Abstract: A method for a completion operation of a well includes performing, by a simulator, an initial simulation based on geological data and an input parameter, the initial simulation providing simulated net pressure values for the well; receiving an indication of an actual net pressure value in the well; adjusting, by an RL agent, the input parameter to the simulator based on a difference between the actual net pressure value and a corresponding simulated net pressure value; performing an updated simulation based on the geological data and the adjusted input parameter, the updated simulation providing updated simulated net pressure values; iteratively adjusting the input parameter to the simulator, with the corresponding simulated net pressure value being from the updated simulated net pressure values; and providing an indication of an event at the well based on the actual net pressure value and the corresponding simulated net pressure value.

Abstract: A method for controlling a power grid includes using a communication device to receive first data messages with first phasor measurement data from a first phasor measurement unit. A reference device is used to determine a deviation between the first phasor measurement data and reference data. The first phasor measurement data are recognized as plausible when the deviation lies below a previously defined upper threshold value and/or above a previously defined lower threshold value. A corresponding grid control arrangement is also provided.

Abstract: An electronics module (100), especially a power electronics module, comprising a metal-ceramic substrate (1) serving as a carrier and having a ceramic element (10) and a primary component metallization (21), an insulation layer (40) directly or indirectly connected to the primary component metallization (21), and a secondary component metallization (22) which is connected to the side of the insulation layer (40) facing away from the metal-ceramic substrate (1) and is especially isolated from the primary component metallization (21) using the insulation layer (40), wherein the ceramic element (10) has a first size (L1, D1) and the insulation layer (40) has a second size (L2, D2) and a ratio of the second size (L2, D2) to the first size (L1, D1) has a value smaller than 0.8, to form an island-like insulation layer (40) on the primary component metallization (21).

Abstract: A computer-implemented method for controlling and/or monitoring equipment (110) of a chemical plant is proposed.

Abstract: An arrangement for the assembly and wiring of electrical components in switchgear construction, the arrangement comprising a robot with an end effector designed as a gripper, a mounting plate holding device, with which a mounting plate is held in a mounting position with respect to the robot, and a component supply in the access area of the robot, via which components to be mounted on the mounting plate are provided for removal by the robot, wherein a controller of the robot has machine data for controlling the robot including position data for the arrangement of components on a mounting plane of a mounting plate to be equipped, wherein the robot has an optical imaging system which is adapted to detect an orientation of a mounting plate with respect to the robot, the controller of the robot being adapted to provide the position data with an offset representing the orientation of the mounting plate with respect to the robot as a function of the detected orientation. A corresponding method is further described.

Abstract: An agricultural production machine comprising a characteristic diagram control is disclosed. The characteristic diagram control comprises one or more characteristic diagrams. Each characteristic diagram is configured to optimize operating parameters of the process units of the agricultural production machine. The particular characteristic diagram is designed as an initial characteristic diagram. In the initial characteristic diagram, at least the relationship between operating parameters of a process unit and quality parameters is described by initial operating points. A control characteristic curve is associated with the particular characteristic diagram, and the control characteristic curve lies around the minimum or maximum of the particular quality parameter.

Abstract: Novel methods for preventing, reducing the risk of development of, and for treating hypercoagulopathy in Cushing's syndrome patients with elevated risk of developing hypercoagulopathy are disclosed. The methods are further useful to prevent, to reduce the risk of developing, and to treat deep vein thrombosis (DVT), pulmonary embolism (PE), and venous thromboembolism (VTE); and to treat inflammatory states. The methods include: administering heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator (HKGRM) to a Cushing's syndrome patient at risk of developing hypercoagulopathy, thereby treating hypercoagulopathy. Methods of preventing, reducing risk of developing, and of treating DVT, PR, or VTE in a Cushing's syndrome patient comprise administering a HKGRM to the patient.

Abstract: The present invention relates to novel high-value polycarbonate polyols, to processes for the production thereof, to polyisocyanate prepolymers obtainable therefrom and also polyurethane (PUR) and polyurethane urea elastomers which under particularly demanding applications show unique combinations of processing characteristics, hydrolysis and oxidation stability, mechanical and dynamic mechanical properties.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: A method of initiating a transfer of an active first-type slave process, executed in a first processing entity of an edge cloud computing layer, to a second processing entity of the edge cloud computing layer, includes, at a first mobile entity, receiving a first heat map relating to the first-type master-slave process, ranking, based on a cost function, possible process sharing connections, between the first mobile entity and one or more second processing entities, for the current location of the first mobile entity and/or a location of the first mobile entity in the near future, determining, based on the ranking, one or more second processing entities as potential target processing entities to transfer the first-type slave process to, and transmitting a processing entity transfer request to a control process executed in the edge cloud computing layer.

