Abstract: The present invention relates to optical measurement devices and systems, and methods of using these systems and devices, and more particularly but not exclusively it relates to a system and apparatus adapted to measure optical properties in-situ.

Abstract: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

Abstract: The present invention relates to optical measurement devices and systems, and methods of using these systems and devices, and more particularly but not exclusively it relates to a system and apparatus adapted to measure optical properties in-situ.

Abstract: A cell culture method using an in vitro microscale cell culture device having a first microscale chamber containing cells attached to an inner surface of the chamber and cell culture medium in contact with the cells. The cells are maintained in culture in the in vitro microscale cell culture device while flowing culture medium through the first chamber at a controlled rate to provide a liquid residence time value for the cells in the first chamber of the in vitro microscale cell culture device that is comparable to a liquid residence time value obtained with respect to comparable cells in vivo, such that metabolism by the cells in culture in the in vitro microscale cell culture device is comparable to metabolism by comparable cells in vivo.

Abstract: The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: The exemplary embodiments relate to misalignment correction devices and methods for mitigating misalignment of a piece of oilfield equipment in or proximate an RCD. A rounded shoulder appears on a first surface within or proximate the RCD, and a socket profile appears on a second surface within or proximate the RCD. The second surface is configured to abut the rounded shoulder. The rounded shoulder is configured to rotate within the socket profile. Further, a floating joint may be implemented into or proximate the RCD and combined with the foregoing rotation mitigation features.

Abstract: A monitoring device arranged to be fitted to a door, wherein the door includes an operating bar mounted on the door for angular movement about its axis and a handle which is connected to the operating bar by a pivotal connection; wherein the device comprises a body element and a cover element arranged to slide relative to the body element and the two elements having a closed configuration and an open configuration in which the cover element is extended relative to the body element thereby allowing the device to be fitted to a door; the body and cover elements being shaped so that when in the closed configuration a pocket is formed that substantially surrounds an operating bar and further wherein the cover element comprises a portion extending over a region of a handle of a door to which the device is fitted such that that handle is prevented from rotating relative to the door; and monitoring circuitry arranged to monitor the device.

Abstract: A transmission system (8) comprising at least one floating gear (14a, 16a, 18a) rotationally mounted upon a first shaft the system comprising a floating gear activation system for controlling torque transfer between the at least one floating gear (14a, 16a, 18a) and the first shaft (10), the gear activation system comprising a first device (28, 30) having a friction interface (28) for frictional engagement with a friction interface (30) disposed on a first side of the at least one floating gear (18a), and a second device (25, 26) having a locking interface (25) for an interpositional engagement with a locking interface (26) disposed on a second side, opposing the first side, of the at least one floating gear (18a), whereby the floating gear (18a) is rotationally coupleable to the first shaft (10) by the friction interface (28/30) and/or the locking interface (25/26).

Abstract: The invention relates to a method of querying technical domains that recognizes the concepts represented by strings of characters, rather than merely comparing strings. It can be used to compute conceptual similarity between terms, The method employs string distance metrics and a cyclic progression of lexical processing to recognize constituent term concepts that are then combined to form full-term concepts by means of a grammar. Terms can be extracted and identified as being conceptually similar (or dissimilar) to other terms even if they have never previously been encountered. A key advantage is the ability to extract terms from documents based on the combination of a limited number of sub-concepts, This avoids the need for the prior identification of all possible terms that current methods require. A second key advantage is the ability to introduce or remove concepts and synonyms individually without the need to alter terms which the concept or synonym constitutes.

Abstract: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

Abstract: The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract: The invention relates to a method of querying technical domains that recognises the concepts represented by strings of characters, rather than merely comparing strings. It can be used to compute conceptual similarity between terms. The method employs string distance metrics and a cyclic progression of lexical processing to recognise constituent term concepts that are then combined to form full-term concepts by means of a grammar. Terms can be extracted and identified as being conceptually similar (or dissimilar) to other terms even if they have never previously been encountered. A key advantage is the ability to extract terms from documents based on the combination of a limited number of sub-concepts. This avoids the need for the prior identification of all possible terms that current methods require. A second key advantage is the ability to introduce or remove concepts and synonyms individually without the need to alter terms which the concept or synonym constitutes.

Abstract: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

Abstract: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

Abstract: Apparatus and corresponding methods for pipe pushing and/or handling in which the auxiliary supply lines of an excavator are used to power a hydraulic clamp for gripping the pipe, and the articulated arm of the excavator is used for manoeuvring the pipe. Such apparatus includes: a pair of jaws having cooperating pipe-gripping surfaces; a hydraulic ram coupled to the jaws and capable of actuating the jaws to grip a pipe between the pipe-gripping surfaces; a connection portion arranged to connect the apparatus to an articulated arm of the excavator; and a hydraulic fluid distributor arranged to distribute pressurised hydraulic fluid from auxiliary hydraulic supply lines of the excavator to the hydraulic ram. Thus, when the apparatus is connected to an excavator the jaws can be actuated by control of the supply of pressurised hydraulic fluid from the auxiliary supply lines of the excavator, and the apparatus (and pipe) can be moved by control of the position and orientation of the excavator arm.

Abstract: Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents —(CRnaRnb)n—; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6-alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.

Abstract: I, Albert Harrison has, invented a pour spout with rotating nozzle that is affixed to a gable top carton, as set forth in the enclosed substitute specification.

Abstract: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

Abstract: With interactive voice response services, it can be frustrating for a user to become stuck in a dialogue where the same question is asked repetitively. Here the wording of questions used by the system are varied throughout the dialogue depending upon how many times a user has visited a particular dialogue state during the call history. Furthermore the wording of the question is also varied in dependence upon the way in which the question was asked the last time the user was in a particular dialogue state.