Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: A system to augment the collected odometer data points with more precise location data which provides an indication of a location of a vehicle associated with the odometer at a given time, such as Global Positioning System (GPS) GPS data points. Additionally, the GPS data points may be collected at a higher sampling rate than the odometer data points, thus providing a more precise indication of a distance traveled by a vehicle at any given time.

Abstract: The present disclosure generally provides compounds that antagonize certain T2R taste receptors, including related uses, methods, and compositions for the reduction of bitter taste and/or the enhancement of sweet taste. In certain aspects, the disclosure provides flavored articles or flavored compositions comprising such compounds, as well as uses of such compounds to reduce the bitter taste and/or enhance the sweet taste of such flavored articles or flavored compositions.

Abstract: A projector sequentially generates light pulses to form a sparse grid array. The light pulses reflect off objects in an environment and are reflected towards a sensor array. The sensor array sequentially senses the reflected light pulses across pixels of the sensor array. A depth sensing system calculates depth information of objects in the environment based on the sequential nature of the pulse generation and the pulse sensing. The depth sensing system calculates depth information based on both the positional and temporal information of generated light pulses, and the positional and temporal information of sensed light pulses. The depth sensing system may generate a representation of the environment based on the depth information.

Abstract: A method of forming a uniaxially oriented crystalline polymer article includes heating a segment of a crystallizable polymer article to a first temperature, applying a stress to the crystallizable polymer article in an amount effective to induce a positive strain within the segment of the crystallizable polymer article, and heating the segment of the crystallizable polymer article to a second temperature greater than the first temperature while continuing to apply the stress.

Abstract: A variable current trans-impedance amplifier (TIA) for an ultrasound device is described. The TIA may be coupled to an ultrasonic transducer to amplify an output signal of the ultrasonic transducer representing an ultrasound signal received by the ultrasonic transducer. During acquisition of the ultrasound signal by the ultrasonic transducer, one or more current sources in the TIA may be varied.

Abstract: In one example, an apparatus comprises: a first photodiode to generate a first charge; a second photodiode to generate a second charge; a quantizer; a first memory bank and a second memory bank; and a controller configured to: control the quantizer to perform a first quantization operation and a second quantization operation of the first charge to generate, respectively, a first digital output and a second digital output, the first and second quantization operations being associated with different intensity ranges; store one of the first digital output or the second digital output in the first memory bank; control the quantizer to perform a third quantization operation of the second charge to generate a third digital output, the third quantization operation being associated with a different intensity range from at least one of the first or second quantization operations; and store the third digital output in the second memory bank.

Abstract: Embodiments described herein relate to flat optical devices with a coating layer including monolayers selected from the group consisting of molybdenum disulfide (MoS2), tungsten disulfide (WS2), tungsten diselenide (WSe2), molybdenum diselenide (MoSe2), molybdenum ditelluride (MoTe2), titanium disulfide (TlS2), zirconium disulfide (ZrS2), zirconium diselenide (ZrSe2), hafnium disulfide (HfS2), platinum disulfide (PtS2), tin disulfide (SnS2), or combinations thereof. The coating layer is disposed over a plurality of optical device structures of the optical device. The monolayers may alternate between the materials to form the coating layer or may be a uniform coating layer of a single material. The coating layer is disposed over each optical device structure of the plurality of optical device structures.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing neural architecture search for machine learning models. In one aspect, a method comprises receiving training data for a machine learning, generating a plurality of candidate neural networks for performing the machine learning task, wherein each candidate neural network comprises a plurality of instances of a layer block composed of a plurality of layers, for each candidate neural network, selecting a respective type for each of the plurality of layers from a set of layer types that comprises, training the candidate neural network and evaluating performance scores for the trained candidate neural networks as applied to the machine learning task, and determining a final neural network for performing the machine learning task based at least on the performance scores for the candidate neural networks.

Abstract: A facility for optimizing machine learning models is described. The facility obtains a description of a machine learning model and a hardware target for the machine learning model. The facility obtains optimization result data from a repository of optimization result data. The facility optimizes the machine learning model for the hardware target based on the optimization result data.

Abstract: An electronic device includes a substrate including a core layer; a cavity formed in the core layer, wherein the cavity includes sidewalls plated with a conductive material; a prefabricated passive electronic component disposed in the cavity; and a cavity sidewall connection providing electrical continuity from the plated cavity sidewalls to a first surface of the substrate and to a second surface of the substrate.

