Abstract: Methods for making, identifying, isolating and/or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.

Abstract: Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

Abstract: Disclosed herein are non-human animals (e.g., rodents, e.g., mice or rats) genetically engineered to express a humanized or human T cell receptor (TCR) comprising a variable domain encoded by (a) at least one human TCR variable region ? gene segment and a (human) TCR ? constant region gene sequence and/or (b) or at least one human TCR variable region ? gene segment and a (human) TCR ? constant region gene sequence. Also provided are embryos, tissues, and cells expressing the same. Methods for making a genetically engineered animal that expresses the humanized or human ? and/or ? TCR are also provided. Methods for using the genetically engineered animals that mount a substantially humanized T cell immune response for developing human therapeutics are also provided.

Abstract: Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end sequences having complementarity and subsequently assembling the overlapping complementary sequences. The nuclease agent (e.g., a gRNA-Cas complex) can create double strand breaks in dsDNA in order to create overlapping end sequences or can create nicks on each strand to produce complementary overhanging end sequences. Assembly using the method described herein can assemble any nucleic acids having overlapping sequences or can use a joiner oligo to assemble sequences without complementary ends.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind to human artemin. Methods for using anti-artemin antibodies and antigen-binding fragments are also provided.

Abstract: Provided herein are methods and compositions related to mice that express human or humanized Foot receptors (FcaR) from an FcaR locus positioned in the mouse leukocyte receptor complex (LRC). In certain embodiments, such mice are useful for in vivo testing of therapeutic agents comprising a human IgA Fc (e.g., the testing of the pharmacokinetic and/or pharmacodynamic properties of such therapeutic agents and dosing regimens). Also provided herein are methods of using such mice, cells from such mice, methods of making such mice, and ES cells comprising the same genetic modifications as such mice. Provided herein are methods and compositions related to mice that express human or humanized Foot receptors (FcaR) from an FcaR locus positioned in the mouse leukocyte receptor complex (LRC). In certain embodiments, such mice are useful for in vivo testing of therapeutic agents comprising a human IgA Fc (e.g.

Abstract: Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Abstract: Secure peer-to-peer connection network and/or protocols for a group-based communication system, in which, a peer-to-peer connection request associated with a first identifier for a first client device and a second identifier for a second client device are received. The first identifier and the second identifier are compared to a group-based communication system validation registry associated with the group-based communication system and, based at least in part on a determination that the peer-to-peer connection request is authorized per the group-based communication system validation registry, a peer-to-peer connection between the second client device and the first client device is established.

Abstract: A method for by an asset tracking system is provided. An example method includes receiving a first plurality of data messages from an asset coupled to the asset tracking system and attempting to identify an asset type fingerprint based on the first plurality of messages. In response to failing to identify an asset type fingerprint based on the first plurality of messages, the example method further includes requesting a determined asset type fingerprint for the asset from an asset data analysis system, providing access to the first plurality of data messages to the asset data analysis system, receiving the determined asset type fingerprint for the asset from the asset data analysis system, and obtaining asset information from the asset by decoding a second plurality of data messages received from the asset in accordance with a set of signal definitions linked to the determined asset type fingerprint.

Abstract: Agnostic domain communication via a user interface of a communication platform is described. A user interface associated with the communication platform can be presented via a client, wherein an instance of a first workspace of the communication platform that is associated with a first domain is presented via the user interface. A request to access a second workspace of the communication platform that is associated with a second domain that is different from the first domain can be received. Based at least partly on a determination that the request is associated with an attribute that satisfies a criteria, an instance of the second workspace can be presented via the user interface.

Abstract: A method for an asset tracking system is provided. An example method includes receiving data messages from an asset coupled to the asset tracking system and attempting to obtain asset information from data messages with reference to a local set of signal definitions indicating how data messages received from the asset are to be decoded into asset information. Upon failing to obtain the asset information the asset tracking system requests from an asset data analysis system the generation of a generated signal definition indicating how the data message of the outstanding type is to be obtained from the asset. The asset tracking system provides access to at least one undecoded data message of the outstanding data type to the asset data analysis system, receives the generated signal definition from the asset data analysis system, and adds the generated signal definition to the local set of signal definitions.

Abstract: Agnostic domain communication via a user interface of a communication platform is described. A user interface associated with the communication platform can be presented via a client, wherein an instance of a first workspace of the communication platform that is associated with a first domain is presented via the user interface. A request to access a second workspace of the communication platform that is associated with a second domain that is different from the first domain can be received. Based at least partly on a determination that the request is associated with an attribute that satisfies a criteria, an instance of the second workspace can be presented via the user interface.

