Abstract: The invention relates to modified G-protein coupled receptors (GPCRs) which (i) have decreased responsiveness to an endogenous activating ligand, and (ii) may be activated by exogenous agonists, which may be relatively benign over the counter drugs such as antihistamines. The modifications comprise mutations at particular amino acid positions, relative to the unmodified GPCRs. The invention also provides methods of use comprising administration of the modified GPCRs, for example in treating a neurological circuit disorder.

Abstract: A coated substrate includes a substrate and a multilayered antireflective coating built up from layers having different refractive indices on at least one side of the substrate. Layers having a relatively high refractive index and layers having a relatively low refractive index alternate and at least one layer having a relatively low refractive index is composed of a composition X containing silicon oxide and zirconium oxide. A proportion of zirconium in a metallic and semiconducting component in the composition X is 0.2% to 10% by weight.

Abstract: A bearing seat arrangement for an automotive auxiliary device. The bearing seat arrangement includes a static support structure, a separate bearing seat element which is press-fitted into the static support structure so as to provide a press-fitted connection, and an adhesive bond which axially fixes the separate bearing seat element.

Abstract: The present invention is directed to 4-methylumbelliferone (hymecromone) or a derivative thereof for use in the treatment of major depressive disorder, mood disorders, anxiety-related disorders and depression associated with diseases or drug treatments including Alzheimer's disease, HIV associated neurocognitive disorders (HAND), psoriasis, chronic fatigue syndrome, Parkinson's disease, Long COVID syndrome and drug treatment regimens with IFN-alpha or vitamin A analogues, promoted by pathogenic extracellular vesicles, wherein 4-methylumbelliferone inhibits hyaluronic acid (HA) synthases and block the incorporation of HA and/or low molecular weight cleavage products into said extracellular vesicles. The present invention is also directed to a method for monitoring the efficacy of the treatment and delivery of therapeutic cargo to cells incorporating pEV by means of HA-binding receptors. The present invention further provides an in vitro screening method for identifying further inhibitors of HA synthases.

Abstract: In an embodiment, a system for of preventively treating hypoglycemia includes a continuous glucose monitoring (CGM) sensor system configured to generate measurements associated with a current glucose level of a patient. The system further includes one or more memories comprising executable instructions and one or more processors in data communication with the one or more memories. The one or more processors are configured to execute the executable instructions to receive, from the CGM sensor system, one or more measurements associated with the current glucose level of the patient and compute a sequence of preventive hypoglycemia treatments over a future time period based on the one or more measurements and a prediction of glucose control to be produced by the sequence. The one or more processors are further configured to prompt the patient with a first preventive hypoglycemia treatment in the sequence of preventive hypoglycemia treatments.

Abstract: A method and system for determining clustering relevance in a volatile data environment and adjusting clustering composition for improved accuracy are disclosed. The method includes plotting a dataset and generating at least one grand truth data value, and clustering the plotted dataset for generating data clusters, in which the clustering is performed based on correlation of individual data values included in the dataset. The method further includes independently training machine learning (ML) algorithm for each of the data clusters for generating a managing ML algorithm for the dataset, applying the managing ML algorithm to the dataset for predicting at least one future data value, and comparing differences between the grand truth data value and the future data value for estimating a clustering error, and adjusting composition of at least one of the plurality of data clusters based on the estimated clustering error.

Abstract: A rolling bearing includes an outer ring having an outer surface configured to be fitted into a first component, an inner ring having an inner surface configured to be fitted onto a second component, at least one rolling element arranged between the outer ring and the inner ring, and a polymer composite sheet bonded to the outer surface of the outer ring and/or to the inner surface of the inner ring by a bonding agent.

Abstract: The present disclosure is directed to input detection for electronic devices using electrostatic charge sensors. The devices and methods disclosed herein utilize electrostatic charge sensors to detect various touch gestures, such as long and short touches, single/double/triple taps, and swipes; and perform in-car detection.

Abstract: In one embodiment, a crosspiece forming a spider for a laundry appliance, may include a plurality of support arms extending from a center, the support arms configured to be attached to a drum of the laundry appliance, wherein the center is configured to receive a shaft of a drive mechanism of the laundry appliance and translation rotational motion to the drum during use; and where the support arms are formed from a first part and a second part, where the first part is coupled to the second part to form a hollow interior and increase inertia momentum of the spider during use.

Abstract: A mounting assembly for a gearbox assembly of a gas turbine engine includes at least one mounting member configured to mount a gear of the gearbox assembly to a component of the gas turbine engine, the at least one mounting member characterized by a lateral impedance parameter, a bending impedance parameter, and a torsional impedance parameter. A gas turbine engine includes the mounting assembly. The at least one mounting member may be a flex mount, a fan frame, or a flex coupling. The gas turbine engine also includes a heat exchanger including an inner peripheral wall and an outer peripheral wall extending between an inlet and an outlet. The inner peripheral wall and the outer peripheral wall define a flow channel therebetween. The heat exchanger includes a plurality of fins disposed in the flow channel and dividing the flow channel into a plurality of flow passages.

