Publication number: 20250034111
Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
Type:
Application
Filed:
April 30, 2024
Publication date:
January 30, 2025
Applicant:
Bayer Pharma Aktiengesellschaft
Inventors:
Ulrich BOTHE, Holger SIEBENEICHER, Nicole SCHMIDT, Reinhard NUBBEMEYER, Ulf BÖMER, Judith GÜNTHER, Holger STEUBER, Martin LANGE, Christian STEGMANN, Andreas SUTTER, Alexandra RAUSCH, Christian FRIEDRICH, Peter HAUFF
Publication number: 20250036112
Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for optimizing a process of manufacturing a product. In one aspect, the method comprises repeatedly performing the following: i) selecting a configuration of input settings for manufacturing a product, based on a causal model that measures causal relationships between input settings and a measure of a quality of the product; ii) determining the measure of the quality of the product manufactured using the configuration of input settings; and iii) adjusting, based on the measure of the quality of the product manufactured using the configuration of input settings, the causal model.
Type:
Application
Filed:
October 16, 2024
Publication date:
January 30, 2025
Inventors:
Brian E. Brooks, Gilles J. Benoit, Peter O. Olson, Tyler W. Olson, Himanshu Nayar, Frederick J. Arsenault, Nicholas A. Johnson, Brett R. Hemes, Thomas J. Strey, Jonathan B. Arthur, Nathan J. Herbst, Aaron K. Nienaber, Sarah M. Mullins, Mark W. Orlando, Cory D. Sauer, Timothy J. Clemens, Scott L. Barnett, Zachary M. Schaeffer, Patrick G. Zimmerman, Gregory P. Moriarty, Jeffrey P. Adolf, Steven P. Floeder, Andreas Backes, Peter J. Schneider, Maureen A. Kavanagh, Glenn E. Casner, Miaoding Dai, Christopher M. Brown, Lori A. Sjolund, Jon A. Kirschhoffer, Carter C. Hughes