Patents by Inventor Andrew Karellas

Andrew Karellas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9770222
    Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: September 26, 2017
    Assignee: University of Massachusetts
    Inventors: Srinivasan Vedantham, Andrew Karellas
  • Publication number: 20170231587
    Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.
    Type: Application
    Filed: March 17, 2017
    Publication date: August 17, 2017
    Inventors: Srinivasan Vedantham, Andrew Karellas
  • Publication number: 20170219503
    Abstract: An x-ray phase contrast imaging apparatus and method of operating the same. The apparatus passes x-rays generated by an x-ray source through, in succession, a source grating, an object of interest, a phase grating, and an analyzer grating. The x-ray source, the source grating, the phase grating, and the analyzer grating move as a single entity relative to an object of interest. The phase grating and the analyzer grating remain in fixed relative location and fixed relative orientation with respect to one another. The detected x-rays are converted to a time sequence of electrical signals. In some cases, the apparatus is controlled, and the electrical signals are analyzed by, by a general purpose programmable computer provided with instructions recorded on a machine readable medium. One or more x-ray phase contrast images of the object of interest are generated, and can be recorded or displayed.
    Type: Application
    Filed: December 20, 2016
    Publication date: August 3, 2017
    Inventors: Srinivasan Vedantham, Andrew Karellas
  • Patent number: 9629597
    Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 25, 2017
    Assignee: University of Massachusetts
    Inventors: Srinivasan Vedantham, Andrew Karellas
  • Publication number: 20170095578
    Abstract: A method of diagnosing a condition of a living subject that uses gadoxeate disodium as a contrast agent for making images such as CT scans of the biliary tree and related anatomical structures. The method uses x-ray radiation generated with excitation voltages in the range of 70 KV to 140 KV. The x-ray radiation is preferably filtered to suppress or practically remove x-rays having energy lower than 50.2 KeV.
    Type: Application
    Filed: December 16, 2016
    Publication date: April 6, 2017
    Inventors: Adib Raphael KARAM, Andrew KARELLAS
  • Publication number: 20160000393
    Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.
    Type: Application
    Filed: March 6, 2014
    Publication date: January 7, 2016
    Inventors: Srinivasan VEDANTHAM, Andrew KARELLAS
  • Publication number: 20150055743
    Abstract: An x-ray phase contrast imaging apparatus and method of operating the same. The apparatus passes x-rays generated by an x-ray source through, in succession, a source grating, an object of interest, a phase grating, and an analyzer grating. The x-ray source, the source grating, the phase grating, and the analyzer grating move as a single entity relative to an object of interest. The phase grating and the analyzer grating remain in fixed relative location and fixed relative orientation with respect to one another. The detected x-rays are converted to a time sequence of electrical signals. In some cases, the apparatus is controlled, and the electrical signals are analyzed by, by a general purpose programmable computer provided with instructions recorded on a machine readable medium. One or more x-ray phase contrast images of the object of interest are generated, and can be recorded or displayed.
    Type: Application
    Filed: February 15, 2013
    Publication date: February 26, 2015
    Inventors: Srinivasan Vedantham, Andrew Karellas
  • Patent number: 8817947
    Abstract: Systems and methods for providing radiographic, stereoscopic and tomographic images of an object of interest. Examples of objects of interest are body parts of living beings, such as the human breast and the human chest. The apparatus includes a high-fluence rate x-ray source and a plurality of satellite x-ray sources operating at lower fluence rate than the high-fluence rate source. A controller controls the operation and locations of the sources, and the operation of a detector. The method provides procedures in which the operation of the high-fluence source and the satellite sources are individually controlled as to location and orientation relative to the object of interest. In some operations, one satellite source may be operating while another satellite source may be repositioning. By proper control, a reduced x-ray dose and reduced operating time can be attained, thereby improving image quality, patient care, and patient experience.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: August 26, 2014
    Assignee: University of Massachusetts
    Inventors: Srinivasan Vedantham, Andrew Karellas
  • Publication number: 20120195403
    Abstract: Systems and methods for providing radiographic, stereoscopic and tomographic images of an object of interest. Examples of objects of interest are body parts of living beings, such as the human breast and the human chest. The apparatus includes a high-fluence rate x-ray source and a plurality of satellite x-ray sources operating at lower fluence rate than the high-fluence rate source. A controller controls the operation and locations of the sources, and the operation of a detector. The method provides procedures in which the operation of the high-fluence source and the satellite sources are individually controlled as to location and orientation relative to the object of interest. In some operations, one satellite source may be operating while another satellite source may be repositioning. By proper control, a reduced x-ray dose and reduced operating time can be attained, thereby improving image quality, patient care, and patient experience.
