the electrical signal determine, using machine learning, that the spectrogram meets or surpasses a similarity threshold to the sound cover profile, and change at least one characteristic of the device based on an adjustment operation associated with the determined cover sound profile.

Abstract: A method of forming a light emitting structure, the light emitting structure comprising: a first light emitting region configured to emit light having a first primary peak wavelength; a second light emitting region configured to emit light having a second primary peak wavelength, wherein the first primary peak wavelength is different to the second primary peak wavelength; and a partially reflective layer positioned at least partially between the first light emitting region and the second light emitting region, wherein the partially reflective layer is configured to reflect light having the first primary peak wavelength emitted by the first light emitting region and allow light having the second primary peak wavelength emitted by the second light emitting region to pass through the partially reflective layer.

Abstract: A method is provided for transmitting a message concurrently with a pulse-encoded signal, the method comprising: assigning an identifier to the message; transmitting an identifier of the message between every two consecutive pulses of the pulse-encoded signal until the whole message is transmitted; transmitting a first portion of a payload of the message between every two consecutive pulses of the pulse-encoded signal until the whole message is transmitted; and transmitting a different part of a second portion of the payload of the message between every two consecutive pulses of the pulse-encoded signal until the whole message is transmitted, wherein the pulse-encoded signal encodes information by varying a frequency of pulses of the pulse-encoded signal, and the message is transmitted over a plurality of transmission periods that are delimited by respective consecutive pulses of the pulse-encoded signal.

Abstract: The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject; and methods of making such antibodies and fragments.

Abstract: A purger device for hollow fiber oxygenators, including a gas inlet, a gas outlet, and a fluid communication feature between the gas inlet and the gas outlet. The purger device further including an accumulation chamber having a variable volume plenum ported to the fluid communication feature, and a flow control unit configured to vary fluid communication patterns in the fluid communication feature and having a first operating condition and a second operating condition, wherein in the first operating condition the flow control unit enables a fluid communication between the gas inlet and gas outlet, and wherein in the second operating condition the flow control unit enables a fluid communication between the gas inlet and the variable volume plenum of the accumulation chamber.

Abstract: An apparatus is for detaching meat strips, which are located on a breastbone crest of a poultry carcass, from poultry carcasses of slaughtered poultry bodies or parts thereof which are already freed from breast fillets. The apparatus has a circulating conveyor having at least one holding apparatus with a support body for receiving and holding the poultry bodies/parts during transport in a transport direction, and at least one processing station along a conveying path of the conveyor. One processing station is a detaching unit for detaching the meat strips from the breastbone crest. The detaching unit has a pre-detaching element and a detaching element. The pre-detaching element is cuts into the meat strip in a region of a breastbone horn of the breastbone crest which leads in the transport direction and the detaching element grips and peels the meat strip off the breastbone crest. A corresponding method is provided.

Abstract: A method for reducing gear induced noise from a wind turbine is disclosed. A first vibration map and a second vibration map are generated, specifying, for each of a plurality of operating points of the generator, a virtual phase of vibrations originating from gear tooth meshing of the gearbox, relative to a first and second reference phase, at the respective operating points. An overlap between operating points of the first vibration map and operating points of the second vibration map is identified and virtual phases within the overlap are compared, thus deriving a phase offset between the first vibration map and the second vibration map. The virtual phase of vibrations of each of the operating points of the second vibration map are adjusted according to the phase offset, so as to align the first vibration map and the second vibration map, and the first vibration map and the second vibration map are combined into a resultant vibration map.

Abstract: An optoelectronic lighting device includes a transparent pane, in particular a glass pane, on which a first at least partially transparent intermediate layer is arranged. The optoelectronic lighting device also includes at least one optoelectronic fiber arranged on the first intermediate layer and including at least one electrical line extending in a longitudinal direction and connected to a plurality of optoelectronic semiconductor components. The optoelectronic fiber includes a flexible support substrate on which the at least one electrical line and the plurality of optoelectronic semiconductor components are arranged. The optoelectronic lighting device further includes a second at least partially transparent intermediate layer, the second intermediate layer being arranged on the first intermediate layer and covering the at least one optoelectronic fiber.

