Abstract: A shoe stud for a sports shoe has a ground-engaging part and a multi-start threaded spigot for engagement in a complementary socket on a receptacle secured in the shoe sole or heel. The stud and receptacle also have a locking device which inter-engages when the spigot is fully inserted into the socket, to resist unscrewing. In order to ensure that the stud takes up a precise position relative to the receptacle, which may be needed if the stud is not rotationally symmetrical, the stud and receptacle have means to determine the initial position of the stud relative to the receptacle, and means to determine the final position of the stud relative to the receptacle. Determination of the initial position may be provided by a thread and complementary groove of the screw-thread connection which are of different dimensions from the others.

Abstract: A fluid leakage monitoring method and system comprising an electronic control, a sensor to monitor fluid inflow to a point of use, a sensor to monitor fluid outflow from a point of use, and a shut off valve. Uneven and asymmetrical fluid usage is monitored by a point of use station and the system is shut down when levels indicate abnormalities between the flows.

Abstract: The invention relates to methods of producing and isolating recombinant proteins using fusion protein constructs comprising specific recognition sites for a maturating protease. The invention specifically relates to the use of caspase proteases for the maturation of engineered recombinant fusion proteins or polypeptides. These molecules are engineered using recombinant DNA technology to comprise a specific target sequence for a caspase between a first fusion part and the polypeptide of interest. After processing, the desired mature format of the protein or polypeptide is obtained.

Abstract: Devices and methods of entraining a substance within an airflow are disclosed. Condensation aerosol delivery devices and methods of consistently producing multiple doses of a substance, such as a drug, having high purity, high yield, characterized by a particle size distribution appropriate for pulmonary delivery, and which can be administered to a user in a single dose are also disclosed.

Abstract: A system and method for empowering consumers in a retail environment. Among many other features, the present invention provides a number of menu and item list features to enhance a shopper's experience in a retail environment. In addition, the invention provides an item-level location mapping feature. By the use of the user's shopping list and a database storing information describing the location of items on the list, the system dynamically generates routing maps that show a path the user can take to locate the items on the list. The display may include a map with a route graphically displayed on the map, and/or a text description of the route.

Abstract: There is provided a medicament dispenser for use with a medicament carrier having a plurality of pockets for containing medicament wherein said pockets are spaced along the length of and defined between two peelable sheets secured to each other. The dispenser has an opening mechanism for opening received pockets of the medicament carrier. The mechanism includes an indexer for indexing pockets of a medicament carrier in use with said medicament dispenser. The indexer comprises an index ratchet, which is moveable between a locked position in which said ratchet locks a lid driver and a release position in which the ratchet releases the lid driver. Actuation of the medicament dispenser releases the index ratchet from the lid driver to enable drivable peeling of the lid sheet from the base sheet of the pocket at an opening station.

Abstract: A hydro-pneumatic tensioner includes a barrel having an inner bore and a pressurized fluid contained within to form at least part of a primary accumulator having a preset volume of gas at a nominal pressure. A piston having a piston rod extending from an aperture in the barrel is slidably carried in the bore of the barrel and is in communication with the pressurized fluid and positioned to increase the fluid pressure when the piston strokes in the direction of the pressurized fluid. A secondary accumulator also has a preset volume of gas at a preselected pressure. A fluid separator maintains functional separation of the fluid volumes of the primary and secondary accumulators when the primary accumulator pressure is less than the preselected secondary accumulator pressure. The fluid separator allows functional combining of the fluid volumes of the primary and secondary accumulators when the primary accumulator pressure equals or is greater than the preselected secondary accumulator pressure.

Abstract: The present invention relates to novel vectors and nucleic acid sequences, which comprise promoters which are induced by nucleotides. The invention further relates to expression vectors utilising elements of the xanthosine operon and methods for the production of heterologous proteins.

Abstract: A hydro-pneumatic tensioner includes a barrel having an inner bore and a pressurized fluid contained within to form at least part of a primary accumulator having a preset volume of gas at a preselected pressure. A piston having a piston rod extending from an aperture in the barrel is slidably carried in the bore of the barrel and is in communication with the pressurized fluid and positioned to increase the fluid pressure when the piston strokes in the direction of the pressurized fluid. A secondary accumulator also has a preset volume of gas at a preselected pressure. A fluid separator maintains functional separation of the fluid volumes of the primary and secondary accumulators when the primary accumulator pressure is less than a preselected secondary accumulator pressure. The fluid separator allows functional combining of the fluid volumes of the primary and secondary accumulators when the primary accumulator pressure equals or is greater than the preselected secondary accumulator pressure.

Abstract: A shoe stud for a sports shoe has a ground-engaging part and a multi-start threaded spigot for engagement in a complementary socket on a receptacle secured in the shoe sole or heel. The stud and receptacle also have a locking device which inter-engages when the spigot is fully inserted into the socket, to resist unscrewing. In order to ensure that the stud takes up a precise position relative to the receptacle, which may be needed if the stud is not rotationally symmetrical, the stud and receptacle have means to determine the initial position of the stud relative to the receptacle, and means to determine the final position of the stud relative to the receptacle. Determination of the initial position may be provided by a thread and complementary groove of the screw-thread connection which are of different dimensions from the others.

