Abstract: A strand-guiding section arranged downstream of a continuous casting mould of a continuous casting line. The strand-guiding section has at least one strand-guiding roller supporting a metal strand cast with the continuous casting mould, is mounted in roller bearings in the strand-guiding section, and has at least one sensor device, which has at least one vibration sensor acoustically coupled to the strand-guiding roller or its roller bearings to detect the vibrations occurring with the rotation of the strand-guiding roller in the roller bearings. The strand-guiding roller is cooled internally by a cooling water. The vibration sensor is acoustically coupled to the strand-guiding roller and/or to the roller bearings via the cooling water. The evaluation device determines the status of the at least one roller bearing by evaluating the vibration data.

Abstract: Methods and compositions relating to sterilized fecal microbiota and compositions derived from the same. A method of sterilizing a fecal composition to obtain a sterilized fecal composition is provided. Methods of further purifying the sterilized composition and optionally freezing or freeze-drying the compositions is also provided. Methods of using the compositions for treatment in beverages, foods, and in supplements are also provided.

Abstract: The invention relates to a system for introducing an additive into a container (2). The system comprises an automated device for transporting the container (2) in a horizontal plane (P), such as a rotary wheel. The system further comprises a static microdoser (5) having a nozzle from which a jet (7) of an additive issues upon passage of an opening of the container (2). Additive is so injected into said container (2). According to the invention, the nozzle of the static microdoser (5) is inclined relative to a direction orthogonal to said horizontal plane (P). This limits splashing, in particular when the jet (7) of additive hits an inner wall of the container (2) that is free of liquid. This can be facilitated by an acceleration applied on the container (2) which inclines the free surface (8) of the liquid material present in the container (2). A preferred application is the introduction of a flavored concentrate into a bottle of water.

Abstract: The present disclosure relates to immunogenic compositions comprising a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen, and a toll-like receptor 9 (TLR9) agonist, such as an oligonucleotide comprising an unmethylated cytidine-phospho-guano sine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against a SARS-CoV-2 in an individual in need thereof.

Abstract: The concepts herein relate to a device for collecting, transferring and storing samples of biological and/or chemical material. The device includes a support body extending along a main longitudinal direction between a first and a second end opposite each other and a collecting portion engaged with one of said ends of the support body and suitable for collecting an amount of a sample of biological and/or chemical material. The support body is defined by at least a first sub-body and a second sub-body extending longitudinally and configured to be selectively engaged and separated with and from each other. The support body is configured to operate between an assembled condition, wherein the first and the second sub-body are engaged with each other, and a separated condition, wherein the first and the second sub-body are separated and bear, respectively, a first and a second sub-collecting portion of the collecting portion.

Abstract: The present disclosure provides a system, including methods and apparatus, for culturing, monitoring, and/or analyzing organoids. In an exemplary method of organoid culture, the method may comprise disposing a scaffold in a receptacle having an open side. A sealing member may be bonded to the open side of the receptacle to create a chamber. An organoid may be formed in the chamber using the scaffold. Fluid and/or at least one substance may be introduced into the chamber from an overlying reservoir for contact with the organoid.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: A method and a system for decelerating a single-track motor vehicle, includes using a control unit to determine a total torque of a wheel of the motor vehicle required for a desired riding maneuver, in particular a controlled slip of a rear wheel, determine, a braking partial torque and a motor partial torque as a function of the total torque required, and generate the braking partial torque on the wheel by controlling a brake system of the motor vehicle and generating the motor partial torque on the wheel by controlling a motor of the motor vehicle The invention further includes a single-track motor vehicle configured to execute the decelerating method.

Abstract: An air-conditioning system having a discharge device (10) for discharging condensed water from the air-conditioning system, wherein the discharge device has a piping system (2) for guiding the condensed water, wherein the discharge device has a regulating element (3) and the regulating element is configured as an open channel rotatable about a longitudinal axis (4) between a first rotational position and a second rotational position. The regulating element (3) is configured and arranged such that the regulating element guides the condensed water inside the piping system (2) in the first rotational position and establishes a continuous connection between a drip-off point for the condensed water and an outer area around the air-conditioning system in the second rotational position.

Abstract: A surgical microscope includes an image capture unit having an image sensor, a detection beam path, an image evaluation unit, a connection region for attaching a protective glass module with an objective protective glass. The image sensor has a detection region which has a used detection region for capturing the object region, and a partial detection region, which is not assigned to the used detection region. The image capture unit is configured such that, when the protective glass module with the objective protective glass is arranged at the connection region, a detail of the protective glass module with the objective protective glass is capturable by the partial detection region of the image sensor. The image evaluation unit is configured to generate a signal when an objective protective glass is detectable by the evaluation of the image data of the partial detection region of the image sensor.

