Abstract: An optical element for a projection exposure apparatus for semiconductor lithography comprises a main body and at least two actuators connected to the main body. The actuators are designed for deforming an optical effective surface of the optical element. The at least two actuators are ring actuators. A corresponding apparatus comprises such an optical element.

Abstract: Paint compositions and paint coatings for radiative cooling, as well as related methods of manufacturing and use of such paint compositions. A composition for paint to be used in radiative cooling, in a wet coating phase, includes nanoplatelets of hexagonal boron nitride, an acrylic binder, and a solvent. A coating of a dried paint on a surface to be cooled by radiative cooling includes nanoplatelets of hexagonal boron nitride and an acrylic binder. A method of manufacturing the composition for paint in the wet paint phase includes forming a first mixture by adding the nanoplatelets of hexagonal boron nitride to the solvent, uniformly distributing the nanoplatelets in the first mixture, and forming a second mixture by adding the acrylic binder to the first mixture.

Abstract: The present disclosure generally relates to the treatment of subjects having osteoarthritis or at risk of developing osteoarthritis by administering a Procollagen Galactosyl Transferase 2 (COLGALT2) inhibitor to the subject.

Abstract: A method for constructing a force sensor group is provided. An expansion body is provided that has integrated force sensor elements. A printed circuit board is provided having electronic components that are configured to receive measurement signals from the force sensor elements. The printed circuit board is electrically connected to the force sensor elements of the expansion body. The electrical connections are protected by applying a potting compound to the electrical connections. Media-tight overmolding of the printed circuit board is performed and at least sections of the expansion body to seal the electronic components and the force sensor elements or to seal and to mechanically protect the electronic components and the force sensor elements.

Abstract: A lamp base 60 supports an upright stem in the base-contacting end of which two headed machine screw are received in a threaded bore. To assemble base 60 to the stem, each screw and head pass axially through a region 61 of an opening 68B, 70B in base 60, each region 61 having a bore diameter enlarged to pass the head. The fixing shanks are then transferred laterally to an adjacent countersunk region 63 of each opening 68B, 70B by relative displacement between the stem and base 60 to capture the fixing heads, preventing axial removal of the fixings from the openings 68B, 70B by cooperation of the fixings' male countersinks with the base's female countersinks 63. The screws are then tightened to secure together the stem and base. Disassembly is accomplished by reversing the foregoing process. The structure described enables supply of the knocked-down lamp as a flat pack with captured fixing(s).

Abstract: The present invention encompasses compounds of formula (V) wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, X, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The invention relates to a knitting needle, in particular for producing knitwear with cable patterns, having at least one rigid needle tip and a shank on which the knitwear can be arranged at least regionally. The invention now proposes that the shank consist at least regionally of a material that is reversibly plastically deformable by bending in very different directions, wherein the transition between the shank and needle tip is flush and smooth. Furthermore, the invention proposes a method for producing such a knitting needle.

Abstract: A gas reservoir that receives a precursor has a gas-receiving unit which is arranged in a first receiving unit of a basic body and a sliding unit which is arranged movably in a second receiving unit of the basic body. The gas-receiving unit has a movable closure unit for opening or closing a gas outlet opening of the gas-receiving unit. In a first position of the sliding unit, a first opening of a sliding-unit line device is fluidically connected to a first basic body opening and a second opening of the sliding-unit line device is fluidically connected to a second basic body opening. In the second position of the sliding unit, the first opening is arranged at an inner wall of the second receiving unit and the second opening is arranged at the movable closure unit.

Abstract: A method for automatic generation of a specification for an IT topology of a control system, the method comprising: creating a system structure from a machine-readable data defining production process requirements and generating specification data of the IT topology based on the extracted system structure; optimizing the generated specification data of the IT topology by utilization of pre-defined rules and generating abstract aggregated IT topology data based on the optimized specification data; and instantiating and mapping the abstract aggregated IT topology data to specific technology instance data.

