Patents by Inventor Andrew A. Brown

Andrew A. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC AZIDE UNITS AND THEIR USE IN POLYMER COATINGS
    Publication number: 20210284609
    Abstract: Described herein are heterocyclic azide-containing monomer units, copolymers comprising such heterocyclic azide-containing monomer units, substrate-bound copolymers, and oligonucleotide-bound copolymers, methods for making such copolymers and reacting them with a substrate and/or oligonucleotide, and methods of using such copolymers for immobilization of oligonucleotides to a substrate, for example for use in DNA sequencing or other diagnostic applications.
    Type: Application
    Filed: December 9, 2019
    Publication date: September 16, 2021
    Inventors: Wayne N. George, Xiaolin Wu, Andrew A. Brown, Donald Wellings
  • Healthcare Decision Platform
    Publication number: 20210272038
    Abstract: A system for the dynamic analysis of unstructured data where feedback loops exist between the user and the machine resulting in improved specificity and content (accuracy and precision) with regard to the results obtained from the machine learning algorithms. A Graphic User Interface (GUI) controls the configuration and deployment of all the features of the Intelligence Augmentation System (IAS) including data capture and processing, analytics, and feedback. Results of one set of algorithms can be forwarded to subsequent tools with the system for further analysis and planning using decision algorithms. The results are configured using a GUI that can manipulate the data in dynamically, allowing immediate visualization of user queries.
    Type: Application
    Filed: May 14, 2021
    Publication date: September 2, 2021
    Inventors: Michael Kowolenko, John C. Bass, Meaghan E. Johnson, Andrew Brown, Michael S. Brown, Jesse Simpson
  • SHAPE MEMORY ALLOY ACTUATION APPARATUS
    Publication number: 20210262453
    Abstract: An SMA actuation apparatus (1) comprises a support structure (2) and a movable element (3) supported thereon by a suspension system (8, 10) that supports the movable element on the support structure and guides movement of the movable element along a movement axis. Two closely spaced lengths of SMA wire (4) that are close to parallel and inclined at the same acute angle with respect to a plane normal to the movement axis are connected to the support structure and to the movable element so as to apply respective forces to the movable element with respective components parallel to the movement axis that are in opposite directions. The two lengths of shape memory alloy wire apply a couple to the movable element perpendicular to the movement axis and the suspension system includes a pair of flexures or bearings that resist the resultant couple applied to the movable element by the lengths of SMA wire.
    Type: Application
    Filed: June 21, 2019
    Publication date: August 26, 2021
    Inventors: Andrew Brown, Andreas Flouris, James Howarth
  • SHAPE MEMORY ALLOY ACTUATION APPARATUS
    Publication number: 20210263392
    Abstract: A shape memory alloy actuation apparatus comprises a support structure (2) and a movable element (10). A helical bearing arrangement (20) supporting the movable element on the support structure guides helical movement of the movable element with respect to the support structure around a helical axis (H). At least one shape memory alloy actuator wire (60) is connected between the support structure and the movable element in, or at an acute angle to, a plane normal to the helical axis, so as to drive rotation of the movable element around the helical axis which the helical bearing arrangement converts into said helical movement.
    Type: Application
    Filed: June 21, 2019
    Publication date: August 26, 2021
    Inventors: Andrew Brown, Stephen Bunting, Daniel Burbridge, Oliver Hart, Nicholas Heijne, James Howarth, Marc-Sebastian Scholz
  • Serial connection between management controller and microcontroller
    Patent number: 11100036
    Abstract: An example computing system includes a baseboard management controller (BMC), a motherboard, and a daughterboard communicatively coupled to the motherboard. The BMC includes a serial interface. The daughterboard includes a universal asynchronous receiver/transmitter (UART) terminal, a bridging chip, and a microcontroller communicatively coupled to the BMC via the bridging chip. The BMC establishes a serial connection, through the serial interface and the UART terminal, with the microcontroller.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: August 24, 2021
    Assignee: Hewlett Packard Enterprise Development LP
    Inventors: Andrew Brown, David Heinrich
  • POLYMER COATINGS
    Publication number: 20210254151
    Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.
