Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: A method is provided for operating a gas turbine engine. The method includes: determining data indicative of an operation of a cooling system of the gas turbine engine during a shutdown of the gas turbine engine, following the shutdown of the gas turbine engine, or both; and modifying a startup schedule of the gas turbine engine in response to the determined data indicative of the operation of the cooling system of the gas turbine engine.

Abstract: To protect the integrity of data stored in a protected area of memory, data in the protected area of memory is retrieved in data blocks and an authentication code is associated with a memory granule contiguously comprising a first data block and a second data block. Calculation of the authentication code comprises a cryptographic calculation based on a first hash value determined from the first data block and a second hash value determined from the second data block. A hash value cache is provided to store hash values determined from data blocks retrieved from the protected area of the memory. When the first data block and its associated authentication code are retrieved from memory, a lookup for the second hash value in the hash value cache is performed, and a verification authentication code is calculated for the memory granule to which that data block belongs. The integrity of the first data block is contingent on the verification authentication code matching the retrieved authentication code.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: A processing system may apply a community detection process to a feature graph database to identify a plurality of communities of features, the feature graph database comprising: a plurality of objects, each associated with one of a feature or a concept, and a plurality of relationships between the plurality of objects. Next, the processing system may label a first plurality of features of the feature graph database with at least a first community label, where the first plurality of features comprises features of at least a first community of the plurality of communities. The processing system may then obtain a search associated with at least one feature of the feature graph database, where the at least one feature is a part of the at least the first plurality of features of the at least the first community, and provide the first plurality of features in response to the search.

Abstract: A processing system may obtain a request to add at least a first feature to a feature graph database, where the request comprises a first feature ontology of the first feature, and where the first feature ontology comprises: a label of the first feature and a relationship of the first feature to a concept or to another feature. The processing system may then identify whether the first feature is a duplicate of a second feature in the feature graph database based at least upon the first feature ontology and a second feature ontology of the second feature and generate an indication of whether the first feature is a duplicate in response to the identifying.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: A modular enclosure system and method for repair of one or more leaks in a pipe. The modular enclosure system including a first enclosure portion configured to be disposed in a mated configuration to create a first enclosure around the pipe. Each enclosure includes a first void section configured to enclose a pipe section of the pipe. Sealant grooves extend along enclosure faces of each enclosure to seal the modular enclosure system. Each enclosure includes a sealant control system having a plurality of blocking members and configured to selectively block sealant injected in the sealant grooves. Each of the blocking members are positionable between a blocking position configured to block sealant flow in at least one of the sealant grooves and a non-blocking position.

Abstract: A processing system including at least one processor may obtain a personal identifier comprising a plurality of characters and generate a first embedding of the personal identifier in accordance with an embedding model. The processing system may then identify one or more embeddings of other personal identifiers that are within a threshold distance of the first embedding and generate an alert in response to the identifying of the one or more embeddings of the other personal identifiers that are within the threshold distance.

Abstract: Disclosed herein is a method and apparatus for automatic extrudate loading and alignment. An extrudate handling system includes a head end assembly and an imaging device (which may be part of the head end assembly). The imaging device is configured to image an end face of an extrudate, and generate, during translation of the extrudate, an imaging output signal indicative of a rotational position of the end face of the extrudate. The head end assembly includes a rotational effector to rotate the extrudate during translation thereof and a fixed effector rotationally fixed relative to a track. The extrudate handling system is able to determine the rotational position of the web angle of the extrudate and precisely adjust the rotational position while linearly translating the extrudate along the track. The extrudate handling system provides greater accuracy, reduced costs, and improved results.

Abstract: A method for detecting threat pathways using sequence graphs includes constructing a sequence graph from a set of data containing information about activities in a telecommunications service provider network, where the sequence graph represents a subset of the activities that occurs as a sequence, providing an embedding of the sequence graph as input to a machine learning model, wherein the machine learning model has been trained to detect when an input embedding of a sequence graph is likely to indicate a threat activity, determining, based on an output of the machine learning model, whether the subset of the activities is indicative of the threat activity, and initiating a remedial action to mitigate the threat activity.

Abstract: Mitigation of temporal generalization losses a target machine learning model is disclosed. Mitigation can be based on identifying, removing, modifying, transforming, etc., features, explanatory variables, models, etc., that can have an unstable relationship with a target outcome over time. Implementation of a more stable representation can be initiated. Temporal stability measures (TSMs) for one or more model feature(s) can be determined based on one or more variable performance metrics (VPMs). A group of one or more VPMs can be selected based on features of a model in either a development or production environment. Model feature modification can be recommended based on a TSM, which can prune a feature, transform a feature, add a feature, etc. Temporal stability information can be presented, e.g., via a dashboard-type user interface. Models can be updated based on mutations of a model comprising a feature modification(s), including competitive champion/challenger model updating.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: The present technique provides an apparatus and method for caching data. The apparatus has a cache storage to cache data associated with memory addresses, a first interface to receive access requests, where each access request is a request to access data at a memory address indicated by that access request, and a second interface to couple to a memory controller used to control access to memory. Further, cache control circuitry is used to control allocation of data into the cache storage in accordance with a power consumption based allocation policy that seeks to select which data is cached in the cache storage with the aim of conserving power associated with accesses to the memory via the second interface.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: A piezoelectric strain sensor unit for a rolling bearing includes a piezoelectric strain sensor, and a sensor holder provided with a main body having a front face intended to be into contact with a component of the rolling bearing and a rear face, and with at least two flexible arms mounted on the main body and supporting opposite ends of the piezoelectric strain sensor, the piezoelectric strain sensor being axially located on the side of the rear face of the main body while remaining spaced apart from the rear face. The sensor holder is provided with a central pin which protrudes axially with regard to the front face of the main body and which is axially moveable with regard the main body, the central pin axially abutting onto the piezoelectric strain sensor.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: A piezoelectric strain sensor unit for a rolling bearing includes a piezoelectric strain sensor, and a sensor holder provided with a main body having a front face intended to be into contact with a component of the rolling bearing and a rear face, and with at least two flexible arms mounted on the main body and supporting opposite ends of the piezoelectric strain sensor, the piezoelectric strain sensor being axially located on the side of the rear face of the main body while remaining spaced apart from the rear face. The sensor holder is provided with a central pin which protrudes axially with regard to the front face of the main body and which is axially moveable with regard the main body, the central pin axially abutting onto the piezoelectric strain sensor.