Abstract: Disclosed herein are system, method and/or device embodiments for using a wireless mouthguard with pressure sensors for measuring bite compression forces generated by a bruxism patient during sleep. A system comprises a mouthguard and a microelectromechanical system (MEMS) coupled to a portion of the mouthguard covering an axial plane of a tooth. The MEMS comprises an antenna, a capacitive sensor, a microcontroller, and a power supply. The sensor generates sensor signals corresponding to a force generated by a mouthguard wearer's bite. The MEMS may then transmit data describing the wearer's bite force over a period of time to an external computing device for display and analysis.

Abstract: Methods and systems for recovering a host image of a client machine to a recovery machine comprise comparing a profile of a client machine of a first type to be recovered to a profile of a recovery machine of a second type different from the first type, to which the client machine is to be recovered, by a first processing device. The first and second profiles each comprise at least one property of the first type of client machine and the second type of recovery machine, respectively. At least one property of a host image of the client machine is conformed to at least one corresponding property of the recovery machine. The conformed host image is provided to the recovery machine, via a network. The recovery machine is configured with at least one conformed property of the host image by a second processing device of the recovery machine.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: Examples are disclosed related to presenting on a client device configured for a first digital rights management technology (DRM-1) content that is protected by a second digital rights management technology (DRM-2).

Abstract: Systems, methods, and control systems for a switching rocker arm assembly are disclosed. A switching rocker arm (10) engages a valve (29), the switching rocker arm (10) is movable by contact with a cam (60) having a lift portion (59) and a base circle (58). The switching rocker arm (10) comprises an inner arm (20), an outer arm (12) pivotably secured to the inner arm (20) and having a latch bore, and a latch pin (28) selectively movable between a first position where the latch pin (28) does not contact the inner arm (20), and a second position wherein the latch pin (28) contacts the inner arm (20). A solenoid assembly (500) is energized while the rocker arm is in contact with the lift portion (59) of the cam. The solenoid assembly is direct-acting and overhead and is calibratable with respect to the rocker arm.

Abstract: Methods and systems for transferring a host image of a first machine to a second machine, such as during disaster recovery or migration, are disclosed. In one example, a first profile of a first machine of a first type is compared to a second profile of a second machine of a second type different from the first type, to which the host image is to be transferred. The first and second profiles each comprise at least one property of the first type of first machine and the second type of second machine, respectively. At least one property of a host image of the first machine is conformed to at least one corresponding property of the second machine. The conformed host image is provided to the second machine, via a network. The second machine is configured with at least one conformed property of the host image.

Abstract: Embodiments of system and methods for providing centralized management of a software defined automation (“SDA”) system are disclosed. The SDA system comprises of a collection of controller nodes and logically centralized and yet physically distributed collection of compute nodes by monitoring activities of the compute nodes. In accordance with some embodiments, one or more components of the system monitor execution, network and security environments of the system to detect an event in a first environment. In response to the detected event, at least one component in the first environment is remediated, the remediation of the first environment creating a trigger to cause remediation of at least one component in each of a second and third environments.

Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.

Abstract: An external beam radiation therapy method is described, wherein radiation therapy is performed on a subject by applying at least one ionizing radiation beam to the subject. While applying the at least one ionizing radiation beam to the subject, an ultrasound probe images the subject, where the ultrasound probe is not located in the ionizing radiation beam. While applying the ionizing radiation beam to the subject, a dosimeter that is integral with or attached to the ultrasound probe measures the radiation dose or radiation exposure received by the ultrasound probe.

Abstract: The present invention is directed to the cells, compositions and methods for the production of recombinant protein, wherein an f-met group on the 5?-terminus is enzymatically removed. In particular, the invention is directed to a production process for obtaining high levels of soluble recombinant CRM197 protein from E. coli. Cells preferably contain one or more mutations of disulfide reductase genes, so that disulfide reductase activity is reduced. The invention also relates to purification method for CRM197 as well as characterization of properly folded CRM197 protein.

Abstract: A method of operating a multi-axis fiber scanner having a base including a base plane includes providing a source of electromagnetic radiation, directing the electromagnetic radiation through a fiber link that passes through the base plane of the base along a longitudinal axis orthogonal to the base plane, and supporting a retention collar positioned a distance from the base plane. The method also includes actuating a first piezoelectric actuator among a plurality of piezoelectric actuators to decrease the distance between a first side of the base and the retention collar, actuating a second piezoelectric actuator among the plurality of piezoelectric actuators to increase the distance between a second side of the base and the retention collar, and scanning the fiber link in a scanning plane.

Abstract: The present invention generally is directed toward a spinal fixation system whereby a coupling element allows the physician to selectively lock or unlock either the connection between the coupling element and a fastener, such as to allow for repositioning of the coupling element, or the connection between the coupling element and an elongate rod. The locking or unlocking of these connections may be made independently and as desired by the physician.

Abstract: A system and method for implementing slot-relation extraction for a task-oriented dialogue system that includes implementing dialogue intent classification machine learning models that predict a category of dialogue of a single utterance based on an input of utterance data relating to the single utterance, wherein the category of dialogue informs a selection of slot-filling machine learning models; implementing the slot-filling machine learning models that predict slot classification labels for each of a plurality of slots within the utterance based on the input of the utterance data; implementing a slot relation extraction machine learning model that predicts semantic relationship classifications between two or more distinct slots of tokens of the utterance; and generating a response to the single utterance or performing actions in response to the single utterance based on the semantic relationship classifications between the distinct pairings of the two or more distinct slots of the single utterance.

Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.

Abstract: The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.

Abstract: Disclosed herein are system, method and/or device embodiments for using a wireless mouthguard with pressure sensors for measuring bite compression forces generated by a bruxism patient during sleep. A system comprises a mouthguard and a microelectromechanical system (MEMS) coupled to a portion of the mouthguard covering an axial plane of a tooth. The MEMS comprises an antenna, a capacitive sensor, a microcontroller, and a power supply. The sensor generates sensor signals corresponding to a force generated by a mouthguard wearer's bite. The MEMS may then transmit data describing the wearer's bite force over a period of time to an external computing device for display and analysis.

Abstract: An electrical machining method comprises machining a workpiece by an electrical machining device comprising an electrode; increasing a feedrate of the electrode at a first acceleration if a discharge current passing through the electrode and the workpiece is lower than a discharge current reference; and decreasing the feedrate of the electrode at a second acceleration if the discharge current is higher than the discharge current reference, wherein the second acceleration has an absolute value higher than that of the first acceleration.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: An ultrasound probe includes an ultrasound probe housing and one or more ultrasound transducers disposed in the ultrasound probe housing. A dosimeter or ionizing radiation detector is disposed in or attached to the ultrasound probe housing. An alarm device receives radiation dose or radiation exposure data acquired by the dosimeter or ionizing radiation detector. The alarm device includes an electronic processor programmed to detect excessive radiation dose or radiation exposure received by the ultrasound probe based on the radiation dose or radiation exposure data acquired by the dosimeter or ionizing radiation detector, and output an alarm warning of the detection of excessive radiation dose or radiation exposure received by the ultrasound probe. In some embodiments, the dosimeter is a one-time use dosimeter that is not resettable.

Abstract: An ultrasound system includes a 3D imaging probe and a needle guide which attaches to the probe for guidance of needle insertion into a volumetric region which can be scanned by the 3D imaging probe. The needle guide responds to the insertion of a needle through the guide by identifying a plane for scanning by the probe which is the insertion plane through which the needle will pass during insertion. The orientation of the insertion plane is communicated to the probe to cause the probe to scan the identified plane and produce images of the needle as it travels through the insertion plane.