Abstract: An approach is provided in which the approach uses a scrolling agent to detect when a browser application requests a set of content from a content provider in response to the browser application receiving a request from a user. The scrolling agent issues a number of browser scroll commands to the browser application and receives sets of next content from the content provider accordingly. The approach searches the sets of next content based on a request invoked by the user and generates a set of search results that the approach provides to the user.

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

Abstract: Embodiments of the present disclosure include techniques for generating accurate time stamps. In one embodiment, a first timing reference signal corresponding to a first clock domain is combined with a first clock signal corresponding to a second clock domain to produce a second timing reference signal that includes quantization noise. The second timing reference signal is filtered to remove the quantization noise and generate a filtered timing reference signal. The filtered timing reference signal may be sampled in the second clock domain to obtain a time stamp. In one embodiment, a phase locked loop (PLL) is used as the filter. The PLL may generate first and second ramps that correspond to time. One of the ramps may be sampled to obtain a time stamp, for example.

Abstract: Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite.

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

Abstract: Optimizing containerized applications includes receiving managed runtime code, creating a first container within a managed runtime environment, and executing the managed runtime code in the first container within the managed runtime environment. Responsive to a determination that the managed runtime environment has performed at least one optimization of the managed runtime code to create optimized managed runtime code during a first lifetime of the managed runtime environment, the first container is checkpointed into a first memory image to create a first checkpointed container including the optimized managed runtime code. The first checkpointed container is stored.

Abstract: Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive, from a sub domain registration settings control panel displayed on a client computer, a profit to be paid to a registrant if a sub domain associated with the domain name is registered, and store the profit to be paid in a database. The server(s) may also render a sub domain registration control panel and receive: a sub domain registration request; and an IP address directing HTTP requests to the sub domain and automatically insert the IP address into an A record or NS record in a zone file for the domain. The server(s) may then select the profit to be paid from the database and update a registrant user profile to include the profit to be paid.

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

Abstract: Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive, from a sub domain registration settings control panel displayed on a client computer, form elements to be displayed on a sub domain settings control panel, and store these form elements in a database. The server(s) may then display an HTML form on the sub domain settings control panel, where each HTML for element corresponds to a database record defining features for updating an email, tertiary domain or record modification to a zone file for a registered sub domain.

Abstract: The present invention relates to a method for increasing the activity and/or the yield of a recombinant vitamin K-dependent protein expressed in cell culture. The present invention further relates to uses and compositions of matter.

Abstract: Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive, from a sub domain registration settings control panel displayed on a client computer, form elements to be displayed on a sub domain settings control panel, and store these form elements in a database. The server(s) may then display an HTML form on the sub domain settings control panel, where each HTML for element corresponds to a database record defining features for updating an email, tertiary domain or record modification to a zone file for a registered sub domain.

Abstract: Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive, from a sub domain registration settings control panel displayed on a client computer, rule or prerequisites required for a sub domain registrant to register a sub domain, and store these rules or prerequisites in a database. The server(s) may then receive: a sub domain registration request, an IP address directing HTTP requests to the sub domain; and an authentication verifying that the prerequisite has been fulfilled. If authenticated, the server(s) may automatically insert the IP address into an A record or NS record in a zone file for the domain.

Abstract: Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive, from a sub domain registration settings control panel displayed on a client computer, rule or prerequisites required for a sub domain registrant to register a sub domain, and store these rules or prerequisites in a database. The server(s) may then receive: a sub domain registration request, an IP address directing HTTP requests to the sub domain; and an authentication verifying that the prerequisite has been fulfilled. If authenticated, the server(s) may automatically insert the IP address into an A record or NS record in a zone file for the domain.

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

Abstract: A turbine inlet includes an annular housing and a main inlet port, a steam outlet, and a flow diversion port in the annular housing. A center axis of flow from the flow diversion port avoids intersecting a center axis of the steam outlet. A turbine system includes a turbine inlet, a fluid supply, and a flow diversion supply conduit. The turbine inlet has an annular housing including a main inlet port therein, a steam outlet therein, and a flow diversion port therein. The flow diversion supply conduit couples the fluid supply to the flow diversion port. A method of retrofitting a turbine inlet in a turbine system comprises opening a flow diversion port through an annular housing of a turbine inlet, connecting a flow diversion supply conduit to the flow diversion port, and connecting the flow diversion supply conduit to the fluid supply.

Abstract: Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive, from a sub domain registration settings control panel displayed on a client computer, a profit to be paid to a registrant if a sub domain associated with the domain name is registered, and store the profit to be paid in a database. The server(s) may also render a sub domain registration control panel and receive: a sub domain registration request; and an IP address directing HTTP requests to the sub domain and automatically insert the IP address into an A record or NS record in a zone file for the domain. The server(s) may then select the profit to be paid from the database and update a registrant user profile to include the profit to be paid.

Abstract: Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive, from a sub domain registration settings control panel displayed on a client computer, form elements to be displayed on a sub domain settings control panel, and store these form elements in a database. The server(s) may then display an HTML form on the sub domain settings control panel, where each HTML for element corresponds to a database record defining features for updating an email, tertiary domain or record modification to a zone file for a registered sub domain.

Abstract: Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive, from a sub domain registration settings control panel displayed on a client computer, rule or prerequisites required for a sub domain registrant to register a sub domain, and store these rules or prerequisites in a database. The server(s) may then receive: a sub domain registration request, an IP address directing HTTP requests to the sub domain; and an authentication verifying that the prerequisite has been fulfilled. If authenticated, the server(s) may automatically insert the IP address into an A record or NS record in a zone file for the domain.

Abstract: A central arterial blood pressure waveform is developed from pressure waveforms obtained from proximal and distal blood pressure cuffs on the brachial artery of an arm that are inflated to a supra-systolic pressure. The proximal and distal cuff pressure waveforms associated with at least one cardiac ejection cycle are sensed. The propagation times of a blood pressure pulse from the entry of the artery to the proximal cuff and from the proximal cuff to the distal cuff are calculated, permitting calculation of a reflection coefficient of the pressure pulse at one of the proximal and distal cuffs. Assuming a physical model of wave propagation along the artery between the aorta and the proximal and distal cuffs, an estimated pressure waveform at the opening of the artery can be determined.