Abstract: Methods, computing devices, and computer-program products are provided for implementing a virtual personal assistant. In various implementations, a virtual personal assistant can be configured to receive sensory input, including at least two different types of information. The virtual personal assistant can further be configured to determine semantic information from the sensory input, and to identify a context-specific framework. The virtual personal assistant can further be configured to determine a current intent. Determining the current intent can include using the semantic information and the context-specific framework. The virtual personal assistant can further be configured to determine a current input state. Determining the current input state can include using the semantic information and one or more behavioral models. The behavioral models can include one or more interpretations of previously-provided semantic information.

Abstract: A sensing system for hand or body part positioning detection on an object, particularly on a rim of a steering wheel, includes at least one electrically conducting signal line that is arrangeable on a surface of the object with a priori knowledge about a relation between a distance of any portion of the at least one signal line from a reference point and information on a position on the object, a signal voltage source for providing a time-dependent measurement signal to be traveling along the signal line, and a control and evaluation unit. From a received reflected measurement signal, the control and evaluation unit determines a position or positions on the object of a portion or portions of the signal line at least partially reflecting the measurement signal. Based on the determined position or positions, a hand or body part positioning on the object is determined.

Abstract: To control movement of a transport unit of a linear motor, a quality functional J(SG) with quality terms JTk(SG) is used as a function of manipulated variables (SG) of active drive coils. The quality functional J(SG) controlling movement of the transport unit along the stator is optimized with regard to the manipulated variable (SG) to determine optimal manipulated variables (SGopt) for the relevant time step of the control of movement, active drive coils are energized according to the determined optimal manipulated variables (SGopt), and at least two movement phases are provided during the movement of the transport unit along the stator. In the at least two novement phases, different quality functionals J(SG) are used for determining the optimal manipulated variables (SGopt), the different quality functionals J(SG) differing by the number k of the quality terms JTk(SG) used and/or by the quality terms JTk(SG) and/or by the weighting factors kk.

Abstract: Systems and methods for cardiac radioablation treatment planning are disclosed. In some examples, a computing device receives a first signal identifying a first event within a first workspace from a second computing device. The computing device determines a first action to apply to a first image displayed within a second workspace based on the first signal. The computing device generates a second image based on applying the first action to the first image within the second workspace, and displays the second image within the second workspace. In some examples, the first workspace is a radiation oncologist workspace and the second workspace is an electrophysiologist workspace. In some examples, the first workspace is an electrophysiologist oncologist workspace and the second workspace is a radiation oncologist workspace.

Abstract: The present disclosure relates to a fluid connection arrangement for establishing a fluid connection, including a receiving part having a receiving wall that has a receiving wall inner side that delimits an interior of the receiving part, a tubular connecting part that is at least partially received in the interior of the receiving part and has a tube wall having a plurality of comb-shaped support points that extend along a longitudinal direction of the tubular connecting part, the comb-shaped support points contacting the receiving wall inner side. The tube wall may have at least one curved wall area that extends between two adjacent comb-shaped support points. Between the at least one curved wall area of the tubular connecting part and the receiving wall inner side of the receiving part at least one gap is arranged where a solder is received to establish a materially bonded and fluid-tight connection.

Abstract: Techniques are described herein for address matching from a single address string to an address matching score. In an embodiment, an address string is received and parsed into parsed address data. Once an address string is parsed into parsed address data, the parsed address data is standardized by converting the parsed address data into a standard format and replacing abbreviations, colloquial names with formal names. Once an address string has been standardized into a standardized street locale, candidate addresses that are identical to or similar to the standardized street locale are identified and are assigned a score. Each score comprises a probability that the respective candidate address and the standardized street locale represent a same place or location.

Abstract: The present invention relates to new isoindolinone or isobenzofuranone substituted indoles and derivatives of formula (I) wherein the groups R1 to R7, R10 and n have the meanings given in the claims and specification, their use as inhibitors of RAS-family proteins and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.