    Type: Application
    Filed: January 27, 2012
    Publication date: August 2, 2012
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Srinivasan Vedantham, Andrew Karellas
  • Patent number: 7869569
    Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. Applications include the imaging of radionuclide distributions within the human body or the use of a dual energy source to provide a dual photon bone densitometry apparatus that uses stationary or scanning acquisition techniques. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. A dual energy x-ray source that delivers two different energy levels provides quantitative information regarding the object being imaged using dual photon absorptiometry techniques.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: January 11, 2011
    Assignee: University of Massachusetts
    Inventor: Andrew Karellas
  • Publication number: 20100208872
    Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a apatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 19, 2010
    Inventor: Andrew Karellas
  • Publication number: 20080304620
    Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. Applications include the imaging of radionuclide distributions within the human body or the use of a dual energy source to provide a dual photon bone densitometry apparatus that uses stationary or scanning acquisition techniques. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. A dual energy x-ray source that delivers two different energy levels provides quantitative information regarding the object being imaged using dual photon absorptiometry techniques.
    Type: Application
    Filed: February 11, 2008
    Publication date: December 11, 2008
    Applicant: University of Massachusetts
    Inventor: Andrew Karellas
  • Patent number: 7330531
    Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. Applications include the imaging of radionuclide distributions within the human body or the use of a dual energy source to provide a dual photon bone densitometry apparatus that uses stationary or scanning acquisition techniques. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. A dual energy x-ray source that delivers two different energy levels provides quantitative information regarding the object being imaged using dual photon absorptiometry techniques.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: February 12, 2008
    Assignee: University of Massachusetts Medical Center
    Inventor: Andrew Karellas
  • Patent number: 6895077
    Abstract: A system for x-ray fluoroscopic imaging of bodily tissue in which a scintillation screen and a charge coupled device (CCD) is used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen re-radiates a spatial intensity pattern corresponding to the image, the pattern being detected by the CCD sensor. In a preferred embodiment the imager uses four 8×8-cm three-side buttable CCDs coupled to a CsI:T1 scintillator by straight (non-tapering) fiberoptics and tiled to achieve a field of view (FOV) of 16×16-cm at the image plane. Larger FOVs can be achieved by tiling more CCDs in a similar manner. The imaging system can be operated in a plurality of pixel pitch modes such as 78, 156 or 234-?m pixel pitch modes. The CCD sensor may also provide multi-resolution imaging.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: May 17, 2005
    Assignee: University of Massachusetts Medical Center
    Inventors: Andrew Karellas, Srinivasan Vedantham, Sankararaman Suryanarayanan
  • Publication number: 20040120457
    Abstract: The present invention related to a system and method for performing scatter correction in x-ray imaging systems. A pixellated solid state imaging detector is used in which an electronic window or slot is scanned across the two dimensional surface of the detector to selectively record image data. In a preferred embodiment, a collimator is used to define relative movement between an x-ray beam and the x-ray detector. A scatter correction program can be used to correct for scattering in the detected image data to provide for improved imaging in medical, scientific and industrial applications.
    Type: Application
    Filed: December 20, 2002
    Publication date: June 24, 2004
    Applicant: University of Massachusetts Medical Center
    Inventors: Andrew Karellas, Sankararaman Suryanarayanan, Srinivasan Vedantham
  • Patent number: 6717174
    Abstract: A system for imaging of bodily tissue in which an x-ray source, an optical storage element, a light source and a detector array are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the storage element. The storage element reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto a CCD or amorphous silicon detector to generate individual electronic representations of separate images.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: April 6, 2004
    Assignee: University of Massachusetts Medical Center
    Inventor: Andrew Karellas
  • Publication number: 20030169847
    Abstract: A system for x-ray fluoroscopic imaging of bodily tissue in which a scintillation screen and a charge coupled device (CCD) is used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen re-radiates a spatial intensity pattern corresponding to the image, the pattern being detected by the CCD sensor. In a preferred embodiment the imager uses four 8×8-cm three-side buttable CCDs coupled to a CsI:T1 scintillator by straight (non-tapering) fiberoptics and tiled to achieve a field of view (FOV) of 16×16-cm at the image plane. Larger FOVs can be achieved by tiling more CCDs in a similar manner. The imaging system can be operated in a plurality of pixel pitch modes such as 78, 156 or 234-&mgr;m pixel pitch modes. The CCD sensor may also provide multi-resolution imaging.
    Type: Application
    Filed: November 21, 2001
    Publication date: September 11, 2003
    Applicant: University of Massachusetts Medical Center
    Inventors: Andrew Karellas, Srinivasan Vedantham, Sankararaman Suryanarayanan
  • Publication number: 20020196899
    Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a apatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images.
    Type: Application
    Filed: August 5, 2002
    Publication date: December 26, 2002
    Applicant: University of Massachusetts Medical Center
    Inventor: Andrew Karellas
  • Publication number: 20020172323
    Abstract: The present invention involves imaging systems for the detection of extravasation. A pixellated detector is preferably used to detect and control the injection of contrast agents or medications used in a variety of diagnostic or therapeutic procedures.
    Type: Application
    Filed: February 1, 2002
    Publication date: November 21, 2002
    Applicant: University of Massachusetts Medical Center
    Inventors: Andrew Karellas, Michael A. Davis
  • Patent number: 6445767
    Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: September 3, 2002
    Assignee: University of Massachussetts Medical Center
    Inventor: Andrew Karellas