Abstract: A compound of formula (I): Ar1??(I) Ar1 is a fused aromatic or heteroaromatic group substituted with at least one group of formula (II): R2 in each occurrence is H or a substituent, Y is O, S or NR9 wherein R9 is H or a substituent; --- is a bond to a ring carbon atom of Ar1; and, for each group of formula (II), a ring carbon atom of Ar1 adjacent to a ring carbon atom bound to the group of formula (II) is substituted with a group of formula —XR1 wherein X is O, S or NR3 wherein R3 is H or C1-12 alkyl and R1 is a photocleavable group. Data may be written to a recording medium containing a compound of formula (I) by exposing it to a wavelength for photolysis of the photocleavable group.

Abstract: A side view mirror assembly includes a base frame configured to couple to a bracket that is connected to a vehicle static structure. The base frame interfacing with the bracket through a guide that is at least partially received within a pocket when the base frame is coupled to the bracket. A mirror housing assembly is adjustably supported by the base frame.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: The invention is directed to an ultrasound probe (1) configured to be operatively coupled to a cable (10), the cable (10) comprising a plurality of lanes adapted to carry signals between the ultrasound probe (1) and a data processing unit, which is adapted to process the signals, in particular to beamform the signals and to reconstruct ultrasound images of an imaging region. The ultrasonic probe (1) comprises a transducer head comprising a plurality of transducer elements, which are adapted to insonify the imaging region according to an insonification scheme and to receive ultrasound signals, and a controller adapted to, responsive to the information of a faulty lane from a fault detection module adapted to detect integrity of each of the plurality of lanes, redistribute and/or reconfigure the signals carried by the faulty lane onto one or more of the non-faulty lanes.

Abstract: A system and method for implementing slot-relation extraction for a task-oriented dialogue system that includes implementing dialogue intent classification machine learning models that predict a category of dialogue of a single utterance based on an input of utterance data relating to the single utterance, wherein the category of dialogue informs a selection of slot-filling machine learning models; implementing the slot-filling machine learning models that predict slot classification labels for each of a plurality of slots within the utterance based on the input of the utterance data; implementing a slot relation extraction machine learning model that predicts semantic relationship classifications between two or more distinct slots of tokens of the utterance; and generating a response to the single utterance or performing actions in response to the single utterance based on the semantic relationship classifications between the distinct pairings of the two or more distinct slots of the single utterance.

Abstract: A pistol, incudes a slide; a lens attached to and rotatable with respect to the slide; a light source that reflects a light off a reflective surface of the lens to aim the pistol; a hood rotatably mounted and in contact with the lens, wherein the hood folds over the lens in a collapsed configuration and is angled from the lens in a deployed configuration, and the lens, the light source, and the hood fit within an outline profile of the slide in the collapsed configuration.

Abstract: The invention is directed to methods and compositions for the expression and purification of products such as peptides and proteins in microorganisms. In particular, pre-products are expressed recombinantly, wherein the cytoplasm of the microorganism alters the expressed pre-products to produce products in an active/final or otherwise desirable form. Alterations associated with expression of a desired recombinant product include shifting of the redox state of the cytoplasm to allow proper protein folding, site-directed cleavage of pre-proteins to activate the protein, site-directed cleavage of an unwanted methionine from the N terminus of the protein, and/or one or more ligations to form desired protein configurations, all within the same cell.

Abstract: Provided are innovative compositions for tethering blocking an inactivating of airborne respiratory infectious viruses. The compositions comprise bispecific proteins with two different antigen binding regions (ABR), which are typically configured as immunoglobulin “single variable domains” (ISV). A first ISV binds to a surface protein found on an airborne infectious virus. A second ISV binds to a mucin protein, e.g. a mucin protein present on ocular, nasopharyngeal, tracheal and/or oral surfaces of a mammal. The two ISV are joined by a polypeptide linker.

Abstract: This document describes a process of producing gel microparticles, which are consistent in size and morphology. Through the process of coacervation, large volumes of gel microparticle slurry can be produced by scaling up reactor vessel size. Particles can be repeatedly dehydrated and rehydrated in accordance to their environment, allowing for the storage of particles in a non-solvent such as ethanol. Gel slurries exhibit a Bingham plastic behavior in which the slurry behaves as a solid at shear stresses that are below a critical value. Upon reaching the critical shear stress, the slurry undergoes a rapid decrease in viscosity and behaves as a liquid. The rheological behavior of these slurries can be adjusted by changing the compaction processes such as centrifugation force to alter the yield-stress. The narrower distribution and reduced size of these particles allows for an increase in FRESH printing fidelity.

