Abstract: A fuel system includes a fuel injector having a split check assembly with a control piece, an outlet piece, and a check sleeve. A trapped volume is formed between the control piece and the outlet piece within the check sleeve, to hydraulically couple the control piece to the outlet piece. A starting rate shape clearance fluidly connects the trapped volume to a fuel cavity and is formed between the check sleeve and one of the control piece or outlet piece received therein, and modulates a starting rate shape of fuel injection from the fuel injector. Related methodology is disclosed.

Abstract: Techniques for fabricating a cored or coreless semiconductor package having one or more magnetic bilayer structures embedded therein are described. A magnetic bilayer structure includes a magnetic layer and a dielectric layer. For one technique, fabricating a cored or coreless semiconductor package includes: depositing a seed layer on a build-up layer; forming a raised pad structure and a trace on the seed layer; removing one or more uncovered portions of the seed layer to uncover top surfaces of one or more portions of the build-up layer; applying a magnetic bilayer structure on the raised pad structure, the trace, any unremoved portion of the seed layer, and the top surfaces of the one or more portions of the build-up layer, the magnetic bilayer structure comprises a magnetic layer and a dielectric layer; and forming a conductive structure on the raised pad structure. Other techniques are also described.

Abstract: A system receives confirmation that a vehicle has accepted automatic control imposition for a drive within a geo-fenced boundary. The system tracks travel of a plurality of vehicles, including the vehicle, within the geo-fenced boundary. The system may determine that the vehicle has a threshold likelihood of encountering at least one of another vehicle or a boundary of the geo-fence at a threshold speed or above and responsive to the determination, impose automatic control on the vehicle, including at least one of controlled braking or speed limiting.

Abstract: Some embodiments described herein relate to new polymer coatings for surface functionalization and new processes for grafting pre-grafted DNA-copolymers to surface(s) of substrates for use in DNA sequencing and other diagnostic applications.

Abstract: Embodiments of the present disclosure relate to nucleotides labeled with photoswitchable compounds. Also provided herein are methods and kits of using these labeled nucleotides for sequencing applications.

Abstract: A system for a well car includes a frame, a hitch coupled to the frame near the first end of the frame, and a first deck coupled to the frame. The frame includes a first pair of sockets located near a first end of the frame and a second pair of sockets located near a second end of the frame. Each socket of the first pair of sockets is configured to engage a support casting of a first pair of support castings located at a first position along a length of a well car. Each socket of the second pair of sockets is configured to engage a support casting of a second pair of support castings located at a second position along the length of the well car. The first deck is configured to hold wheels of a trailer when the trailer is coupled to the hitch.

Abstract: In one example, an unsaturated cyclic dione is coupled to the substrate, and is reacted with an indole or indazole including a first functional group to form a first adduct coupling the first functional group to the substrate. In another example, an unsaturated cyclic dione is coupled to a substrate and reacted with a diene including a functional group to form an adduct coupling the functional group to the substrate. In another example, an indole or indazole is coupled to a substrate, and is reacted with an unsaturated cyclic dione including an oligonucleotide to form an adduct coupling the oligonucleotide to the substrate. In another example, a diene is coupled to a substrate, and is reacted with an unsaturated cyclic dione including an oligonucleotide to form an adduct coupling the oligonucleotide to the substrate.

Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.

Abstract: Systems and methods for monitoring a fleet of self-driving vehicles are disclosed. The system comprises one or more self-driving vehicles having at least one sensor for collecting current state information, a fleet-management system, and computer-readable media for storing reference data. The method comprises autonomously navigating a self-driving vehicle in an environment, collecting current state information using the vehicle's sensor, comparing the current state information with the reference data, identifying outlier data in the current state information, and generating an alert based on the outlier data. A notification based on the alert may be sent to one or more monitoring devices according to the type and severity of the outlier.

Abstract: A method for the reduction of ship fuel consumption through the optimisation of vessel draft, speed and trim using historical vessel data. Historical global, online data, is collected for multiple vessel operating parameters associated with its previous voyages. After initial filtering and cleaning of the gathered data, a process of analysing the data to determine the optimum draft, speed and trim for the vessels' given speed is described. The determined optimum draft, speed and trim values are then presented to the Captain or an automatic draft and trim optimisation system for the current draft and trim to be adjusted. This application therefore discloses a method for analysing historical vessel data to provide advice on optimum draft, trim and speed. A method for predicting the achievable fuel savings and recording the fuel savings achieved is also disclosed.

