Abstract: A perforation tool for use in a well bore is described herein. The perforation tool comprises a housing; a plurality of frames that fit inside the housing, each frame having a cylindrical shape with a central axis and a plurality of liners, each liner having an axis perpendicular to the central axis, wherein the axes of the liners of each frame are disposed in a plane perpendicular to the central axis, and the frames are axially stackable; an electrical conductor disposed along a central passage of each frame; a plurality of shaped charges secured in the liners of the frames; a bulkhead member disposed in the housing and forming a seal with the housing; and an initiator module disposed in the housing with the bulkhead member between the initiator module and the plurality of frames.

Abstract: A client application is specified by a target tenant and represented in an OAuth provider, along with a corresponding secret. A source tenant consents to permissions to be executed by the client application on a resource of the source tenant. A target service uses the secret to obtain an access token from an authorization server coupled to the source tenant and uses the access token to obtain access, specified by the permissions, to the resource served by a source service acting on behalf of the source tenant.

Abstract: The present disclosure is drawn to loop-mediated isothermal amplification (LAMP) reaction assemblies including a substantially hygroscopic agent free LAMP reagent mixture in combination with a solid-phase reaction medium. The present disclosure also includes systems for a chromatic LAMP analysis including a substantially non-reactive solid phase reaction medium, and a non-interfering reagent mixture. The present disclosure also includes solid phase LAMP reaction mediums comprising a substrate, an adhesive layer disposed on the substrate, a reaction layer disposed on the adhesive layer, and a spreading layer disposed on the reaction layer. The present disclosure also includes methods of testing for a presence of a target nucleotide sequence including providing a biological sample, and dispensing the sample into a test environment having a solid phase reaction medium in combination with a LAMP reagent mixture and a pH sensitive dye.

Abstract: A liquid biological sample test cartridge is disclosed. The cartridge can include a tray. The cartridge can also include a chemical reaction pad supported by the tray. The cartridge can further include a chemical reaction pad cover disposed over the chemical reaction pad and coupled to the tray. The chemical reaction pad cover can have a sample opening to facilitate depositing a liquid biological sample at a predetermined location on the chemical reaction pad. In addition, the cartridge can include an outer cover operable to at least partially form an enclosure about the chemical reaction pad.

Abstract: A heating device for testing a biological sample is disclosed. The heating device can include a heat source operable to generate heat. In addition, the heating device can include a controller in communication with the heat source and operable to control heat generation by the heat source to heat a biological sample at less than or equal to about 2 degrees C./s. Furthermore, a heating device for testing a biological sample is disclosed that can include a heat source operable to generate heat to heat a biological sample. The biological sample can be at least partially contained within a removable enclosure distinct from the heating device. Additionally, the heating device can include an enclosure interface associated with the heat source. The enclosure interface can be configured to interface with the enclosure such that heat is transferred from the heat source to the enclosure by conduction.

Abstract: In one embodiment the invention provides a process of capturing a biopotential signal at a surface of a body using a sensor receiver which forms a first signal connection the body wherein one or more parameters of impedance of the first signal connection are unknown. The process comprises receiving the biopotential signal at an output of a first signal channel having a first transfer function which is dependent on the one of more unknown first impedance parameters. The process also comprises receiving the biopotential signal at an output of a second signal channel having a second transfer function dependent on the one of more unknown first impedance parameters. The process also comprises deriving a set of relations for the biopotential signal.

Abstract: Embodiments of the present disclosure include techniques for generating accurate time stamps. In one embodiment, a first timing reference signal corresponding to a first clock domain is combined with a first clock signal corresponding to a second clock domain to produce a second timing reference signal that includes quantization noise. The second timing reference signal is filtered to remove the quantization noise and generate a filtered timing reference signal. The filtered timing reference signal may be sampled in the second clock domain to obtain a time stamp. In one embodiment, a phase locked loop (PLL) is used as the filter. The PLL may generate first and second ramps that correspond to time. One of the ramps may be sampled to obtain a time stamp, for example.

Abstract: Embodiments of the present disclosure include techniques for generating accurate time stamps. In one embodiment, a first timing reference signal corresponding to a first clock domain is combined with a first clock signal corresponding to a second clock domain to produce a second timing reference signal that includes quantization noise. The second timing reference signal is filtered to remove the quantization noise and generate a filtered timing reference signal. The filtered timing reference signal may be sampled in the second clock domain to obtain a time stamp. In one embodiment, a phase locked loop (PLL) is used as the filter. The PLL may generate first and second ramps that correspond to time. One of the ramps may be sampled to obtain a time stamp, for example.

Abstract: A central arterial blood pressure waveform is developed from pressure waveforms obtained from proximal and distal blood pressure cuffs on the brachial artery of an arm that are inflated to a supra-systolic pressure. The proximal and distal cuff pressure waveforms associated with at least one cardiac ejection cycle are sensed. The propagation times of a blood pressure pulse from the entry of the artery to the proximal cuff and from the proximal cuff to the distal cuff are calculated, permitting calculation of a reflection coefficient of the pressure pulse at one of the proximal and distal cuffs. Assuming a physical model of wave propagation along the artery between the aorta and the proximal and distal cuffs, an estimated pressure waveform at the opening of the artery can be determined.

