Abstract: Forward-looking sales activities are poorly served by existing Customer Relationship Managements systems, as the customer information those systems maintain by definition does not include the speculatively interested “leads” pursued in initial sales contacts. An Enrichment database, asynchronously loaded with corporate and optionally individual contact information in anticipation of use, provides real-time access to information in support of such first customer contacts. The Enrichment information may also be used to expedite creation and revision of CRM records.

Abstract: An imprinting apparatus includes a silicon master having a plurality of nanofeatures defined therein. An anti-stick layer coats the silicon master, the anti-stick layer including a molecule having a cyclosiloxane with at least one silane functional group. A method includes forming a master template by: depositing a formulation on a silicon master including a plurality of nanofeatures defined therein, the formulation including a solvent and a molecule having a cyclosiloxane with at least one silane functional group; and curing the formulation, thereby forming an anti-stick layer on the silicon master, the anti-stick layer including the molecule. The method further includes depositing a silicon-based working stamp material on the anti-stick layer of the master template; curing the silicon-based working stamp material to form a working stamp including a negative replica of the plurality of nanofeatures; and releasing the working stamp from the master template.

Abstract: Forward-looking sales activities are poorly served by existing Customer Relationship Managements systems, as the customer information those systems maintain by definition does not include the speculatively interested “leads” pursued in initial sales contacts. An Enrichment database, asynchronously loaded with corporate and optionally individual contact information in anticipation of use, provides real-time access to information in support of such first customer contacts. The Enrichment information may also be used to expedite creation and revision of CRM records.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating prurigo nodularis.

Abstract: A method of discovering relationships between iris physiology and cognitive states and/or emotional states of a subject includes providing a computing device and a video camera to record a close-up view of the subject's eye. A first light is held to the lower eyelid skin and a second light a distance away illuminating the stroma of the eye. The first and second light are electronically synced together and configured to flash alternatively. The user engages in a plurality of tasks while recording ocular information which is processed to identify correlations between the responses in the iris musculature and the distortions in the stroma through the use optimized algorithms. One can then identifying at least one predictive distortion is identified in the stroma capturable solely with a visible-spectrum camera correlating to a predicted responses in the iris musculature.

Abstract: This invention, in embodiments, relates to a roofing system that includes a roof deck, a plurality of tapered insulation panels applied onto the roof deck, at least one non-tapered insulation panel applied onto the plurality of tapered insulation panels, and a membrane layer applied onto the at least one non-tapered insulation panel. This invention, in embodiments, further relates to a roof assembly kit that includes a plurality of tapered insulation panels and instructions for installation, as well as a method of installing such a roofing system.

Abstract: A power tool includes a housing with a motor housing portion, a handle portion extending from the motor housing portion, and a battery receptacle configured to receive a battery pack. An electric motor is supported in the motor housing portion. A trigger extends from the handle portion. An actuator is located on a top surface of the housing opposite the battery receptacle and includes a magnet. A sensor is positioned adjacent the actuator to detect a position of the magnet and output an actuator signal representative of a position of the actuator based on the detected position of the magnet. A controller is configured to control the electric motor based on the actuator signal received from the sensor such that the electric motor rotates in a first direction when the actuator is in the first position and rotates in an opposite direction when the actuator is in the second position.

Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: The present application provides a collector terminal dust mitigation assembly for use with collector terminals of generators to prevent dust entry into a collector terminal bore in a collector ring, wherein the collector terminals may have varying positions with respect to the collector rings. The collector terminal dust mitigation assembly may include one of a number of inner elements configured for a specific position of a collector terminal with respect to a collector ring and a standard outer element sized to accommodate the inner element.

Abstract: A faulty meter socket detection system configured to detect faulty sockets as evidenced by series arcs in an input current waveform or an increased temperature of the meter is disclosed. The system includes a metering circuit configured to receive an input current waveform, and a controller including a power monitoring module. The meter may also include a temperature sensor. The power monitoring module is configured detect series arc currents input current waveform data by filtering the input current waveform data to produce filtered data, performing feature recognition on the filtered data, classifying the features of the filtered data, performing temporal processing on the filtered data, (optionally) scaling the temporal processing of the filtered data, and, scoring the input current waveform based on the temporal processing of the filtered data. The temperature sensor may detect an increased temperature of the meter, which may indicate a faulty socket.

