Abstract: DNS request obfuscation includes generating decoy domain name system (DNS) requests for obfuscating DNS request activity being handled by a private DNS server for an organization, and sending the decoy DNS requests to external DNS server(s) for resolution, receiving a DNS request seeking a DNS lookup for a client device, obfuscating the DNS request by sending, to an external DNS server of the external DNS server(s), the DNS request interspersed with at least some of the generated decoy DNS requests sent to the external DNS server, receiving, from the external DNS server, a DNS response to the sent DNS request, and providing the DNS response to a source of the DNS request.

Abstract: The present invention relates to a method for increasing the activity and/or the yield of a recombinant vitamin K-dependent protein expressed in cell culture. The present invention further relates to uses and compositions of matter.

Abstract: A process of capturing a biopotential signal at a surface of a body includes using a sensor receiver which forms a first signal connection with the body wherein one or more parameters of impedance of the first signal connection are unknown. The biopotential signal is received at an output of a first signal channel having a first transfer function dependent on the one or more unknown first impedance parameters. The biopotential signal is received at an output of a second signal channel having a second transfer function dependent on the one or more unknown first impedance parameters. The process also comprises deriving a set of relations for the biopotential signal based on the transfer function of the first signal channel, the transfer function of the second signal channel, and outputs of the first and second signal channels. The set of relations is solved to determine the captured biopotential signal.

Abstract: The present invention relates to a method for increasing the activity and/or the yield of a recombinant vitamin K-dependent protein expressed in cell culture. The present invention further relates to uses and compositions of matter.

Abstract: Techniques and methods are disclosed for detecting long-form audio content in one or more audio files. A computing system receives first audio data corresponding to a first version of an audio file and second audio data corresponding to a second version of the audio file. The computing system generates a first transcript of the first audio data and a second transcript of the second audio data. The computing system compares the first audio data and the second audio data and the first transcript and the second transcript to identify advertisement portions and content portions of the audio data. Using a semantic model based on a machine learning (ML) transformer, the computing system can determine advertisement segments within the advertisement portions, the advertisement segments corresponding to separate advertisements. Information corresponding to the duration and location of the advertisement segments is stored in a data store of the computing system.

Abstract: Embodiments of the present invention provide an approach for applying cognitive diagnostic modeling (CDM) and deep learning algorithms to improve knowledge transfer (KT) progress. Specifically, the approach aims to improve the process of transferring knowledge by breaking down a learning task into smaller subtasks that are related to a specific learning goal. The provided responses for each subtask are then evaluated using a deep learning algorithm, which generates a continuous score based on the difference between the provided response and the expected response. Each continuous score is then converted into a binary value to obtain a set of binary values. Based on the set of binary values, a diagnostic report is generated that reflects the progress of knowledge transfer for the assigned learning task. This approach allows for a more detailed and accurate assessment of the learning process, which can help to identify areas where further improvement is needed.

Abstract: DNS request obfuscation includes generating decoy domain name system (DNS) requests for obfuscating DNS request activity being handled by a private DNS server for an organization, and sending the decoy DNS requests to external DNS server(s) for resolution, receiving a DNS request seeking a DNS lookup for a client device, obfuscating the DNS request by sending, to an external DNS server of the external DNS server(s), the DNS request interspersed with at least some of the generated decoy DNS requests sent to the external DNS server, receiving, from the external DNS server, a DNS response to the sent DNS request, and providing the DNS response to a source of the DNS request.

Abstract: In one embodiment the invention provides a process of capturing a biopotential signal at a surface of a body using a sensor receiver which forms a first signal connection the body wherein one or more parameters of impedance of the first signal connection are unknown. The process comprises receiving the biopotential signal at an output of a first signal channel having a first transfer function which is dependent on the one of more unknown first impedance parameters. The process also comprises receiving the biopotential signal at an output of a second signal channel having a second transfer function dependent on the one of more unknown first impedance parameters. The process also comprises deriving a set of relations for the biopotential signal.

Abstract: Techniques for privacy centric data security. A request to permit a data processor to access private data associated with a user is received at a cloud data privacy service. The request includes a request for a data access block relating to the private data, and a data filter describing one or more access parameters. The cloud privacy data service generates the first data access block, based on the private data and the data filter. The first data access block is transmitted from the cloud privacy service to a user device, which is configured to transmit the first data access block to the first data processor. The cloud data privacy service receives a request for the private data that includes the first data access block. The cloud data privacy service determines that the first data access block is valid, and grants the first data processor access to the private data.

