Patents by Inventor Andrew Karellas
Andrew Karellas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9770222Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.Type: GrantFiled: March 17, 2017Date of Patent: September 26, 2017Assignee: University of MassachusettsInventors: Srinivasan Vedantham, Andrew Karellas
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Publication number: 20170231587Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.Type: ApplicationFiled: March 17, 2017Publication date: August 17, 2017Inventors: Srinivasan Vedantham, Andrew Karellas
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Publication number: 20170219503Abstract: An x-ray phase contrast imaging apparatus and method of operating the same. The apparatus passes x-rays generated by an x-ray source through, in succession, a source grating, an object of interest, a phase grating, and an analyzer grating. The x-ray source, the source grating, the phase grating, and the analyzer grating move as a single entity relative to an object of interest. The phase grating and the analyzer grating remain in fixed relative location and fixed relative orientation with respect to one another. The detected x-rays are converted to a time sequence of electrical signals. In some cases, the apparatus is controlled, and the electrical signals are analyzed by, by a general purpose programmable computer provided with instructions recorded on a machine readable medium. One or more x-ray phase contrast images of the object of interest are generated, and can be recorded or displayed.Type: ApplicationFiled: December 20, 2016Publication date: August 3, 2017Inventors: Srinivasan Vedantham, Andrew Karellas
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Patent number: 9629597Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.Type: GrantFiled: March 6, 2014Date of Patent: April 25, 2017Assignee: University of MassachusettsInventors: Srinivasan Vedantham, Andrew Karellas
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Publication number: 20170095578Abstract: A method of diagnosing a condition of a living subject that uses gadoxeate disodium as a contrast agent for making images such as CT scans of the biliary tree and related anatomical structures. The method uses x-ray radiation generated with excitation voltages in the range of 70 KV to 140 KV. The x-ray radiation is preferably filtered to suppress or practically remove x-rays having energy lower than 50.2 KeV.Type: ApplicationFiled: December 16, 2016Publication date: April 6, 2017Inventors: Adib Raphael KARAM, Andrew KARELLAS
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Publication number: 20160000393Abstract: The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.Type: ApplicationFiled: March 6, 2014Publication date: January 7, 2016Inventors: Srinivasan VEDANTHAM, Andrew KARELLAS
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Publication number: 20150055743Abstract: An x-ray phase contrast imaging apparatus and method of operating the same. The apparatus passes x-rays generated by an x-ray source through, in succession, a source grating, an object of interest, a phase grating, and an analyzer grating. The x-ray source, the source grating, the phase grating, and the analyzer grating move as a single entity relative to an object of interest. The phase grating and the analyzer grating remain in fixed relative location and fixed relative orientation with respect to one another. The detected x-rays are converted to a time sequence of electrical signals. In some cases, the apparatus is controlled, and the electrical signals are analyzed by, by a general purpose programmable computer provided with instructions recorded on a machine readable medium. One or more x-ray phase contrast images of the object of interest are generated, and can be recorded or displayed.Type: ApplicationFiled: February 15, 2013Publication date: February 26, 2015Inventors: Srinivasan Vedantham, Andrew Karellas
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Patent number: 8817947Abstract: Systems and methods for providing radiographic, stereoscopic and tomographic images of an object of interest. Examples of objects of interest are body parts of living beings, such as the human breast and the human chest. The apparatus includes a high-fluence rate x-ray source and a plurality of satellite x-ray sources operating at lower fluence rate than the high-fluence rate source. A controller controls the operation and locations of the sources, and the operation of a detector. The method provides procedures in which the operation of the high-fluence source and the satellite sources are individually controlled as to location and orientation relative to the object of interest. In some operations, one satellite source may be operating while another satellite source may be repositioning. By proper control, a reduced x-ray dose and reduced operating time can be attained, thereby improving image quality, patient care, and patient experience.Type: GrantFiled: January 27, 2012Date of Patent: August 26, 2014Assignee: University of MassachusettsInventors: Srinivasan Vedantham, Andrew Karellas
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Publication number: 20120195403Abstract: Systems and methods for providing radiographic, stereoscopic and tomographic images of an object of interest. Examples of objects of interest are body parts of living beings, such as the human breast and the human chest. The apparatus includes a high-fluence rate x-ray source and a plurality of satellite x-ray sources operating at lower fluence rate than the high-fluence rate source. A controller controls the operation and locations of the sources, and the operation of a detector. The method provides procedures in which the operation of the high-fluence source and the satellite sources are individually controlled as to location and orientation relative to the object of interest. In some operations, one satellite source may be operating while another satellite source may be repositioning. By proper control, a reduced x-ray dose and reduced operating time can be attained, thereby improving image quality, patient care, and patient experience.Type: ApplicationFiled: January 27, 2012Publication date: August 2, 2012Applicant: UNIVERSITY OF MASSACHUSETTSInventors: Srinivasan Vedantham, Andrew Karellas
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Patent number: 7869569Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. Applications include the imaging of radionuclide distributions within the human body or the use of a dual energy source to provide a dual photon bone densitometry apparatus that uses stationary or scanning acquisition techniques. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. A dual energy x-ray source that delivers two different energy levels provides quantitative information regarding the object being imaged using dual photon absorptiometry techniques.Type: GrantFiled: February 11, 2008Date of Patent: January 11, 2011Assignee: University of MassachusettsInventor: Andrew Karellas
