Abstract: A system executes a query associated with an application against a graph database by providing, to a first shard of the graph database, the query and a first query header that specifies the first shard. The query includes a subject, a predicate and an object, and the graph database stores a graph that includes nodes, edges between the nodes, and predicates to represent and store data. In response to the query, the system receives results and associated result headers from the first shard and a second shard, where the result headers specify that the results are partial results that are particular fractions of a total result. Furthermore, a combination of the partial results provides the total result to the query that includes a subset of the graph. Note that the subset of the graph may include desired information expressed within an associated structure of the graph.

Abstract: A bone repair composition including a cancellous bone matrix with cortical and/or cancellous bone particles loaded therein; and a kit comprising the cancellous bone matrix and the cortical and/or cancellous bone particles.

Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.

Abstract: A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry.

Abstract: In order to request desired information from a graph database, a system executes a query against the graph database. The graph database may store a graph that includes nodes, edges between the nodes, and predicates to represent and store data with index-free adjacency. Moreover, the query may identify a first edge associated with a predicate that specifies one or more of the nodes in the graph. In response to the query, the system receives a result that includes a subset of the graph. In particular, the subset of the graph may include the desired information expressed within an associated structure of the graph.

Abstract: A system executes a query associated with an application against a graph database by providing, to a first shard of the graph database, the query and a first query header that specifies the first shard. The query includes a subject, a predicate and an object, and the graph database stores a graph that includes nodes, edges between the nodes, and predicates to represent and store data. In response to the query, the system receives results and associated result headers from the first shard and a second shard, where the result headers specify that the results are partial results that are particular fractions of a total result. Furthermore, a combination of the partial results provides the total result to the query that includes a subset of the graph. Note that the subset of the graph may include desired information expressed within an associated structure of the graph.

Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

Abstract: A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry.

Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymetbylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.

Abstract: In order to facilitate efficient storage and extraction of data, a system may represent a compound relationship in a graph stored in a graph database. In particular, the system (or a user) may define the compound relationship based on two or more predicates associated with two or more edges between two or more nodes in the graph. Then, the system may generate, in the graph, a hub node that corresponds to the compound relationship and that has an identifier that is hidden from users of the graph so that the identifier of the hub node is not visible external to the graph database. Moreover, the identifier of the hub node may be specified in a query using the two or more predicates, thereby allowing data associated with the compound relationship to be readily identified, modified and/or extracted.

Abstract: In order to request desired information from a graph database, a system executes a query against the graph database. The graph database may store a graph that includes nodes, edges between the nodes, and predicates to represent and store data with index-free adjacency. Moreover, the query may identify a first edge associated with a predicate that specifies one or more of the nodes in the graph. In response to the query, the system receives a result that includes a subset of the graph. Then, the system may use the result of the query in a concatenated set of queries. In particular, the system may execute a second query against the subset of the graph. Furthermore, in response to the second query, the system may receive a second result that includes a second subset of the graph.

Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone.

Abstract: A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone. A method for treating a bone comprising: selecting at least one reinforcing element to be combined with an injectable matrix material to form a composite implant capable of supporting the bone; positioning the at least one reinforcing element in a cavity in the bone; flowing the injectable matrix material into the cavity wherein the injectable matrix material interfaces with the at least one reinforcing element; and transforming the injectable matrix material from a flowable state to a nonflowable state to establish a static structure that supports the adjacent bone.

Abstract: An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation.

Abstract: A bone repair composition including a cancellous bone matrix with cortical and/or cancellous bone particles loaded therein; and a kit comprising the cancellous bone matrix and the cortical and/or cancellous bone particles.

Abstract: Devices, such as dressing and implants, for treatment of chronic wounds comprising controlled delivery systems for butyric acid or salts, polymers, or derivatives thereof are provided. These devices are particularly useful when it is desirable to promote angiogenesis in a chronic wound. In the preferred embodiment, the implants are resorbable, provide a temporary scaffold for the in-growth of cells, tissues, and blood vessels to help regenerate the extracellular matrix, and deliver butyric acid to the chronic wound. The dressings and implants may also contain one or more antibiotics to treat or prevent infection in the wound, and/or inhibitors of proteases to modulate protease activity in the wound.

Abstract: An encapsulated three-dimensional (3-D) bone matrix composition for inducing bone growth includes a 3-D bone matrix, an oxygen carrier incorporated into the 3-D bone matrix, and an encapsulation material which encapsulates the 3-D bone matrix incorporated with the oxygen carrier. Methods are disclosed for preparing an encapsulated 3-D bone matrix that can be maintained in packaging.

Abstract: Compositions of P4HB and processes to injection mold these compositions have been developed. These compositions are prepared from P4HB polymers and blends having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g, moisture contents of less than 0.5% by weight, and more preferably less than 0.05% by weight, and using a polymer melt temperature during molding of at least 150° C. A preferred embodiment comprises a P4HB molding with an intrinsic viscosity of less than 3.2 dl/g that degrades rapidly in vivo.

Abstract: A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry.

Abstract: An improved composition for inducing bone growth is provided that is a mixture of DBM and a perfluorocarbon oxygen carrier. Injection/implantation of a composition of DBM and a perfluorocarbon results in enhancement of bone formation.