Abstract: Described herein are novel systems for targeting, editing or manipulating DNA in a cell, using novel M-SmallCas9 nucleases and variants thereof. The M-SmallCas9 nucleases are derived from wildtype or parental small type II CRISPR Cas9 endonucleases, and display improved fidelity compared to parental type II CRISPR Cas9 enzymes in combination with a simple PAM sequences and are small endonuclease size.

Abstract: An electronic device may include wireless circuitry. The wireless circuitry may include a radio-frequency amplifier having a data input configured to receive a radio-frequency signal generated from a baseband signal, supply modulation blocks configured to output a power supply voltage, derived from the baseband signal, for powering the radio-frequency amplifier, and load modulation blocks configured to output a load control signal, derived from the baseband signal and a bandwidth reduced envelope signal output from the supply modulation circuitry, for tuning an adjustable load component of the radio-frequency amplifier. The supply modulation blocks can include a full envelope generator, a bandwidth reduction block for outputting the bandwidth reduced envelope signal, an envelope shaping block, and an envelope tracker. The load modulation blocks can include an inverse amplifier gain model and a load shaping block.

Abstract: The invention is notably directed to a physical reservoir for a magnetic reservoir computing apparatus. The physical reservoir includes a ferromagnetic film, which comprises a two-dimensional arrangement of point deformations. The point deformations are dimensioned to act as pinning sites for magnetic domains of the ferromagnetic film. The invention further concerns a magnetic reservoir computing apparatus comprising such a physical reservoir, as well as methods of operating and fabricating such a reservoir computing apparatus. The proposed approach results in a low-power-consumption physical reservoir, which is easy to fabricate.

Abstract: A radar sensor system comprises a first radar sensor and at least a second radar sensor and one or more processors configured to assign different pulse rate intervals (PRI) to the first radar sensor and the second radar sensor. The processor(s) s are further configured to: receive ambiguous velocity estimates from the first and second radar sensors, respectively; determine maximum detectable velocity (Vmax) values for the first and second radar sensors based on their respective PRIs; generate a first velocity vector for the first radar sensor based on the first Vmax and the first ambiguous velocity estimate; generate a second velocity vector for the second radar sensor based on the second Vmax and the second ambiguous velocity estimate; compare velocity values in the first and second velocity vectors; and identify and output a velocity value common to the first and second velocity vectors as a correct unambiguous velocity of the object.

Abstract: The present invention relates to anti-HLA-G antibodies and methods of using the same.

Abstract: An electrical heating device comprises two heating chambers between which an electrical heating assembly is formed. Via a distributor a flow of a medium to be heated entering the electrical heating device in the inflow direction is divided into a first partial flow and a second partial flow. The first partial flow flows through the first heating chamber, while the second partial flow flows through the second heating chamber. For this purpose, the distributor has a distributing body, which may be configured as a conical bod that is rotationally symmetrical about an axis of symmetry. The axis of symmetry may be parallel to an inlet axis. Alternatively, the distributing body can also be configured as an overflow edge.

Abstract: A secure method for self-(re)calibration or self-calibration of devices, more particularly measuring devices, by the operator, wherein a digitized process flow in a data chain (DLT), more particularly blockchain established and secured using distributed ledge technology, is used. The method includes a digitized process sequence set up in a data chain (DLT), a device is registered with its implemented measuring device properties, an inspection authority gains access to the measurement information from the device, the inspection authority establishes an operative connection between the device and a working standard, the determined measurement data for the working standard are read out in encrypted form and are transmitted to the inspection authority in encrypted form, in the event of successful calibration or gaging of the device, the inspection authority stores this result in the data chain.

Abstract: Provided herein is a two-component polyurethane adhesive composition.

Abstract: A method for producing one or more hydrocarbons, includes subjecting a first feed stream to a steam cracking to obtain a first product stream and subjecting a second feed stream containing ethane to an oxidative dehydrogenation to obtain a second product stream At least a portion of the first product stream is subjected to a treatment to obtain hydrocarbon fractions. The treatment includes a selective hydrogenation of hydrocarbons having two carbon atoms and a demethanization. At least a portion of the second product stream is subjected to a trace removal, which comprises the removal of oxygen and/or acetylene, to obtain an subsequent stream. At least a portion of the subsequent stream is fed to the treatment at a position downstream of the selective hydrogenation and upstream of the demethanization. A portion of the subsequent stream is subjected to a carbon dioxide removal upstream of the feed point into the treatment.

Abstract: A bulk capacitor assembly for an inverter includes a stacked busbar, the stacked busbar including a first direct current (DC) busbar and a second DC busbar; one or more first capacitors on a first side of the stacked busbar, the one or more first capacitors electrically connected to the first DC busbar and the second DC busbar; and one or more second capacitors on a second side of the stacked busbar, the first side being opposite to the second side, the one or more second capacitors electrically connected to the first DC busbar and the second DC busbar.

