Abstract: A vasculature navigation system may include a dilator having a proximal end and a distal end located opposite the proximal end, the dilator comprising a guidewire lumen extending between the proximal end and the distal end, the dilator defining a proximal portion and a distal portion located opposite the proximal portion. In some embodiments, the vasculature navigation system also includes an access port located at the proximal end of the dilator, a distal port located at the distal end of the dilator, and a hemostasis valve coupled to the proximal portion of the dilator. The hemostasis valve may be configured to control fluid flow between the proximal portion and the distal portion. In some embodiments, a flush port is coupled to the proximal portion of the dilator and located distal to the hemostasis valve, and the flush port is coupled to a fluid supply source.

Abstract: A vasculature navigation system may include a dilator having a proximal end and a distal end located opposite the proximal end, the dilator comprising a guidewire lumen extending between the proximal end and the distal end, the dilator defining a proximal portion and a distal portion located opposite the proximal portion. In some embodiments, the vasculature navigation system also includes an access port located at the proximal end of the dilator, a distal port located at the distal end of the dilator, and a hemostasis valve coupled to the proximal portion of the dilator. The hemostasis valve may be configured to control fluid flow between the proximal portion and the distal portion. In some embodiments, a flush port is coupled to the proximal portion of the dilator and located distal to the hemostasis valve, and the flush port is coupled to a fluid supply source.

Abstract: A vasculature navigation system may include a dilator having a proximal end and a distal end located opposite the proximal end, the dilator comprising a guidewire lumen extending between the proximal end and the distal end, the dilator defining a proximal portion and a distal portion located opposite the proximal portion. In some embodiments, the vasculature navigation system also includes an access port located at the proximal end of the dilator, a distal port located at the distal end of the dilator, and a hemostasis valve coupled to the proximal portion of the dilator. The hemostasis valve may be configured to control fluid flow between the proximal portion and the distal portion. In some embodiments, a flush port is coupled to the proximal portion of the dilator and located distal to the hemostasis valve, and the flush port is coupled to a fluid supply source.

Abstract: A vasculature navigation system may include a dilator having a proximal end and a distal end located opposite the proximal end, the dilator comprising a guidewire lumen extending between the proximal end and the distal end, the dilator defining a proximal portion and a distal portion located opposite the proximal portion. In some embodiments, the vasculature navigation system also includes an access port located at the proximal end of the dilator, a distal port located at the distal end of the dilator, and a hemostasis valve coupled to the proximal portion of the dilator. The hemostasis valve may be configured to control fluid flow between the proximal portion and the distal portion. In some embodiments, a flush port is coupled to the proximal portion of the dilator and located distal to the hemostasis valve, and the flush port is coupled to a fluid supply source.

Abstract: A vasculature navigation system may include a dilator having a proximal end and a distal end located opposite the proximal end, the dilator comprising a guidewire lumen extending between the proximal end and the distal end, the dilator defining a proximal portion and a distal portion located opposite the proximal portion. In some embodiments, the vasculature navigation system also includes an access port located at the proximal end of the dilator, a distal port located at the distal end of the dilator, and a hemostasis valve coupled to the proximal portion of the dilator. The hemostasis valve may be configured to control fluid flow between the proximal portion and the distal portion. In some embodiments, a flush port is coupled to the proximal portion of the dilator and located distal to the hemostasis valve, and the flush port is coupled to a fluid supply source.

Abstract: A catheter system may comprise an elongated access assist device configured to receive a guidewire during a thrombectomy. The device may include a hemostasis valve coupled to a proximal end of the device, whereby the valve controls fluid flow between a proximal portion and a distal portion of the device. The device may also include a flush port coupled to the proximal portion, where the flush port is configured to couple to a fluid supply source and facilitate the release of fluid from the fluid supply source through the elongated access assist device. The fluid may be configured to be released through a plurality of microperforations located along the body of the device, as well as on a distal tapered portion of the device. The distal tapered portion, combined with the release of fluid through the microperforations, may ease navigation of the system through the vasculature.

Abstract: In one aspect, a sighting device for a weapon includes an orientation sensor configured to detect a weapon cant, a display having one or more visual indicators, and a processor. The processor is configured to receive information regarding weapon cant from the orientation sensor and is further configured to control the one or more visual indicators of the display output to provide a visual indication of excessive weapon cant. In a further aspect, a method of sighting a target is provided.

Abstract: The present disclosure includes a method for altering one or more properties of a primary material. The method includes reducing the elasticity of a primary material and creating a delivery aperture through an outer layer of the primary material. Once the delivery aperture is created, or as the delivery aperture is created, introducing through the delivery aperture a secondary material into a sublayer of the primary material and applying a closure treatment to the primary material to close the delivery aperture. The secondary material includes one or more properties that are different from the primary material. By introducing the secondary material into the primary material, the secondary material locally changes the properties of the primary material. Examples of the variable properties include color, strength, flexibility, magnetism, and optical.

Abstract: A coupling for attaching to an end of a tube, pipe, conduit or other round solid or hollow section. The coupling includes an inner body and a collar to be provided around the inner body. The inner body has an interior bore passing through at least a portion thereof to receive a tube and the bore has one or more interior annular protuberances extending into the bore. When the collar is provided around the inner body it applies a circumferential compressive force to deform the inner body such that the one or more annular protuberances engage the tube to seal with it.

