Abstract: The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention relates to a drive system, in particular a downhole drilling assembly (10). In the preferred embodiment, a bearing mechanism (14,24) of the assembly (10) is isolated from a gear mechanism (20) of the assembly (10), to prevent failure of the bearing mechanism (14, 24) due to vibration and heat generated by the gear mechanism (20) in use. A lower bearing unit (24) of the bearing mechanism (24) is coupled to the gear mechanism (20) by a shock eliminating coupling assembly (22), which prevents the transmission of shock loads to the gear mechanism (20). Also, the gear mechanism (20) is coupled through a shock eliminating coupling assembly (18) to a turbine (16) and thus to an upper bearing unit (14). Sealing assemblies (60, 116) are provided for the gear mechanism (20) and the upper bearing unit (14) to prevent drilling fluid ingress and consequent damage. The assembly (10) may also carry a torsionally flexible drive shaft (46).

Abstract: The invention relates to a drive system, in particular a downhole drilling assembly (10). In the preferred embodiment, a bearing mechanism (14, 24) of the assembly (10) is isolated from a gear mechanism (20) of the assembly (10), to prevent failure of the bearing mechanism (14, 24) due to vibration and heat generated by the gear mechanism (20) in use. A lower bearing unit (24) of the bearing mechanism (24) is coupled to the gear mechanism (20) by a shock eliminating coupling assembly (22), which prevents the transmission of shock loads to the gear mechanism (20). Also, the gear mechanism (20) is coupled through a shock eliminating coupling assembly (18) to a turbine (16) and thus to an upper bearing unit (14). Sealing assemblies (60, 116) are provided for the gear mechanism (20) and the upper bearing unit (14) to prevent drilling fluid ingress and consequent damage. The assembly (10) may also carry a torsionally flexible drive shaft (46).

Abstract: Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: A downhole tool including a selectively releasable joint, a downhole drilling assembly including the downhole tool, and a corresponding method. In one embodiment of the invention, a downhole drilling assembly includes a downhole tool having a first body and a second body mounted for relative rotation; a joint part for use in forming a selectively releasable joint between the second body and a part of the assembly coupled to the second body; and one or more locking member(s) for locking the first and second bodies relative to one another against relative rotation so as to allow a release force to be applied through the first body to release the releasable joint and allow the tool to be separated from the part of the assembly.

Abstract: A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophbic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.

Abstract: A compound is provided, having the general structure (A): wherein A is an (un)substituted aryl or (un)substituted heteroaryl moiety, G is N, CH, or CR, R is an unsubstituted or substituted lower alkyl, Y is a hydrophobic linking moiety, and L is a substitutent as defined. The compound (A) can be used for treatment of various angiogenic and hematological-associated disorders, such as myeloproliferative disorder in patients who do not respond to kinase-inhibition therapy that comprises administering approved medications.

Abstract: This invention provides a reduced-fat flat bread. More specifically, the present invention relates to a reduced-fat flat bread, wherein a reduction of trans-fat containing hard fat chips is accomplished by partial replacement with starch-based particulate fat mimetics. In one embodiment, a reduced-fat flat bread is prepared from a dough comprising, in baker's percentages, about 100% flour, about 0.5% to about 15% sugar, about 5% to about 10% corn meal, about 0.5% to about 4% salt, about 50% to about 65% water, about 2% to about 10% soybean oil, about 0% to about 2% hard fat chips, an effective amount of a starch-based particulate fat mimetic to reduce the hard fat content of the reduced-fat flat bread by at least about 25%, about 0.5% to about 4% compressed yeast, an effective amount of a texturizing agent to provide tenderness to the crumb grain and crispiness to the surface of the reduced-fat flat bread, about 0.1% to about 0.8% of a flavoring agent, and about 0.2% to about 0.

Abstract: A turbine is disclosed which includes a turbine blade housing having an inner facing portion of a first material having a first coefficient of expansion, and a turbine blade body having an outer facing portion of a second coefficient of expansion greater than said first coefficient. In a preferred embodiment, the blade housing comprises a number of steel shroud rings and the turbine blade body comprises a number of stators and rotors of a thermoplastic material. An interference fit between stator blades and the shroud rings is enhanced in use due to the difference in thermal and/or hydrophilic coefficients of expansion of the first and second materials.

Abstract: Methods for providing cooked rice with enhanced levels of fiber, wherein the fiber-containing cooked rice is suitable and especially adapted for use in preparing fiber-containing rice-based cereal products and especially for preparing fiber-containing puffed rice-based cereal products, are provided.

Abstract: A process for grinding edible seeds, such as grain and/or pulses, in a single unit operation in a continuous, short-duration controlled-temperature manner. Grinding may be effected without the need for moving mechanical parts. The granulated product obtained from the grinding treatment is stable to lipid oxidation. It also may be used in preparing instant whole grain food products.

Abstract: A process for preparing shelf-stable granular bakery mixes from combinations of edible dry ingredients and edible liquid and/or plastic ingredients.

Abstract: The invention provides pyrimidine compounds having formula A. The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, and various other specific receptor and non-receptor kinases.

Abstract: Plant sterols and plant sterol esters have been shown to be cholesterol-reducing agents in human serum. In the present invention, plant sterols and plant stanols are incorporated into compositions which are dispersible in water by complexing the hydrophobic lipids with water-soluble carbohydrates. The resulting plant sterol-carbohydrate complexes are in an aqueous or powder form which can be readily incorporated with food products in an amount effective to reduce serum cholesterol levels in a human consuming such food product, without adversely modifying the organoleptic properties of the food product.

Abstract: The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention relates to a downhole tool including a selectively releasable joint, a downhole drilling assembly including the downhole tool, and to a corresponding method. In one embodiment of the invention, a downhole drilling assembly includes a downhole tool having a first body and a second body mounted for relative rotation; a joint part for use in forming a selectively releasable joint between the second body and a part of the assembly coupled to the second body; and one or more locking member(s) for locking the first and second bodies relative to one another against relative rotation so as to allow a release force to be applied through the first body to release the releasable joint and allow the tool to be separated from the part of the assembly.

Abstract: A turbine is disclosed which includes a turbine blade housing having an inner facing portion of a first material having a first coefficient of expansion, and a turbine blade body having an outer facing portion of a second coefficient of expansion greater than said first coefficient. In a preferred embodiment, the blade housing comprises a number of steel shroud rings and the turbine blade body comprises a number of stators and rotors of a thermoplastic material. An interference fit between stator blades and the shroud rings is enhanced in use due to the difference in thermal and/or hydrophilic coefficients of expansion of the first and second materials.

Abstract: This invention relates to simulated nut production. More specifically, it relates to a method for producing a simulated nut, said method comprising providing a premix by mixing soy bean particles having surfaces, a nut flavoring, and a binder comprising a saccharide in a wet flowable form wherein the surfaces of the soy bean particles are coated with the binder, and forming the premix into a self-supporting shape that is substantially similar to a natural nut shape. The resulting simulated nut product is healthier due to the substantial soy content used instead of real nutmeat, while replicating authentic nut flavor, crunch, appearance, texture, and the like. The simulated nuts of the present invention can be made at less cost than obtaining real nuts.