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

Abstract: The present disclosure is drawn to loop-mediated isothermal amplification (LAMP) reaction assemblies including a substantially hygroscopic agent free LAMP reagent mixture in combination with a solid-phase reaction medium. The present disclosure also includes systems for a chromatic LAMP analysis including a substantially non-reactive solid phase reaction medium, and a non-interfering reagent mixture. The present disclosure also includes solid phase LAMP reaction mediums comprising a substrate, an adhesive layer disposed on the substrate, a reaction layer disposed on the adhesive layer, and a spreading layer disposed on the reaction layer. The present disclosure also includes methods of testing for a presence of a target nucleotide sequence including providing a biological sample, and dispensing the sample into a test environment having a solid phase reaction medium in combination with a LAMP reagent mixture and a pH sensitive dye.

Abstract: A liquid biological sample test cartridge is disclosed. The cartridge can include a tray. The cartridge can also include a chemical reaction pad supported by the tray. The cartridge can further include a chemical reaction pad cover disposed over the chemical reaction pad and coupled to the tray. The chemical reaction pad cover can have a sample opening to facilitate depositing a liquid biological sample at a predetermined location on the chemical reaction pad. In addition, the cartridge can include an outer cover operable to at least partially form an enclosure about the chemical reaction pad.

Abstract: A heating device for testing a biological sample is disclosed. The heating device can include a heat source operable to generate heat. In addition, the heating device can include a controller in communication with the heat source and operable to control heat generation by the heat source to heat a biological sample at less than or equal to about 2 degrees C./s. Furthermore, a heating device for testing a biological sample is disclosed that can include a heat source operable to generate heat to heat a biological sample. The biological sample can be at least partially contained within a removable enclosure distinct from the heating device. Additionally, the heating device can include an enclosure interface associated with the heat source. The enclosure interface can be configured to interface with the enclosure such that heat is transferred from the heat source to the enclosure by conduction.

Abstract: In one embodiment the invention provides a process of capturing a biopotential signal at a surface of a body using a sensor receiver which forms a first signal connection the body wherein one or more parameters of impedance of the first signal connection are unknown. The process comprises receiving the biopotential signal at an output of a first signal channel having a first transfer function which is dependent on the one of more unknown first impedance parameters. The process also comprises receiving the biopotential signal at an output of a second signal channel having a second transfer function dependent on the one of more unknown first impedance parameters. The process also comprises deriving a set of relations for the biopotential signal.

Abstract: Optimizing containerized applications includes receiving managed runtime code, creating a first container within a managed runtime environment, and executing the managed runtime code in the first container within the managed runtime environment. Responsive to a determination that the managed runtime environment has performed at least one optimization of the managed runtime code to create optimized managed runtime code during a first lifetime of the managed runtime environment, the first container is checkpointed into a first memory image to create a first checkpointed container including the optimized managed runtime code. The first checkpointed container is stored.

Abstract: Techniques for privacy centric data security. A request to permit a data processor to access private data associated with a user is received at a cloud data privacy service. The request includes a request for a data access block relating to the private data, and a data filter describing one or more access parameters. The cloud privacy data service generates the first data access block, based on the private data and the data filter. The first data access block is transmitted from the cloud privacy service to a user device, which is configured to transmit the first data access block to the first data processor. The cloud data privacy service receives a request for the private data that includes the first data access block. The cloud data privacy service determines that the first data access block is valid, and grants the first data processor access to the private data.

Abstract: Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite.

Abstract: Embodiments of the present disclosure include techniques for generating accurate time stamps. In one embodiment, a first timing reference signal corresponding to a first clock domain is combined with a first clock signal corresponding to a second clock domain to produce a second timing reference signal that includes quantization noise. The second timing reference signal is filtered to remove the quantization noise and generate a filtered timing reference signal. The filtered timing reference signal may be sampled in the second clock domain to obtain a time stamp. In one embodiment, a phase locked loop (PLL) is used as the filter. The PLL may generate first and second ramps that correspond to time. One of the ramps may be sampled to obtain a time stamp, for example.

Abstract: An approach is provided in which the approach uses a scrolling agent to detect when a browser application requests a set of content from a content provider in response to the browser application receiving a request from a user. The scrolling agent issues a number of browser scroll commands to the browser application and receives sets of next content from the content provider accordingly. The approach searches the sets of next content based on a request invoked by the user and generates a set of search results that the approach provides to the user.

Abstract: An approach is provided in which the approach uses a scrolling agent to detect when a browser application requests a set of content from a content provider in response to the browser application receiving a request from a user. The scrolling agent issues a number of browser scroll commands to the browser application and receives sets of next content from the content provider accordingly. The approach searches the sets of next content based on a request invoked by the user and generates a set of search results that the approach provides to the user.