Abstract: The disclosures herein relate to novel compounds of formula (1) and salts thereof, wherein V; W; X; Y; Z; R1; R2; R3; R4 and R5 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

Abstract: A vaporizer device is provided, including: a cartridge including a reservoir, the reservoir being configured to hold a vaporizable substance; a wick element located within the cartridge and including a susceptor material in a form of a tube, the wick element being configured to contact the vaporizable substance located in the cartridge; and an induction heating element, disposed around at least a portion of the cartridge, the wick element being at least partially surrounded by the induction heating element, and the wick element being further configured to heat the vaporizable substance based on induction heating of the wick element by the induction heating element.

Abstract: A method of passing an object on the side of the road by receiving a first signal from a first sensor configured to detect a presence of the object positioned on a shoulder of a road; determining a first value; assigning a first confidence value to a confidence level, wherein the first confidence value is associated with the first value; responsive to the first confidence value exceeding a confidence threshold, adjusting a first operating parameter of a vehicle; responsive to entering a threshold range of the object, receiving a second signal from a second sensor; determining a second value associated with the second signal; assigning a second confidence value to the confidence level, wherein the second confidence value is associated with the second value; responsive to the second confidence value exceeding a second confidence threshold, adjusting a second operating parameter of the vehicle.

Abstract: A computer-implemented method (300) of operating a telecommunications network (110-1), said telecommunications network comprising a plurality of nodes (150), and the method comprising the steps of: storing: a set of historic reconfiguration instructions, said instructions having been used to reconfigure the telecommunications network; first status information from each of the plurality of nodes, wherein said first status information is received prior to reconfiguring the telecommunications network according to a given historic reconfiguration instruction; and second status information from each of the plurality of nodes, wherein said second status information is received after reconfiguring the telecommunications network according to the given historic reconfiguration instruction; receiving a new reconfiguration instruction (310); prior to reconfiguring the telecommunications network according to the new reconfiguration instruction, identifying from the set a similar historic reconfiguration instruction havin

Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: A system and method are provided for quantifying greenhouse gas (GHG) emissions associated with vehicle traffic. The method includes receiving data from a plurality of devices located at a plurality of traffic intersections in a traffic network, each device comprising at least one sensor configured to obtain data from the corresponding traffic intersection; using the received data and a traffic model to determine vehicle trajectory data; using the vehicle trajectory data and an emissions model to obtain corresponding GHG emissions data; and evaluating the corresponding GHG emissions data to a baseline of GHG emissions using a GHG quantification methodology to determine a GHG reduction that can achieve a carbon offset credit.

Abstract: The present invention relates to methods and compositions for editing a polynucleotide, e.g., a polynucleotide comprising a SNP associated with a disease or disorder.

Abstract: The present invention relates to methods and compositions for editing a polynucleotide, e.g., a polynucleotide comprising a SNP associated with a disease or disorder.

Abstract: A cooking system positionable on a support surface includes a housing having an internal cooking compartment and an opening formed in the housing for accessing said internal cooking compartment. At least one heating element is provided for heating said internal cooking compartment. The heating element is operable to heat the internal cooking compartment while the opening is at least partially exposed to an ambient environment to allow fluid transfer between the ambient environment and the internal cooking compartment. An output from said at least one heating element is variable across said internal cooking compartment during operation of the system.

Abstract: A computer-implemented method (200) of managing a telecommunications network (110), the telecommunication network comprising a network orchestrator (120), a plurality of network nodes (150) and a network ledger (140) for electronically storing data, the method comprising the steps of: the network orchestrator generating an instruction for reconfiguring at least one of the plurality of nodes (210); in response to generating said instruction, requesting and retrieving first status information from the at least one of the plurality of nodes (240); recording the instruction and the first status information to the network ledger (240)); communicating the instruction to the at least one of the plurality of nodes thereby to effect the instructed reconfiguration (230); in response to effecting the instructed reconfiguration, requesting and retrieving second status information from the at least one of the plurality of nodes; and recording said second status information in the network ledger (280).