    Type: Application
    Filed: March 1, 2021
    Publication date: August 19, 2021
    Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
  • GIP/GLP1 co-agonist compounds
    Patent number: 11084861
    Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: August 10, 2021
    Assignee: Eli Lilly and Company
    Inventors: Milata Mary Abraham, Jorge Alsina-Fernandez, Robert Andrew Brown, Over Cabrera, Tamer Coskun, Robert Chadwick Cummins, Mohamed ElSayed Hamed Elsayed, Hongchang Qu, James Lincoln Wallis, Amita Datta-Mannan, Xianyin Lai
  • Method and apparatus for adaptive trailer content monitoring
    Patent number: 11062463
    Abstract: A load-monitoring system includes a vehicle processor and a camera mounted in a trailer. The vehicle, via the processor, displays a first image of a trailer load, received from a trailer-mounted camera and receives selection of a monitoring point on the image, via a touch-sensitive user interface displaying the image or other selection mechanism. The vehicle also receives selection of a fixed point on the image, via the user interface. If the monitoring point moves more than a threshold amount, relative to the fixed point, for example, in subsequent images captured by the camera, the vehicle alerts the driver.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: July 13, 2021
    Assignee: Ford Global Technologies, LLC
    Inventors: Brian Gabel, Joshua Sharpe, Keith Weston, Andrew Brown
  • CATALYST-FREE SURFACE FUNCTIONALIZATION AND POLYMER GRAFTING
    Publication number: 20210189082
    Abstract: Some embodiments described herein relate to a substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives. Method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications are also disclosed.
    Type: Application
    Filed: March 5, 2021
    Publication date: June 24, 2021
    Inventors: Lorenzo Berti, Andrew A. Brown, Wayne N. George
  • NANOPARTICLE WITH SINGLE SITE FOR TEMPLATE POLYNUCLEOTIDE ATTACHMENT
    Publication number: 20210187469
    Abstract: Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from one or more scaffold DNA molecules and one or more scaffold polypeptides, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.
    Type: Application
    Filed: December 22, 2020
    Publication date: June 24, 2021
    Applicants: ILLUMINA, INC., ILLUMINA CAMBRIDGE LIMITED, ILLUMINA SINGAPORE PTE. LTD.
    Inventors: Wayne N. GEORGE, Jonathan Mark BOUTELL, Mathieu LESSARD-VIGER, Saurabh NIRANTAR, Pietro GATTI LAFRANCONI, Seth MCDONALD, Yin Nah TEO, Maria Rogert BACIGALUPO, Sergio PEISAJOVICH, Eric BRUSTAD, Michael HOWARD, Xiangyuan YANG, M. Shane Bowen, Alex NEMIROSKI, Jeffrey BRODIN, Ludovic VINCENT, Lorenzo BERTI, Andrew A. BROWN, Fei SHEN, Lena STORMS, Olivia BENICE
  • NANOPARTICLE WITH SINGLE SITE FOR TEMPLATE POLYNUCLEOTIDE ATTACHMENT
    Publication number: 20210187470
    Abstract: Provided is a nanoparticle including a scaffold, a single template site for bonding a template polynucleotide to the scaffold, and a plurality of accessory sites for bonding accessory oligonucleotides to the scaffold, wherein the scaffold is selected from an asymmetrical acrylamide polymer one or a dendrimer including lysyl constitutional repeating units, the single template site for bonding a template polynucleotide to the scaffold is selected from a covalent template bonding site and a noncovalent template bonding site and the plurality of accessory sites for bonding accessory oligonucleotides to the scaffold are selected from covalent accessory oligonucleotide bonding sites and noncovalent accessory oligonucleotide bonding sites. Also provided are methods of using the nanoparticle.
    Type: Application
    Filed: December 22, 2020
    Publication date: June 24, 2021
    Applicants: LLUMINA, INC., ILLUMINA CAMBRIDGE LIMITED, ILLUMINA SINGAPORE PTE. LTD.
    Inventors: Xiangyuan YANG, Wayne N. GEORGE, Pietro GATTI LAFRANCONI, Yin Nah TEO, Andrew A. BROWN, Maria Rogert BACIGALUPO, Eric BRUSTAD, Hassan BOHRA, Clifford WANG
  • FLOW CELLS
    Publication number: 20210139975
    Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.
