Abstract: A device and method for the reduction of vortex-induced vibration of a deepwater riser. A device for attachment to a structure, which is subject to movement relative to a fluid surrounding the structure, for reducing vortex-induced vibration effects on the structure, the device comprising: a flexible netting (4) interconnecting a plurality of relatively inflexible members comprising a plurality of elongate members (3) and a plurality of spacer members (6), wherein each elongate member has a first cuter boundary and each spacer member has a second outer boundary wherein the second boundary extends radially outward of the first outer boundary relative to the netting, over at least: a substantial portion of the boundary.

Abstract: Combination of one or more CB2 modulators and one or more PDE4 inhibitors, and method of treating conditions which are mediated by the activity of CB2 receptors or conditions which are mediated by PDE4.

Abstract: This invention relates to a method for identification of an agent that modulates activity of G-protein coupled receptor 41 (GPR 41), or G-protein coupled receptor 42 (GPR 42) which method comprises: (i) contacting a test agent with GPR 41, GPR42 or a variant of either thereof which is capable of coupling to a G-protein; and (ii) monitoring for GPR 41 or GPR 42 activity in the presence of a G-protein; thereby determining whether the test agent modulates GPR 41 or GPR 42 activity. An agent identifiable by this method is provided for use in the treatment of dyslipidaemia, coronary heart disease, atheroselerosis, thrombosis or obesity, angina, chronic renal failure, peripheral vascular disease, stroke, type II diabetes or metabolic syndrome (syndrome X).

Abstract: A chimeric G&agr; protein having yeast G&agr; (Gpa1p) amino acid sequences modified by a minimum of 3 amino acids positions within the C-terminal 10 amino acids by substitution by alternative amino acids, a transformed yeast cell comprising said chimeric G&agr; protein and a method of screening for a compound able to interact with a receptor comprising contacting a compound of interest with said yeast cell and observing the growth response of the cell or observing production of a reporter gene product.

Abstract: A trenching charge case having an upper casing part and lower casing part separately injection moulded from an electrically conductive plastics material, and formed with interengaging screw-threads to join the parts together with the cone of the case clamped between them, each of the parts of the casing being nestable with other like parts and the lower casing part comprising a depending wall to stand off the base of the cone from the surface to be excavated.