Abstract: A method for by an asset tracking system is provided. An example method includes receiving data messages from an asset coupled to the asset tracking system and attempting to obtain asset information from data messages with reference to a local set of signal definitions indicating how data messages received from the asset are to be decoded into asset information. Upon failing to obtain the asset information the asset tracking system requests from an asset data analysis system the generation of a generated signal definition indicating how the data message of the outstanding type is to be obtained from the asset. The asset tracking system provides access to at least one undecoded data message of the outstanding data type to the asset data analysis system, receives the generated signal definition from the asset data analysis system, and adds the generated signal definition to the local set of signal definitions.

Abstract: A method for by an asset tracking system is provided. An example method includes receiving a first plurality of data messages from an asset coupled to the asset tracking system and attempting to identify an asset type fingerprint based on the first plurality of messages. In response to failing to identify an asset type fingerprint based on the first plurality of messages, the example method further includes requesting a determined asset type fingerprint for the asset from an asset data analysis system, providing access to the first plurality of data messages to the asset data analysis system, receiving the determined asset type fingerprint for the asset from the asset data analysis system, and obtaining asset information from the asset by decoding a second plurality of data messages received from the asset in accordance with a set of signal definitions linked to the determined asset type fingerprint.

Abstract: Example systems, methods, and instructions to be executed by a processor for the animation of realistic facial performances of avatars are provided. Such an example system includes a memory to store a facial gesture model of a subject head derived from a photogrammetric scan of the subject head, and a video of a face of the subject head delivering a facial performance. The system further includes a processor to generate a dynamic texture map that combines the video of the face of the subject head delivering the facial performance with a static portion of the facial gesture model of the subject head, apply the dynamic texture map to the facial gesture model, and animate the facial gesture model of the subject head to emulate the facial performance.

Abstract: Methods for asset type fingerprinting are provided. An example method involves an asset tracking system failing to identify an asset type fingerprint and requesting an asset type fingerprint from an asset data analysis system. The asset data analysis system generates a proposed asset type fingerprint, links the asset type fingerprint to a set of signal definitions that indicate how to decode data messages from the asset. The asset data analysis system transmits the proposed asset type fingerprint to the asset data analysis system, which then decodes at least some data messages from the asset thus obtaining asset information. The method may be used to identify vehicle types and decode proprietary or non-standard data messages via a vehicle's diagnostic port.

Abstract: Techniques are described for performing intelligence on supply chains used by organizations. A system performs a risk assessment of a labor supply chain of a particular organization by accessing, from a database, a first set of coded confidential labor supply chain data for the particular organization and a second set of coded confidential labor supply chain data for other organizations that are different from the particular organization. The system analyzes a combination of the first set of data and the second set of data to assess whether risks exist within the labor supply chain of the particular organization. Based on the analysis, the system generates a risk report for the labor supply chain data of the particular organization by desensitizing at least a portion of the second set of data for inclusion in the risk report and integrating the desensitized portion of the second set of data with confidential labor supply chain data of the particular organization.

Abstract: Example systems, methods, and instructions to be executed by a processor for the animation of realistic facial performances of avatars are provided. Such an example system includes a memory to store a facial gesture model of a subject head derived from a photogrammetric scan of the subject head, and a video of a face of the subject head delivering a facial performance. The system further includes a processor to generate a dynamic texture map that combines the video of the face of the subject head delivering the facial performance with a static portion of the facial gesture model of the subject head, apply the dynamic texture map to the facial gesture model, and animate the facial gesture model of the subject head to emulate the facial performance.

Abstract: A retainer system, device and method are provided for retaining a severed pipe string such as a landing string suspended from a rig of a floating vessel or platform during a failure of a primary or secondary heave compensation system and prevent the severed pipe string from flying over the rig floor. The retainer system includes a retainer device including a housing mounted to a platform or vessel, the housing defining a through bore for receiving a pipe string suspended from the platform or vessel. A safety sleeve extends through the housing. A stop arrangement is mountable on the pipe string, to permit engagement between the safety sleeve and the stop arrangement in order to limit relative movement between the housing and the pipe string in order to retain a severed pipe string in an emergency situation.

Abstract: Secure peer-to-peer connection network and/or protocols for a group-based communication system are described. In an example, a peer-to-peer connection request associated with a first identifier for a first client device and a second identifier for a second client device can be received. The first identifier and the second identifier can be compared to a group-based communication system validation registry associated with the group-based communication system and, based at least in part on a determination that the peer-to-peer connection request is authorized per the group-based communication system validation registry, a peer-to-peer connection between the second client device and the first client device can be established.