Abstract: Data indicating a corresponding safety state information indicating an extent to which that operating zone currently is or is not available to the robotic system to perform tasks using one or more robotic instrumentalities associated with a robotic system is used, for each of a plurality of operating zones, to dynamically schedule and perform tasks associated with a higher level objective. The corresponding safety state information associated with the first operating zone indicating one of a plurality of safety states associated with a presence of a human worker in the first operating zone is received from one or more sensors associated with a first operating zone of the plurality of operating zones. Autonomous behavior of the one or more robotic instrumentalities is altered based on the one of the plurality of safety states associated with the presence of the human worker in the first operating zone indicated by the corresponding safety state information.

Abstract: Provided is a system for controlling digital cinematic content based on emotional state of characters. A focus on one or more computer-controlled characters appearing in digital cinematic content is determined based on emotion indicators of a first user actively interacting with at least the one or more computer-controlled characters. A set of emotion indicators is inferred for each of the one or more computer-controlled characters based on one or more criteria and multifactor feedback loops are created. A story line of the digital cinematic content and behavioural characteristics of the one or more computer-controlled characters are controlled to achieve a target emotional arc of the first user based on the multifactor feedback loops.

Abstract: In some examples, novel nanogel particles are described having dual functionality, temperature responsiveness and pH responsiveness. For nucleic acid sequencing, amplification primers are grafted to nanogel particles to form primer-grafted nanogel particles, and the primer-grafted nanogel particles are captured onto surfaces within a flow cell. Within flow cells such as used in SBS nucleic acid sequencing, each primer-grafted nanogel particle functions as a nano-well in the flow cell, thus eliminating the need for nano-wells in some examples.

Abstract: Systems and methods for adjusting insurance premiums are provided. Embodiments provide systems and methods for providing a time-based adjustment to insurance premiums, as well as premium adjustment, and risk management. Some embodiments use collected data, such as telematics to take in data and determine, on a periodic basis, when a vehicle is actually moving and when it is not. In some embodiments, an insurance policy can be adjusted in real-time based on driving behaviors or restrictions.

Abstract: Systems and methods for adjusting insurance premiums are provided. Embodiments provide systems and methods for providing a time-based adjustment to insurance premiums, as well as premium adjustment, and risk management. Some embodiments use collected data, such as telematics to take in data and determine, on a periodic basis, when a vehicle is actually moving and when it is not. In some embodiments, an insurance policy can be adjusted in real-time based on driving behaviors or restrictions.

Abstract: Methods, systems, and apparatuses for audience metric determination are described herein. An audience segment may be targeted for delivery of content. A clustering algorithm may be used to categorize a quantity of users or devices into subsets based on a propensity to consume, present or output a particular type of content, and a quantity of time to output the particular type of content. A weight may be assigned to each subset based on its relevance to other subsets, such as based on data variance, e.g., on a distance to a midpoint of a specific subset of the subsets. An index parameter may be determined for the datasets, e.g., based on each weight for each subset, and data may be generated that reflects a ranking of content delivery spots for delivery of content to the audience segment.

Abstract: A magneto-electrophoretic medium that can be globally and locally addressed and erased. The medium provides a writeable display with no perceivable lag and the ability to write and erase with only minimal power requirements. In particular, the magneto-electrophoretic medium can be erased by providing a subthreshold electric stimulus and supplementing a second non-electric stimulus that disturbs the written state and allows the magneto-electrophoretic particles to return to their original state.

Abstract: Methods and apparatus for forming plasma in a process chamber use an annular exciter formed of a first conductive material with a first end electrically connected to an RF power source that provides RF current and a second end connected to a ground and an annular applicator, physically separated from the annular exciter, formed of a second conductive material with at least one angular split with an angle forming an upper overlap portion and a lower overlap portion separated by a high K dielectric material which is configured to provide capacitance in conjunction with an inductance of the annular applicator to form a resonant circuit that is configured to resonate when the annular exciter flows RF current that inductively excites the annular applicator to a resonant frequency which forms azimuthal plasma from the annular applicator.

Abstract: Disclosed are methods of making selective estrogen receptor degraders (SERDs) of Formula A, as well as intermediates thereof, salts thereof including a pharmaceutically acceptable salt, and pharmaceutical compositions thereof: wherein either R1 or R2 is independently Cl, F, —CF3, or —CH3, and the other is H; and R7 is H or PG.