Abstract: The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1×106 to 3×106 international units (IU) Human IL-2 is preferably administered in cycles of 3 to 7 days of once-daily sub-cutaneous injection of 0.1×106 to 3×106 HI human IL-2. The treatment does not comprise the administration of regulatory T cells to the subject, who is preferably also under riluzole treatment. The administered human IL-2 is preferably not complexed with anti-hIL-2 antibodies and the treatment also preferably does not comprise the administration of rapamycin or any other suppressive agent of effector T cells (Teffs) to the subject.

Abstract: A fingerprint sensing system for sensing a finger surface of a finger, comprising: a plurality of pixel elements, each pixel element in the plurality of pixel elements comprising: a photo-sensitive element configured to provide a current including a fingerprint signal current component and a common-mode signal current component; and an integrating capacitor including a first electrode coupled to the photo-sensitive element for receiving the current provided by the photo-sensitive element, and a second electrode; and a current source arrangement coupled to the first electrode of the integrating capacitor of each pixel element in the plurality of pixel elements.

Abstract: Molybdenum is etched in a highly controllable manner by performing one or more etch cycles, where each cycle involves exposing the substrate having a molybdenum layer to an oxygen-containing reactant to form molybdenum oxide followed by treatment with boron trichloride to convert molybdenum oxide to a volatile molybdenum oxychloride with subsequent treatment of the substrate with a fluorine-containing reactant to remove boron oxide that has formed in a previous reaction, from the surface of the substrate. In some embodiments the method is performed in an absence of plasma and results in a substantially isotropic etching. The method can be used in a variety of applications in semiconductor processing, such as in wordline isolation in 3D NAND fabrication.

Abstract: An apparatus for processing an audio input signal having one or more audio input channels to obtain an audio output signal having one or more audio output channels has an estimation unit configured to estimate a radiation resistance of each driver of one or more drivers of each loudspeaker of one or more loudspeakers as an estimated radiation resistance; or as an estimated radiation impedance, wherein said estimated radiation impedance has estimated information on the radiation resistance of said driver; and a processing unit configured to obtain the audio output channels by processing each audio input channel depending on the estimated radiation resistance or the estimated radiation impedance of each driver of each loudspeaker.

Abstract: A loyalty program management system associated with an enterprise location is provided. The loyalty program management system is programmed to: a) receive a plurality of input data associated with a plurality of patrons, wherein the plurality of input data represents actions of the plurality of patrons; b) determine a current location of a patron of the plurality of patrons, wherein the current location of the patron is not at the enterprise location; and c) transmit a message to a computer device associated with the patron including a prize to be awarded if the patron visits the enterprise location.

Abstract: A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer, NSCLC, pancreatic cancer (PC), renal cell carcinoma (RCC), benign prostate hyperplasia (BPH), prostate cancer (PCA), ovarian cancer (OC), melanoma, breast cancer (BRCA), CLL, Merkel cell carcinoma (MCC), SCLC, Non-Hodgkin lymphoma (NHL), AML, gallbladder cancer and cholangiocarcinoma (GBC, CCC), urinary bladder cancer (UBC), and uterine cancer (UEC) includes administering to said patient a composition containing a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide.

Abstract: Cooling device 1, in particular a freezer 2, having a closable cooling space 3, an electrically operated cooling circuit, and preferably a cold storage pack 4, wherein the at least one closable cooling space 3 and the cold storage pack 4 can be cooled by the electrically operated cooling circuit. The cooling device has a power distributor 5 for distributing electrical power of at least one regenerative power source 6 to an electrically operated cooling circuit of the cooling device 1 and to at least one further electricity consuming device 7. In addition, the power distributor 5 has a control system with a computing unit 23, a memory 24 and priority logic. The priority logic is used to preferentially supply the electrically operated cooling circuit of the cooling device 1 with electricity if there is a lack of electrical power of the at least one regenerative power source 6.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: An ophthalmic surgical cartridge has a fluid pump with a pump chamber and a drive chamber which are separated by a fluid-tight and ion-tight partition element. A body fluid is suppliable to the pump chamber and a drive fluid is suppliable to the drive chamber. A deformation or change in position of a portion of the partition element is achievable with the drive fluid which increases the second volume in size and decreases the first volume in size to drain the body fluid from the pump chamber. The drive chamber has a front side wall with an edge zone in which only a single passage opening is provided, through which the drive fluid is suppliable into the drive chamber to fill the drive chamber with the drive fluid, and through which said drive fluid can be drained from the drive chamber to remove the drive fluid from the drive chamber.

Abstract: An aerosol-generating device is provided, including: a device housing defining a cavity; an adjustable retaining element positioned in or adjacent to the cavity and defining a passage; and an actuator configured to actuate the element between receiving and retaining positions, in which a cross-sectional dimension of the passage is greater when the element is in the receiving position than when in the retaining position, the element defining a passage entrance and a passage exit and includes a surface defined between the entrance and the exit, a longitudinal cross-section of the surface having a curved shape when the element is in the retaining position, a portion of the curved shape including a convex curve defining a constriction in the passage at a turning point of the curve, and the element being compressed in a longitudinal direction when the element is actuated from the receiving position to the retaining position.