Abstract: Disclosed is a process for preparing Compound 8: (8) comprising the step of reacting Compound of 7: (7) wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: Methods, systems, computer-readable media, and apparatuses for performing, providing, managing, executing, and/or running a spatially-optimized simulation are presented. In one or more aspects, authority over one or more components may be changed from one worker to another worker during the simulation. The components may be configured to, for example, indicate behaviors of entities executing in the simulation. The system may determine to hand over authority over the one or more components to another worker, such as based on network and/or simulation conditions. The incumbent worker may be notified that authority will change to another worker, e.g., after a period of time. Authority over the one or more components may be assigned to the other worker, and the incumbent worker may be notified that it is no longer authoritative over the one or more components. The second worker may be notified that it is now authoritative over the one or more components.

Abstract: The present invention relates to an expandable prosthetic implant device for engagement between vertebrae generally comprising an inner member, outer member, and gear member positioned coaxial with respect to each other such that the inner and outer members are moveable relative to each other along an axis. The gear member is axially fixed to the outer member and freely rotatable with respect to the outer member and the gear member threadedly engages a threaded portion of the inner member to translate inner member along the axis. The implant is configured to engage the vertebrae in a predetermined alignment and the gear member includes gear teeth exposed to the exterior and configured to be accessible by a tool member at a plurality of angular positions around the perimeter of the implant device.

Abstract: A method of operating a multi-axis fiber scanner having a base including a base plane includes providing a source of electromagnetic radiation, directing the electromagnetic radiation through a fiber link that passes through the base plane of the base along a longitudinal axis orthogonal to the base plane, and supporting a retention collar positioned a distance from the base plane. The method also includes actuating a first piezoelectric actuator among a plurality of piezoelectric actuators to decrease the distance between a first side of the base and the retention collar, actuating a second piezoelectric actuator among the plurality of piezoelectric actuators to increase the distance between a second side of the base and the retention collar, and scanning the fiber link in a scanning plane.

Abstract: A method includes receiving summary messages summarizing respective aggregated traffic metadata packets output from the at least one traffic management device and an engine. Each summary message identifies an origination pair having a traffic management device and an aggregation engine and a sequence number. The method further includes tracking per subinterval of a series of sub-intervals, highest and lowest sequence numbers and a count of summary messages received for each unique origination pair from the beginning of the subinterval. The method further includes accumulating, per interval, accumulated highest and lowest sequence numbers and an accumulated count of summary messages for each unique origination pair from the beginning of the interval and for all previous subintervals for tracking dropped aggregated traffic metadata packets for the interval.

Abstract: A firing mechanism for a firearm includes a frame, a barrel attached to the frame, a cylinder attached to the frame and including a chamber that is alignable with the barrel, and a latch pin in direct contact with the cylinder that moves forward to force the cylinder forward to directly contact the chamber with the barrel when a trigger is pulled.

Abstract: Ultrasound imaging systems are provided. An ultrasound system according to some embodiments includes a console configured to selectively communicate with a first ultrasound imaging device and a second ultrasound imaging device. The console includes a housing, a computing device disposed within the housing, and a connector receptacle assembly coupled to the housing. The connector receptacle assembly includes a first connector bank including a first plurality of electrical connections; and a second connector bank including a second plurality of electrical connections. The connector receptacle assembly is selectively matable to a first connector of the first ultrasound imaging device via only the first connector bank and to a second connector of the second ultrasound imaging device via the first and second connector banks.

Abstract: Embodiments of a software defined automation (SDA) system that provides a reference architecture for designing, managing and maintaining a highly available, scalable and flexible automation system. A method is disclosed for arranging workloads in an SDA system including determining tasks of predetermined device functions, assessing industrial operational parameters for each task of the device functions; and ranking the tasks by the industrial operational parameters. The method continues by distributing tasks over automation devices based on the industrial operational parameters.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: Certain aspects provide a method of commissioning a virtualized network function (VNF), including: at a commissioning virtual machine instantiated in a virtualized environment of a customer network, configuring a remote access connection facility for accessing the commissioning virtual machine remotely from outside of the customer network, wherein the commissioning virtual machine has access to a virtual infrastructure manager (VIM) component of the virtualized environment; causing, via the remote access connection facility, configuration of a VNF manager component within the commissioning virtual machine; and causing, via the remote access connection facility, the configured VNF manager component to instruct the VIM component to instantiate one or more virtual machines in the virtualized environment, the one or more virtual machines being operable to perform at least a part of the VNF.

Abstract: According to a first aspect, there is provided a method of testing a plurality of virtual network functions (VNFs) during commissioning of the plurality of VNFs in a virtualized environment in a customer network, the method comprising: at a VNF testing component configured to have access to the virtualized environment of the customer network, performing interoperability testing between a first VNF component instantiation (VNFCI) within a first VNF of the plurality of VNFs and a second VNFCI within a second VNF of the plurality of VNFs, the second VNF being different from the first VNF, the first VNF and the second VNF comprising a subset of VNFs within the plurality of VNFs, wherein performing the interoperability testing comprises: instructing the first VNFCI to interoperate directly with the second VNFCI in a predetermined manner; and determining whether the second VNFCI reacts to the instructed direct interoperation in an expected manner.