Abstract: An image-sensing system includes multiple sensing modules. Each of the multiple sensing modules includes multiple optical sensors arranged in an array. Each of the multiple sensors is configured to be switched on and off to generate analog sensing data. The image-sensing system also includes an analog-to-digital converter (ADC) shared by the multiple optical sensors configured to convert analog sensing data generated by the multiple optical sensors into digital data. The image-sensing system also includes a processor configured to control the multiple sensing modules.

Abstract: A method of manufacturing a vertical FET device includes providing a semiconductor substrate structure including a marker layer; forming a hardmask layer coupled to the semiconductor substrate structure, wherein the hardmask layer comprises a set of openings operable to expose an upper surface portion of the semiconductor substrate structure; etching the upper surface portion of the semiconductor substrate structure to form a plurality of fins; etching at least a portion of the marker layer; detecting the etching of the at least a portion of the marker layer; epitaxially growing a semiconductor layer in recess regions disposed between adjacent fins of the plurality of fins; forming a source metal layer on each of the plurality of fins; and forming a gate metal layer coupled to the semiconductor layer.

Abstract: Computer-implemented methods and structures deploy a heating ventilation and air conditioning (HVAC) energy optimization program. A standard operating control platform (OCP) is deployed in an energy optimization control engine (EOCE) computing system communicatively coupled to a plurality of HVAC components via a building automation system (BAS). An energy optimization portal (EOP), which receives from the EOCE computing system a first data set identifying the plurality of HVAC components, a second data set including operational control parameters for each of the plurality of HVAC components, and a third data set including measured operations data associated with each of the plurality of HVAC components. The EOP generates an energy optimized operating control platform based on the first, second, and third data sets, which is automatically communicated from the EOP to the EOCE computing system.

Abstract: Systems and methods directed to returning personalized image-based search results are described. In examples, a query including an image may be received, and a personalized item embedding may be generated based on the image and user profile information associated with a user. Further, a plurality of candidate images may be obtained based on the personalized item embedding. The candidate images may then be ranked according to a predicted level of user engagement for a user, and then diversified to ensure visual diversity among the ranked images. A portion of the diversified images may then be returned in response to an image-based search.

Abstract: Disclosed herein are methods of identifying a compound for treating or preventing an infection with an infectious microbe, such as a coronavirus, in a subject in need thereof. Also disclosed herein are compounds and compositions identified by said methods, and methods of use thereof.

Abstract: A heterogeneous procatalyst includes a preformed heterogeneous procatalyst and a metal-ligand complex. The preformed heterogeneous procatalyst includes a titanium species and a magnesium chloride (MgCl2) support. The metal-ligand complex has a structural formula (L)aM(Y)m(XR2)b, where M is a metal cation; each L is a neutral ligand or (?O); each Y is a halide or (C1-C20)alkyl; each XR2 is an anionic ligand in which X is a heteroatom or a heteroatom-containing functional group and R2 is (C1-C20)hydrocarbyl or (C1-C20) heterohydrocarbyl; n is 0, 1, or 2; m is 0-4; and b is 1-6. The metal-ligand complex is overall charge neutral. The heterogeneous procatalyst exhibits improved average molecular weight capability. A catalyst system includes the heterogeneous procatalyst and a cocatalyst. Processes for producing the heterogeneous procatalyst and processes for producing ethylene-based polymers utilizing the heterogeneous procatalyst are also disclosed.

Abstract: A downhole tool has a directional pad that contacts a wellbore wall at a pad contact location and a drill bit with at least one active cutting element that contacts the wellbore wall at a cutting element contact location. A contact distance between the pad contact location and the cutting element contact location being 3 in. (7.6 cm) or less.

Abstract: Systems and methods are described for generating a dynamic label for a real-time communication session. An ongoing communication session is monitored to identify a content characteristic of the communication session. A size of a sliding window is determined based on the content characteristic, where the size of the sliding window defines a segment of the communication session to include in the most recent subset of communications. The most recent subset of communications is analyzed to identify relevant words based on one or more relevancy criteria. A dynamic label associated with the communication session is generated, where the dynamic label includes at least a selected one of the relevant words.

Abstract: A system for predicting and summarizing medical events from electronic health records includes a computer memory storing aggregated electronic health records from a multitude of patients of diverse age, health conditions, and demographics including medications, laboratory values, diagnoses, vital signs, and medical notes. The aggregated electronic health records are converted into a single standardized data structure format and ordered arrangement per patient, e.g., into a chronological order. A computer (or computer system) executes one or more deep learning models trained on the aggregated health records to predict one or more future clinical events and summarize pertinent past medical events related to the predicted events on an input electronic health record of a patient having the standardized data structure format and ordered into a chronological order.