Abstract: Disclosed herein are methods of identifying homologous recombination deficiency (HRD) in omics data, comprising generating a mutational spectrum from omics data; and using the mutational spectrum in a trained model to identify HRD. Further disclosed herein are methods of treating a tumor that has HRD score indicating significant HRD events, comprising: obtaining omics data from a tumor sample and generating a mutational spectrum from omics data; using the mutational spectrum in a trained model to identify HRD in the omics data from the tumor sample; identifying the cancer as likely responsive to treatment with a PARP inhibitor upon determination of HRD; and administering a PARP inhibitor treatment for the tumor upon determination of a high HRD score.

Abstract: Systems and methods for prediction of the treatment outcome for immune therapy are presented in which omics data of a patient tumor sample are used. Most typically, the omics data are processed to identify mutational signatures (especially APOBEC/POLE signatures), immune checkpoint expression, and MSI status as leading indicators to predict the treatment outcome for immune therapy. Such prediction advantageously integrates various parameters that would otherwise, when individually considered, skew prediction outcome.

Abstract: A method is disclosed to estimate the delay between an original signal and the corresponding captured signal. The signals are transformed and buffered to two sets of spectral descriptors for a similarity measure. The method advantageously offers robust delay estimation for inconsistent delays and adverse spectral distortions.

Abstract: Disclosed herein are self-assembling protein nanoparticles comprising passenger molecules of interest.

Abstract: A method for preparing a geothermal system involves preparing a wellbore that extends into an underground magma reservoir. Characteristics of the drilling process and the borehole are monitored to detect when the magma reservoir is reached, such that specially configured drilling operations can be performed to drill to a target depth within the magma reservoir.

Abstract: A robotic line kitting system is disclosed. Data indicating for each of a plurality of operating zones comprising a workspace with which the robotic line kitting system is associated a corresponding safety state information is stored. The data is used to dynamically schedule and perform tasks associated with a higher level objective, including by operating the one or more robotic instrumentalities in one or more operating zones, if any, indicated by the data to currently be available to perform tasks using the one or more robotic instrumentalities and by not operating the one or more robotic instrumentalities in one or more operating zones, if any, indicated by the data to not currently be available to perform tasks using the one or more robotic instrumentalities.

Abstract: Systems and methods for prediction of the treatment outcome for immune therapy are presented in which omics data of a patient tumor sample are used. Most typically, the omics data are processed to identify mutational signatures (especially APOBEC/POLE signatures), immune checkpoint expression, and MSI status as leading indicators to predict the treatment outcome for immune therapy. Such prediction advantageously integrates various parameters that would otherwise, when individually considered, skew prediction outcome.

Abstract: Embodiments of symmetric flow valves for use in a substrate processing chamber are provided herein. In some embodiments, a symmetric flow valve includes a valve body having sidewalls, a bottom plate, and a top plate that together define an interior volume, wherein the top plate includes one or more axisymmetrically disposed openings; a poppet disposed in the interior volume, wherein the poppet includes a central opening and a plurality of portions configured to selectively seal the one or more axisymmetrically disposed openings of the top plate when the symmetric flow valve is in a closed position; and a first actuator coupled to the poppet to position the poppet within the interior volume in at least an open position, where the poppet is spaced apart from the top plate to allow flow through the one or more axisymmetrically disposed openings of the top plate, and the closed position.

Abstract: Embodiments disclosed herein include a method for cleaning a bevel area of a substrate support disposed within a plasma processing chamber. In one example the method begins by placing a cover substrate on a substrate support disposed in an interior volume of a processing chamber. A cleaning gas is provided into the interior volume of the processing chamber. A plasma is struck in the interior volume of the processing chamber. A cleaning gas is provided through the substrate support to a bevel edge area defined between an outer diameter of the cover substrate and an edge ring disposed on the substrate support.

Abstract: The lighted surgical access system is provided that includes a circumferential retractor/protector and a light emitter system attached thereto. The circumferential retractor/protector retracts and protects a patient's body opening while the light emitter system illuminates the internal surgical site, body cavity or body opening.

Abstract: A method of preparing a vaccine includes providing an immune epitope database; providing a neural network; receiving data corresponding to at least one protein into the neural network; receiving data corresponding to one or more candidate peptides corresponding to potential cleavage products of the at least one protein, or determining, using the neural network, data corresponding to one or more candidate peptides corresponding to potential cleavage products of the at least one protein; calculating, using the neural network, a probability of cleavage of the protein to result in each of the one or more candidate peptides; and outputting a signal corresponding to the calculated probability. An architecture having two channel output, i.e., output of a C-terminal cleavage and an N-terminal cleavage, is described. Related devices, apparatuses, systems, techniques, articles and non-transitory computer-readable storage medium are also described.