Abstract: A shoe stud for a sports shoe has a ground-engaging part and a multi-start threaded spigot for engagement in a complementary socket on a receptacle secured in the shoe sole or heel. The stud and receptacle also have a locking device which inter-engages when the spigot is fully inserted into the socket, to resist unscrewing. In order to ensure that the stud takes up a precise position relative to the receptacle, which may be needed if the stud is not rotationally symmetrical, the stud and receptacle have means to determine the initial position of the stud relative to the receptacle, and means to determine the final position of the stud relative to the receptacle. Determination of the initial position may be provided by a thread and complementary groove of the screw-thread connection which are of different dimensions from the others.

Abstract: In a combination of shoe cleat and holder, a screw-threaded spigot (12) on the cleat is inserted with rotation into a complementary socket (18) of the holder, and has a ring of free-standing posts (34, 42) extending axially from the cleat and a ring of radially-projective teeth (26) on the holder, the rings being co-axial with the screw axis so that during at least later stages of insertion of the spigot (12) into the socket (18), on relative rotation of the rings, engagement of the teeth (26) with the posts (34, 42) causes the posts (34, 42) to deflect resiliently and engagement of the teeth (26) between the posts (34, 42) causes interengagement of the locking means.

Abstract: An outsole for an article of studded footwear in which said outsole (1) includes receptacles (2) for specifically-oriented studs (5). The outsole (1) also includes traction elements (7) formed integrally with the outsole (1). The studs (5) and traction elements (7) being so constructed and arranged to interact in use of the footwear. The traction elements (7) are designed to complement the spike configuration of the stud (5).

Abstract: A shoe stud and receptacle combination for specifically oriented studs, the shoe stud (1) including a ground-engaging part (4). The stud (1) and receptacle (2) are adapted to be secured together by a multi-start threaded connection comprising a screw-threaded spigot (5) on one of the components adapted to be inserted with rotation into a screw-threaded socket on the other component. A locking means (7) of the components is arranged to become interengaged at least when the spigot (5) is fully inserted into the socket (22) to resist unscrewing of the components. The locking means (7) comprises at least one locking assembly (8), the arrangement is such that the relative number and/or position of the threads of the threaded connection and the locking assemblies (8) determine the initial and final positions of the stud (1) relative to the receptacle (2).

Abstract: A method of compression moulding an article from rubber moulding material incorporating hollow inserts avoids damage to the inserts. Where compression moulding takes place in an enclosed mould at an elevated pressure, the pressure can distort and damage the hollow inserts especially if they are of plastics. In order to avoid such distortion and damage, the method compresses during moulding creating a pressure in a cavity of the insert which substantially balances the pressure exerted on the exterior of the insert by the rubber moulding material in the mould. The pressure in the cavity is preferably produced by introducing some rubber moulding material into the cavity of the insert. This material becomes pressurised during moulding and supports the interior of the insert.

Abstract: A shoe stud for a sports shoe has a ground-engaging part and a multi-start threaded spigot for engagement in a complementary socket on a receptacle secured in the shoe sole or heel. The stud and receptacle also have a locking device which inter-engages when the spigot is fully inserted into the socket, to resist unscrewing. In order to ensure that the stud takes up a precise position relative to the receptacle, which may be needed if the stud is not rotationally symmetrical, the stud and receptacle have means to determine the initial position of the stud relative to the receptacle, and means to determine the final position of the stud relative to the receptacle. Determination of the initial position may be provided by a thread and complementary groove of the screw-thread connection which are of different dimensions from the others.

Abstract: A method of compression moulding an article from rubber moulding material incorporating hollow inserts avoids damage to the inserts. Where compression moulding takes place in an enclosed mould at an elevated pressure, the pressure can distort and damage the hollow inserts especially if they are of plastics. In order to avoid such distortion and damage, the method compresses during moulding creating a pressure in a cavity of the insert which substantially balances the pressure exerted on the exterior of the insert by the rubber moulding material in the mould. The pressure in the cavity is preferably produced by introducing some rubber moulding material into the cavity of the insert. This material becomes pressurized during moulding and supports the interior of the insert.

Abstract: In a combination of shoe cleat and holder, a screw-threaded spigot (12) on the cleat is inserted with rotation into a complementary socket (18) of the holder, and has a ring of free-standing posts (34, 42) extending axially from the cleat and a ring of radially-projective teeth (26) on the holder, the rings being co-axial with the screw axis so that during at least later stages of insertion of the spigot (12) into the socket (18), on relative rotation of the rings, engagement of the teeth (26) with the posts (34, 42) causes the posts (34, 42) to deflect resiliently and engagement of the teeth (26) between the posts (34, 42) causes interengagement of the locking means.

Abstract: In a combination of shoe cleat and holder, a screw-threaded spigot (12) on the cleat is inserted with rotation into a complementary socket (18) of the holder, and has a ring of free-standing posts (34, 42) extending axially from the cleat and a ring of radially-projective teeth (26) on the holder. the rings being co-axial with the screw axis so that during at least later stages of insertion of the spigot (12) into the socket (18), on relative rotation of the rings, engagement of the teeth (26) with the posts (34, 42) causes the posts (34, 42) to deflect resiliently and engagement of the teeth (26) between the posts (34, 42) causes interengagement.

Abstract: A method of compression moulding an article from rubber moulding material incorporating hollow inserts avoids damage to the inserts. Where compression moulding takes place in an enclosed mould at an elevated pressure, the pressure can distort and damage the hollow inserts especially if they are of plastics. In order to avoid such distortion and damage, the method compresses during moulding creating a pressure in a cavity of the insert which substantially balances the pressure exerted on the exterior of the insert by the rubber moulding material in the mould. The pressure in the cavity is preferably produced by introducing some rubber moulding material into the cavity of the insert. This material becomes pressurised during moulding and supports the interior of the insert.