Abstract: Transgenic INHT26 soybean plants comprising modifications of the DAS44406-6 soybean locus which provide for facile excision of the modified DAS44406-6 transgenic locus or portions thereof as well as modifications of the DAS44406-6 soybean locus, methods of making such plants, and use of such plants to facilitate breeding are disclosed.

Abstract: A topically applicable preparation, particularly a cosmetic or dermatological preparation, comprising a substance combination of water, hyaluronic acid and/or hyaluronate salt, one or more fruit acids, one or more skin moisturizers and one or more alcohols can be successfully used for skin care, especially for preventing and treating the damage caused by atopic dermatitis of the skin and caring for such skin, without containing lipids and emollients that are typically included.

Abstract: The invention relates to a method for operating a fuel cell system (1), wherein, via a fuel line (20), hydrogen from a tank (21) and recirculated hydrogen from a recirculation circuit (50) as the anode gas are supplied to at least one fuel cell (101), and water (6) contained in the anode gas is removed by means of a water separator (2) integrated into the recirculation circuit (50), is collected in a container (3) and is removed from the system by intermittently opening a drain valve (41). The following steps are carried out to detect whether the container (3) is full: opening the drain valve (41) located on the container (3), detecting an erratic change in pressure in the fuel line (20) upstream of a hydrogen metering valve (51), identifying that the container (3) is empty. The invention further relates to a control device (27) for carrying out the method or individual method steps.

Abstract: The invention relates to a method for operating a drive train (2) having an electromotive drive (4), wherein a speed and a drive torque of the electromotive drive (4) can be converted via a toothed transmission stage (12) for an output (19), and the electromotive drive (4) is controlled with a control signal (40), wherein a periodic torque change signal (5) which alternately reduces and amplifies the drive torque is superimposed on the control signal (40) in order to damp transmission noises, wherein the periodic torque change signal (5) is in phase with a periodic change in the tooth stiffness of the toothed transmission stage (12).

Abstract: Disclosed are a measuring apparatus and a measuring method for preparing laser treatment of the eye. The measuring apparatus for preparing laser treatment has a device for determining a subjective refraction of the eye, wherein: the device for determining the subjective refraction has a housing which can be positioned in front of the eye and contains an opening; the housing has a device for providing different optical elements for the subjective visual compensation for refractive errors in the opening; and the housing is provided with a device for registration of the eye through the opening.

Abstract: Systems are provided for contactless determining a physical feature of a target item. Such systems comprise a scanner unit, a detector unit and a determiner unit. The scanner unit is configured to operate according to a relative position between the target item and the scanner unit, said operation including emitting a scanning radiation onto the target item and measuring an interaction radiation caused by interaction of the scanning radiation with the target item. The detector unit includes one or more measurers configured to measure, irrespective of the relative position or variations thereof, a condition potentially distorting the operation by the scanner unit. The determiner unit is configured to determine the physical feature of the target item depending on the interaction radiation measured by the scanner unit and the potentially distorting condition measured by the detector unit. Methods and computer programs performable at or by said systems are also provided.

Abstract: A device is configured for determining the conductivity of a tire. The device includes a frame, a supporting device attached to the frame with a supporting surface that extends in a contact plane on which a tire can rest, a first measuring device attached to the frame and having an electrically conductive first segment, and a second measuring device attached to the frame and having an electrically conductive second segment. When a tire having a radially outer tread and a radially inner bead is resting on the supporting surface with a first side that faces toward the contact plane, the first measuring device can be moved from a second side of the tire opposite the first side to the bead so that in a test configuration the first segment contacts the bead and the second segment contacts the tread.

Abstract: An electrical property sensor is presented that includes a printed circuit board with a first face separated from a second face by a thickness, the first face having a length and a width. The sensor also includes an aperture extending from a first face of the printed circuit board to a second face of the printed circuit board. The aperture includes a receiving electrode and a transmitting electrode. When a fluid flows through the aperture and a voltage is provided at the transmitting electrode, a cunent flow is measured at the receiving electrode.

Abstract: A rolling bearing includes an outer ring having an outer surface configured to be fitted into a first component, an inner ring having an inner surface configured to be fitted onto a second component, at least one rolling element arranged between the outer ring and the inner ring, and an antimony-free composite coating on the outer surface of the outer ring and/or the inner surface of the inner ring. The antimony-free composite comprises a binder and polytetrafluorethylene as a solid lubricant.

Abstract: A closure system (10) for a medication container (1), the interior (4) of which is accessible via a mouth region (6) designed in the manner of a bottle mouth, wherein the closure system (10) comprises, in addition to a bounce cap (28) which can be pushed onto the mouth region (6) and is provided with a sealing element (24), a locking ring (60) which, in a position pushed completely onto the bounce cap (28), can be pushed onto the bounce cap (28), can be fixed to the bounce cap (28) in a latchable manner by means of a number of snap ribs (62), is intended to be particularly suitable for automated filling operations by simple means. For this purpose, according to the invention, the or each snap rib (62) is guided in a corresponding guiding groove (82) during a movement of the inner lateral surface (84) of the retaining ring (60) relative to an outer lateral surface (80) of the bounce cap (28) corresponding to the latter.