Abstract: Methods, systems, and devices for latency reduction of boot procedures for memory systems are described. A memory system may receive a first command to perform a first reset of one or more components as part of a first phase of a boot procedure of a host system. The memory system may initiate an initialization process of a second phase of the boot procedure upon determining whether the value of a flag has been set from a first value to a second value. Upon completing the initialization process, the flag may be set to the first value. Parameters corresponding to the characteristics of the memory system may be communicated to the host system based on receiving a second command. The memory system may perform a configuration operation of a logical-to-physical mapping concurrently with communicating the parameters with the host system.

Abstract: A method for controlling a gear pump by a control device to compensate a tooth engagement-induced volume flow pulsation to reduce noise emissions. The method includes acquiring a gear angle and an actual speed of the gear pump; keeping a relationship between a respective modulation angle and an amplitude of a pilot control torque of the gear pump to compensate the volume flow pulsation to an actual speed; modulating the pilot control torque on the basis of the acquired gear angle, a predetermined correction angle, the modulation angle, a number of teeth of the gear pump and the amplitude; and driving the gear pump with a drive torque overlaid with the modulated pilot control torque. The modulation angle is calculated using a PT element with the actual speed as the input variable.

Abstract: Implementations relate to providing information items for display during a communication session. In some implementations, a computer-implemented method includes receiving, during a communication session between a first computing device and a second computing device, first media content from the communication session. The method further includes determining a first information item for display in the communication session based at least in part on the first media content. The method further includes sending a first command to at least one of the first computing device and the second computing device to display the first information item.

Abstract: A taping unit for a box closing machine is disclosed, including: an enclosure frame; a gummed tape reel and a plurality of running rollers mounted on the frame; at least an applicator roller arranged in the bottom part of the enclosure frame; and a guiding and sliding path of the gummed tape within the enclosure frame. The taping unit further includes: an operating assembly provided with a respective frame movably mounted on the enclosure frame, whereon a drive motor of a drive roller and at least an actuator to operate a cutting blade are installed; and a wetting system provided with a tank storing wetting liquid arranged in a position below the operating assembly. Between the drive roller and the wetting system, the guiding and sliding path is provided, arranged according to a substantially vertical plane.

Abstract: A seal device for a door with a pivotable door leaf includes a drop-down seal for arrangement on or in the door leaf. The drop-down seal has a housing profile rail, a sealing strip which can be raised and lowered relative to the housing profile rail, a lowering mechanism for raising and lowering the sealing strip, and an actuating part, wherein the actuating part actuates the lowering mechanism when the door leaf is being closed. The seal device includes a triggering module with a wheel, wherein the triggering module acts on the actuating part when the door leaf is being closed. The triggering module is designed for arrangement on or in the door leaf and/or is arranged fixedly on the housing profile rail. This seal device is suitable in particular for pivot doors.

Abstract: The invention relates to a polyribonucleotide, a cosmetic and pharmaceutical compound that has the polyribonucleotide and a medicinal product that has the polyribonucleotide and the compound.

Abstract: A fan assembly (1) for an extractor hood to be used in a kitchen over a hob includes a body or casing (2) and an impeller (22) driven by an electric motor (20), with the casing having an internal cavity (4) which is bounded by a wall (3) and suitable to contain the impeller and the electric motor. The impeller (22) is located in the cavity (4) in such a manner as to define, with the wall of cavity, a spiral duct (25) for the vapours taken into the cavity, with the duct opening into a terminal outlet (5) and the casing (2) being open (at 8, 9) on opposite sides (6, 7) to favour the entry of vapours at the level of the impeller (22). The wall (3) of the casing includes a plurality of transversal portions having radii or radial configurations which differ from one another.