Abstract: A central arterial blood pressure waveform is developed from pressure waveforms obtained from proximal and distal blood pressure cuffs on the brachial artery of an arm that are inflated to a supra-systolic pressure. The proximal and distal cuff pressure waveforms associated with at least one cardiac ejection cycle are sensed. The propagation times of a blood pressure pulse from the entry of the artery to the proximal cuff and from the proximal cuff to the distal cuff are calculated, permitting calculation of a reflection coefficient of the pressure pulse at one of the proximal and distal cuffs. Assuming a physical model of wave propagation along the artery between the aorta and the proximal and distal cuffs, an estimated pressure waveform at the opening of the artery can be determined.

Abstract: A central arterial blood pressure waveform is developed from pressure waveforms obtained from proximal and distal blood pressure cuffs on the brachial artery of an arm that are inflated to a supra-systolic pressure, The proximal and distal cuff pressure waveforms associated with at least one cardiac ejection cycle are sensed, The propagation times of a blood pressure pulse from the entry of the artery to the proximal cuff and from the proximal cuff to the distal cuff are calculated, permitting calculation of a reflection coefficient of the pressure pulse at one of the proximal and distal cuffs. Assuming a physical model of wave propagation along the artery between the aorta and the proximal and distal cuffs, an estimated pressure waveform at the opening of the artery can be determined.

Abstract: A physics-based mathematical model is used to estimate central pressure waveforms from measurements of a brachial pressure waveform measured using a supra-systolic cuff. The method has been tested in numerous subjects undergoing cardiac catheterisation. Central pressure agreement was within 11 mm Hg and as good as the published non-invasive blood pressure agreement between the oscillometric device in use and the so-called “gold standard.” It also exceeds international standards for the performance of non-invasive blood pressure measurement devices. The method has a number of advantages including simplicity of application, fast calculation and accuracy of prediction. Additionally, model parameters have physical meaning and can therefore be tuned to individual subjects. Accurate estimation of central waveforms also allow continuous measurement (with intermittent calibration) using other non-invasive sensing systems including photoplethysmography.

Abstract: A method and apparatus determine certain cardiac medical parameters that are useful is diagnosing cardiovascular disease. The apparatus is designed to carry out the method, which includes the steps of: (a) inflating a blood pressure cuff on the brachial artery to a supra-systolic pressure; (b) sensing a sequence of pressure pulse waveforms associated with the brachial artery that result from a plurality of cardiac ejection cycles; (c) averaging the waveforms to produce an average, representative waveform having an initial, incident wave portion and a reflected wave portion; (d) analyzing the representative waveform to determine a value of one or more cardiac medical parameters including the reflection wave ratio (RWR), the reflected wave transit time (RWTT), the maximum amplitude of the initial pressure wave (PS1), the maximum rise (slope) of the initial pressure wave (dp/dt), and/or the systolic ejection period (SEP); and (e) displaying the value of the medical parameter(s).

Abstract: A reaching device that in one embodiment comprises an elongated member, a jaw, and an actuator for opening and closing the jaw. The jaw includes a pair of holding members, one of which has a tapered lateral side edge. In one embodiment, the reaching device may allow a rural mail carrier to remain seated in the driver's side of a conventional (North American) vehicle, reach through the passenger's window, and perform the following tasks: open a mail box, retrieve mail from the mail box, place mail into the mail box, close the mail box, and raise or lower the indicator flag on the side of the mail box.

Abstract: There is provided a reaching device particularly suitable for rural mail delivery. In one embodiment, the reaching device comprises an elongated member, a jaw, and an actuator for opening and closing the jaw. The jaw includes a pair of holding members, one of which has a tapered lateral side edge. In an illustrated embodiment, a reaching device is provided that allows a rural mail carrier to remain seated in the driver's side of a conventional (North American) vehicle, reach through the passenger's window, and perform the following tasks: open a mail box, retrieve mail from the mail box, place mail into the mail box, close the mail box, and raise or lower the indicator flag on the side of the mail box.

Abstract: Iceberg Reclamation industry invention provides an economical method of adapting offshore marine structures for arctic waters into fresh water production plants. The key condition of the invention is that icebergs are not towed or transported, instead the processing plant systematically breaks down icebergs and processes the ice pieces, melts the ice, and enables the transport of fresh water to arid climates and other areas in need of water reserves augmentation. The invention also claims that by decreasing the ice melt into oceans from icebergs this method acts as a sea level rise countermeasure. The method can also be used to clean oceans of floating debris and process the waste economically.

Abstract: In a scanning microscope, slides are fed automatically from a magazine to the imaging system. Each slide is labeled in some fashion with information for selecting the appropriate modality of operation of the scanner for that slide and the modality is implemented automatically. The information is preferably tied to and defined by a laboratory information system (LIS). For example, the instructions may regard the type of microscopy (i.e., trans- or epi-illumination), multi-spectral imaging with particular spectral bands combined with a particular set of z-positions, alternative filters, settings for the numerical aperture of the condenser, alternative detector operation for different resolutions, and alternative post-scan analyses of the data, as deemed optimal for the scan. The label may also contain the slide's identity, a pathologist's name, desired post-scan handling protocol, etc. The preferred array microscope to carry out the invention is also described.

Abstract: A method for estimating an intra-arterial blood pressure waveform, from pressure waveforms obtained from a blood pressure cuff, comprises the steps of: a. inflating a blood pressure cuff on a brachial artery of an arm to a pressure at least as great as the diastolic pressure; b. holding the molar amount of fluid in the blood pressure cuff constant; c. sensing a sequence of cuff pressure waveforms associated with the brachial artery that result from at least one cardiac ejection cycle; and cc.

Abstract: A method and apparatus are disclosed for determining certain cardiac medical parameters that are useful is diagnosing and treating cardiovascular disease.