Abstract: A composition may include microcapsules containing at least one odor-neutralizing agent, and agents may include such a composition. Furthermore, such compositions or agents may reduce malodors and/or be used for treating a surface, for treating room air, or for washing and/or caring for textiles using such compositions or agents.

Abstract: The present invention relates to new stable pharmaceutical compositions containing sodium 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)-phenyl]-4H-quinazolin-4-yl]acetate that are essentially free of complexing solubilizing agents, such as PEG, cyclodextrin, lysin, arginine, in particular HPBCD. The invention further relates to methods of preparation of said pharmaceutical compositions. The invention further relates to use of said pharmaceutical compositions in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.

Abstract: A method for the distribution of supports includes positioning a plurality di tubular containers, each containing a plurality of supports impregnated with antibiotics and stacked, in a corresponding plurality of seats of a dispenser. Extraction of at least a first support from a first container, is performed using an extractor, moving the first support between a first position inside of the first container and a second position extracted from the first container. Collection of the first support from the second position by a collector is performed. Transportation of the first support towards a culture plate by the collector is performed, the first support is held at least at the end of extraction, in substantial correspondence of the second position and/or during collection and/or of transportation through the collector, a vacuum is created between the first support and a striking surface using a vacuum holder.

Abstract: A distributed acoustic sensing (DAS) system for determining an acoustic event may include an interferometer and an acoustic event detection processing device. The interferometer may measure DAS data from sensed signals from a sensing fiber deployed in a wellbore. The acoustic event detection processing device may determine an acoustic event in the wellbore from an out-of-band signal using the DAS data by performing operations. The operations can include determining a first acoustic event and a second acoustic event from the DAS data. The operations can include determining a first set of aliased frequencies from the first acoustic event and a second set of aliased frequencies form the second acoustic event. The operations can include determining, using an intersection of the first set of aliased frequencies and the second set of aliased frequencies, a frequency or amplitude of out-of-band signals that are usable to determine the at least one acoustic event.

Abstract: The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated by Autotaxin.

Abstract: A vaporization device includes a body having first portion including a receptacle configured to receive a vaporizer cartridge, and a second portion configured to contain a power source. Various embodiments of the vaporizer device are described that include one or more features for a one-piece metal body. In some embodiments, the aspect ratio of the one-piece metal body is 11:1 or 12:1.

Abstract: An aerosol-generating system is provided, including: an aerosol-generating article including an aerosol-forming substrate, and an aerosol-generating device having a housing, a heating chamber defining a heating zone and sized to receive the substrate therein, an induction element around the zone, a power supply, and a controller connected to the element to provide an alternating electric current to the element to generate an alternating magnetic field within the zone, the element being controlled to sequentially provide a first alternating magnetic field having a first frequency for a first period of time followed by a second alternating magnetic field having a second frequency for a second period of time, the element being first and second coils, the first and the second coils being actuatable to provide the first and the second fields, respectively, and the article and the chamber being arranged so the article is partially received within the chamber.

Abstract: An installation device for carrying out installation steps on a wall, and a method for exchanging a tool received by the installation apparatus, include an installation apparatus having a drive unit coupled to a tool holder. The tool holder receives a tool that extends away from the tool holder in a tool direction and which tool is driven by the drive unit. The tool holder can assume a locked state and an unlocked state, wherein a tool received by the tool holder can be removed from the tool holder in the unlocked state and is fixed in the tool holder, and therefore cannot be removed, in the locked state. The installation apparatus has an unlocking device controllable by an actuator and the tool holder can be brought from the locked state into the unlocked state by the actuator to release the tool.

Abstract: Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucosa.

Abstract: A thermal management module for a thermal management system is disclosed. The thermal management module includes a first heat exchanger for flowing through by a refrigerant and by a working medium fluidically separately with respect to the refrigerant. A second heat exchanger is provided including at least a first fluid path and at least a second fluid path, separate from the first fluid path, respectively for flowing through by the refrigerant. A connecting arrangement is arranged between the first heat exchanger and the second heat exchanger. The connecting arrangement connects the first heat exchanger and the second heat exchanger to one another mechanically and fluidically, so that the refrigerant can flow between the first heat exchanger and the second heat exchanger.

