Abstract: A prosthetic socket fitment system for fitting a prosthesis to a patient can include at least one transceiver assembly in contact with an external frame coupled to a patient, and a processing module in electrical communication with the at least one transceiver assembly. The at least one transceiver assembly can be aligned to the bone of the patient and configured to generate a signal directed to the bone of the patient and receive a reflected signal from the bone of the patient.

Abstract: The present disclosure is directed to a bicycle parking structure comprising a plurality of bicycle hangers supported by a crossbar assembly. Each bicycle hanger is configured to support a bicycle in a substantially vertical position. The bicycle hangers are spaced apart from one another along the length of the crossbar assembly. Each of the bicycle hangers may be secured to the crossbar assembly so that the bicycle hanger is fixed at a desired position or unsecured from the crossbar assembly so that the position of the bicycle hanger along the length of the crossbar assembly may be adjusted. In this manner, the distance between adjacent bicycles need not be fixed and the bicycle parking structure can be adapted for a particular space. The bicycle parking structure is designed to provide for a space-efficient, high-volume parking of bicycles.

Abstract: A method of additive manufacturing is disclosed, comprising using a powder comprising a first particulate component (1) with a first mean particle diameter, and a second particulate component (2) with a second mean particle diameter. The first mean particle diameter is at least twice the second mean particle diameter. The particles (2) of the second component are bonded to the particles (1) of the first component, and the first and second components comprise different materials. The powder is deposited.

Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.

Abstract: This invention discloses reagents and methods for increasing specificity and efficiency of RNA-guided genome editing.

Abstract: Virtual machines can be remotely configured on distributed host devices by communicating management instructions over remote access tunnels. The management instructions prompt virtual remote agents on instantiated on the distributed host devices to configure virtual machines on the distributed host devices. The management instruction may prompt the virtual remote agents to instantiate a new virtual machine, to re-configure an existing virtual machine, or to create, remove, and/or modify virtual paths between two or more virtual machines on the distributed host device. Management signaling can be broadcast over multiple management tunnels to coordinate the configuration of multiple virtual machines at different distributed host devices based on a single virtual machine installation instance in an MSP server.

Abstract: A virtual edge router network for providing managed services to distributed remote office locations can include routing components that are capable of being autonomously deployed at the network edge, as well as remotely managed, thereby obviating the need for on-site technical support in remote offices of the a small and medium business (SMB) client. Autonomous deployment and remote management is achieved through abstraction of the control and management planes from the data plane. Virtual edge routers may include virtual forwarding units and virtual remote agents instantiated on host devices in each remote office location, as well as a virtual network controller instantiated on a host device in a head-office location. A data plane of the virtual edge router communicatively couples the virtual forwarding units to one another, while a control plane communicatively couples the virtual network controller to each virtual data forwarding unit.

Abstract: The invention relates to inhibitors of Sphingosine Kinase enzymatic activity, and methods of treating diseases and disorders by administering inhibitors of Sphingosine Kinase enzymatic activity.

Abstract: The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided.

Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.

Abstract: Detailed is electricity generation for powering devices associated with swimming pools or other structures utilizing recirculating fluid. The recirculating fluid is used to produce electricity for direct or indirect supply to electrical devices. Turbines may be placed in by-pass channels so as to have access to some fluid flow yet not unduly disrupt main flow of the recirculating fluid.

Abstract: A succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof, for use in treating pulmonary disorders.

Abstract: Detailed is electricity generation for powering devices associated with swimming pools or other structures utilizing recirculating fluid. The recirculating fluid is used to produce electricity for direct or indirect supply to electrical devices. Turbines may be placed in by-pass channels so as to have access to some fluid flow yet not unduly disrupt main flow of the recirculating fluid.

Abstract: A system and method include and control multiple controllable interactive components (10) that may be employed in various environments including sporting environments. The system may also include controllable (10) or non-controllable non-interactive components (30). These components (40) may include power supplies (42) that supply energy to the components (non-interactive and interactive) via a plurality of bus bars (20a, 20b) coupled together to form a bus bar system. Low speed data may be communicated on the bus bar system between components and a system controller (210). The system controller (210) may monitor and modify the operation of components (10) via the bus bar system (20a, 20b) are provided for interacting one or more individuals.

Abstract: A succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof, for use in treating pulmonary disorders.

Abstract: The invention relates to a method for purifying water by forming in an electrolytic cell molecular halogen, hypohalic acid, hypohalite ions or combinations thereof, from halide ions dissolved in the water; and dissolving one or more soluble metal salts in the water to provide corresponding metal ions. The invention also relates to a system for purifying water, having an electrolytic cell comprising a plurality of electrodes sufficient to electrolytically convert halide ion in the water into molecular halogen, hypohalic acid, or hypohalite ions, or combinations thereof; and a metal generator, which provides concentrations of one or more metals to the water.

Abstract: The invention relates to an apparatus for electrolytic purification, comprising: (a) a pressure vessel having at least one access opening, at least one fluid flow inlet, and at least one fluid flow outlet, wherein the fluid flow inlet and fluid flow outlet are in fluid communication with a chamber inside the pressure vessel; (b) an removable electrode assembly, at least a portion of which is disposed within the chamber inside the pressure vessel, comprising: a plurality of substantially parallel spaced planar electrodes, an electrical coupling between the electrode plates and a voltage source, and a radially extending circumferential sealing plate substantially normal to the planes of the electrodes, disposed near the electrical coupling, adapted to prevent fluid flow from the chamber to the electrical coupling; (c) a removable locking ring, comprising: a proximal portion adapted to removably attach to the access opening of the pressure vessel and retain the radially extending circumferential sealing p

Abstract: The disclosed technology can execute a sequence of transactions to process a request associated with a health care company and/or other entities interacting in a health care industry. Execution of at least some of the transaction sequence can result in the formation of an instance of a semantic network that can be used to support such processing. The request can correspond to a change in a relationship associated with such entities, where such request corresponds to an electronic document exhibiting a structured natural language format with a fixed context and a fixed grammar.