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Publication number: 20100208872Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a apatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images.Type: ApplicationFiled: February 2, 2010Publication date: August 19, 2010Inventor: Andrew Karellas
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Publication number: 20080304620Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. Applications include the imaging of radionuclide distributions within the human body or the use of a dual energy source to provide a dual photon bone densitometry apparatus that uses stationary or scanning acquisition techniques. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. A dual energy x-ray source that delivers two different energy levels provides quantitative information regarding the object being imaged using dual photon absorptiometry techniques.Type: ApplicationFiled: February 11, 2008Publication date: December 11, 2008Applicant: University of MassachusettsInventor: Andrew Karellas
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Patent number: 7330531Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. Applications include the imaging of radionuclide distributions within the human body or the use of a dual energy source to provide a dual photon bone densitometry apparatus that uses stationary or scanning acquisition techniques. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. A dual energy x-ray source that delivers two different energy levels provides quantitative information regarding the object being imaged using dual photon absorptiometry techniques.Type: GrantFiled: May 11, 1995Date of Patent: February 12, 2008Assignee: University of Massachusetts Medical CenterInventor: Andrew Karellas
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Patent number: 6895077Abstract: A system for x-ray fluoroscopic imaging of bodily tissue in which a scintillation screen and a charge coupled device (CCD) is used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen re-radiates a spatial intensity pattern corresponding to the image, the pattern being detected by the CCD sensor. In a preferred embodiment the imager uses four 8×8-cm three-side buttable CCDs coupled to a CsI:T1 scintillator by straight (non-tapering) fiberoptics and tiled to achieve a field of view (FOV) of 16×16-cm at the image plane. Larger FOVs can be achieved by tiling more CCDs in a similar manner. The imaging system can be operated in a plurality of pixel pitch modes such as 78, 156 or 234-?m pixel pitch modes. The CCD sensor may also provide multi-resolution imaging.Type: GrantFiled: November 21, 2001Date of Patent: May 17, 2005Assignee: University of Massachusetts Medical CenterInventors: Andrew Karellas, Srinivasan Vedantham, Sankararaman Suryanarayanan
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Publication number: 20040120457Abstract: The present invention related to a system and method for performing scatter correction in x-ray imaging systems. A pixellated solid state imaging detector is used in which an electronic window or slot is scanned across the two dimensional surface of the detector to selectively record image data. In a preferred embodiment, a collimator is used to define relative movement between an x-ray beam and the x-ray detector. A scatter correction program can be used to correct for scattering in the detected image data to provide for improved imaging in medical, scientific and industrial applications.Type: ApplicationFiled: December 20, 2002Publication date: June 24, 2004Applicant: University of Massachusetts Medical CenterInventors: Andrew Karellas, Sankararaman Suryanarayanan, Srinivasan Vedantham
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Patent number: 6717174Abstract: A system for imaging of bodily tissue in which an x-ray source, an optical storage element, a light source and a detector array are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the storage element. The storage element reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto a CCD or amorphous silicon detector to generate individual electronic representations of separate images.Type: GrantFiled: June 29, 2001Date of Patent: April 6, 2004Assignee: University of Massachusetts Medical CenterInventor: Andrew Karellas
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Publication number: 20030169847Abstract: A system for x-ray fluoroscopic imaging of bodily tissue in which a scintillation screen and a charge coupled device (CCD) is used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen re-radiates a spatial intensity pattern corresponding to the image, the pattern being detected by the CCD sensor. In a preferred embodiment the imager uses four 8×8-cm three-side buttable CCDs coupled to a CsI:T1 scintillator by straight (non-tapering) fiberoptics and tiled to achieve a field of view (FOV) of 16×16-cm at the image plane. Larger FOVs can be achieved by tiling more CCDs in a similar manner. The imaging system can be operated in a plurality of pixel pitch modes such as 78, 156 or 234-&mgr;m pixel pitch modes. The CCD sensor may also provide multi-resolution imaging.Type: ApplicationFiled: November 21, 2001Publication date: September 11, 2003Applicant: University of Massachusetts Medical CenterInventors: Andrew Karellas, Srinivasan Vedantham, Sankararaman Suryanarayanan
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Publication number: 20020196899Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a apatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images.Type: ApplicationFiled: August 5, 2002Publication date: December 26, 2002Applicant: University of Massachusetts Medical CenterInventor: Andrew Karellas
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Publication number: 20020172323Abstract: The present invention involves imaging systems for the detection of extravasation. A pixellated detector is preferably used to detect and control the injection of contrast agents or medications used in a variety of diagnostic or therapeutic procedures.Type: ApplicationFiled: February 1, 2002Publication date: November 21, 2002Applicant: University of Massachusetts Medical CenterInventors: Andrew Karellas, Michael A. Davis
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Patent number: 6445767Abstract: A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images.Type: GrantFiled: September 2, 1999Date of Patent: September 3, 2002Assignee: University of Massachussetts Medical CenterInventor: Andrew Karellas