Abstract: Methods and apparatus for storing data about biological entities are provided. A computing device can receive a plurality of data items about a biological entity from a plurality of sources. The computing device can verify each data item of the plurality of data items using the computing device by at least: determining a source of the data item from among the plurality of sources, determining a provenance for the data item associated with the source of the data item, and verifying that the data item is associated with the biological entity based at least on the provenance for the data item associated with the source of the data item. After verifying that a particular data item is associated with the biological entity, the computing device can store the particular data item in a data log associated with the biological entity.

Abstract: Disclosed herein are systems, devices, and methods for orthopedic surgical guides adapted to the anatomy of a patient and configured to align a bone shaping device or acetabular implant in a predetermined orientation. Certain embodiments constitute alignment guides for conducting hip surgery on a specific patient. Such guides include a first or inner surface structured to fit in a predetermined configuration relative to a portion of a patient's anatomy based on topography data of the patient's anatomy, a receiving surface configured to receive or constrain a bone shaping device or acetabular implant, and a reference surface with an alignment site that directs placement of the orthopedic device in a predetermined orientation relative to the patient's anatomy when the first surface is in the predetermined configuration.

Abstract: Methods and apparatus for providing rule-based access to data stored on wearable devices are provided. A wearable computing device can store data that includes data about a wearer of the wearable computing device. The wearable computing device can receive a request for a portion of the stored data. The wearable computing device can determine a designated role associated with the request for the portion of the stored data. The wearable computing device can determine one or more rules regarding access to the portion of the stored data based on the designated role. The wearable computing device can determine a response to the request for the portion of the stored data by at least: determining whether the request is validated by at least applying the one or more rules to the request, and after determining that the request is validated, providing the requested portion of the stored data.

Abstract: A method for tagging and organizing data is provided. In one example, physiological data detected from a wearer of a wearable device is received and associated with a tag based, at least in art, on an input by the wearer. The input may be a state of the wearer, such as physical or mental state, or a rule. The collected physiological data may be organized based on the tag and, in some examples, on other types of received data, such as a wearer's personal data. In other example methods, data may be stored in a database based on one or more tags associated with the data.

Abstract: A sample analysis and medical data acquisition system for patient management includes a first user interface (UI) display module for displaying a medical chart page that includes selectable items associated with patient management. The first UI display module displays a set of medical delivery systems associated with a selectable medical delivery selection item, from which a medical delivery system is chosen. The system includes a second UI display module, in communication with the first UI display module, for displaying parameter fields for entry of operation data associated with the chosen medical delivery system. Medical data is captured from a patient by an analyzer configured to perform analysis of samples from the patient. The medical data is analyzed in accordance with entered operation data. The system includes an analysis display module, in communication with at least the first UI display module, for displaying sample analysis results.

Abstract: A sample analysis and medical data acquisition system for patient management includes a first user interface (UI) display module for displaying a medical chart page that includes selectable items associated with patient management. The first UI display module displays a set of medical delivery systems associated with a selectable medical delivery selection item, from which a medical delivery system is chosen. The system includes a second UI display module, in communication with the first UI display module, for displaying parameter fields for entry of operation data associated with the chosen medical delivery system. Medical data is captured from a patient by an analyzer configured to perform analysis of samples from the patient. The medical data is analyzed in accordance with entered operation data. The system includes an analysis display module, in communication with at least the first UI display module, for displaying sample analysis results.

Abstract: A femoral cutting guide includes guide slots for guiding the movement of cutting tools relative to a distal portion of a femur, a surface feature adapted to at least partially conform to a resected surface of the distal portion of the femur, and either a posterior-facing surface adapted to conform to an anterior, unaltered surface of the distal portion of the femur or an anterior-facing surface adapted to conform to a posterior, unaltered surface of the distal portion of the femur.

Abstract: The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.

Abstract: A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory.

Abstract: Systems, devices, and methods are provided for implanting and aligning orthopedic implants. A patient-matched alignment guide is used to orient tools and implants intraoperatively. In certain embodiments, the systems, devices, and methods include an orthopedic guide comprising a body having a bottom surface, wherein at least a portion of the bottom surface has predetermined surface characteristics that correspond to respective characteristics of a patient's bony anatomy, and a pliable flange that extends from the bottom surface and is shaped to be received within an undercut of an implant to releasably couple the orthopedic guide to the implant.

Abstract: A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory.

Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions.

Abstract: Instruments for use in anterior approach total hip arthroplasty. Instruments according to certain embodiments of the invention connect to a shaping member such as a broach, reamer or osteotome that is used to prepare the intramedullary canal of a desired femur or other bone for total hip arthroplasty. Such an instrument according to such embodiments can be configurable to allow operation on either the left or right leg, and in doing so to provide lateral offset and anterior offset of the instrument handle relative to the shaping member so that the patient's gut, musculature or other bodily portions may be avoided while still providing desired leverage and control over the shaping member to prepare the intramedullary canal.

Abstract: Systems and methods provide patient-specific cutting blocks that allow for bone resurfacing procedures, such as milling or burring, with simplified devices. A computer assisted surgical cutting block is produced having a surface region that matches with the surface region of a patient's bone to be altered. A cutting tool may be provided having a contoured bone mating surface and a contoured and patient-specific shaped cutting guide surface, which is located in a plane above the bone mating surface. One or more channels are provided in the cutting block, and as the surgeon moves the cutting tool (a milling or burring, for example) in the channels the tool cuts the bone both laterally along the surface of the bone and vertically into the bone according to the cutting guide surface and other preselected surface features of the cutting block.

Abstract: A system and method for facilitating automatic objective-based feature improvement, the method including receiving a request to identify an optimal alternative for each of one or more features of a computer-implemented entity, determining an alternative feature range for each of the one or more features, the alternative feature range defining a range of possible alternative features available with respect to the feature, selecting one or more alternative features for each feature from the alternative feature range of the feature, generating a plurality of alternative sets, each including an alternative feature for at least one of the one or more features, selecting a plurality of user groups from a pool of users and assigning each user group of the plurality of users groups to one of the plurality of alternative sets based on user characteristics of the users and historical information regarding the interaction of the user with the computer-implemented entity.

Abstract: Patient-matched surgical instruments, and methods for making patient-matched surgical instruments, may include patient-matched surgical instruments having an anatomy facing side with several discrete, physically separate anatomy contacting portions configured to match the anatomy of a particular patient. The anatomy contacting portions may be one or more of non-uniform in distribution, non-uniform in shape or non-uniform in surface area.

Abstract: A patient-matched cutting block including a surface or point contact features adapted to at least partially conform to or reference a patient specific anatomy. The cutting block having guide slots configured for guiding the movement of cutting tools relative to the patient specific anatomy or features configured to mate to and guide standard cutting guides relative to patient specific anatomy in order to form plateau and eminence resections of the patient specific anatomy.

Abstract: Systems, devices, and methods are provided for aligning acetabular implants. A patient-matched acetabular alignment tool is used to orient tools and implants intraoperatively. The patient-matched acetabular alignment tool includes a mounting member and leg members which are configured based on the particular patient's anatomic landmark sites (e.g., acetabular bony landmarks). The leg members are attached to the mounting member and configured to connect with a respective anatomic landmark site to achieve a desired implant angle and axis. For example, the leg members may form a tripod support base through which an acetabular shell may be inserted into the patient's acetabulum at desired angles of version and inclination. In some embodiments, the leg members may be retractable and expandable with respect to the mounting member, thereby providing a tool with reduced profile for inserting the device in the patient's soft tissue.

Abstract: The present disclosure relates to a method and system for identifying potential condition onset based upon a combination of Heart Rate Variability (HRV), Respiratory Rate Variability (RRV) and/or confounding factors. The present method and system may involve data collection, a temporal abstraction (TA)-based approach, and data analysis to identify potential condition onset in patients. The present method and system may generate and amend a classification scheme to be operable to determine that a patient is facing potential condition onset. The present method and system may further be operable to provide clinical decision making support. Embodiments of the present method and system may be operable to identify trends, such as temporal patterns, and to undertake a variety of analyses of collected and/or TA data to provide indicators, and determinations of potential condition onset in patients.

Abstract: Instrumentation for a modular prosthesis having a stem and a neck comprises a handle and an adaptor. The handle extends along an axis. The handle has a distal end and a proximal end. The proximal end has a blunt surface configured to be struck. The adaptor has a male end configured to mate inside the bore of the stem. The adaptor further has a surface configured to mate with the distal end of the handle. The adaptor is configured to have a medial portion and a lateral portion. The medial portion has a relief such that the adaptor is configured to disengage the stem when the adaptor is rotated relative the stem.