    Type: Application
    Filed: December 31, 2020
    Publication date: May 13, 2021
    Inventors: Jeffrey S. Fisher, Brian D. Mather, Maria Candelaria Rogert Bacigalupo, Justin Fullerton, Ludovic Vincent, Lewis J. Kraft, Sahngki Hong, Boyan Boyanov, M. Shane Bowen, Sang Park, Wayne N. George, Andrew A. Brown, Dajun Yuan
  • CANTILEVER-FREE SCANNING PROBE MICROSCOPY
    Publication number: 20210123948
    Abstract: A system includes a probe assembly, a camera, and a control system. The probe assembly includes a rigid substrate, a compliant layer provided on the rigid substrate, one or more rigid probes can be arranged on the compliant layer to cover at least a portion of the compliant layer, and a reflective layer can cover the one or more rigid probes and uncovered portions of the compliant layer. The camera is configured to generate image data from the probe assembly. The control system is configured to receive image data from the camera and develop a topographical image of a surface of a sample, based at least in part on the received image data.
    Type: Application
    Filed: October 27, 2020
    Publication date: April 29, 2021
    Inventors: Keith Andrew BROWN, Wenhan CAO, Nourin ALSHARIF
  • Cantilever-free scanning probe microscopy
    Patent number: 10989736
    Abstract: A system includes a probe assembly, a camera, and a control system. The probe assembly includes a rigid substrate, a compliant layer provided on the rigid substrate, one or more rigid probes can be arranged on the compliant layer to cover at least a portion of the compliant layer, and a reflective layer can cover the one or more rigid probes and uncovered portions of the compliant layer. The camera is configured to generate image data from the probe assembly. The control system is configured to receive image data from the camera and develop a topographical image of a surface of a sample, based at least in part on the received image data.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: April 27, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Keith Andrew Brown, Wenhan Cao, Nourin Alsharif
  • Electronic device and method of managing data transfer
    Patent number: 10977273
    Abstract: A method of managing data transfer from a server to an electronic device via a wireless communication, includes initiating a synchronization of a database of the electronic device with the server and determining, by the electronic device, a length of time since the synchronization of the database of the electronic device with the server. The method also includes, in response to determining that the length of time meets the threshold period, determining a quantity of data records for sending from the server to the electronic device to perform a further synchronization and requesting one of complete data records or incomplete data records based on the quantity of data records for transfer to the electronic device.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: April 13, 2021
    Assignee: BlackBerry Limited
    Inventors: Andrew John Ewanchuk, Ronesh Puri, David Andrew Brown
  • Catalyst-free surface functionalization and polymer grafting
    Patent number: 10975210
    Abstract: The present application relates to a method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications. A substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene can be used for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: April 13, 2021
    Assignee: Illumina, Inc.
    Inventors: Lorenzo Berti, Andrew A. Brown, Wayne N. George
  • Polymer coatings
    Patent number: 10954561
    Abstract: The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: March 23, 2021
    Assignee: Illumina, Inc.
    Inventors: Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
  • Restrict communications to device based on internet access
    Patent number: 10944719
    Abstract: Examples disclosed herein relate to securing a controller of a device. The controller is to determine whether a network interface of the device is connected to the Internet. Communications are restricted on the network interface in response to the port having access to the Internet. In some examples, the restriction can be related to a vulnerability.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 9, 2021
    Assignee: Hewlett Packard Enterprise Development LP
    Inventors: Peter Hansen, Andrew Brown
  • Fluid outputting hand device
    Patent number: 10918083
    Abstract: A fluid outputting hand device 11 comprises: a front portion 13, for going in front of a user's hand; and a fluid output point, for outputting fluid; wherein the hand device 11 is configured for: pressure-activated outputting, so that fluid can be outputted onto a target, by applying pressure to the target; and selectable distance outputting of fluid, so that fluid can be outputted at a target, from a distance. Preferably the fluid outputting hand device comprises a thumb selecting arrangement, so that distance outputting can be selected by a thumb of a user.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: February 16, 2021
    Inventors: Jethro Bennett, Andrew Brown
  • Plug
    Patent number: D924154
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: July 6, 2021
    Assignee: POWER PRODUCTS, LLC
    Inventors: Thom Dykas, Danny Ascencio-Hall, Andrew Brown