Abstract: A method includes transmitting an instruction to a motive power supply of an elastically deformable device to drive the elastically deformable device in accordance with a drive setting; measuring a force exerted on the elastically deformable device with a sensor; outputting an observed value representative of the force; comparing the observed value with a reference value corresponding with a predetermined force to be exerted on the elastically deformable device; and adjusting the drive setting based on a determination that the observed value is outside of a predetermined range of the reference value. The method prevents slack in the elastically deformable device over time. Related apparatuses, systems, techniques and articles are also described.

Abstract: A method of firing a firearm includes rotating a trigger to force a latch pin lever to move; forcing a latch pin forward by the latch pin lever to force a cylinder forward toward a barrel; sealing or substantially sealing the barrel and the cylinder; and releasing a hammer to strike a cartridge while the barrel and the cylinder are sealed.

Abstract: An improved headset is provided to selectively distribute the weight of the headset while securely registering the headset comfortably on a wearer's head. The headset comprises one or more compliant arms and a frame to selectively distribute the weight of the headset and secure the headset to the wearer's head without the need for straps or leavers. The compliant arms provide a normalizing force through elastic body deformation to selectively distribute the weight of the headset.

Abstract: Methods and systems for recovering a host image of a client machine to a recovery machine comprise comparing a profile of a client machine of a first type to be recovered to a profile of a recovery machine of a second type different from the first type, to which the client machine is to be recovered, by a first processing device. The first and second profiles each comprise at least one property of the first type of client machine and the second type of recovery machine, respectively. At least one property of a host image of the client machine is conformed to at least one corresponding property of the recovery machine. The conformed host image is provided to the recovery machine, via a network. The recovery machine is configured with at least one conformed property of the host image by a second processing device of the recovery machine.

Abstract: Mutated Pseudomonas aeruginosa sulfatase (PaS) enzymes with enhanced enzymatic activity as compared to the parental wild type enzyme are provided. The variant sulfatases of the invention advantageously allow for accurate analysis of bodily samples for the presence of drugs. Methods of using the mutated enzymes for hydrolysis of sulfate ester linkages are also provided, including with substrates such as opioids or steroids containing a sulfate ester linkage.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: Techniques are described for generating a virtualized network function (VNF) descriptor (VNFD) indicative of resources for managing VNF components (VNFCs) across a plurality of virtualized infrastructure managers (VIMs) implemented in a virtualized computing environment configured in a user-specific configuration. A VNFD generator receives a solution description file (SDF) encoding user input pertaining to the user-specific configuration, and a VNFC descriptor encoding VNFC specific information. The SDF and VNFC descriptor are validated and translated to generate an abstracted VNFD that is independent of renderers implemented at the virtualized computing environment. The abstracted VNFD is translated to a VNFD that is specific to the renderers and VIM and VNFD-specific information at the virtualized computing environment.

Abstract: Aspects of the present disclosure relate to a dynamic resource management system. In various examples, a dynamic resource management system enables resource-consuming tasks to be assigned to resources at least according to resource profiles and resource groupings. Resources may include primary resources and secondary resources and may be grouped into resource groups such that each resource group have a selection of primary resources and secondary resources. In some instances, resource groups may be updated to have updated selections of primary resources and secondary resources. To assign tasks to resources, the dynamic resource management system may first identify multiple resource-consuming tasks associated with a resource-consuming event then assign each resource-consuming task to a resource. The task assignment may be performed based on resource information such as availability, performance, and/or experience.

Abstract: This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to peptides or proteins either directly or through a spacer. These reagents include 1-cyano-4-dimethylaminopyridinium bromide, or a functional derivative or modification thereof. The examples illustrate the use of these reagents with a variety of polysaccharides and proteins showing that the methods are generally applicable.

Abstract: Chimeric and other variant ?-glucuronidase enzymes with enhanced properties as compared to unmodified enzyme are provided. The enzymes of the invention advantageously exhibit enhanced enzymatic activity, enhanced substrate range, enhanced pH range, enhanced temperature range and/or enhanced enzyme stability. Methods of using the variant enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.

Abstract: Matching an internet service with an IP host address to attribute network traffic to the internet service by mapping one or more server names to an internet service by a network device by detecting a DNS Response to a DNS Query. Inspect the DNS Response to determine an association of a service consumer's IP address with an internet service's server IP address relating to a certain internet service to maintain an array of indexed entries having an association of the service consumer's IP address with an internet service's server IP address relating to a certain internet service for a certain length of time using a probabilistic data structure for the indexed entries.