Abstract: An example system includes a memory, a processor in communication with the memory, and a supervisor. The supervisor is configured to allocate a memory space in the memory to a workload executing on the processor. The supervisor is configured to store data written by the workload as dirty memory in the memory space at least until the data is written back to a data storage. Based on a type of the workload being a first type, the supervisor is configured to trigger write back of at least a portion of the dirty memory into the data storage in response to the dirty memory exceeding a threshold level. Based on the type of the workload being a second type, the supervisor is configured to delay write back of the dirty memory into the data storage in response to the dirty memory exceeding the threshold level.

Abstract: The invention relates to a process for the preparation of Melphalan (4-[bis(2-5 chloroethyl)amino]-L-phenylalanine of formula (I) said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: —N(CH2CH2OS(O)nO—)2, wherein n is 1 or 2 followed by conversion of the ?N(CH2CH2OS(O)nO—)2 group into a —N(CH2CH2Cl)2 group. The invention also provides novel intermediates useful for the preparation of Melphalan.

Abstract: The invention discloses a bioreactor with a vessel defining an inner volume, agitation means and at least one addition tube, wherein a delivery orifice in the addition tube is located within the inner volume and a check valve is arranged in proximity of the delivery orifice for allowing flow of a fluid in the direction from the addition tube into the inner volume of the vessel and blocking flow in the reverse direction.

Abstract: A process for producing alkyl methacrylates, in particular methyl methacrylate (MMA), includes production of methacrolein (MAL) in a first reaction stage; direct oxidative esterification (DOE) of the methacrolein with an alcohol, preferably methanol, to afford an alkyl methacrylate in a second reaction stage: and workup of the alkyl methacrylate crude product from the second reaction stage. An optimized workup of the reactor output from the oxidative esterification of methacrolein involves minimizing the amount of employed water, the amount of employed acid, and/or the amount of aqueous waste streams, through an optimized recycling of the generated process water streams.

Abstract: The invention relates to a method for a chemical and/or electrolytic surface treatment of a substrate in a process station and a process station for a chemical and/or electrolytic surface treatment of a substrate.

Abstract: A driver assistance system of an agricultural harvesting machine with a harvesting header designed as a draper is disclosed. The driver assistance system comprises a memory for storing data and a computing device for processing the data saved in the memory. The draper comprises a central belt and at least one transverse conveyor belt arranged on the left side and the right side of the central belt for conveying the harvested material to the central belt. The draper forms, together with the driver assistance system, an automatic draper. The computing device operates the automatic draper as a characteristic diagram controller using the saved characteristic diagrams, with the automatic draper optimizing operating parameters of the draper and specifying the optimized operating parameters for the draper. The characteristic diagrams describe the relationship between the operating parameters and quality parameters, and a control characteristic curve is assigned to the particular characteristic diagram.

Abstract: A computer-implemented system and method for estimating a Cumulative Distribution Function (CDF) are provided. The method includes: receive input data representing a volume V of a target space indicating a future target event; compute, using the trained neural network, an estimation of a first flux through a boundary of the volume V; compute, using the trained neural network, an estimation of a second flux through a boundary of a volume W of a base space based on the estimation of the first flux through the boundary of the volume V; generate, using the trained neural network, an estimation of a CDF for the volume V based on the second flux through the boundary of the volume W; compute a probability for the future target event based on the estimated CDF for the volume V; and generate a control command based on the probability for the future target event.

Abstract: Coaxial gear mechanism (1) includes a toothing (5) which is oriented axially with respect to an axis of rotation (3) of the coaxial gear mechanism (1), a tooth carrier (7) which in each case has axially oriented guides (9), and tooth pins (11) which each comprise a body (50), which is mounted so as to be axially displaceable in a guide (9) of the tooth carrier (7), and a head region (51), wherein the head region (51) includes at least one tooth (52) for engagement with the toothing (5), and wherein the tooth carrier (7) wherein the tooth carrier has an irregular angular pitch.

Abstract: A loudspeaker including a first diaphragm, a second diaphragm spaced from the first diaphragm, a first voice coil coupled to the first diaphragm, a second voice coil coupled to the second diaphragm, and a magnet assembly. The magnet assembly includes a magnet, a magnetic piece and a spacer of non-magnetic material connecting the magnet and the magnetic piece such that a gap is provided between the magnet and the magnetic piece. The first voice coil is arranged at a first end of the gap and the second voice coil is arranged at a second end of the gap opposite the first end of the gap.

Abstract: Systems and methods for starting and restarting an engine of a vehicle are disclosed. Power systems for an engine are disclosed.