Abstract: An apparatus comprises a housing and a plurality of electrical contacts. Each of the plurality of electrical contacts are arranged to sequentially contact a contact device as the contact device moves through the housing. The contact device comprises a first end configured to couple to a bolt, a second end opposite the first end, and a conductive region between a first insulated region and a second insulated region.

Abstract: The present disclosure includes a method for altering one or more properties of a primary material. The method includes reducing the elasticity of a primary material and creating a delivery aperture through an outer layer of the primary material. Once the delivery aperture is created, or as the delivery aperture is created, introducing through the delivery aperture a secondary material into a sublayer of the primary material and applying a closure treatment to the primary material to close the delivery aperture. The secondary material includes one or more properties that are different from the primary material. By introducing the secondary material into the primary material, the secondary material locally changes the properties of the primary material. Examples of the variable properties include color, strength, flexibility, magnetism, and optical.

Abstract: An amplifier calibration system has a calibration controller, a comparator coupled between an amplifier to be tested and the calibration controller, and an analog test signal generator driven by the calibration controller and coupled to the amplifier input. The system applies a cycle of analog tests to the amplifier input. The cycle has an upward path and a downward path. The upward path includes three signal levels: lowest, medium low, and medium high. The downward path includes: highest, medium high, and medium low. The comparator determines successive polarities of the amplifier's responses to the cycle of analog tests. Based on the polarities, the system determines amplifier characteristics, and calibrates amplifier parameters to change the amplifier characteristics to desired values. Characteristics may include hysteresis, offset, input range values, and other amplifier specifications.

Abstract: An apparatus comprises a housing and a plurality of electrical contacts. Each of the plurality of electrical contacts are arranged to sequentially contact a contact device as the contact device moves through the housing. The contact device comprises a first end configured to couple to a bolt, a second end opposite the first end, and a conductive region between a first insulated region and a second insulated region.

Abstract: A valve assembly (1) controls the flow through a fluid pathway. The valve assembly (1) comprises a valve body (2) having a bore, and a spindle (20) received within the bore which is actuatable to open and close the valve. The spindle (20) has an axially upstream end arranged towards the fluid pathway and an opposing downstream end. A first seal (50) is provided about the spindle between the spindle and the bore and a biasing element (64) is arranged to impart an axial compressive force to the sealing element (50). The biasing element (64) is located within the valve body (2) between the spindle (20) and the bore on the downstream side of the seal to enables a more direct compressive force to be applied to the seal to improve sealing efficiency.

Abstract: A valve assembly (1) controls the flow through a fluid pathway. The valve assembly (1) comprises a valve body (2) having a bore, and a spindle (20) received within the bore which is actuatable to open and close the valve. The spindle (20) has an axially upstream end arranged towards the fluid pathway and an opposing downstream end. A first seal (50) is provided about the spindle between the spindle and the bore and a biasing element (64) is arranged to impart an axial compressive force to the sealing element (50). The biasing element (64) is located within the valve body (2) between the spindle (20) and the bore on the downstream side of the seal to enables a more direct compressive force to be applied to the seal to improve sealing efficiency.

Abstract: A coupling for attaching to an end of a tube, pipe, conduit or other round solid or hollow section. The coupling includes an inner body and a collar to be provided around the inner body. The inner body has an interior bore passing through at least a portion thereof to receive a tube and the bore has one or more interior annular protuberances extending into the bore. When the collar is provided around the inner body it applies a circumferential compressive force to deform the inner body such that the one or more annular protuberances engage the tube to seal with it.

Abstract: The present invention relates to a tap assembly for dispensing fluids from a flexible film bag such as a “bag-in-box”. Known taps associated with such flexible bags do not efficiently dispense fluid from a bag which is partially collapsed and/or can damage the opposite wall of the partially collapsed bag. The tap assembly includes a body with a bore, an actuation member to cover at least a portion of the bore and a piercer which is configured to pivot within the bore and pierce and cut a sterility membrane positioned over an open end of the bore upon movement of the actuation member by a user. The piercer comprises a curved surface which functions to position the piercer away from the plane of the adjacent bag wall after initial piercing.

Abstract: The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

Abstract: This invention provides an attachment for mounting electromagnetic identification tags onto the necks of bottles. The tag has a portion which provides a receptacle portion for an RFI tag. This receptacle portion is connected to a portion that embraces a neck of a bottle to attach the receptacle portion, and thereby, the RFID tag to the neck of the bottle. The identification tag may be formed from a material that does not interfere with electromagnetic signals.

Abstract: Known fluid dispensers can suffer from the disadvantage of inadvertent disconnection of a connector causing potentially hazardous spillage of fluid. The present invention relates to a fluid dispensing assembly comprising a tap and a connector body. The tap comprises a first valve, movable between an open and closed position to allow fluid flow through; and a first portion of an interlocking coupling, configured for rotational engagement with a second complementary interlocking coupling portion of the connector body by rotation about a first fluid dispensing assembly axis. The connector body also comprises a second valve, movable between an open and closed position to allow fluid flow through. By this configuration, the first and second interlocking coupling portions remain interlocked preventing disconnection of the connector body from the tap unless the first and second valves are both in the closed position.