Abstract: In a Boundaryless Control High Availability (“BCHA”) system (e.g., industrial control system) comprising multiple computing resources (or computational engines) running on multiple machines, technology for computing in real time the overall system availability based upon the capabilities/characteristics of the available computing resources, applications to execute and the distribution of the applications across those resources is disclosed. In some embodiments, the disclosed technology can dynamically manage, coordinate recommend certain actions to system operators to maintain availability of the overall system at a desired level. High Availability features may be implemented across a variety of different computing resources distributed across various aspects of a BCHA system and/or computing resources. Two example implementations of BCHA systems described involve an M:N working configuration and M:N+R working configuration.

Abstract: Systems and methods for constructing an artificially diverse corpus of training data includes evaluating a corpus of utterance-based training data samples, identifying a slot replacement candidate; deriving distinct skeleton utterances that include the slot replacement candidate, wherein deriving the distinct skeleton utterances includes replacing slots of each of the plurality of distinct utterance training samples with one of a special token and proper slot classification labels; selecting a subset of the distinct skeleton utterances; converting each of the distinct skeleton utterances of the subset back to distinct utterance training samples while still maintaining the special token at a position of the slot replacement candidate; altering a percentage of the distinct utterance training samples with a distinct randomly-generated slot token value at the position of the slot replacement candidate; and constructing the artificially diverse corpus of training samples based on a collection of the percentage of

Abstract: A firing mechanism for a firearm includes a frame, a barrel attached to the frame, a cylinder attached to the frame and including a chamber that is alignable with the barrel, and a latch pin in direct contact with the cylinder that moves forward to force the cylinder forward to directly contact the chamber with the barrel when a trigger is pulled.

Abstract: A collapsible reflective optical sight for a firearm, including a base configured to mount the collapsible reflective optical sight to a firearm; a lens attached to and able to rotate with respect to the base, wherein the lens includes an optic with a reflective surface, and the lens is able to be folded with respect to the base to store the lens in a collapsed configuration and is able to be angled with respect to the base to aim the firearm with the lens in a deployed configuration; a light source on the base that reflects a light off the reflective surface of the optic to aim the firearm; and a mechanical sight adjustably mounted to the base to aim the firearm. Additionally, the collapsible reflective optical sight can include a firearm and a hood.

Abstract: A collapsible reflective optical sight for a firearm, including a base configured to mount the collapsible reflective optical sight to a firearm; a lens attached to and able to rotate with respect to the base, wherein the lens includes an optic with a reflective surface, and the lens is able to be folded with respect to the base to store the lens in a collapsed configuration and is able to be angled with respect to the base to aim the firearm with the lens in a deployed configuration; a light source on the base that reflects a light off the reflective surface of the optic to aim the firearm; and a mechanical sight adjustably mounted to the base to aim the firearm. Additionally, the collapsible reflective optical sight can include a firearm and a hood.

Abstract: The inventors have unexpectedly discovered that shock and/or potential multi-organ failure due to shock can be effectively treated by administration of liquid high-dose protease inhibitor formulations to a location upstream of where pancreatic proteases are introduced into the gastrointestinal tract. Most preferably, administration is directly to the stomach, for example, via nasogastric tube under a protocol effective to treat shock by such administration without the need of providing significant quantities of the protease inhibitor to the jejunum and/or ileum.

Abstract: Methods and systems for transferring a host image of a first machine to a second machine, such as during disaster recovery or migration, are disclosed. In one example, a first profile of a first machine of a first type, such as a first client machine, is compared to a second profile of a second machine, such as a recovery machine or a second client machine of a second type different from the first type, to which the host image is to be transferred, by a first processing device. The first and second profiles each comprise at least one property of the first type of first machine and the second type of second machine, respectively. At least one property of a host image of the first machine is conformed to at least one corresponding property of the second machine. The conformed host image is provided to the second machine, via a network. The second machine is configured with at least one conformed property of the host image by a second processing device of the second machine.

Abstract: A collapsible reflective optical sight for a firearm, including a base configured to mount the collapsible reflective optical sight to a firearm; a lens attached to and able to rotate with respect to the base, wherein the lens includes an optic with a reflective surface, and the lens is able to be folded with respect to the base to store the lens in a collapsed configuration and is able to be angled with respect to the base to aim the firearm with the lens in a deployed configuration; a light source on the base that reflects a light off the reflective surface of the optic to aim the firearm; and a mechanical sight adjustably mounted to the base to aim the firearm. Additionally, the collapsible reflective optical sight can include a firearm and a hood.