Abstract: A order matching system which allows users to define and modify buy/sell order schedules for execution within one or more transaction destinations. The system uses order schedules and associated evaluation heuristics to evaluate and update order characteristics such as price and quantity based on user-specified criteria. The matching system comprises a user interface which can be connected over the internet to various transaction destinations through a schedule manager and a transaction order interface. The user interface provides users with the ability to obtain information concerning the status of their order account as well as the ability to enter or modify their order schedules. The order manager uses a schedule supervisor server to maintain a database containing order schedules and order status information and to execute variable evaluations on the basis of these order schedules and associated evaluation heuristics.

Abstract: A tradable security comprising a voting right associated with an underlying financial security and an instrument for permitting at least said voting right to be separated from at least some residual rights in the underlying financial security to create a voting right security wherein the ownership and control of the voting right security is tradable separate from the residual rights in the underlying security to permit a value of said voting right security to be established in an open market. In another aspect the invention is directed to a method of creating such a voting right security. In another aspect the invention is directed to a method of clearing and setting trades of the voting right security. In another aspect the invention is directed to a method of creating an index from the voting right security.

Abstract: A method of delivering electrical energy to a point in an electrical power grid, the method including the steps of accessing a source of energy at a first location and converting the energy into a form of transportable energy. The next step is transporting the transportable energy via a bulk transportation network from the first location to the point on said electrical power grid at a second location having a need for additional electrical power without the transportable energy going through the electrical power grid to get to the point. The next step is converting the form of transportable energy into electrical energy suitable for connecting to the power grid and discharging the electrical energy into the power grid at the second location. A system for delivering electrical energy is also provided. The transportable energy preferably takes the form of charged electrolytes, compressed air or thermal storage units, transported, for example, by way of trains.

Abstract: The present invention provides compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells.

Abstract: A order matching system which allows users to define and modify buy/sell order schedules for execution within one or more transaction destinations. The system uses order schedules and associated evaluation heuristics to evaluate and update order characteristics such as price and quantity based on user-specified criteria. The matching system comprises a user interface which can be connected over the internet to various transaction destinations through a schedule manager and a transaction order interface. The user interface provides users with the ability to obtain information concerning the status of their order account as well as the ability to enter or modify their order schedules. The order manager uses a schedule supervisor server to maintain a database containing order schedules and order status information and to execute variable evaluations on the basis of these order schedules and associated evaluation heuristics.

Abstract: The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome.

Abstract: The present invention provides compositions useful for treating and preventing ryanodine receptor associated disorders comprising a PDE-associated agent and a pharmaceutically acceptable carrier. The present invention also provides methods for treating or preventing ryanodine receptor associated disorders including cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases malignant hyperthermia, diabetes and sudden infant death syndrome. The present invention further provides methods for regulating PKA phosphorylation of a ryanodine receptor as well as methods for regulating Ca+2 release and reuptake in cells. Also provided are kits for use in delivering a PDE-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter.

Abstract: A order matching system which allows users to define and modify buy/sell order schedules for execution within one or more transaction destinations. The system uses order schedules and associated evaluation heuristics to evaluate and update order characteristics such as price and quantity based on user-specified criteria. The matching system comprises a user interface which can be connected over the internet to various transaction destinations through a schedule manager and a transaction order interface. The user interface provides users with the ability to obtain information concerning the status of their order account as well as the ability to enter or modify their order schedules. The order manager uses a schedule supervisor server to maintain a database containing order schedules and order status information and to execute variable evaluations on the basis of these order schedules and associated evaluation heuristics.

Abstract: The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of Formula I. The invention additionally provides pharmaceutical compositions comprising the compounds of Formula I and methods of using the pharmaceutical compositions of Formula I to treat and prevent disorders and diseases associated with the RyR receptors that regulate calcium channel functioning in cells. Such disorders and diseases include, by way of example only, cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases, malignant hyperthermia, diabetes, and sudden infant death syndrome.

Abstract: The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac death in a subject. Additionally, the present invention provides use of JTV-519 in a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject who has, or is a candidate for, atrial fibrillation. Also provided are uses of 1,4-benzothiazepine derivatives in methods for treating and preventing atrial and ventricular cardiac arrhythmias and heart failure in a subject, and for preventing exercise-induced sudden cardiac death. The present invention also provides methods for identifying agents for use in treating and preventing atrial fibrillation and heart failure, and agents identified by these methods.

Abstract: The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level of RyR2-bound FKBPl2.6 in a subject; to prevent exercise-induced sudden cardiac death in a subject; and to treat or prevent heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmia in a subject. The present invention further provides methods for identifying an agent that enhances binding of RyR2 and FKBP12.6, and agents identified by these methods. Additionally, the present invention provides methods for identifying agents for use in treating or preventing heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmia, and in preventing exercise-induced sudden cardiac death. Also provided are agents identified by such methods.

Abstract: A order matching system which allows users to define and modify buy/sell order schedules for execution within one or more transaction destinations. The system uses order schedules and associated evaluation heuristics to evaluate and update order characteristics such as price and quantity based on user-specified criteria. The matching system comprises a user interface which can be connected over the internet to various transaction destinations through a schedule manager and a transaction order interface. The user interface provides users with the ability to obtain information concerning the status of their order account as well as the ability to enter or modify their order schedules. The order manager uses a schedule supervisor server to maintain a database containing order schedules and order status information and to execute variable evaluations on the basis of these order schedules and associated evaluation heuristics.