Abstract: A hydrogel includes a dendritic core with 2 to 30 arms, and first and second acrylamide monomers incorporated into each arm. The first acrylamide monomer is: (I), wherein R1 and R2 are independently selected from an alkyl, an alkylamino, an alkylamido, an alkylthio, an aryl, a glycol, and optionally substituted variants thereof; and the second acrylamide monomer is: (II), wherein R3 and R4 are independently hydrogen or an alkyl; L is a linker including a linear chain of 2 to 20 atoms selected from carbon, oxygen, and nitrogen and optional substituents on the carbon and any nitrogen atoms; A is an N substituted amide: (III), where R5 is hydrogen or an alkyl; E is a linear chain of 1 to 4 atom(s) selected from carbon, oxygen and nitrogen, and optional substituents on the carbon and any nitrogen atoms; and Z is an optional nitrogen containing heterocycle.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: A fuel system includes a fuel injector having a split check assembly with a control piece, an outlet piece, and a check sleeve. A trapped volume is formed between the control piece and the outlet piece within the check sleeve, to hydraulically couple the control piece to the outlet piece. A starting rate shape clearance fluidly connects the trapped volume to a fuel cavity and is formed between the check sleeve and one of the control piece or outlet piece received therein, and modulates a starting rate shape of fuel injection from the fuel injector. Related methodology is disclosed.

Abstract: An example of a kit includes a flow cell and a cleavage mix. An example flow cell includes a substrate; a catalytic polymeric hydrogel on the substrate, the catalytic polymeric hydrogel including a deblocking catalyst; and an amplification primer attached to the catalytic polymeric hydrogel. The deblocking catalyst accelerates cleavage of a blocking group of a 3? OH blocked nucleotide introduced to the flow cell and incorporated into a template strand attached to the amplification primer. An example of the cleavage mix includes a component to initiate cleavage of the blocking group.

Abstract: An example system for programmatically extracting data from a big data source includes: a processor; and system memory encoding instructions which, when executed by the processor, cause the system to: extract metadata from the big data source using the utility; transform the metadata into a standard format; and load the metadata in a repository.

Abstract: At least one aspect of the present disclosure is directed to systems and methods of selecting and acknowledging content to broadcast. A system can receive, at a first time, a request for content to broadcast identifying a content publisher. The system can obtain cluster data of the content publisher corresponding to a first time, the cluster data identifying content selection metrics based on predicted characteristics of the cluster corresponding to the first time. The system can determine a subset of content items having cluster filtering criteria that satisfy the content selection metrics. The system can rank the subset of content items based on the content selection metrics to create an ordered list of content items. The system can transmit data identifying the order of the content items to the content publisher. The content publisher can insert the content into a broadcast in the order identified by the system.

Abstract: An imprinting apparatus includes a silicon master having a plurality of nanofeatures defined therein. An anti-stick layer coats the silicon master, the anti-stick layer including a molecule having a cyclosiloxane with at least one silane functional group. A method includes forming a master template by: depositing a formulation on a silicon master including a plurality of nanofeatures defined therein, the formulation including a solvent and a molecule having a cyclosiloxane with at least one silane functional group; and curing the formulation, thereby forming an anti-stick layer on the silicon master, the anti-stick layer including the molecule. The method further includes depositing a silicon-based working stamp material on the anti-stick layer of the master template; curing the silicon-based working stamp material to form a working stamp including a negative replica of the plurality of nanofeatures; and releasing the working stamp from the master template.

Abstract: A fuel injector includes an injector housing, an outlet check, an injection control valve assembly, and a valve seat orifice plate integrating a valve seat and various orifices for outlet check control. In the valve seat orifice plate a drain orifice extends between a valve seat surface and a check control chamber formed between a closing hydraulic surface of the outlet check and the valve seat orifice plate. First and second re-pressurization orifices extend between an outer surface of the valve seat orifice plate and the check control chamber.

Abstract: A railcar system that includes a railcar with a discharge opening and a longitudinal gate positioned adjacent to the discharge opening. The system further includes a driving system connected to the longitudinal gate that is configured to move the longitudinal gate between a closed position and an open position. The system further includes a controller connected to the driving system that causes the driving system to position the longitudinal gate in the closed position, position the longitudinal gate in the open position, and position the longitudinal gate to remain an at least partially open position. The longitudinal gate is less than fully open when the longitudinal gate is in the at least partially open position.