Abstract: An example of a flow cell includes a substrate having depressions separated by interstitial regions. First and second primers are immobilized within the depressions. First transposome complexes are immobilized within the depressions, and the first transposome complexes include a first amplification domain. Second transposome complexes are also immobilized within the depressions, and the second transposome complexes include a second amplification domain. Some of the first transposome complexes, or some of the second transposome complexes, or some of both of the first and second transposome complexes include a modification to reduce tagmentation efficiency.

Abstract: Variants of Squalene Hopene Cyclase (SHC) isolated from Gluconobacter morbifer are provided as is a method for using the variant G. morbifer SHC to biocatalytically convert homofarnesol to ambrox.

Abstract: In some embodiments, a method includes in response to an integration tag included in a webpage at a first user interface being executed at a mobile device, receiving a mobile device identifier and a request to retrieve a purchase identifier. The method includes sending a first signal causing a frame to be provided within the webpage at the first user interface. The method includes in response to a first user input, receiving a Hyper Text Transfer Protocol (HTTP) POST request and determining a uniform resource identifier (URI). The method includes retrieving purchase information and sending a HTTP response message including the URI of the second user interface and the purchase information to deeplink to the second user interface and to cause the second user interface to be rendered at the mobile device with the purchase information pre-populated in an input field of a text message.

Abstract: Disclosed systems and methods relate to a smart access control device in a security system for monitoring an area. According to embodiments, a method can include receiving, by the smart access control device, from one or more sensors in the area, sensor data about the area. The method can also include analyzing the received sensor data and generating an alert for a user about the area based on the analyzed sensor data. The method can further include transmitting, by the smart access control device, a first signal comprising the alert to a monitoring server of the security system. Moreover, the method can include enabling, by the smart access control device, a person requesting access to the area to enter identification information and granting access to the area to the person based on the received identification information that is evaluated by the user.

Abstract: Improvements in tooling for machining systems that utilize machining fluids comprising a supercritical fluid are disclosed. In some embodiments a tool may include a plurality of orifices configured to direct a supercritical machining fluid towards a cutting interface of the tool. In other embodiments, a tool holder may include one or more outlets configured to direct a supercritical machining fluid towards a cutting interface. Moreover, some embodiments, may relate to machining systems including one or more venting channels configured to provide pressure relief for a cavity located behind a tool holder. Embodiments related to machine tools including upstream fluid restrictions for controlling a flow of supercritical machining fluid through a tool are also disclosed.

Abstract: A chainsaw including a body including a bar stud extending therefrom; a guide bar including a bar stud slot that receives the bar stud, wherein the bar stud slot has a length, and wherein the guide bar is configured to receive a chain; a yoke having a groove defining a length extending in a direction angularly offset from the length of the bar stud slot of the guide bar, wherein the yoke is coupled to the guide bar; a ratchet gear including a one-way motion feature and a post extending into the groove of the yoke, wherein rotating the ratchet gear in a first direction moves the guide bar to tighten the chain, and wherein rotating the ratchet gear in a second direction moves the guide bar to loosen the chain; and a pawl selectively engaged with the one-way motion feature of the ratchet gear.

Abstract: This disclosure relates to methods of promoting immune responses against HIV and compositions related thereto. In certain embodiments, this disclosure relates to methods of vaccinating for HIV comprising administering to the subject a priming composition followed by a boosting composition. In certain embodiments, the priming composition comprises a recombinant virus such as recombinant MVA that encodes an Env protein of HIV or segment thereof. In certain embodiments, the boosting composition comprises a trimeric cyclically permuted gp120 chimeric protein reported herein or DNA encoding the same.

Abstract: An inlet assembly for an abatement apparatus includes: an effluent stream conduit configured to convey an effluent stream along a major direction of flow within the effluent stream conduit; an inlet nozzle fluidly coupled with the effluent stream conduit and configured to convey the effluent stream received from the effluent stream conduit to an abatement chamber of the abatement apparatus; and a baffle interposed between the effluent stream conduit and the inlet nozzle, the baffle being shaped and configured to redirect flow of the effluent stream from the effluent stream conduit into the inlet nozzle by inhibiting effluent stream flow along the major direction of flow into the inlet nozzle. A line-of-sight flow from the effluent stream conduit into the inlet nozzle is prevented by the baffle and the effluent stream instead follows a non-line-of-sight or diversionary path from the effluent stream conduit into the inlet nozzle, which improves DRE.

Abstract: Compounds of formula (I): and related aspects.

Abstract: Methods for delivery of a biologic agent to the dermis or superficial muscles by topical application of the agent are provided. The methods comprise, in one embodiment, treating or conditioning a skin area to disrupt the stratum corneum in the skin area to define a treated skin area and applying a formulation comprising a biologic agent to the treated skin area.

Abstract: Medical imaging systems, methods, and devices are disclosed herein. In some embodiments, an imaging system includes (i) a camera array configured to capture intraoperative image data of a surgical scene in substantially real-time and (ii) a processing device communicatively coupled to the camera array. The processing device can be configured to synthesize a three-dimensional (3D) image corresponding to a virtual perspective of the scene based on the intraoperative image data from the cameras. The imaging system is further configured to receive and/or store initial image data, such as medical scan data corresponding to a portion of a patient in the scene. The processing device can register the initial image data to the intraoperative image data, and overlay the registered initial image data over the corresponding portion of the 3D image of the scene to present a mediated-reality view.

Abstract: The present invention relates to a method for receiving data transmitted acoustically. The method includes the steps of receiving an acoustically transmitted signal; and decoding the signal using, at least, a first plurality of voters to extract the data. The first plurality of voters comprise differing values for a first acoustic characteristic to address interference. A system and software are also disclosed.

Abstract: According to aspects of the disclosure, a display system is provided comprising a support, a first display coupled to the support, wherein the first display is configured to display output information received from at least one computing device, and a second display rotatably coupled to the first display and rotatably coupled to the support, wherein the second display is configured to display output information received from the at least one computing device.

Abstract: An gas turbine engine for an aircraft includes, in axial flow sequence, a compressor module, a combustor module, and a turbine module, together with a first electrical machine rotationally connected to the turbine module. The combustor module has a combustor volume V (cm3). In use, at a full power condition, the gas turbine engine has a maximum corrected core flow Q (m3/sec), and a ratio T of: T = ( Maximum ? Corrected ? Core ? Flow = Q ) ( Combustor ? volume = V ) is in a range of between 450 and 2,500.

Abstract: Compounds of formula (I) and related aspects.

Abstract: A chainsaw including a body including a bar stud extending therefrom; a guide bar including a bar stud slot that receives the bar stud, wherein the bar stud slot has a length, and wherein the guide bar is configured to receive a chain; a yoke having a groove defining a length extending in a direction angularly offset from the length of the bar stud slot of the guide bar, wherein the yoke is coupled to the guide bar; a ratchet gear including a one-way motion feature and a post extending into the groove of the yoke, wherein rotating the ratchet gear in a first direction moves the guide bar to tighten the chain, and wherein rotating the ratchet gear in a second direction moves the guide bar to loosen the chain; and a pawl selectively engaged with the one-way motion feature of the ratchet gear.

Abstract: Embodiments are directed to systems and techniques to provide smart access control devices with legacy access control systems.

Abstract: The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another.