Abstract: A method for distribution of supports impregnated with antibiotics includes a step of positioning of a plurality of tubular containers, each one containing a plurality of supports impregnated with antibiotics and stacked, in a corresponding plurality of seats of a dispenser. Extraction of at least a first support from a first container is performed using an extractor, the step of extraction being performed in correspondence of an upper end of the first container and comprising a movement of the first support between a first position inside of the first container and a second position extracted from the first container, said first position and said second position lying substantially in correspondence of an upper surface of the dispenser. Collection of the first support from the second position is performed using a collector. Transportation of the first support towards a culture plate by the collector is performed.

Abstract: This relates generally to intelligent automated assistants and, more specifically, to provide a handsfree notification management system. An example method includes displaying one or more notifications by the electronic device. In response to displaying the one or more notifications, the method includes detecting a visual interaction of a user with the one or more notifications, identifying a notification from the one or more notifications based on the visual interaction, receiving a speech input related to the notification from the user, determining one or more actions associated with the notification based on the speech input, and performing the one or more actions.

Abstract: The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.

Abstract: There is disclosed a method for treatment, prevention, and/or slowing of progression for various chronic inflammatory disorder groups including (1) type 2 diabetes group (metabolic syndrome (MET), obesity, hyperglycemia); (2) ARDS (acute respiratory distress syndrome); (3) chronic autoimmune inflammatory disorders (rheumatoid arthritis (RA), lupus, and psoriasis); (4) inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis; (5) metabolome-mediated diseases (atherosclerosis, hypertension, and congestive heart failure); and (6) hyperphagia disorders such as Prader-Willi Syndrome and other monogenic and syndromic obesity disorders including leptin pathway deficiencies, each comprising administering orally a pharmaceutical composition comprising a denatonium salt.

Abstract: The present invention relates to an improved orthopaedic device for athrodesis, in particular for the arthrodesis or fusion of a joint, for example an ankle joint, of the type comprising of a nail having head and tip ends opposed to each other; at least a first portion of the nail having an axis of symmetry; a single circular first transverse hole made in the first portion near the head of the nail and extended according to its own axis perpendicularly to the axis of symmetry; a slotted second transverse hole still made in the first portion of the nail and extended perpendicular to both the first axis of symmetry; and to the axis of the first transverse hole; and the slotted second transverse hole being made at a greater distance with respect to the head of the nail than the distance from the head of the first transverse hole.

Abstract: A device (1) for rolling rings, comprising: a rolling device (10) with a main roll (11) and at least one mandrel roll (13a) onto which a ring is loadable, wherein the rolling device (10) is designed to roll the ring, with the mandrel roll (13a) impacting an interior face of the ring and the main roll (11) impacting an exterior face of the ring ;and a manipulator (20) comprising at least one robot (21) designed to manipulate the ring, comprising loading the ring onto the mandrel roll (13a) and/or unloading the ring from the mandrel roll (13a).

Abstract: In some implementations, a server device may receive, from a client device, a script identifier, that identifies a script, and an indication of whether the script was successfully executed by the client device. The server device may determine whether a condition associated with disabling the script is satisfied based on the script identifier, the indication of whether the script was successfully executed by the client device, and stored information determined based on a plurality of indications of whether the script was successfully executed by a plurality of other client devices. The server device may selectively cause a data structure to be updated to indicate that the script is disabled based on determining whether the condition is satisfied. The data structure may be used to indicate whether the script is enabled prior to execution of the script.

Abstract: Provided is a gas sensor system with a gas sensor, and a microprocessor programmed to control the gas sensor with at least two operational modes. The first operational mode controls the gas sensor from a baseline level through analyte detection. Upon initiation of the recovery phase after analyte withdrawal, the gas sensor system switches to the second operational mode, which changes conditions of the gas sensor to (i) accelerate removal of the analyte from the gas sensor and (ii) accelerate recovery of the gas sensor output towards the baseline level. When no further analyte is detected, the gas sensor switches back to the first operational mode or to an additional operational mode to complete recovery.

Abstract: An electropermanent magnet array is provided. The electropermanent magnet array includes one or more of a plurality of electropermanent magnets, arranged in a parallel fashion, a plurality of switching circuits, each switching circuit coupled to a different electropermanent magnet of the plurality of electropermanent magnets, and a control circuit, coupled to the plurality of switching circuits. The control circuit is configured to receive commands to control the plurality of switching circuits to demagnetize the plurality of electropermanent magnets, magnetize the plurality of electropermanent magnets to produce a first magnetic field with a strength and an attraction distance and magnetize the plurality of electropermanent magnets to produce a second magnetic field with a lower strength and greater attraction distance than the first magnetic field.

Abstract: A method for a multi-cluster warehouse includes allocating a plurality of compute clusters as part of a virtual warehouse. The compute clusters are used to access and perform queries against one or more databases in one or more cloud storage resources. The method includes providing queries for the virtual warehouse to each of the plurality of compute clusters. Each of the plurality of compute clusters of the virtual warehouse receives a plurality of queries so that the computing load is spread across the different clusters. The method also includes dynamically adding compute clusters to and removing compute clusters from the virtual warehouse as needed based on a workload of the plurality of compute clusters.