Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.

Abstract: A bone repair composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into various implant shapes conducive to introduction into a patient through minimally invasive surgery. The bone fiber compositions may be in the form of a pellet or cylinder. A method includes producing the bone fiber graft efficiently with control of key parameters of cohesiveness, rehydration and swelling of the bone fiber graft. Another method includes introducing the bone fiber graft into the cannula efficiently. A method is also provided to allow introduction of a bone graft into a patient by placing the implant in a tube and expelling it through the action of a plunger.

Abstract: A composition for healing or improving skin includes a fabric or material impregnated with an oxygen generating material. The fabric may include a first side in contact with the skin for providing oxygen to the skin and a second side between the oxygen generating material and the air surrounding the skin to form a barrier for retaining heat and inhibiting evaporation.

Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymethylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

Abstract: A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

Abstract: A composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into shapes that are used to augment rotator cuff and acl repair. Sheets of bone fibers may be used as an interface between bone and tissue, tendons, and/or ligaments. The physical presence of the fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation. A delivery system and methods of use are also provided.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the tendon to bone repair.

Abstract: The disclosed embodiments provide a system for processing queries of a graph database. During operation, the system stores intermediate results of the query in a structure comprising rows in a set of tables and links between pairs of rows in different tables in the set of tables. Next, the system tracks, in the structure, representations of data, relationships, and path consistency in the query. The system then applies one or more operations to existing rows in the structure to generate a final result of the query. Finally, the system provides the final result in a response to the query.

Abstract: A composition for healing or improving skin includes a fabric or material impregnated with an oxygen generating material. The fabric may include a first side in contact with the skin for providing oxygen to the skin and a second side between the oxygen generating material and the air surrounding the skin to form a barrier for retaining heat and inhibiting evaporation.

Abstract: The disclosed technologies are capable of selectively using data structure operations for path query evaluation. One technique involves reading a query that traverses at least two nodes and at least one edge of a graph in a graph database; compiling the query into a set of variables and a set of constraints, where the set of variables and the set of constraints correspond to the two nodes and the one edge of the graph; creating an in-memory data structure that comprises a table; using the set of variables and the set of constraints to determine an operation that is performable using the in-memory data structure; checking for an existence of a condition relating to the in-memory data structure or the operation; skipping the operation if the condition exists or executing the operation if the condition does not exist; and storing a set of intermediate query results in the table.

Abstract: A composition and methods of making or use thereof include a plurality of fibers forming a shape for augmenting fixation of a bone screw, or the plurality of fibers form a shape having a peg portion and a sheet portion to augment tendon to bone repair. The physical presence of the plurality of fibers provides initial fixation, while the use of an osteoinductive material provides long term enhancement of bone formation around the site of the bone screw or the tendon to bone repair.

Abstract: A composition for the treatment of wounds includes demineralized bone fibers (DBF) derived from allogeneic or xenogenic cortical bone and/or polymeric fibers made from resorbable and/or non-resorbable polymer, and the composition may also include an oxygen-generating material and/or an oxygen carrier.

Abstract: The disclosed embodiments provide a system for processing queries of a graph database storing a graph, wherein the graph comprises a set of edges defined by a first linkage, a second linkage, and a third linkage. During operation, the system maintains the base version of an index of the graph database. Upon branching a version of the graph database from a first offset representing a virtual time in the base version of the graph database, the system creates a branched version of the index from a second offset corresponding to the virtual time in the base version of the index. The system then processes queries of the graph database based on the offsets and references from the branched version of the index to the base version of the index.

Abstract: The disclosed technologies are capable of decentralized query evaluation for a distributed graph database. In one technique, a query is divided into first and second sets of operations. The query comprises variables and constraints that correspond to at least two nodes and at least one edge of a graph in a graph database. The first set of operations for processing the query is assigned to multiple shards. A limit is communicated to the shards. The second set of operations for processing the query is executed. A list of completed operations is received from each shard. The lists of operations received from the shards are merged into a merged set of operations, which is used to determine whether query processing is finished. If query processing is not finished, then an updated limit is communicated to the shards; otherwise, query results are provided in response to the query.

Abstract: The disclosed technologies are capable of selectively using data structure operations for path query evaluation. One technique involves reading a query that traverses at least two nodes and at least one edge of a graph in a graph database; compiling the query into a set of variables and a set of constraints, where the set of variables and the set of constraints correspond to the two nodes and the one edge of the graph; creating an in-memory data structure that comprises a table; using the set of variables and the set of constraints to determine an operation that is performable using the in-memory data structure; checking for an existence of a condition relating to the in-memory data structure or the operation; skipping the operation if the condition exists or executing the operation if the condition does not exist; and storing a set of intermediate query results in the table.

Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.

Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.