Abstract: Braking system (1) and method aimed to produce a forced increase in a damping layer (7) temperature of a brake pad (3), arranged between a metal support (5) and a friction material block (6) thereof, wherein the damping layer (7) is heated such as to stay at a temperature above a glass transition temperature of rubber components thereof, so assuring a maximum damping behavior; the heating is caused by magnetic induction generated by one or more electrically conducting coils (15) fed in AC by a power source (10) carried by the vehicle and arranged either integrated in the brake pad (3), e.g. carried by the support (5), or in the vicinity thereof.

Abstract: A network node configured to communicate with a wireless device (WD) is described. An indication indicating to the WD to perform one of a single-TRP operation and a multi-TRP operation for one or more physical channels is determined. The determined indication includes at least one of a first dedicated bit field in a downlink related downlink control information (DCI) scheduling a downlink physical channel; a second dedicated bit field in an uplink related DCI scheduling an uplink physical channel; a first transmission configuration indicator (TCI) bit field in the downlink related DCI, at least one codepoint of the first TCI bit field indicating a single third unified TCI state; a second TCI bit field in the uplink related DCI, at least one other codepoint of the second TCI bit field indicating a single fourth unified TCI state. The determined indication is transmitted to the WD.

Abstract: A cable feeding device includes a conveyor unit configured to transport at least one pulling member, in particular fish tapes, provided at least for pulling cables into conduits, with at least one receiving unit, in particular a pulling drum, which is configured to receive the at least one pulling member and which has at least one bearing unit, for a coiled storage of at least the at least one pulling member.

Abstract: The present invention relates to a process for the manufacturing of a mixture comprising the intermediate 1-[bis[2-hydroxy-3-[4,7,10-tris[2-(1,1-dimethylethoxy)-2-oxoethyl]-1,4,7,10-tetraazacyclododec-1-yl]propyl]amino]-1-deoxy-D-glucitol. Such intermediate is useful for the synthesis of the dimeric gadolinium complex [?-[1-[bis[2-(hydroxy-?O)-3-[4,7,10-tris[(carboxy-?O)methyl]-1,4,7,10-tetraazacyclododec-1-yl-?N1,?N4,?N7,?N10]propyl]amino]-1-deoxy-D-glucitolate(6-)]]digadolinium complex, which can be employed as a contrast agent in the field of diagnostic imaging, and in particular of Magnetic Resonance Imaging (MRI).

Abstract: A dental implant system that can include a prosthetic assembly and a dental implant. The prosthetic assembly can include a dental component and a retention screw. The dental component and the retention screw each have interference elements that are configured to engage when a removal torque is applied to the screw. When the interference element engage each other, a portion of the removal torque is converted into a linear force that is exerted on the dental component in a removal direction thereby separating the dental component from the dental implant.

Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl) thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.

Abstract: The adaptive street lighting system (1) comprises a plurality of light members (2) positioned along a road network (R), wherein each of the light members is provided with one lighting element (3) adapted to illuminate one section of the road network, one adjusting device (4) configured to adjust the light intensity of the lighting element (3), one weather detecting unit (5) provided with a set of sensors (6) configured to detect weather data representative of the weather conditions in the proximity of the road network (R) and one traffic monitoring assembly (7) provided with one traffic sensor (8) configured to detect traffic data on the road network (R), wherein each of the light members (2), the weather detecting unit (5) and the monitoring assembly (7) comprises a related communication device (9) configured to define a transceiver network for the data, and wherein each of the light members (2) comprises at least one control device (10) configured to control in real time the adjusting device (4) to dim in r

Abstract: Aspects of the present disclosure are directed to a two-dimensional (2D) user interface (UI) content overlay for an artificial reality (XR) environment. In some implementations, the content overlay can be a default home screen when a user launches into an immersive XR application that helps the user navigate and control immersive destinations, and complete relevant and frequent actions related to the XR application. In some implementations, the content overlay can serve dynamic content based on the user's context to help them, e.g., A) find and play with other users, B) learn relevant actions that can be taken, C) quickly travel to a destination, D) see relevant content, etc. The content overlay can provide these functions 2D cards in the XR environment, which can be specific to the executing XR application, or can be system-level for multiple providing content XR applications.

Abstract: The present disclosure relates to a wheel holder for a vehicle, preferably a bike front wheel holder, with a load connecting portion, which is preferably releasably attachable to a load carrier, and a wheel holding member, wherein the wheel holder comprises a docking device configured for releasable attachment of the wheel holding member to the load connecting portion to allow for attachment of a wheel to the wheel holding member at a location remote from the load connecting portion. Furthermore, the present disclosure relates to load carrier attachment devices.

Abstract: A method for automatically detecting, by means of computerized processing, information about temperature evolution and/or about location/distribution of hot spots and/or bands and/or zones on the surface of a brake disc under dynamic operating conditions. The method includes the steps of acquiring a plurality of digital images and/or a digital video, obtaining a representation of each of the digital images and/or digital video frames in the form of matrix data, on which to perform a processing by means of algorithms comprising image analysis or “computer vision” algorithms, to obtain and provide information about temperature evolution and/or about location/distribution of hot spots and/or bands and/or zones on the zone of interest of the surface of a brake disc.